hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14415.1
Complex Portal: CPX-15780
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRMT6 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) | 5 | UniProt NCBI |
| ARHGEF12 | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | 5 | UniProt NCBI |
| TRMT61A | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031515 | 0.00421361424067 | 0.666666666667 | TRMT61A TRMT6 | tRNA (m1A) methyltransferase complex |
| REAC:R-HSA-6782315 | 0.00453384142373 | 0.666666666667 | TRMT61A TRMT6 | tRNA modification in the nucleus and cytosol |
| GO:0043527 | 0.0294899169624 | 0.666666666667 | TRMT61A TRMT6 | tRNA methyltransferase complex |
| REAC:R-HSA-72306 | 0.0329299631783 | 0.666666666667 | TRMT61A TRMT6 | tRNA processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TRMT6 | TRMT61A | 1.0 | 0.914 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction | |
| ARHGEF12 | TRMT61A | 0.995 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRMT6 | ARHGEF12 | 0.827 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| TRMT6 | huMAP3_00087.1 huMAP3_03434.1 huMAP3_06512.1 huMAP3_13494.1 huMAP3_14415.1 |
| ARHGEF12 | huMAP3_01601.1 huMAP3_07436.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_14415.1 |
| TRMT61A | huMAP3_14415.1 |