hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14370.1
Complex Portal: CPX-15752
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | 5 | UniProt NCBI |
| DPYSL4 | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | 5 | UniProt NCBI |
| PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2960 | 0.0249718442456 | 0.333333333333 | PLCG1 | SLP-76-PLC-gamma-1-ITK complex, alpha-TCR stimulated |
| CORUM:2961 | 0.0249718442456 | 0.333333333333 | PLCG1 | SLP-76-PLC-gamma-1-VAV complex, alpha-TCR stimulated |
| REAC:R-HSA-167021 | 0.0498224659464 | 0.333333333333 | PLCG1 | PLC-gamma1 signalling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DPYSL4 | PLCG1 | 0.982 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DPYSL4 | MAP4K2 | 0.976 | 0.05 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAP4K2 | PLCG1 | 0.462 | bioplex3_WMM WMM_only |
Related Complexes