hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14403.1

Complex Portal: CPX-20051

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RBMXL3	RNA-binding motif protein, X-linked-like-3	2	UniProt NCBI
CBARP	Voltage-dependent calcium channel beta subunit-associated regulatory protein	5	UniProt NCBI
CACNB4	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4)	5	UniProt NCBI
CACNB2	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)	5	UniProt NCBI
CACNB1	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)	5	UniProt NCBI
CACNB3	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)	5	UniProt NCBI
BIN1	Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-112308	1.24872445941e-10	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Presynaptic depolarization and calcium channel opening
GO:1903169	2.38702192482e-08	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of calcium ion transmembrane transport
REAC:R-HSA-419037	6.24091028415e-08	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	NCAM1 interactions
GO:0051924	2.20685143847e-07	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of calcium ion transport
REAC:R-HSA-375165	3.97050332478e-07	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	NCAM signaling for neurite out-growth
WP:WP2118	7.52481276022e-07	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Arrhythmogenic right ventricular cardiomyopathy
KEGG:05412	7.74681871196e-07	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Arrhythmogenic right ventricular cardiomyopathy
GO:0008331	9.20349554216e-07	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	high voltage-gated calcium channel activity
GO:0061577	9.20349554216e-07	0.571428571429	CACNB2 BIN1 CACNB1 CACNB3	calcium ion transmembrane transport via high voltage-gated calcium channel
KEGG:04260	9.77989176275e-07	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Cardiac muscle contraction
GO:1904062	1.15066454941e-06	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of monoatomic cation transmembrane transport
GO:0070588	1.15066454941e-06	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	calcium ion transmembrane transport
KEGG:05410	1.21881878023e-06	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Hypertrophic cardiomyopathy
KEGG:05414	1.21881878023e-06	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Dilated cardiomyopathy
GO:0034765	2.04574701914e-06	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of monoatomic ion transmembrane transport
GO:1901385	3.56078348733e-06	0.571428571429	CACNB2 CACNB3 CBARP CACNB4	regulation of voltage-gated calcium channel activity
GO:0010959	4.07877202556e-06	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of metal ion transport
GO:0006816	6.36255217755e-06	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	calcium ion transport
GO:0007528	6.71679244503e-06	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	neuromuscular junction development
KEGG:04921	7.23974092484e-06	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Oxytocin signaling pathway
KEGG:04261	7.4903203623e-06	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Adrenergic signaling in cardiomyocytes
GO:0043269	9.85233037068e-06	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of monoatomic ion transport
GO:0034762	1.44863747255e-05	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of transmembrane transport
GO:0005245	2.88491178252e-05	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	voltage-gated calcium channel activity
GO:0030315	3.29649973093e-05	0.571428571429	CACNB2 BIN1 CACNB1 CACNB3	T-tubule
GO:0005891	3.75057231239e-05	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	voltage-gated calcium channel complex
WP:WP382	0.000106586503568	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	MAPK signaling pathway
KEGG:04010	0.000130964006708	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	MAPK signaling pathway
GO:0098662	0.000156054697816	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	inorganic cation transmembrane transport
GO:0098655	0.000165482160715	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	monoatomic cation transmembrane transport
GO:0034704	0.000228371329052	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	calcium channel complex
REAC:R-HSA-112315	0.000237250215483	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Transmission across Chemical Synapses
GO:0098660	0.000255915362845	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	inorganic ion transmembrane transport
GO:1990454	0.000282244947588	0.428571428571	CACNB2 CACNB1 CACNB3	L-type voltage-gated calcium channel complex
GO:1901019	0.000288863510592	0.571428571429	CACNB2 CACNB3 CBARP CACNB4	regulation of calcium ion transmembrane transporter activity
GO:0034220	0.000384151115459	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	monoatomic ion transmembrane transport
GO:0030001	0.000430067905982	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	metal ion transport
GO:0042383	0.000617288463902	0.571428571429	CACNB2 BIN1 CACNB1 CACNB3	sarcolemma
GO:0006812	0.000803146417894	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	monoatomic cation transport
GO:1902514	0.000960187650128	0.428571428571	CACNB2 CACNB1 BIN1	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0005262	0.0010475236298	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	calcium channel activity
REAC:R-HSA-112316	0.00109485698971	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Neuronal System
GO:2001257	0.00116762839146	0.571428571429	CACNB2 CACNB3 CBARP CACNB4	regulation of cation channel activity
GO:0022843	0.00159023569175	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	voltage-gated monoatomic cation channel activity
REAC:R-HSA-5576893	0.00171179400053	0.285714285714	CACNB2 CACNB1	Phase 2 - plateau phase
GO:0006811	0.00193994158254	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	monoatomic ion transport
GO:0015085	0.0023201010514	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	calcium ion transmembrane transporter activity
GO:0022832	0.00341296393133	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	voltage-gated channel activity
GO:0005244	0.00341296393133	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	voltage-gated monoatomic ion channel activity
GO:0055085	0.00701887400633	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	transmembrane transport
REAC:R-HSA-422475	0.00732241318188	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Axon guidance
REAC:R-HSA-9675108	0.00845717716544	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	Nervous system development
REAC:R-HSA-400042	0.0087631788483	0.285714285714	CACNB2 CACNB3	Adrenaline,noradrenaline inhibits insulin secretion
GO:0034703	0.0102459046675	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	cation channel complex
REAC:R-HSA-5576892	0.0104655132242	0.285714285714	CACNB2 CACNB1	Phase 0 - rapid depolarisation
GO:0032412	0.0158957528863	0.571428571429	CACNB2 CACNB3 CBARP CACNB4	regulation of monoatomic ion transmembrane transporter activity
GO:0022898	0.019209729773	0.571428571429	CACNB2 CACNB3 CBARP CACNB4	regulation of transmembrane transporter activity
GO:0032409	0.025426163185	0.571428571429	CACNB2 CACNB3 CBARP CACNB4	regulation of transporter activity
GO:0034702	0.0280218637102	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	monoatomic ion channel complex
WP:WP5356	0.028073243565	0.285714285714	CACNB2 CACNB1	Affected pathways in Duchenne muscular dystrophy
GO:0022836	0.0361823866547	0.571428571429	CACNB2 CACNB3 CACNB4 CACNB1	gated channel activity
GO:0051049	0.0393075723879	0.857142857143	CACNB2 BIN1 CACNB1 CACNB4 CACNB3 CBARP	regulation of transport

