hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14463.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
TRAF6	TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)	5	UniProt NCBI
ECI2	Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)	5	UniProt NCBI
TRAF3	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)	5	UniProt NCBI
TRAF1	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)	5	UniProt NCBI
ECH1	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP3941	8.59264085102e-06	0.6	TRAF6 TRAF3 TRAF1	Oxidative damage response
WP:WP2018	1.82496091606e-05	0.6	TRAF6 TRAF3 TRAF1	RANKL RANK signaling pathway
KEGG:04064	7.6067273377e-05	0.6	TRAF6 TRAF3 TRAF1	NF-kappa B signaling pathway
KEGG:05222	9.46922201828e-05	0.6	TRAF6 TRAF3 TRAF1	Small cell lung cancer
WP:WP4658	0.000135925027505	0.6	TRAF6 TRAF3 TRAF1	Small cell lung cancer
WP:WP5116	0.00016455851106	0.4	TRAF6 TRAF3	SARS CoV 2 B 1 1 7 variant antagonises innate immune activation
WP:WP262	0.00135500760343	0.4	TRAF6 TRAF1	Ebstein Barr virus LMP1 signaling
WP:WP4868	0.00148385269311	0.4	TRAF6 TRAF3	Type I interferon induction and signaling during SARS CoV 2 infection
WP:WP5183	0.00161852668418	0.4	TRAF6 TRAF3	SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction
WP:WP3851	0.00175902717245	0.4	TRAF6 TRAF3	TLR4 signaling and tolerance
WP:WP3858	0.00205749802636	0.4	TRAF6 TRAF3	Toll like receptor signaling related to MyD88
WP:WP2112	0.00221546358612	0.4	TRAF6 TRAF3	IL 17 signaling pathway
WP:WP5406	0.00221546358612	0.4	TRAF3 TRAF1	13q12 12 copy number variation
WP:WP5038	0.00237924603132	0.4	TRAF6 TRAF3	Mitochondrial immune response to SARS CoV 2
WP:WP4880	0.00237924603132	0.4	TRAF6 TRAF3	Host pathogen interaction of human coronaviruses interferon induction
GO:0032813	0.00249322401434	0.6	TRAF6 TRAF3 TRAF1	tumor necrosis factor receptor superfamily binding
WP:WP4329	0.00272425197171	0.4	TRAF6 TRAF3	miRNA role in immune response in sepsis
WP:WP2036	0.00368839425913	0.4	TRAF3 TRAF1	TNF related weak inducer of apoptosis TWEAK signaling pathway
WP:WP5039	0.00774618498599	0.4	TRAF6 TRAF3	SARS CoV 2 innate immunity evasion and cell specific immune response
WP:WP3865	0.00835727861991	0.4	TRAF6 TRAF3	Novel intracellular components of RIG I like receptor pathway
REAC:R-HSA-5689896	0.00900400267976	0.4	TRAF6 TRAF3	Ovarian tumor domain proteases
KEGG:04146	0.00908648748607	0.4	ECH1 ECI2	Peroxisome
KEGG:04622	0.00937366158534	0.4	TRAF6 TRAF3	RIG-I-like receptor signaling pathway
REAC:R-HSA-9692916	0.0106339701454	0.4	TRAF6 TRAF3	SARS-CoV-1 activates/modulates innate immune responses
KEGG:05200	0.0130900202546	0.6	TRAF6 TRAF3 TRAF1	Pathways in cancer
KEGG:04657	0.0131645270498	0.4	TRAF6 TRAF3	IL-17 signaling pathway
WP:WP254	0.0153080129813	0.4	TRAF3 TRAF1	Apoptosis
KEGG:04620	0.0168082536599	0.4	TRAF6 TRAF3	Toll-like receptor signaling pathway
WP:WP1772	0.0174803785097	0.4	TRAF6 TRAF3	Apoptosis modulation and signaling
WP:WP75	0.0197951791935	0.4	TRAF6 TRAF3	Toll like receptor signaling pathway
KEGG:04668	0.0200391528804	0.4	TRAF3 TRAF1	TNF signaling pathway
GO:0070534	0.0237169649094	0.6	TRAF6 TRAF3 TRAF1	protein K63-linked ubiquitination
KEGG:05162	0.0340898047114	0.4	TRAF6 TRAF3	Measles
KEGG:04936	0.0340898047114	0.4	TRAF6 TRAF3	Alcoholic liver disease
KEGG:05160	0.0380272112444	0.4	TRAF6 TRAF3	Hepatitis C
REAC:R-HSA-168928	0.0417637628913	0.4	TRAF6 TRAF3	DDX58/IFIH1-mediated induction of interferon-alpha/beta
WP:WP4630	0.0434056741534	0.4	TRAF6 TRAF3	Measles virus infection
KEGG:04621	0.0471742362289	0.4	TRAF6 TRAF3	NOD-like receptor signaling pathway
KEGG:05161	0.0484667159694	0.4	TRAF6 TRAF3	Hepatitis B
CORUM:2073	0.0498708842806	0.2	TRAF6	TNFRSF11A-TRAF6-SRC complex
CORUM:2074	0.0498708842806	0.2	TRAF6	TRAF6 homo-oligomer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
ECI2	ECH1	1.0	0.122	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM
TRAF1	TRAF6	0.999	0.162	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TRAF1	ECH1	0.988	0.066	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ECH1	TRAF3	0.965	0.164	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
TRAF1	TRAF3	0.922	0.122	bioplex_WMM bioplex3_WMM WMM_only
TRAF1	ECI2	0.917	0.068	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TRAF6	TRAF3	0.857	0.238	bioplex_WMM bioplex3_WMM WMM_only
ECH1	TRAF6	0.832	0.154	bioplex_WMM bioplex3_WMM WMM_only
ECI2	TRAF6	0.084	0.074	bioplex_WMM bioplex3_WMM WMM_only
ECI2	TRAF3	0.012	0.116	bioplex_WMM bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
TRAF6	huMAP3_09006.1 huMAP3_14463.1
ECI2	huMAP3_03660.1 huMAP3_07198.1 huMAP3_10013.1 huMAP3_13432.1 huMAP3_14093.1 huMAP3_14463.1
TRAF3	huMAP3_09407.1 huMAP3_11228.1 huMAP3_14463.1
TRAF1	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_14463.1 huMAP3_15146.1 huMAP3_15257.1
ECH1	huMAP3_03660.1 huMAP3_07198.1 huMAP3_10013.1 huMAP3_13432.1 huMAP3_14463.1

hu.MAP 3.0: Complex View

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Complex: huMAP3_14463.1