hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14334.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFAP5 | Microfibrillar-associated protein 5 (MFAP-5) (MP25) (Microfibril-associated glycoprotein 2) (MAGP-2) | 5 | UniProt NCBI |
| CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) | 5 | UniProt NCBI |
| PLAAT4 | Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 7.27326653199e-05 | 0.6 | CASTOR1 CASTOR2 MIOS | Amino acids regulate mTORC1 |
| GO:0061700 | 8.06911104389e-05 | 0.6 | CASTOR1 CASTOR2 MIOS | GATOR2 complex |
| GO:0035859 | 0.000274621184043 | 0.6 | CASTOR1 CASTOR2 MIOS | Seh1-associated complex |
| KEGG:04150 | 0.000486709886236 | 0.6 | CASTOR1 CASTOR2 MIOS | mTOR signaling pathway |
| REAC:R-HSA-9711097 | 0.00179850740956 | 0.6 | CASTOR1 CASTOR2 MIOS | Cellular response to starvation |
| GO:1903577 | 0.00468200720083 | 0.4 | CASTOR1 CASTOR2 | cellular response to L-arginine |
| GO:1904262 | 0.0109904490822 | 0.6 | CASTOR1 CASTOR2 MIOS | negative regulation of TORC1 signaling |
| GO:1903576 | 0.0140440992017 | 0.4 | CASTOR1 CASTOR2 | response to L-arginine |
| GO:0032007 | 0.0310683011928 | 0.6 | CASTOR1 CASTOR2 MIOS | negative regulation of TOR signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PLAAT4 | CASTOR1 | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PLAAT4 | CASTOR2 | 0.97 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CASTOR1 | CASTOR2 | 0.917 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CASTOR1 | MIOS | 0.9 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MIOS | MFAP5 | 0.847 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PLAAT4 | MIOS | 0.779 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes