hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14365.1
Complex Portal: CPX-20440
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TOP2B | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | 5 | UniProt NCBI |
| MDC1 | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | 5 | UniProt NCBI |
| PHIP | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | 5 | UniProt NCBI |
| BRWD1 | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | 5 | UniProt NCBI |
| ZNF451 | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | 5 | UniProt NCBI |
| ORC1 | Origin recognition complex subunit 1 (Replication control protein 1) | 5 | UniProt NCBI |
| SCAPER | S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ORC1 | PHIP | 0.998 | 0.2 | hein_WMM bioplex3_WMM hein () | |
| PHIP | TOP2B | 0.966 | hein_WMM bioplex3_WMM gupta_WMM fraction | ||
| BRWD1 | PHIP | 0.955 | 0.55 | hein_WMM gupta_WMM WMM_only | |
| ORC1 | TOP2B | 0.95 | hein_WMM bioplex3_WMM WMM_only | ||
| ZNF451 | TOP2B | 0.949 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | ||
| SCAPER | ORC1 | 0.945 | 0.206 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| MDC1 | PHIP | 0.852 | 0.218 | hein_WMM gupta_WMM WMM_only | |
| MDC1 | TOP2B | 0.681 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| BRWD1 | TOP2B | 0.656 | hein_WMM gupta_WMM WMM_only | ||
| MDC1 | ORC1 | 0.232 | 0.342666666667 | hein_WMM WMM_only | |
| ORC1 | BRWD1 | 0.048 | 0.156 | hein_WMM WMM_only | |
| MDC1 | BRWD1 | 0.035 | 0.212 | gupta_WMM WMM_only | |
| MDC1 | ZNF451 | 0.03 | 0.16452 | youn_WMM WMM_only | |
| SCAPER | MDC1 | 0.007 | 0.18 | youn_WMM WMM_only |
Related Complexes