hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14409.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RTL9 | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | 2 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| FUT1 | Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP698 | 0.000390164573598 | 0.5 | UGT1A7 UGT1A8 | Glucuronidation |
| KEGG:00053 | 0.000578341586214 | 0.5 | UGT1A7 UGT1A8 | Ascorbate and aldarate metabolism |
| KEGG:00040 | 0.000750887219606 | 0.5 | UGT1A7 UGT1A8 | Pentose and glucuronate interconversions |
| REAC:R-HSA-156588 | 0.00122873738811 | 0.5 | UGT1A7 UGT1A8 | Glucuronidation |
| KEGG:00860 | 0.0013205961284 | 0.5 | UGT1A7 UGT1A8 | Porphyrin metabolism |
| KEGG:00140 | 0.00194963326435 | 0.5 | UGT1A7 UGT1A8 | Steroid hormone biosynthesis |
| KEGG:00830 | 0.00318369788962 | 0.5 | UGT1A7 UGT1A8 | Retinol metabolism |
| KEGG:05204 | 0.0034402616107 | 0.5 | UGT1A7 UGT1A8 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 0.00357225272753 | 0.5 | UGT1A7 UGT1A8 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 0.00412492963649 | 0.5 | UGT1A7 UGT1A8 | Bile secretion |
| KEGG:00980 | 0.00426927356048 | 0.5 | UGT1A7 UGT1A8 | Metabolism of xenobiotics by cytochrome P450 |
| REAC:R-HSA-9749641 | 0.00444848198459 | 0.5 | UGT1A7 UGT1A8 | Aspirin ADME |
| KEGG:00983 | 0.00551283411821 | 0.5 | UGT1A7 UGT1A8 | Drug metabolism - other enzymes |
| WP:WP5224 | 0.0138131669346 | 0.5 | UGT1A7 UGT1A8 | 2q37 copy number variation syndrome |
| GO:0052696 | 0.0168521501606 | 0.5 | UGT1A7 UGT1A8 | flavonoid glucuronidation |
| GO:0051552 | 0.0168521501606 | 0.5 | UGT1A7 UGT1A8 | flavone metabolic process |
| KEGG:01240 | 0.0220824431074 | 0.5 | UGT1A7 UGT1A8 | Biosynthesis of cofactors |
| GO:0009804 | 0.0280843539964 | 0.5 | UGT1A7 UGT1A8 | coumarin metabolic process |
| GO:0009698 | 0.0280843539964 | 0.5 | UGT1A7 UGT1A8 | phenylpropanoid metabolic process |
| REAC:R-HSA-156580 | 0.0321680026233 | 0.5 | UGT1A7 UGT1A8 | Phase II - Conjugation of compounds |
| KEGG:05207 | 0.0326315237827 | 0.5 | UGT1A7 UGT1A8 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-9748784 | 0.0329793636325 | 0.5 | UGT1A7 UGT1A8 | Drug ADME |
| GO:0052697 | 0.042122686785 | 0.5 | UGT1A7 UGT1A8 | xenobiotic glucuronidation |
| REAC:R-HSA-9033807 | 0.0499436884912 | 0.25 | FUT1 | ABO blood group biosynthesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RTL9 | UGT1A7 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UGT1A7 | FUT1 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UGT1A8 | UGT1A7 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTL9 | FUT1 | 0.904 | bioplex3_WMM WMM_only | |
| RTL9 | UGT1A8 | 0.415 | bioplex3_WMM WMM_only | |
| UGT1A8 | FUT1 | 0.146 | bioplex3_WMM WMM_only |
Related Complexes