hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14332.1
Complex Portal: CPX-23716
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ABCA10 | ATP-binding cassette sub-family A member 10 (EC 7.6.2.-) | 5 | UniProt NCBI |
| PMM2 | Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8) | 5 | UniProt NCBI |
| PMM1 | Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22) | 5 | UniProt NCBI |
| ABCA9 | ATP-binding cassette sub-family A member 9 (EC 7.6.2.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446205 | 0.000102497642323 | 0.5 | PMM2 PMM1 | Synthesis of GDP-mannose |
| REAC:R-HSA-1369062 | 0.000931962666506 | 0.5 | ABCA10 ABCA9 | ABC transporters in lipid homeostasis |
| KEGG:00051 | 0.0014030052018 | 0.5 | PMM2 PMM1 | Fructose and mannose metabolism |
| KEGG:02010 | 0.0014030052018 | 0.5 | ABCA10 ABCA9 | ABC transporters |
| KEGG:01250 | 0.00148789987369 | 0.5 | PMM2 PMM1 | Biosynthesis of nucleotide sugars |
| KEGG:00520 | 0.00247340401034 | 0.5 | PMM2 PMM1 | Amino sugar and nucleotide sugar metabolism |
| GO:0004615 | 0.0028092043205 | 0.5 | PMM2 PMM1 | phosphomannomutase activity |
| GO:0006013 | 0.00842684400117 | 0.5 | PMM2 PMM1 | mannose metabolic process |
| GO:0009298 | 0.0168521501606 | 0.5 | PMM2 PMM1 | GDP-mannose biosynthetic process |
| REAC:R-HSA-446219 | 0.0168610262513 | 0.5 | PMM2 PMM1 | Synthesis of substrates in N-glycan biosythesis |
| KEGG:01240 | 0.0220824431074 | 0.5 | PMM2 PMM1 | Biosynthesis of cofactors |
| REAC:R-HSA-446193 | 0.0267695204965 | 0.5 | PMM2 PMM1 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| GO:0019673 | 0.042122686785 | 0.5 | PMM2 PMM1 | GDP-mannose metabolic process |
| REAC:R-HSA-382556 | 0.0444386798825 | 0.5 | ABCA10 ABCA9 | ABC-family proteins mediated transport |
| REAC:R-HSA-4043911 | 0.0499436884912 | 0.25 | PMM2 | Defective PMM2 causes PMM2-CDG |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PMM2 | PMM1 | 1.0 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ABCA9 | PMM1 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ABCA10 | ABCA9 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ABCA9 | PMM2 | 0.027 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| ABCA10 | huMAP3_02707.1 huMAP3_10648.1 huMAP3_12932.1 huMAP3_14023.1 huMAP3_14332.1 |
| PMM2 | huMAP3_03351.1 huMAP3_10483.1 huMAP3_14332.1 |
| PMM1 | huMAP3_03351.1 huMAP3_10483.1 huMAP3_14332.1 |
| ABCA9 | huMAP3_02707.1 huMAP3_10483.1 huMAP3_12932.1 huMAP3_14324.1 huMAP3_14332.1 |