hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14460.1
Complex Portal: CPX-24517
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TGFA | Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)] | 5 | UniProt NCBI |
| FLRT3 | Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3) | 5 | UniProt NCBI |
| SPPL2A | Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2) | 5 | UniProt NCBI |
| ADCY9 | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04915 | 0.0104133784038 | 0.5 | TGFA ADCY9 | Estrogen signaling pathway |
| KEGG:04020 | 0.036316189849 | 0.5 | TGFA ADCY9 | Calcium signaling pathway |
| CORUM:6528 | 0.049938562206 | 0.25 | FLRT3 | FLRT3-LPHN3-UNC5D complex |
| CORUM:6529 | 0.049938562206 | 0.25 | FLRT3 | FLRT3-LPHN3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TGFA | SPPL2A | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SPPL2A | ADCY9 | 0.896 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| TGFA | ADCY9 | 0.893 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FLRT3 | ADCY9 | 0.838 | 0.124 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes