hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14455.1

Complex Portal: CPX-19638

Confidence: Medium

Show entries

Search:

Genename	Protein Name	Uniprot Annotation Score	Links
BCR	Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)	5	UniProt NCBI
CASTOR2	Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2)	5	UniProt NCBI
MIOS	GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog)	5	UniProt NCBI
SEC13	Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)	5	UniProt NCBI
SEC16B	Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B)	5	UniProt NCBI
SEC31A	Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein)	5	UniProt NCBI
SESN2	Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)	5	UniProt NCBI
WDR24	GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24)	5	UniProt NCBI

Showing 1 to 8 of 8 entries

Show entries

Search:

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9639288	2.09173590301e-09	0.714285714286	MIOS SESN2 SEC13 CASTOR2 WDR24	Amino acids regulate mTORC1
CORUM:6216	7.02050133195e-08	0.428571428571	MIOS SEC13 WDR24	GATOR2 complex
KEGG:04150	1.07318896867e-07	0.714285714286	MIOS SESN2 SEC13 CASTOR2 WDR24	mTOR signaling pathway
GO:0061700	1.1594342202e-07	0.571428571429	MIOS SEC13 CASTOR2 WDR24	GATOR2 complex
GO:1904262	1.6017646366e-07	0.714285714286	MIOS SESN2 SEC13 CASTOR2 WDR24	negative regulation of TORC1 signaling
CORUM:6753	3.92905941962e-07	0.428571428571	MIOS SEC13 WDR24	SOG complex
CORUM:6217	3.92905941962e-07	0.428571428571	MIOS SEC13 WDR24	GATOR complex
REAC:R-HSA-9711097	4.71302084746e-07	0.714285714286	MIOS SESN2 SEC13 CASTOR2 WDR24	Cellular response to starvation
GO:0035859	6.57500588447e-07	0.571428571429	MIOS SEC13 CASTOR2 WDR24	Seh1-associated complex
GO:0032007	9.40846017629e-07	0.714285714286	MIOS SESN2 SEC13 CASTOR2 WDR24	negative regulation of TOR signaling

Showing 1 to 10 of 29 entries

Show entries

Search:

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
SEC31A	SEC13	1.0	0.29	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
SEC16B	SEC13	0.997		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SEC13	SESN2	0.995	0.334	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
WDR24	MIOS	0.994	0.108	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
MIOS	CASTOR2	0.993	0.064		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
WDR24	SESN2	0.987	0.142		hein_WMM bioplex_WMM bioplex3_WMM hein ()
WDR24	CASTOR2	0.98	0.084		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
SEC13	WDR24	0.978	0.102	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
MIOS	SESN2	0.977	0.096		hein_WMM bioplex_WMM bioplex3_WMM hein ()
SEC31A	SESN2	0.96	0.122	mutually_exclusive (P55735)	bioplex_WMM bioplex3_WMM WMM_only

Showing 1 to 10 of 20 entries

Related Complexes

Genename	Complexes
SEC13	huMAP3_00267.1 huMAP3_06536.1 huMAP3_07705.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_12394.1 huMAP3_12581.1 huMAP3_14455.1
SEC16B	huMAP3_00267.1 huMAP3_06536.1 huMAP3_14455.1
WDR24	huMAP3_04081.1 huMAP3_04144.1 huMAP3_08030.1 huMAP3_12581.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14455.1
BCR	huMAP3_05067.1 huMAP3_09073.1 huMAP3_12452.1 huMAP3_14455.1
SESN2	huMAP3_04144.1 huMAP3_06536.1 huMAP3_08030.1 huMAP3_12581.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14455.1
MIOS	huMAP3_04081.1 huMAP3_04144.1 huMAP3_08030.1 huMAP3_12581.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14334.1 huMAP3_14455.1
SEC31A	huMAP3_00267.1 huMAP3_06536.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13877.1 huMAP3_14440.1 huMAP3_14455.1
CASTOR2	huMAP3_04081.1 huMAP3_04144.1 huMAP3_04179.1 huMAP3_04621.1 huMAP3_08030.1 huMAP3_10719.1 huMAP3_12581.1 huMAP3_12663.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14334.1 huMAP3_14455.1