hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14472.1
Complex Portal: CPX-10841
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPGRIP1L | Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) | 5 | UniProt NCBI |
| TRAIP | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) | 5 | UniProt NCBI |
| RPGR | X-linked retinitis pigmentosa GTPase regulator | 5 | UniProt NCBI |
| CDC25C | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | 5 | UniProt NCBI |
| NPHP1 | Nephrocystin-1 (Juvenile nephronophthisis 1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5399 | 0.000114838123418 | 0.5 | RPGRIP1L NPHP1 | NPHP1 deletion syndrome |
| HP:0032599 | 0.0051092979876 | 0.5 | RPGRIP1L NPHP1 | Abnormal renal tubular epithelial morphology |
| HP:0000092 | 0.0051092979876 | 0.5 | RPGRIP1L NPHP1 | Renal tubular atrophy |
| WP:WP4656 | 0.0063063631888 | 0.5 | RPGRIP1L NPHP1 | Joubert syndrome |
| HP:0002118 | 0.00654468420453 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal cerebral ventricle morphology |
| HP:0000276 | 0.00905423426659 | 0.75 | RPGRIP1L TRAIP NPHP1 | Long face |
| HP:0100729 | 0.0120511721551 | 0.75 | RPGRIP1L TRAIP NPHP1 | Large face |
| GO:0097733 | 0.0131184183431 | 0.75 | RPGRIP1L RPGR NPHP1 | photoreceptor cell cilium |
| HP:0000811 | 0.013341386737 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal external genitalia |
| GO:0097731 | 0.0167406494658 | 0.75 | RPGRIP1L RPGR NPHP1 | 9+0 non-motile cilium |
| HP:0000090 | 0.018706736024 | 0.5 | RPGRIP1L NPHP1 | Nephronophthisis |
| HP:0002419 | 0.018706736024 | 0.5 | RPGRIP1L NPHP1 | Molar tooth sign on MRI |
| HP:0000556 | 0.019095104138 | 0.75 | RPGRIP1L RPGR NPHP1 | Retinal dystrophy |
| HP:0011821 | 0.0242493726833 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal facial skeleton morphology |
| HP:0002612 | 0.0246976114972 | 0.5 | RPGRIP1L NPHP1 | Congenital hepatic fibrosis |
| HP:0012243 | 0.0257797800958 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal reproductive system morphology |
| HP:0002795 | 0.0285838989014 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal respiratory system physiology |
| HP:0002536 | 0.0297221025438 | 0.75 | RPGRIP1L TRAIP NPHP1 | Abnormal cortical gyration |
| WP:WP4803 | 0.030443565418 | 0.5 | RPGRIP1L NPHP1 | Ciliopathies |
| HP:0005105 | 0.0305105137394 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal nasal morphology |
| HP:0000238 | 0.0318501377451 | 0.75 | RPGRIP1L RPGR NPHP1 | Hydrocephalus |
| HPA:0060873 | 0.0333763741956 | 0.5 | RPGR NPHP1 | bronchus; ciliated cells (ciliary rootlets)[High] |
| HP:0011297 | 0.0360876399144 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal digit morphology |
| GO:0097730 | 0.0364824972322 | 0.75 | RPGRIP1L RPGR NPHP1 | non-motile cilium |
| HP:0001627 | 0.0377963135776 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal heart morphology |
| REAC:R-HSA-5620912 | 0.0434971593242 | 0.5 | RPGRIP1L NPHP1 | Anchoring of the basal body to the plasma membrane |
| HP:0032581 | 0.0476300363671 | 0.5 | RPGRIP1L NPHP1 | Abnormal renal insterstitial morphology |
| HP:0100957 | 0.0476300363671 | 0.5 | RPGRIP1L NPHP1 | Abnormal renal medulla morphology |
| HP:0031703 | 0.0490742875352 | 1.0 | RPGRIP1L TRAIP NPHP1 RPGR | Abnormal ear morphology |
| HP:0001883 | 0.0496281638505 | 0.75 | RPGRIP1L TRAIP NPHP1 | Talipes |
| CORUM:6750 | 0.049938562206 | 0.25 | NPHP1 | AHI1-NPHP1 heterotetramer |
| CORUM:6743 | 0.049938562206 | 0.25 | NPHP1 | AHI1-NPHP1 heterodimer |
| CORUM:6600 | 0.049938562206 | 0.25 | NPHP1 | NPHP1-PKD1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPGRIP1L | RPGR | 0.999 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt bioplex3_HCT116 boldt_WMM | |
| RPGR | NPHP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| RPGRIP1L | NPHP1 | 0.993 |
structurally_consistent (O75161)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM | |
| TRAIP | NPHP1 | 0.983 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CDC25C | RPGR | 0.941 | 0.118 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RPGRIP1L | TRAIP | 0.25 | bioplex3_WMM WMM_only |
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