hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14355.1
Complex Portal: CPX-12663
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TPD52L2 | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | 5 | UniProt NCBI |
| TPD52L1 | Tumor protein D53 (hD53) (Tumor protein D52-like 1) | 5 | UniProt NCBI |
| GRIN3B | Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B) | 5 | UniProt NCBI |
| TPD52 | Tumor protein D52 (Protein N8) | 5 | UniProt NCBI |
| GRIN3A | Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L) | 5 | UniProt NCBI |
| GUCY1A2 | Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) | 5 | UniProt NCBI |
| TPD52L3 | Tumor protein D55 (hD55) (Testis development protein NYD-SP25) (Tumor protein D52-like 3) | 3 | UniProt NCBI |
| GUCY1B1 | Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) | 5 | UniProt NCBI |
| MXRA7 | Matrix-remodeling-associated protein 7 | 3 | UniProt NCBI |
| C19orf44 | Uncharacterized protein C19orf44 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5398 | 0.00278824374686 | 0.222222222222 | GRIN3A GRIN3B | NRXN1 deletion syndrome |
| KEGG:05033 | 0.0046708432359 | 0.222222222222 | GRIN3A GRIN3B | Nicotine addiction |
| KEGG:05030 | 0.0138019713376 | 0.222222222222 | GRIN3A GRIN3B | Cocaine addiction |
| KEGG:05031 | 0.0267263448961 | 0.222222222222 | GRIN3A GRIN3B | Amphetamine addiction |
| WP:WP4539 | 0.0287089830042 | 0.222222222222 | GRIN3A GRIN3B | Synaptic signaling pathways associated with autism spectrum disorder |
| CORUM:407 | 0.0499842271994 | 0.111111111111 | GUCY1B1 | Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GUCY1B1 | MXRA7 | 1.0 | 0.09 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TPD52L2 | TPD52L1 | 0.999 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| TPD52L2 | TPD52 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | ||
| TPD52L3 | TPD52 | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TPD52L1 | TPD52 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| TPD52L3 | TPD52L1 | 0.994 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TPD52L3 | TPD52L2 | 0.994 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TPD52L1 | GRIN3B | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GUCY1A2 | GUCY1B1 | 0.993 |
mutually_exclusive (Q02108)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TPD52 | GRIN3B | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GRIN3B | GRIN3A | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GUCY1B1 | GRIN3B | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TPD52L2 | GRIN3B | 0.96 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GRIN3B | C19orf44 | 0.925 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MXRA7 | GRIN3B | 0.903 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GUCY1A2 | MXRA7 | 0.572 |
mutually_exclusive (Q02153)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MXRA7 | GRIN3A | 0.415 | bioplex3_WMM WMM_only | ||
| GRIN3A | C19orf44 | 0.415 | bioplex3_WMM WMM_only | ||
| TPD52L1 | GRIN3A | 0.278 | bioplex3_WMM WMM_only | ||
| GUCY1B1 | GRIN3A | 0.254 | bioplex3_WMM WMM_only | ||
| MXRA7 | C19orf44 | 0.25 | bioplex3_WMM WMM_only | ||
| TPD52 | GRIN3A | 0.21 | bioplex3_WMM WMM_only | ||
| TPD52 | MXRA7 | 0.118 | bioplex3_WMM WMM_only | ||
| TPD52L1 | GUCY1B1 | 0.116 | 0.1 | bioplex3_WMM WMM_only | |
| GUCY1B1 | C19orf44 | 0.102 | bioplex3_WMM WMM_only | ||
| TPD52 | GUCY1B1 | 0.096 | bioplex3_WMM WMM_only | ||
| TPD52L2 | GRIN3A | 0.093 | bioplex3_WMM WMM_only | ||
| TPD52L2 | GUCY1B1 | 0.08 | 0.094 | bioplex3_WMM WMM_only | |
| TPD52L1 | MXRA7 | 0.078 | 0.042 | bioplex3_WMM WMM_only | |
| TPD52L1 | C19orf44 | 0.076 | bioplex3_WMM WMM_only | ||
| TPD52 | C19orf44 | 0.076 | bioplex3_WMM WMM_only | ||
| TPD52L2 | MXRA7 | 0.065 | 0.06 | bioplex3_WMM WMM_only | |
| TPD52L2 | C19orf44 | 0.015 | bioplex3_WMM gupta_WMM WMM_only |
Related Complexes