hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14455.1
Complex Portal: CPX-19638
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC13 | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | 5 | UniProt NCBI |
| SEC16B | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | 5 | UniProt NCBI |
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| BCR | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| SEC31A | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 2.09173590301e-09 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | Amino acids regulate mTORC1 |
| CORUM:6216 | 7.02050133195e-08 | 0.428571428571 | SEC13 WDR24 MIOS | GATOR2 complex |
| KEGG:04150 | 1.07318896867e-07 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | mTOR signaling pathway |
| GO:0061700 | 1.1594342202e-07 | 0.571428571429 | SEC13 CASTOR2 WDR24 MIOS | GATOR2 complex |
| GO:1904262 | 1.6017646366e-07 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | negative regulation of TORC1 signaling |
| CORUM:6753 | 3.92905941962e-07 | 0.428571428571 | SEC13 WDR24 MIOS | SOG complex |
| CORUM:6217 | 3.92905941962e-07 | 0.428571428571 | SEC13 WDR24 MIOS | GATOR complex |
| REAC:R-HSA-9711097 | 4.71302084746e-07 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | Cellular response to starvation |
| GO:0035859 | 6.57500588447e-07 | 0.571428571429 | SEC13 CASTOR2 WDR24 MIOS | Seh1-associated complex |
| GO:0032007 | 9.40846017629e-07 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | negative regulation of TOR signaling |
| GO:1903432 | 6.14603730372e-06 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | regulation of TORC1 signaling |
| GO:0038202 | 7.77374413874e-06 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | TORC1 signaling |
| REAC:R-HSA-2262752 | 1.8673790515e-05 | 0.857142857143 | SEC13 SEC31A MIOS SESN2 CASTOR2 WDR24 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 1.97806453975e-05 | 0.857142857143 | SEC13 SEC31A MIOS SESN2 CASTOR2 WDR24 | Cellular responses to stimuli |
| GO:0032006 | 4.1998164774e-05 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | regulation of TOR signaling |
| GO:0031929 | 7.21864524745e-05 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | TOR signaling |
| GO:1904263 | 0.000210494508038 | 0.571428571429 | SEC13 MIOS WDR24 SESN2 | positive regulation of TORC1 signaling |
| REAC:R-HSA-204005 | 0.000463730815151 | 0.428571428571 | SEC13 SEC31A SEC16B | COPII-mediated vesicle transport |
| GO:0032008 | 0.000617288463902 | 0.571428571429 | SEC13 MIOS WDR24 SESN2 | positive regulation of TOR signaling |
| REAC:R-HSA-199977 | 0.00604553029649 | 0.428571428571 | SEC13 SEC31A SEC16B | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.0104945039722 | 0.428571428571 | SEC13 SEC31A SEC16B | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-983170 | 0.0133002920771 | 0.285714285714 | SEC13 SEC31A | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| GO:1902532 | 0.0134243874038 | 0.714285714286 | SEC13 MIOS WDR24 CASTOR2 SESN2 | negative regulation of intracellular signal transduction |
| GO:0031669 | 0.02419782013 | 0.571428571429 | SEC13 MIOS WDR24 SESN2 | cellular response to nutrient levels |
| GO:0031668 | 0.0300947153732 | 0.571428571429 | SEC13 MIOS WDR24 SESN2 | cellular response to extracellular stimulus |
| WP:WP1982 | 0.039968890476 | 0.285714285714 | SEC13 SEC31A | Sterol regulatory element binding proteins SREBP signaling |
| GO:0034198 | 0.0411777400956 | 0.428571428571 | MIOS WDR24 SESN2 | cellular response to amino acid starvation |
| REAC:R-HSA-446203 | 0.0459981559702 | 0.428571428571 | SEC13 SEC31A SEC16B | Asparagine N-linked glycosylation |
| GO:1990928 | 0.0473277551461 | 0.428571428571 | MIOS WDR24 SESN2 | response to amino acid starvation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SEC31A | SEC13 | 1.0 | 0.29 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SEC16B | SEC13 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SEC13 | SESN2 | 0.995 | 0.334 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| WDR24 | MIOS | 0.994 | 0.108 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | SESN2 | 0.987 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SEC13 | WDR24 | 0.978 | 0.102 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| MIOS | SESN2 | 0.977 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| SEC31A | SESN2 | 0.96 | 0.122 |
mutually_exclusive (P55735)
|
bioplex_WMM bioplex3_WMM WMM_only |
| SEC13 | BCR | 0.949 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SEC13 | MIOS | 0.948 | 0.128 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| SEC31A | WDR24 | 0.902 | 0.136 |
mutually_exclusive (P55735)
|
bioplex_WMM bioplex3_WMM WMM_only |
| SEC31A | MIOS | 0.868 | 0.036 |
mutually_exclusive (P55735)
|
bioplex_WMM bioplex3_WMM WMM_only |
| SESN2 | BCR | 0.86 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | BCR | 0.848 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| CASTOR2 | SESN2 | 0.664 | 0.114 | hein_WMM hein () | |
| MIOS | BCR | 0.641 | 0.052 | bioplex_WMM bioplex3_WMM fraction | |
| SEC31A | BCR | 0.618 | 0.114 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SEC13 | CASTOR2 | 0.063 | 0.084 | hein_WMM WMM_only |
Related Complexes