hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14324.1
Complex Portal: CPX-10616
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ABCA9 | ATP-binding cassette sub-family A member 9 (EC 7.6.2.-) | 5 | UniProt NCBI |
| SGTA | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | 5 | UniProt NCBI |
| PDE12 | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | 5 | UniProt NCBI |
| GET4 | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | 5 | UniProt NCBI |
| SGTB | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | 5 | UniProt NCBI |
| SCN1B | Sodium channel subunit beta-1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0072379 | 0.000548960443183 | 0.5 | SGTB SGTA GET4 | ER membrane insertion complex |
| GO:0006620 | 0.000698569295426 | 0.5 | SGTB SGTA GET4 | post-translational protein targeting to endoplasmic reticulum membrane |
| REAC:R-HSA-9609523 | 0.00309047926945 | 0.333333333333 | SGTA GET4 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
| KEGG:03060 | 0.0031464101682 | 0.333333333333 | SGTA GET4 | Protein export |
| GO:0045047 | 0.00627357313526 | 0.5 | SGTB SGTA GET4 | protein targeting to ER |
| GO:0072380 | 0.00702301080125 | 0.333333333333 | SGTA SGTB | TRC complex |
| GO:0072599 | 0.00860399003151 | 0.5 | SGTB SGTA GET4 | establishment of protein localization to endoplasmic reticulum |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDE12 | GET4 | 0.972 | 0.096 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| GET4 | SGTA | 0.9 | 0.118 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ABCA9 | GET4 | 0.894 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SGTA | SGTB | 0.872 | 0.098 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GET4 | SCN1B | 0.869 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GET4 | SGTB | 0.466 | 0.086 | hein_WMM bioplex3_WMM hein () | |
| ABCA9 | SGTA | 0.084 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDE12 | SGTB | 0.039 | 0.106 | hein_WMM bioplex3_HEK293 hein () bioplex3_HCT116 | |
| SCN1B | SGTA | 0.019 |
structurally_consistent (Q7L5D6)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PDE12 | ABCA9 | 0.012 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDE12 | SGTA | 0.009 | 0.098 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| PDE12 | SCN1B | 0.005 | bioplex3_HEK293 bioplex3_HCT116 WMM_only |
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