hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14457.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CLIP2 | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | 5 | UniProt NCBI |
| COMT | Catechol O-methyltransferase (EC 2.1.1.6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001136 | 0.00180445241025 | 1.0 | CLIP2 COMT | Retinal arteriolar tortuosity |
| HP:0012841 | 0.00453163616665 | 1.0 | CLIP2 COMT | Retinal vascular tortuosity |
| HP:0000627 | 0.00470934738887 | 1.0 | CLIP2 COMT | Posterior embryotoxon |
| HP:0008048 | 0.00470934738887 | 1.0 | CLIP2 COMT | Abnormal line of Schwalbe morphology |
| WP:WP4238 | 0.00622025938483 | 0.5 | COMT | Flavan 3 ol metabolic pathway |
| HP:0000630 | 0.00625406801279 | 1.0 | CLIP2 COMT | Abnormal retinal artery morphology |
| HP:0002999 | 0.00667442340382 | 1.0 | CLIP2 COMT | Patellar dislocation |
| HP:0001081 | 0.00710844888886 | 1.0 | CLIP2 COMT | Cholelithiasis |
| HP:3000036 | 0.00849254590808 | 1.0 | CLIP2 COMT | Abnormal head blood vessel morphology |
| HP:0005562 | 0.00873519007688 | 1.0 | CLIP2 COMT | Multiple renal cysts |
| HP:0012437 | 0.009230730985 | 1.0 | CLIP2 COMT | Abnormal gallbladder morphology |
| HP:0005264 | 0.0133830220427 | 1.0 | CLIP2 COMT | Abnormality of the gallbladder |
| HP:0003045 | 0.0149379952371 | 1.0 | CLIP2 COMT | Abnormal patella morphology |
| HP:0002414 | 0.0220122688909 | 1.0 | CLIP2 COMT | Spina bifida |
| HP:0010301 | 0.0260620342435 | 1.0 | CLIP2 COMT | Spinal dysraphism |
| HP:0004363 | 0.026485807158 | 1.0 | CLIP2 COMT | Abnormal circulating calcium concentration |
| HP:0000389 | 0.0291002126388 | 1.0 | CLIP2 COMT | Chronic otitis media |
| HP:0000089 | 0.0291002126388 | 1.0 | CLIP2 COMT | Renal hypoplasia |
| WP:WP704 | 0.0310970405539 | 0.5 | COMT | Methylation pathways |
| HP:0010927 | 0.0323058496858 | 1.0 | CLIP2 COMT | Abnormal blood inorganic cation concentration |
| HP:0012732 | 0.0387034536857 | 1.0 | CLIP2 COMT | Anorectal anomaly |
| HP:0001646 | 0.0392194997349 | 1.0 | CLIP2 COMT | Abnormal aortic valve morphology |
| HP:0000670 | 0.0402618444037 | 1.0 | CLIP2 COMT | Carious teeth |
| HP:0006705 | 0.0418509928331 | 1.0 | CLIP2 COMT | Abnormal atrioventricular valve morphology |
| HP:0001636 | 0.0456786191579 | 1.0 | CLIP2 COMT | Tetralogy of Fallot |
| WP:WP4220 | 0.049750157242 | 0.5 | COMT | Neurotransmitter disorders |
| REAC:R-HSA-379397 | 0.0499419797295 | 0.5 | COMT | Enzymatic degradation of dopamine by COMT |
| REAC:R-HSA-379398 | 0.0499419797295 | 0.5 | COMT | Enzymatic degradation of Dopamine by monoamine oxidase |
| REAC:R-HSA-379401 | 0.0499419797295 | 0.5 | COMT | Dopamine clearance from the synaptic cleft |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CLIP2 | COMT | 0.9 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| CLIP2 | huMAP3_01058.1 huMAP3_02559.1 huMAP3_06475.1 huMAP3_10804.1 huMAP3_10940.1 huMAP3_14457.1 |
| COMT | huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1 huMAP3_14457.1 |