hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14428.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCSER1 | Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) | 3 | UniProt NCBI |
| KIF20B | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | 5 | UniProt NCBI |
| ANKRD26 | Ankyrin repeat domain-containing protein 26 | 5 | UniProt NCBI |
| NDE1 | Nuclear distribution protein nudE homolog 1 (NudE) | 5 | UniProt NCBI |
| SHTN1 | Shootin-1 (Shootin1) | 5 | UniProt NCBI |
| PAFAH1B3 | Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma) | 5 | UniProt NCBI |
| CEP135 | Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) | 5 | UniProt NCBI |
| NDEL1 | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | 5 | UniProt NCBI |
| PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | 5 | UniProt NCBI |
| CCSER2 | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | 4 | UniProt NCBI |
| PAFAH1B2 | Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) | 5 | UniProt NCBI |
| DIXDC1 | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5409 | 6.37387064498e-09 | 0.333333333333 | PAFAH1B2 NDEL1 PAFAH1B3 PAFAH1B1 | PAFAH1B1 copy number variation |
| GO:0008247 | 2.11464090368e-05 | 0.25 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | 1-alkyl-2-acetylglycerophosphocholine esterase complex |
| GO:0015631 | 4.72963902918e-05 | 0.583333333333 | CEP135 KIF20B CCSER2 NDE1 NDEL1 PAFAH1B1 DIXDC1 | tubulin binding |
| KEGG:00565 | 0.000168134627057 | 0.25 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | Ether lipid metabolism |
| GO:0008017 | 0.000342388327372 | 0.5 | CEP135 KIF20B CCSER2 NDE1 NDEL1 PAFAH1B1 | microtubule binding |
| GO:0030010 | 0.000516879718045 | 0.416666666667 | NDEL1 PAFAH1B1 SHTN1 KIF20B NDE1 | establishment of cell polarity |
| GO:0008092 | 0.00062102810733 | 0.666666666667 | CEP135 KIF20B SHTN1 NDE1 NDEL1 CCSER2 PAFAH1B1 DIXDC1 | cytoskeletal protein binding |
| REAC:R-HSA-8856688 | 0.000671552380622 | 0.333333333333 | PAFAH1B2 PAFAH1B1 KIF20B PAFAH1B3 | Golgi-to-ER retrograde transport |
| GO:0005875 | 0.00146978806891 | 0.416666666667 | NDEL1 PAFAH1B1 SHTN1 KIF20B NDE1 | microtubule associated complex |
| REAC:R-HSA-6811436 | 0.00220413551192 | 0.25 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6811442 | 0.00365000217184 | 0.333333333333 | PAFAH1B2 PAFAH1B1 KIF20B PAFAH1B3 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-68877 | 0.00380153641026 | 0.333333333333 | CEP135 PAFAH1B1 NDE1 NDEL1 | Mitotic Prometaphase |
| GO:0007163 | 0.00484427162173 | 0.416666666667 | NDEL1 PAFAH1B1 SHTN1 KIF20B NDE1 | establishment or maintenance of cell polarity |
| REAC:R-HSA-380284 | 0.00510802930332 | 0.25 | CEP135 NDE1 PAFAH1B1 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-380259 | 0.00510802930332 | 0.25 | CEP135 NDE1 PAFAH1B1 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-8854518 | 0.00584044581838 | 0.25 | CEP135 NDE1 PAFAH1B1 | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 0.00844506693194 | 0.25 | CEP135 NDE1 PAFAH1B1 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.00844506693194 | 0.25 | CEP135 NDE1 PAFAH1B1 | Centrosome maturation |
