hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14454.1
Complex Portal: CPX-17554
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PAK6 | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | 5 | UniProt NCBI |
| TNXB | Tenascin-X (TN-X) (Hexabrachion-like protein) | 5 | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04510 | 4.43012045406e-05 | 1.0 | PAK4 PAK6 TNXB | Focal adhesion |
| WP:WP306 | 6.57372712538e-05 | 1.0 | PAK4 PAK6 TNXB | Focal adhesion |
| REAC:R-HSA-428540 | 0.000531572756485 | 0.666666666667 | PAK4 PAK6 | Activation of RAC1 |
| WP:WP4564 | 0.000634541489717 | 0.666666666667 | PAK4 PAK6 | Neural crest cell migration during development |
| WP:WP4565 | 0.000712521586106 | 0.666666666667 | PAK4 PAK6 | Neural crest cell migration in cancer |
| WP:WP4534 | 0.00088200834918 | 0.666666666667 | PAK4 PAK6 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| KEGG:05211 | 0.00158324752529 | 0.666666666667 | PAK4 PAK6 | Renal cell carcinoma |
| WP:WP4205 | 0.00180332266367 | 0.666666666667 | PAK4 PAK6 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04012 | 0.00216826178203 | 0.666666666667 | PAK4 PAK6 | ErbB signaling pathway |
| WP:WP4263 | 0.00365686215758 | 0.666666666667 | PAK4 PAK6 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.00365686215758 | 0.666666666667 | PAK4 PAK6 | ErbB signaling pathway |
| REAC:R-HSA-9013407 | 0.00381957013228 | 0.666666666667 | PAK4 PAK6 | RHOH GTPase cycle |
| WP:WP185 | 0.0039339723602 | 0.666666666667 | PAK4 PAK6 | Integrin mediated cell adhesion |
| KEGG:04660 | 0.00399150940056 | 0.666666666667 | PAK4 PAK6 | T cell receptor signaling pathway |
| REAC:R-HSA-9013424 | 0.00405087414568 | 0.666666666667 | PAK4 PAK6 | RHOV GTPase cycle |
| WP:WP4541 | 0.00514316015145 | 0.666666666667 | PAK4 PAK6 | Hippo Merlin signaling dysregulation |
| KEGG:05206 | 0.00824863650471 | 0.666666666667 | PAK4 TNXB | MicroRNAs in cancer |
| KEGG:04360 | 0.00893090716082 | 0.666666666667 | PAK4 PAK6 | Axon guidance |
| WP:WP51 | 0.00915401629696 | 0.666666666667 | PAK4 PAK6 | Regulation of actin cytoskeleton |
| WP:WP4223 | 0.0120750625641 | 0.666666666667 | PAK4 PAK6 | Ras signaling |
| KEGG:04014 | 0.0127453972967 | 0.666666666667 | PAK4 PAK6 | Ras signaling pathway |
| KEGG:05170 | 0.0140204887763 | 0.666666666667 | PAK4 PAK6 | Human immunodeficiency virus 1 infection |
| KEGG:04810 | 0.01431202154 | 0.666666666667 | PAK4 PAK6 | Regulation of actin cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAK6 | PAK4 | 0.966 | 0.115529411765 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| PAK6 | TNXB | 0.838 | 0.05 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PAK4 | TNXB | 0.005 | 0.054 | youn_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PAK6 | huMAP3_00492.1 huMAP3_08705.1 huMAP3_11881.1 huMAP3_14454.1 |
| TNXB | huMAP3_11881.1 huMAP3_14454.1 |
| PAK4 | huMAP3_00492.1 huMAP3_08705.1 huMAP3_12105.1 huMAP3_12737.1 huMAP3_13353.1 huMAP3_14454.1 huMAP3_14794.1 |