hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14408.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MRI1 | Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) | 5 | UniProt NCBI |
| FAAP20 | Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa) | 5 | UniProt NCBI |
| FANCG | Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9) | 5 | UniProt NCBI |
| FANCA | Fanconi anemia group A protein (Protein FACA) | 5 | UniProt NCBI |
| POU2F2 | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6783310 | 2.03584684634e-05 | 0.6 | FANCA FAAP20 FANCG | Fanconi Anemia Pathway |
| CORUM:91 | 4.09448956317e-05 | 0.4 | FANCG FANCA | FA complex (Fanconi anemia complex), cytoplasmic |
| CORUM:3083 | 8.18785830799e-05 | 0.4 | FANCG FANCA | FA core complex 1 (Fanconi anemia core complex 1) |
| CORUM:1623 | 8.18785830799e-05 | 0.4 | FANCG FANCA | FA core complex 1 (Fanconi anemia core complex 1) |
| CORUM:1625 | 0.000204640425412 | 0.4 | FANCG FANCA | FA core complex (Fanconi anemia core complex) |
| GO:0043240 | 0.000211268761872 | 0.6 | FANCA FAAP20 FANCG | Fanconi anaemia nuclear complex |
| CORUM:1152 | 0.000286457379015 | 0.4 | FANCG FANCA | FA complex (Fanconi anemia complex) |
| CORUM:1624 | 0.00038189088864 | 0.4 | FANCG FANCA | FA core complex (Fanconi anemia core complex) |
| CORUM:245 | 0.00038189088864 | 0.4 | FANCG FANCA | FA core complex (Fanconi anemia core complex) |
| CORUM:6884 | 0.000490935356523 | 0.4 | FANCG FANCA | Fanconi anemia FAAP100 complex |
| CORUM:248 | 0.000490935356523 | 0.4 | FANCG FANCA | BRAFT complex |
| CORUM:2739 | 0.000613585186048 | 0.4 | FANCG FANCA | FA complex (Fanconi anemia complex) |
| CORUM:244 | 0.000749834781753 | 0.4 | FANCG FANCA | BRAFT complex |
| GO:0036297 | 0.00522817157061 | 0.6 | FANCA FAAP20 FANCG | interstrand cross-link repair |
| KEGG:03460 | 0.00531136476892 | 0.4 | FANCG FANCA | Fanconi anemia pathway |
| GO:0006513 | 0.0135806930791 | 0.6 | FANCA FAAP20 FANCG | protein monoubiquitination |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | FANCA FAAP20 FANCG | DNA Repair |
| HP:0005522 | 0.0147751514018 | 0.4 | FANCG FANCA | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 0.0161800923797 | 0.4 | FANCG FANCA | Absent testis |
| HP:0010293 | 0.0224351839587 | 0.4 | FANCG FANCA | Aplasia/Hypoplasia of the uvula |
| HP:0012848 | 0.0224351839587 | 0.4 | FANCG FANCA | Small intestinal stenosis |
| HP:0100867 | 0.0224351839587 | 0.4 | FANCG FANCA | Duodenal stenosis |
| HP:0002245 | 0.0241576577336 | 0.4 | FANCG FANCA | Meckel diverticulum |
| HP:0100760 | 0.0241576577336 | 0.4 | FANCG FANCA | Clubbing of toes |
| HP:0100587 | 0.0277928629638 | 0.4 | FANCG FANCA | Abnormal preputium morphology |
| HP:0001924 | 0.0316815705386 | 0.4 | FANCG FANCA | Sideroblastic anemia |
| WP:WP4946 | 0.0366585107731 | 0.4 | FANCG FANCA | DNA repair pathways full network |
| HP:0001549 | 0.0425110382594 | 0.4 | FANCG FANCA | Abnormal ileum morphology |
| WP:WP5316 | 0.0477224874935 | 0.4 | FANCG FANCA | Primary ovarian insufficiency |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FANCG | FANCA | 1.0 | 0.232 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FAAP20 | FANCA | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FAAP20 | FANCG | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| POU2F2 | FAAP20 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FANCG | MRI1 | 0.895 | 0.06 | hein_WMM bioplex3_WMM WMM_only |
| POU2F2 | FANCG | 0.356 | 0.096 | bioplex3_WMM WMM_only |
| POU2F2 | FANCA | 0.188 | 0.148 | bioplex3_WMM WMM_only |
| MRI1 | FANCA | 0.025 | 0.052 | bioplex3_WMM WMM_only |
Related Complexes