| GO:0015630 | 0.0100620199596 | 0.666666666667 | CEP135 KIF20B SHTN1 PAFAH1B1 NDEL1 CCSER2 ANKRD26 NDE1 | microtubule cytoskeleton |
| REAC:R-HSA-2565942 | 0.010175973432 | 0.25 | CEP135 NDE1 PAFAH1B1 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-380320 | 0.0129690076343 | 0.25 | CEP135 NDE1 PAFAH1B1 | Recruitment of NuMA to mitotic centrosomes |
| WP:WP5376 | 0.0136056357253 | 0.166666666667 | NDEL1 PAFAH1B1 | 17p13 3 YWHAE copy number variation |
| REAC:R-HSA-141424 | 0.0138503617857 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.0138503617857 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-5620912 | 0.0143054151355 | 0.25 | CEP135 NDE1 PAFAH1B1 | Anchoring of the basal body to the plasma membrane |
| REAC:R-HSA-69618 | 0.0223503721045 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.0255731910989 | 0.25 | NDEL1 NDE1 PAFAH1B1 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 0.0313378649398 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.0405630540002 | 0.25 | NDEL1 NDE1 PAFAH1B1 | RHO GTPases Activate Formins |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| PAFAH1B3 | PAFAH1B2 | 1.0 | 0.406 |
| NDEL1 | DIXDC1 | 1.0 | 0.094 |
| CCSER1 | NDEL1 | 1.0 | |
| NDEL1 | CCSER2 | 1.0 | 0.122 |
| NDE1 | NDEL1 | 0.999 | |
| CCSER1 | NDE1 | 0.999 | |
| KIF20B | NDEL1 | 0.999 | |
| PAFAH1B1 | PAFAH1B3 | 0.999 | 0.048 |
| PAFAH1B1 | PAFAH1B2 | 0.997 | 0.52 |
| KIF20B | SHTN1 | 0.997 | |
| NDEL1 | PAFAH1B1 | 0.996 | 0.266 |
| NDE1 | CCSER2 | 0.994 | |
| NDE1 | DIXDC1 | 0.991 | |
| NDE1 | PAFAH1B1 | 0.985 | |
| CCSER2 | PAFAH1B1 | 0.982 | 0.0977 |
| CEP135 | NDEL1 | 0.975 | 0.216 |
| CCSER2 | ANKRD26 | 0.969 | 0.108 |
| DIXDC1 | PAFAH1B1 | 0.961 | 0.1 |
| PAFAH1B1 | SHTN1 | 0.951 | 0.086 |
| NDEL1 | SHTN1 | 0.925 | 0.102 |
| CEP135 | PAFAH1B1 | 0.911 | 0.234 |
| CCSER2 | DIXDC1 | 0.902 | 0.108 |
| CEP135 | CCSER2 | 0.899 | 0.222 |
| CCSER1 | PAFAH1B1 | 0.893 | |
| CCSER1 | CCSER2 | 0.885 | |
| KIF20B | PAFAH1B1 | 0.877 | |
| NDEL1 | ANKRD26 | 0.845 | 0.158 |
| KIF20B | CCSER1 | 0.788 | |
| KIF20B | DIXDC1 | 0.788 | |
| CCSER1 | DIXDC1 | 0.735 | |
| CEP135 | DIXDC1 | 0.638 | 0.152 |
| KIF20B | CCSER2 | 0.59 | |
| NDE1 | SHTN1 | 0.497 | |
| NDEL1 | PAFAH1B3 | 0.354 | 0.102 |
| KIF20B | ANKRD26 | 0.327 | |
| CEP135 | NDE1 | 0.318 | |
| KIF20B | NDE1 | 0.298 | |
| DIXDC1 | SHTN1 | 0.22 | 0.098 |
| CCSER1 | SHTN1 | 0.201 | |
| CEP135 | PAFAH1B3 | 0.192 | 0.086 |
| CCSER2 | PAFAH1B2 | 0.192 | 0.076 |
| CCSER2 | PAFAH1B3 | 0.192 | 0.048 |
| CEP135 | PAFAH1B2 | 0.187 | 0.068 |
| CCSER2 | SHTN1 | 0.17 | 0.1 |
| DIXDC1 | ANKRD26 | 0.164 | 0.196 |
| CCSER1 | ANKRD26 | 0.164 | |
| CEP135 | CCSER1 | 0.143 | |
| CEP135 | ANKRD26 | 0.095 | 0.32 |
| KIF20B | CEP135 | 0.071 | |
| DIXDC1 | PAFAH1B3 | 0.063 | 0.06 |
| DIXDC1 | PAFAH1B2 | 0.063 | 0.04 |
| NDEL1 | PAFAH1B2 | 0.062 | 0.312 |
| NDE1 | PAFAH1B2 | 0.056 | |
| NDE1 | ANKRD26 | 0.047 | |
| CEP135 | SHTN1 | 0.044 | 0.074 |
| ANKRD26 | PAFAH1B1 | 0.044 | 0.134 |
| NDE1 | PAFAH1B3 | 0.043 | |
| ANKRD26 | SHTN1 | 0.016 | 0.12 |
| ANKRD26 | PAFAH1B3 | 0.014 | 0.132 |
| PAFAH1B2 | SHTN1 | 0.008 | 0.076 |
| PAFAH1B3 | SHTN1 | 0.005 | 0.084 |
Related Complexes