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CACNB3	CACNB2	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CACNB3	CACNB1	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CBARP	CACNB3	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RBMXL3	CACNB1	0.998			bioplex3_WMM bioplex3_HCT116 WMM_only
CACNB2	CACNB1	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CBARP	CACNB1	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CACNB4	CACNB3	0.995		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CACNB3	RBMXL3	0.904			bioplex3_WMM WMM_only
CACNB4	CACNB2	0.902			bioplex3_WMM WMM_only
CBARP	BIN1	0.838	0.072		bioplex3_HEK293 bioplex3_WMM WMM_only
CACNB4	CBARP	0.768		structurally_consistent (P54284)	bioplex3_WMM WMM_only
CBARP	CACNB2	0.754	0.09		bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
CBARP	RBMXL3	0.478			bioplex3_WMM WMM_only
CACNB2	RBMXL3	0.214			bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RBMXL3	huMAP3_01863.1 huMAP3_02609.1 huMAP3_06519.1 huMAP3_08329.1 huMAP3_09033.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_10586.1 huMAP3_11209.1 huMAP3_13029.1 huMAP3_13440.1 huMAP3_13920.1 huMAP3_14403.1
CBARP	huMAP3_00355.1 huMAP3_08329.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_12693.1 huMAP3_12897.1 huMAP3_14403.1
CACNB4	huMAP3_00355.1 huMAP3_00599.1 huMAP3_09795.1 huMAP3_10193.1 huMAP3_10522.1 huMAP3_10929.1 huMAP3_10945.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1
CACNB2	huMAP3_00355.1 huMAP3_08329.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1
CACNB1	huMAP3_01863.1 huMAP3_08329.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1
CACNB3	huMAP3_00355.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1
BIN1	huMAP3_04492.1 huMAP3_12693.1 huMAP3_14403.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14403.1

Complex Portal: CPX-20051