hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14386.1
Complex Portal: CPX-20229
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLITRK5 | SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11) | 5 | UniProt NCBI |
| SLITRK4 | SLIT and NTRK-like protein 4 | 5 | UniProt NCBI |
| RXFP2 | Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2) | 5 | UniProt NCBI |
| LRRTM2 | Leucine-rich repeat transmembrane neuronal protein 2 (Leucine-rich repeat neuronal 2 protein) | 5 | UniProt NCBI |
| GPC3 | Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] | 5 | UniProt NCBI |
| CHAD | Chondroadherin (Cartilage leucine-rich protein) | 4 | UniProt NCBI |
| LRRTM3 | Leucine-rich repeat transmembrane neuronal protein 3 | 5 | UniProt NCBI |
| CNPY4 | Protein canopy homolog 4 | 3 | UniProt NCBI |
| OGN | Mimecan (Osteoglycin) (Osteoinductive factor) (OIF) | 5 | UniProt NCBI |
| CNPY3 | Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6794362 | 1.41485573053e-05 | 0.444444444444 | LRRTM2 LRRTM3 SLITRK5 SLITRK4 | Protein-protein interactions at synapses |
| REAC:R-HSA-112316 | 0.00466586914188 | 0.444444444444 | LRRTM2 LRRTM3 SLITRK5 SLITRK4 | Neuronal System |
| REAC:R-HSA-388844 | 0.00724150508664 | 0.222222222222 | SLITRK5 SLITRK4 | Receptor-type tyrosine-protein phosphatases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CHAD | CNPY3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| OGN | CNPY3 | 0.994 | 0.016 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LRRTM3 | CNPY3 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CNPY4 | CHAD | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SLITRK5 | CNPY3 | 0.952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRRTM2 | CNPY3 | 0.951 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CNPY4 | LRRTM2 | 0.92 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRTM3 | GPC3 | 0.912 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RXFP2 | CNPY4 | 0.908 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LRRTM2 | GPC3 | 0.851 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CNPY3 | SLITRK4 | 0.844 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CNPY4 | CNPY3 | 0.679 | 0.032 |
mutually_exclusive (O43300)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| LRRTM3 | CNPY4 | 0.622 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RXFP2 | CNPY3 | 0.286 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CNPY4 | GPC3 | 0.281 |
structurally_consistent (O43300)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| SLITRK5 | OGN | 0.129 | bioplex3_HEK293 bioplex () | ||
| CNPY4 | SLITRK5 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CNPY3 | GPC3 | 0.052 |
structurally_consistent (O43300)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| SLITRK5 | LRRTM2 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SLITRK5 | GPC3 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes