List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_14477.1

Confidence: Medium   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
HSP90AB1	Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)	5	UniProt   NCBI
CDC37L1	Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37)	5	UniProt   NCBI
SRMS	Tyrosine-protein kinase Srms (EC 2.7.10.2)	5	UniProt   NCBI
MAP3K14	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)	5	UniProt   NCBI
HSP90AA1	Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)	5	UniProt   NCBI
AGO3	Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)	5	UniProt   NCBI
STK35	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1)	5	UniProt   NCBI
TSSK6	Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase)	5	UniProt   NCBI
CDK11A	Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)	5	UniProt   NCBI
PDIK1L	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like)	4	UniProt   NCBI
CDC37	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	5	UniProt   NCBI
AKT3	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)	5	UniProt   NCBI
IKBKG	NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)	5	UniProt   NCBI
CFAP54	Cilia- and flagella-associated protein 54	4	UniProt   NCBI
EPHB6	Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)	5	UniProt   NCBI
UNC45B	Protein unc-45 homolog B (Unc-45B) (SMUNC45)	5	UniProt   NCBI
CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)	5	UniProt   NCBI
CTDSPL2	CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-)	4	UniProt   NCBI
FKBP5	Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)	5	UniProt   NCBI
STK11	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)	5	UniProt   NCBI
IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)	5	UniProt   NCBI
A6NIL8		None	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5266	1.71243187129e-16	0.35	IKBKG IKBKB HSP90AB1 HSP90AA1 MAP3K14 CDC37 CHUK	TNF-alpha/NF-kappa B signaling complex 6
CORUM:5286	2.55693262895e-11	0.25	CDC37 CHUK HSP90AB1 IKBKG HSP90AA1	TNF-alpha/NF-kappa B signaling complex 10
CORUM:5234	4.6486501452e-10	0.2	IKBKB CDC37 HSP90AB1 HSP90AA1	IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex
CORUM:5285	4.6486501452e-10	0.2	CDC37 FKBP5 HSP90AB1 CHUK	TNF-alpha/NF-kappa B signaling complex 9
CORUM:5269	1.39337328034e-09	0.2	CDC37 FKBP5 HSP90AB1 HSP90AA1	TNF-alpha/NF-kappa B signaling complex 8
CORUM:5268	6.49102014914e-09	0.2	CDC37 FKBP5 HSP90AB1 HSP90AA1	TNF-alpha/NF-kappa B signaling complex 7
WP:WP262	8.94620270478e-09	0.25	IKBKB MAP3K14 CHUK HSP90AA1 IKBKG	Ebstein Barr virus LMP1 signaling
CORUM:5194	1.94389534135e-08	0.2	MAP3K14 CHUK IKBKB IKBKG	TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2)
CORUM:5844	7.99830998738e-08	0.15	IKBKG IKBKB CHUK	I-kappa-B kinase complex
CORUM:2121	7.99830998738e-08	0.15	IKBKG IKBKB CHUK	I-kappa-B kinase complex
CORUM:2100	7.99830998738e-08	0.15	MAP3K14 IKBKB CHUK	CHUK-IKBKB-MAP3K14 complex
CORUM:2112	7.99830998738e-08	0.15	CDC37 HSP90AB1 HSP90AA1	CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex
KEGG:05215	9.97334365574e-08	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	Prostate cancer
KEGG:04151	1.20000503986e-07	0.4	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK CDC37 STK11	PI3K-Akt signaling pathway
WP:WP231	1.34909459164e-07	0.3	IKBKG IKBKB HSP90AA1 MAP3K14 CDC37 CHUK	TNF alpha signaling pathway
WP:WP3849	1.54725880549e-07	0.2	MAP3K14 CHUK IKBKB IKBKG	MAPK and NFkB signaling pathways inhibited by Yersinia YopJ
WP:WP4172	1.61685444738e-07	0.4	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK CDC37 STK11	PI3K Akt signaling pathway
CORUM:2118	3.19653235925e-07	0.15	IKBKG IKBKB CHUK	CHUK-ERC1-IKBKB-IKBKG
KEGG:05418	4.89955050969e-07	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	Fluid shear stress and atherosclerosis
REAC:R-HSA-5602636	6.80601533088e-07	0.15	IKBKG IKBKB CHUK	IKBKB deficiency causes SCID
REAC:R-HSA-5603027	6.80601533088e-07	0.15	IKBKG IKBKB CHUK	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
CORUM:2105	7.9843579229e-07	0.15	MAP3K14 IKBKB CHUK	IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14)
CORUM:2727	7.9843579229e-07	0.15	IKBKG IKBKB CHUK	SRC-3 complex
KEGG:04920	1.11818661568e-06	0.25	IKBKB IKBKG STK11 AKT3 CHUK	Adipocytokine signaling pathway
WP:WP3932	2.9513046062e-06	0.35	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CDC37 STK11	Focal adhesion PI3K Akt mTOR signaling pathway
KEGG:04657	3.10565660467e-06	0.25	IKBKB IKBKG CHUK HSP90AB1 HSP90AA1	IL-17 signaling pathway
GO:0004672	3.8991608939e-06	0.5	STK35 CDK11A TSSK6 AKT3 MAP3K14 PDIK1L IKBKB CHUK STK11 SRMS	protein kinase activity
CORUM:5212	4.45954635237e-06	0.15	CDC37 HSP90AB1 HSP90AA1	Kinase maturation complex 2
WP:WP1433	4.61602910877e-06	0.2	IKBKB IKBKG HSP90AA1 CHUK	Nucleotide binding oligomerization domain NOD pathway
KEGG:04625	5.12067191665e-06	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	C-type lectin receptor signaling pathway
WP:WP4481	6.31087596574e-06	0.2	IKBKB IKBKG AKT3 CHUK	Resistin as a regulator of inflammation
KEGG:05417	6.45747697597e-06	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	Lipid and atherosclerosis
KEGG:04659	6.83157473268e-06	0.25	IKBKB IKBKG CHUK HSP90AB1 HSP90AA1	Th17 cell differentiation
KEGG:04668	8.96783068432e-06	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	TNF signaling pathway
WP:WP4479	9.43659586623e-06	0.15	IKBKG IKBKB CHUK	Supression of HMGB1 mediated inflammation by THBD
GO:0004674	9.48845006528e-06	0.45	STK35 AKT3 TSSK6 MAP3K14 PDIK1L IKBKB CHUK STK11 CDK11A	protein serine/threonine kinase activity
KEGG:04660	1.34565717472e-05	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	T cell receptor signaling pathway
REAC:R-HSA-168928	1.40943745769e-05	0.25	IKBKB IKBKG CHUK HSP90AB1 HSP90AA1	DDX58/IFIH1-mediated induction of interferon-alpha/beta
WP:WP4562	1.50853790191e-05	0.15	IKBKG IKBKB CHUK	Canonical NF kB pathway
WP:WP4480	1.50853790191e-05	0.15	IKBKG IKBKB CHUK	Altered glycosylation of MUC1 in tumor microenvironment
WP:WP288	2.26083242921e-05	0.15	IKBKG IKBKB CHUK	Nod like receptor NLR signaling pathway
KEGG:04380	2.33499598839e-05	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	Osteoclast differentiation
KEGG:05132	2.35138884611e-05	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	Salmonella infection
REAC:R-HSA-5603029	2.37380206573e-05	0.15	IKBKG IKBKB CHUK	IkBA variant leads to EDA-ID
GO:0016773	2.63974849106e-05	0.5	STK35 CDK11A TSSK6 AKT3 MAP3K14 PDIK1L IKBKB CHUK STK11 SRMS	phosphotransferase activity, alcohol group as acceptor
CORUM:6344	2.88356265155e-05	0.15	IKBKG IKBKB CHUK	TNF-R1-associated signaling complex
KEGG:04210	2.88703694952e-05	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	Apoptosis
KEGG:04936	3.39905908933e-05	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	Alcoholic liver disease
WP:WP2795	3.40784703494e-05	0.2	MAP3K14 CHUK IKBKB IKBKG	Cardiac hypertrophic response
REAC:R-HSA-9705683	4.33441308337e-05	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	SARS-CoV-2-host interactions
CORUM:5199	4.42851204858e-05	0.15	CDC37 HSP90AB1 HSP90AA1	Kinase maturation complex 1
WP:WP1434	4.43317436968e-05	0.15	MAP3K14 IKBKB CHUK	Osteopontin signaling
GO:0016301	5.23321893236e-05	0.5	STK35 CDK11A TSSK6 AKT3 MAP3K14 PDIK1L IKBKB CHUK STK11 SRMS	kinase activity
WP:WP195	5.89313138161e-05	0.2	MAP3K14 CHUK IKBKB IKBKG	IL 1 signaling pathway
WP:WP3863	6.41133867481e-05	0.2	MAP3K14 CHUK IKBKB IKBKG	T cell antigen receptor TCR pathway during Staphylococcus aureus infection
CORUM:5829	6.49329465809e-05	0.1	IKBKG CHUK	IKBKG-CHUK complex
CORUM:5849	6.49329465809e-05	0.1	CDC37 HSP90AB1	HSP90-CDC37-LRRK2 complex
CORUM:6152	6.49329465809e-05	0.1	IKBKG CHUK	IKBKG-CHUK complex
CORUM:2101	6.49329465809e-05	0.1	CHUK IKBKB	IKKA-IKKB complex
CORUM:2104	6.49329465809e-05	0.1	MAP3K14 IKBKB	IKKB-NIK complex
CORUM:5828	6.49329465809e-05	0.1	IKBKG IKBKB	IKBKG-IKBKB complex
KEGG:05221	6.62150972079e-05	0.2	IKBKB IKBKG AKT3 CHUK	Acute myeloid leukemia
KEGG:04621	7.64186215643e-05	0.25	IKBKB IKBKG CHUK HSP90AB1 HSP90AA1	NOD-like receptor signaling pathway
KEGG:05120	8.6358123027e-05	0.2	MAP3K14 CHUK IKBKB IKBKG	Epithelial cell signaling in Helicobacter pylori infection
WP:WP5072	8.82980568047e-05	0.2	MAP3K14 CHUK IKBKB IKBKG	Modulators of TCR signaling and T cell activation
REAC:R-HSA-9705671	0.000106127473845	0.25	IKBKB IKBKG CHUK HSP90AB1 HSP90AA1	SARS-CoV-2 activates/modulates innate and adaptive immune responses
REAC:R-HSA-933543	0.000111517740355	0.15	IKBKG IKBKB CHUK	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
KEGG:04662	0.000117550743137	0.2	IKBKB IKBKG AKT3 CHUK	B cell receptor signaling pathway
CORUM:5233	0.000121147915214	0.15	IKBKG IKBKB CHUK	TNF-alpha/NF-kappa B signaling complex 5
REAC:R-HSA-168643	0.000124542972252	0.2	IKBKB IKBKG HSP90AB1 CHUK	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
WP:WP5293	0.000136517546095	0.2	IKBKB IKBKG AKT3 CHUK	Acute myeloid leukemia
KEGG:05212	0.000147978224659	0.2	IKBKB IKBKG AKT3 CHUK	Pancreatic cancer
WP:WP69	0.000156258826918	0.2	MAP3K14 CHUK IKBKB IKBKG	T cell receptor signaling pathway
KEGG:05220	0.000165212517602	0.2	IKBKB IKBKG AKT3 CHUK	Chronic myeloid leukemia
REAC:R-HSA-937039	0.000192960242756	0.15	IKBKG IKBKB CHUK	IRAK1 recruits IKK complex
REAC:R-HSA-975144	0.000192960242756	0.15	IKBKG IKBKB CHUK	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
CORUM:6512	0.000194638873543	0.1	CDC37 HSP90AA1	ILK-HSP90-CDC37 complex
KEGG:05169	0.000214198645154	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	Epstein-Barr virus infection
WP:WP4961	0.000217905056084	0.15	IKBKG IKBKB CHUK	STING pathway in Kawasaki like disease and COVID 19
KEGG:05235	0.000225898222095	0.2	IKBKB IKBKG AKT3 CHUK	PD-L1 expression and PD-1 checkpoint pathway in cancer
KEGG:04064	0.000225898222095	0.2	MAP3K14 CHUK IKBKB IKBKG	NF-kappa B signaling pathway
REAC:R-HSA-5684264	0.000245371480287	0.15	IKBKG IKBKB CHUK	MAP3K8 (TPL2)-dependent MAPK1/3 activation
WP:WP1544	0.000257046350968	0.2	MAP3K14 CHUK IKBKB IKBKG	MicroRNAs in cardiomyocyte hypertrophy
KEGG:05222	0.000301715606556	0.2	IKBKB IKBKG AKT3 CHUK	Small cell lung cancer
WP:WP712	0.000303895176401	0.15	IKBKG IKBKB CHUK	Estrogen signaling pathway
WP:WP4482	0.000303895176401	0.15	IKBKG IKBKB CHUK	Vitamin D in inflammatory diseases
KEGG:04620	0.000315978605449	0.2	IKBKB IKBKG AKT3 CHUK	Toll-like receptor signaling pathway
KEGG:05142	0.000330734728007	0.2	IKBKB IKBKG AKT3 CHUK	Chagas disease
GO:0016772	0.000332317697134	0.5	STK35 CDK11A TSSK6 AKT3 MAP3K14 PDIK1L IKBKB CHUK STK11 SRMS	transferase activity, transferring phosphorus-containing groups
KEGG:01523	0.000334415429194	0.15	IKBKG IKBKB CHUK	Antifolate resistance
KEGG:05166	0.000341410166719	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	Human T-cell leukemia virus 1 infection
KEGG:05208	0.000376401743665	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	Chemical carcinogenesis - reactive oxygen species
REAC:R-HSA-9758274	0.000376836118419	0.15	IKBKG IKBKB CHUK	Regulation of NF-kappa B signaling
REAC:R-HSA-1810476	0.000376836118419	0.15	IKBKG IKBKB CHUK	RIP-mediated NFkB activation via ZBP1
KEGG:05145	0.000378070889626	0.2	IKBKB IKBKG AKT3 CHUK	Toxoplasmosis
REAC:R-HSA-9694516	0.000388422245215	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	SARS-CoV-2 Infection
KEGG:04915	0.000394909062226	0.2	AKT3 FKBP5 HSP90AB1 HSP90AA1	Estrogen signaling pathway
WP:WP4263	0.000489505241367	0.2	IKBKB IKBKG AKT3 CHUK	Pancreatic adenocarcinoma pathway
WP:WP75	0.000539715821946	0.2	IKBKB IKBKG AKT3 CHUK	Toll like receptor signaling pathway
REAC:R-HSA-1606322	0.000548146259094	0.15	IKBKG IKBKB CHUK	ZBP1(DAI) mediated induction of type I IFNs
WP:WP3851	0.000610451737231	0.15	IKBKG IKBKB CHUK	TLR4 signaling and tolerance
CORUM:2055	0.000647731199222	0.1	CHUK IKBKB	CASP8-CHUK-IKBKB-MALT1-BCL10 complex
REAC:R-HSA-168927	0.000650355736822	0.15	IKBKG IKBKB CHUK	TICAM1, RIP1-mediated IKK complex recruitment
WP:WP5113	0.000689473786117	0.15	IKBKG IKBKB CHUK	Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway
WP:WP4658	0.000713347363334	0.2	IKBKB IKBKG AKT3 CHUK	Small cell lung cancer
WP:WP382	0.000757481664647	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	MAPK signaling pathway
REAC:R-HSA-937041	0.000764456810202	0.15	IKBKG IKBKB CHUK	IKK complex recruitment mediated by RIP1
WP:WP3858	0.000774981250946	0.15	IKBKG IKBKB CHUK	Toll like receptor signaling related to MyD88
WP:WP2112	0.000867221695943	0.15	MAP3K14 IKBKB IKBKG	IL 17 signaling pathway
REAC:R-HSA-933542	0.000891088110704	0.15	IKBKG IKBKB CHUK	TRAF6 mediated NF-kB activation
KEGG:04068	0.000893384881109	0.2	IKBKB CHUK AKT3 STK11	FoxO signaling pathway
KEGG:04010	0.00092310561864	0.25	IKBKB MAP3K14 CHUK AKT3 IKBKG	MAPK signaling pathway
KEGG:05135	0.000957552743354	0.2	IKBKB IKBKG AKT3 CHUK	Yersinia infection
WP:WP4880	0.000966441791659	0.15	IKBKG IKBKB CHUK	Host pathogen interaction of human coronaviruses interferon induction
WP:WP4496	0.00107288731695	0.15	MAP3K14 IKBKB CHUK	Signal transduction through IL1R
REAC:R-HSA-9013418	0.00118448450801	0.15	CDC37 HSP90AB1 HSP90AA1	RHOBTB2 GTPase cycle
WP:WP4329	0.00118680316094	0.15	IKBKG IKBKB CHUK	miRNA role in immune response in sepsis
KEGG:05200	0.00125940577974	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	Pathways in cancer
REAC:R-HSA-8939211	0.00127047662365	0.25	AGO3 AKT3 FKBP5 HSP90AB1 HSP90AA1	ESR-mediated signaling
KEGG:05162	0.00128914579273	0.2	IKBKB IKBKG AKT3 CHUK	Measles
REAC:R-HSA-8863795	0.00135251547195	0.15	CDC37 HSP90AA1 AKT3	Downregulation of ERBB2 signaling
GO:1902911	0.00136721637995	0.3	CDK11A IKBKB IKBKG TSSK6 CHUK STK11	protein kinase complex
WP:WP4136	0.00143802092488	0.15	IKBKG IKBKB CHUK	Fibrin complement receptor 3 signaling pathway
KEGG:05160	0.00160019699432	0.2	IKBKB IKBKG AKT3 CHUK	Hepatitis C
REAC:R-HSA-5607764	0.00187625985367	0.2	MAP3K14 CHUK IKBKB IKBKG	CLEC7A (Dectin-1) signaling
WP:WP2036	0.0018769462497	0.15	MAP3K14 IKBKB CHUK	TNF related weak inducer of apoptosis TWEAK signaling pathway
REAC:R-HSA-5260271	0.00194948699772	0.15	IKBKG IKBKB CHUK	Diseases of Immune System
REAC:R-HSA-5602358	0.00194948699772	0.15	IKBKG IKBKB CHUK	Diseases associated with the TLR signaling cascade
KEGG:04062	0.0020195730844	0.2	IKBKB IKBKG AKT3 CHUK	Chemokine signaling pathway
GO:0008385	0.00218580514948	0.15	IKBKG IKBKB CHUK	IkappaB kinase complex
KEGG:05164	0.00231955083229	0.2	IKBKB IKBKG AKT3 CHUK	Influenza A
WP:WP3929	0.00241324627289	0.2	IKBKB IKBKG AKT3 CHUK	Chemokine signaling pathway
REAC:R-HSA-9679506	0.00247065407915	0.3	AKT3 IKBKB HSP90AB1 HSP90AA1 IKBKG CHUK	SARS-CoV Infections
KEGG:05161	0.00258208802176	0.2	IKBKB IKBKG AKT3 CHUK	Hepatitis B
KEGG:04150	0.00258208802176	0.2	IKBKB CHUK AKT3 STK11	mTOR signaling pathway
CORUM:5193	0.00290284517391	0.1	IKBKG CHUK	TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2)
CORUM:5230	0.00290284517391	0.1	IKBKG CHUK	CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex
GO:0006468	0.00312939565119	0.5	CDK11A IKBKB TSSK6 HSP90AA1 HSP90AB1 SRMS CHUK CDC37 STK11 AKT3	protein phosphorylation
WP:WP2637	0.00322441192789	0.15	MAP3K14 IKBKB CHUK	Interleukin 1 IL 1 structural pathway
REAC:R-HSA-168638	0.00329140060027	0.15	IKBKG IKBKB CHUK	NOD1/2 Signaling Pathway
REAC:R-HSA-5357956	0.00329140060027	0.15	IKBKG IKBKB CHUK	TNFR1-induced NF-kappa-B signaling pathway
REAC:R-HSA-9665250	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to AEE788
REAC:R-HSA-9665249	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to afatinib
REAC:R-HSA-9665251	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to lapatinib
REAC:R-HSA-9665246	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to neratinib
REAC:R-HSA-9665247	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to osimertinib
REAC:R-HSA-9665244	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to sapitinib
REAC:R-HSA-9665245	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to tesevatinib
REAC:R-HSA-9665233	0.0033097676309	0.1	CDC37 HSP90AA1	Resistance of ERBB2 KD mutants to trastuzumab
REAC:R-HSA-9665230	0.0033097676309	0.1	CDC37 HSP90AA1	Drug resistance in ERBB2 KD mutants
REAC:R-HSA-9665737	0.0033097676309	0.1	CDC37 HSP90AA1	Drug resistance in ERBB2 TMD/JMD mutants
REAC:R-HSA-9652282	0.0033097676309	0.1	CDC37 HSP90AA1	Drug-mediated inhibition of ERBB2 signaling
GO:0006457	0.00333177800222	0.3	HSP90AB1 HSP90AA1 CDC37L1 UNC45B CDC37 FKBP5	protein folding
WP:WP4666	0.00393367954632	0.2	IKBKB IKBKG AKT3 CHUK	Hepatitis B infection
WP:WP2018	0.00395580401245	0.15	IKBKG IKBKB CHUK	RANKL RANK signaling pathway
KEGG:05167	0.00423304939699	0.2	IKBKB IKBKG AKT3 CHUK	Kaposi sarcoma-associated herpesvirus infection
REAC:R-HSA-9706574	0.00433183088977	0.15	CDC37 HSP90AB1 HSP90AA1	RHOBTB GTPase Cycle
REAC:R-HSA-445989	0.00472151075236	0.15	IKBKG IKBKB CHUK	TAK1-dependent IKK and NF-kappa-B activation
REAC:R-HSA-9006931	0.00518035492607	0.25	AGO3 AKT3 FKBP5 HSP90AB1 HSP90AA1	Signaling by Nuclear Receptors
WP:WP4223	0.00518423853631	0.2	IKBKB IKBKG AKT3 CHUK	Ras signaling
KEGG:04622	0.00543015768543	0.15	IKBKG IKBKB CHUK	RIG-I-like receptor signaling pathway
REAC:R-HSA-162582	0.00545716567483	0.55	AGO3 AKT3 IKBKB HSP90AA1 HSP90AB1 IKBKG STK11 SRMS CHUK CDC37 FKBP5	Signal Transduction
GO:0031072	0.00570436490179	0.25	CDC37L1 UNC45B FKBP5 HSP90AB1 CDC37	heat shock protein binding
CORUM:5232	0.00585094907044	0.1	IKBKG CHUK	TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I)
REAC:R-HSA-5621481	0.0058750665582	0.2	MAP3K14 CHUK IKBKB IKBKG	C-type lectin receptors (CLRs)
KEGG:04014	0.00602481776188	0.2	IKBKB IKBKG AKT3 CHUK	Ras signaling pathway
WP:WP3865	0.00641877767763	0.15	IKBKG IKBKB CHUK	Novel intracellular components of RIG I like receptor pathway
KEGG:04623	0.00677547143451	0.15	IKBKG IKBKB CHUK	Cytosolic DNA-sensing pathway
KEGG:05163	0.00710262865496	0.2	IKBKB IKBKG AKT3 CHUK	Human cytomegalovirus infection
GO:0016310	0.00712538715135	0.5	CDK11A IKBKB TSSK6 HSP90AA1 HSP90AB1 SRMS CHUK CDC37 STK11 AKT3	phosphorylation
KEGG:05170	0.00724657165787	0.2	IKBKB IKBKG AKT3 CHUK	Human immunodeficiency virus 1 infection
KEGG:04658	0.00799566364052	0.15	IKBKG IKBKB CHUK	Th1 and Th2 cell differentiation
REAC:R-HSA-1227986	0.00811109832792	0.15	CDC37 HSP90AA1 AKT3	Signaling by ERBB2
REAC:R-HSA-5336415	0.00826083671942	0.1	HSP90AB1 HSP90AA1	Uptake and function of diphtheria toxin
REAC:R-HSA-5357905	0.00869699914005	0.15	IKBKG IKBKB CHUK	Regulation of TNFR1 signaling
GO:1990459	0.00915637133828	0.15	IKBKG IKBKB CHUK	transferrin receptor binding
WP:WP3303	0.0101960072228	0.15	IKBKG IKBKB CHUK	RAC1 PAK1 p38 MMP2 pathway
KEGG:04914	0.0108473666096	0.15	AKT3 HSP90AB1 HSP90AA1	Progesterone-mediated oocyte maturation
WP:WP4655	0.0111955102897	0.15	IKBKG IKBKB CHUK	Cytosolic DNA sensing pathway
WP:WP2034	0.0128115184765	0.15	IKBKG IKBKB CHUK	Leptin signaling pathway
KEGG:05131	0.01352256309	0.2	IKBKB IKBKG AKT3 CHUK	Shigellosis
REAC:R-HSA-3371497	0.0144115309135	0.15	FKBP5 HSP90AB1 HSP90AA1	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
REAC:R-HSA-75893	0.0152628957945	0.15	IKBKG IKBKB CHUK	TNF signaling
GO:0140096	0.0153711715169	0.6	STK35 CDK11A TSSK6 AKT3 CTDSPL2 MAP3K14 STK11 PDIK1L IKBKB CHUK FKBP5 SRMS	catalytic activity, acting on a protein
WP:WP254	0.0158303895991	0.15	IKBKG IKBKB CHUK	Apoptosis
WP:WP5098	0.016484886765	0.15	IKBKG IKBKB CHUK	T cell activation SARS CoV 2
WP:WP23	0.0178462700734	0.15	IKBKG IKBKB CHUK	B cell receptor signaling pathway
REAC:R-HSA-450294	0.0180133673228	0.15	IKBKG IKBKB CHUK	MAP kinase activation
REAC:R-HSA-9634285	0.0197772182237	0.1	CDC37 HSP90AA1	Constitutive Signaling by Overexpressed ERBB2
REAC:R-HSA-1834949	0.0210701770183	0.15	IKBKG IKBKB CHUK	Cytosolic sensors of pathogen-associated DNA
GO:0097110	0.0218974502789	0.2	IKBKB CDC37 HSP90AA1 CHUK	scaffold protein binding
REAC:R-HSA-448424	0.0244483192953	0.15	IKBKG IKBKB CHUK	Interleukin-17 signaling
GO:0051604	0.0262164796614	0.35	IKBKB HSP90AB1 HSP90AA1 CDC37L1 UNC45B CDC37 FKBP5	protein maturation
REAC:R-HSA-1169091	0.0281626190518	0.15	IKBKG IKBKB CHUK	Activation of NF-kappaB in B cells
GO:1902554	0.0307335447473	0.25	IKBKB IKBKG STK11 CDK11A CHUK	serine/threonine protein kinase complex
GO:0005524	0.0356814839445	0.3	AKT3 TSSK6 HSP90AB1 HSP90AA1 STK11 CDK11A	ATP binding
KEGG:05165	0.0360876338831	0.2	IKBKB IKBKG AKT3 CHUK	Human papillomavirus infection
REAC:R-HSA-3371511	0.0361690191951	0.1	HSP90AB1 HSP90AA1	HSF1 activation
REAC:R-HSA-5637812	0.0361690191951	0.1	CDC37 HSP90AA1	Signaling by EGFRvIII in Cancer
REAC:R-HSA-5637810	0.0361690191951	0.1	CDC37 HSP90AA1	Constitutive Signaling by EGFRvIII
REAC:R-HSA-1280215	0.0372563171244	0.3	AKT3 IKBKG IKBKB HSP90AA1 MAP3K14 CHUK	Cytokine Signaling in Immune system
WP:WP2882	0.0409085583191	0.2	CDC37 FKBP5 HSP90AB1 HSP90AA1	Nuclear receptors meta pathway
REAC:R-HSA-1168372	0.0414681934151	0.15	IKBKG IKBKB CHUK	Downstream signaling events of B Cell Receptor (BCR)
REAC:R-HSA-198323	0.0427101208228	0.1	CHUK AKT3	AKT phosphorylates targets in the cytosol
REAC:R-HSA-3371568	0.0427101208228	0.1	HSP90AB1 HSP90AA1	Attenuation phase
REAC:R-HSA-9665348	0.0427101208228	0.1	CDC37 HSP90AA1	Signaling by ERBB2 ECD mutants
REAC:R-HSA-2871837	0.0431583545333	0.15	IKBKG IKBKB CHUK	FCERI mediated NF-kB activation
CORUM:2123	0.0499436884912	0.05	IKBKG	IKBKG homodimer complex
CORUM:5827	0.0499436884912	0.05	IKBKG	IKBKG homotetramer complex
CORUM:5716	0.0499436884912	0.05	HSP90AA1	NOS3-HSP90 complex, VEGF induced
CORUM:5730	0.0499436884912	0.05	IKBKG	IKBKG homotrimer complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
IKBKG	IKBKB	1.0	0.29
HSP90AB1	HSP90AA1	1.0	0.954
CTDSPL2	PDIK1L	1.0
STK35	CTDSPL2	0.999	0.048
CHUK	IKBKG	0.999	0.176
CDC37L1	STK35	0.999	0.056
CHUK	IKBKB	0.998	0.07
CDC37	HSP90AA1	0.998	0.667333333333
CDC37	CHUK	0.998	0.25
CDC37	IKBKB	0.997	0.21
CDC37	STK35	0.997	0.108
CDK11A	FKBP5	0.996
CDC37	HSP90AB1	0.996	0.502
CDK11A	CDC37	0.994
HSP90AA1	STK35	0.994	0.334152808277
HSP90AB1	STK35	0.993	0.25618165364
CDK11A	HSP90AA1	0.993
CDK11A	HSP90AB1	0.992
CDC37	IKBKG	0.991	0.22
CDC37	STK11	0.991	0.139
IKBKG	HSP90AA1	0.988	0.314
CDC37	PDIK1L	0.987
CDC37L1	HSP90AB1	0.986	0.351110091582
TSSK6	CDC37	0.986
STK11	HSP90AB1	0.985	0.259625454545
FKBP5	HSP90AA1	0.984	0.346
TSSK6	FKBP5	0.983
TSSK6	HSP90AA1	0.98
FKBP5	HSP90AB1	0.978	0.367396470588
TSSK6	HSP90AB1	0.978
IKBKG	HSP90AB1	0.976	0.316097846684
FKBP5	CDC37	0.975	0.16
FKBP5	STK11	0.974	0.236
STK11	HSP90AA1	0.971	0.422591988764
FKBP5	IKBKB	0.969	0.16
MAP3K14	IKBKG	0.969
CDC37L1	HSP90AA1	0.966	0.479316479401
HSP90AB1	UNC45B	0.963	0.144
MAP3K14	IKBKB	0.961
FKBP5	CHUK	0.958	0.126
CDC37	AKT3	0.957	0.27735483871
A6NIL8	CDC37	0.952
HSP90AA1	UNC45B	0.952	0.207431818182
FKBP5	AGO3	0.949	0.214366013072
HSP90AB1	SRMS	0.949
HSP90AA1	SRMS	0.939
HSP90AB1	AKT3	0.937	0.188
FKBP5	SRMS	0.92
FKBP5	IKBKG	0.914	0.118
CDC37	SRMS	0.91
CHUK	MAP3K14	0.901
HSP90AA1	AKT3	0.897	0.343398197956
HSP90AA1	AGO3	0.887	0.438582568807
FKBP5	EPHB6	0.861	0.124
A6NIL8	CHUK	0.843
IKBKB	HSP90AA1	0.838	0.617333333333
STK35	PDIK1L	0.83
HSP90AB1	AGO3	0.83	0.31
CHUK	HSP90AB1	0.784	0.4015
A6NIL8	IKBKB	0.762
A6NIL8	STK35	0.745
HSP90AA1	PDIK1L	0.723
A6NIL8	HSP90AB1	0.712
A6NIL8	HSP90AA1	0.712
IKBKB	HSP90AB1	0.712	0.47
A6NIL8	IKBKG	0.709
A6NIL8	STK11	0.703
HSP90AB1	PDIK1L	0.702
A6NIL8	SRMS	0.666
FKBP5	A6NIL8	0.664
CHUK	HSP90AA1	0.648	0.28219047619
CHUK	CDC37L1	0.634	0.096
CDC37L1	CTDSPL2	0.625	0.066
CDC37	CTDSPL2	0.619	0.048
CDC37	CDC37L1	0.611	0.226
CDC37	MAP3K14	0.551
CDK11A	CHUK	0.512
CDK11A	IKBKG	0.464
STK11	STK35	0.405	0.08
IKBKB	STK35	0.401	0.146
FKBP5	PDIK1L	0.389
STK11	IKBKB	0.356	0.206
A6NIL8	CTDSPL2	0.334
MAP3K14	HSP90AB1	0.331
CDK11A	STK35	0.295
CDC37	EPHB6	0.294	0.192
IKBKG	CDC37L1	0.249	0.138
HSP90AB1	EPHB6	0.249	0.432
FKBP5	STK35	0.249	0.088
CDK11A	IKBKB	0.227
IKBKG	STK35	0.22	0.08
CDK11A	STK11	0.22
CHUK	STK35	0.188	0.12
A6NIL8	CDC37L1	0.188
FKBP5	AKT3	0.179	0.138
HSP90AA1	EPHB6	0.175	0.285
HSP90AA1	CTDSPL2	0.164	0.163065589526
HSP90AB1	CTDSPL2	0.164	0.13
STK11	IKBKG	0.157	0.164
STK11	CHUK	0.147	0.18
CDK11A	A6NIL8	0.13
MAP3K14	HSP90AA1	0.118
FKBP5	CTDSPL2	0.116	0.092
FKBP5	CDC37L1	0.093	0.082
CDC37	AGO3	0.037	0.192
AKT3	AGO3	0.01	0.234
FKBP5	UNC45B	0.01	0.044
AGO3	CTDSPL2	0.01	0.144
AGO3	PDIK1L	0.009
A6NIL8	AGO3	0.007
IKBKB	AGO3	0.006	0.192
CHUK	AGO3	0.005	0.102
STK11	AGO3	0.003	0.22
UNC45B	AGO3	0.002	0.054
AGO3	SRMS	0.002
AGO3	STK35	0.002	0.126
TSSK6	AGO3	0.002
IKBKG	AGO3	0.001	0.116
CDK11A	AGO3	0.001





Related Complexes

Genename	Complexes
HSP90AB1	huMAP3_01040.1 huMAP3_01350.1 huMAP3_06978.1 huMAP3_07570.1 huMAP3_08596.1 huMAP3_10304.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14477.1
CDC37L1	huMAP3_00862.1 huMAP3_03822.1 huMAP3_04697.1 huMAP3_05953.1 huMAP3_06978.1 huMAP3_07570.1 huMAP3_08596.1 huMAP3_08942.1 huMAP3_10304.1 huMAP3_10591.1 huMAP3_11340.1 huMAP3_12065.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13837.1 huMAP3_14185.1 huMAP3_14202.1 huMAP3_14477.1 huMAP3_14847.1
SRMS	huMAP3_04833.1 huMAP3_13837.1 huMAP3_14477.1
MAP3K14	huMAP3_00283.1 huMAP3_02424.1 huMAP3_06738.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_12315.1 huMAP3_12825.1 huMAP3_13837.1 huMAP3_14477.1
HSP90AA1	huMAP3_01040.1 huMAP3_01350.1 huMAP3_06978.1 huMAP3_07570.1 huMAP3_08596.1 huMAP3_10304.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14185.1 huMAP3_14477.1
AGO3	huMAP3_02184.1 huMAP3_02426.1 huMAP3_04863.1 huMAP3_06571.1 huMAP3_09102.1 huMAP3_09157.1 huMAP3_10669.1 huMAP3_11061.1 huMAP3_11083.1 huMAP3_13205.1 huMAP3_13637.1 huMAP3_13837.1 huMAP3_14477.1
STK35	huMAP3_03822.1 huMAP3_04697.1 huMAP3_06216.1 huMAP3_06978.1 huMAP3_09698.1 huMAP3_10304.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14185.1 huMAP3_14202.1 huMAP3_14469.1 huMAP3_14477.1 huMAP3_14920.1
TSSK6	huMAP3_00133.1 huMAP3_01040.1 huMAP3_07570.1 huMAP3_09784.1 huMAP3_10304.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14256.1 huMAP3_14477.1
CDK11A	huMAP3_00133.1 huMAP3_02101.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14373.1 huMAP3_14389.1 huMAP3_14477.1
PDIK1L	huMAP3_08322.1 huMAP3_09665.1 huMAP3_09698.1 huMAP3_10336.1 huMAP3_13837.1 huMAP3_14185.1 huMAP3_14202.1 huMAP3_14477.1 huMAP3_14920.1
CDC37	huMAP3_00133.1 huMAP3_05923.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14477.1
AKT3	huMAP3_02055.1 huMAP3_10657.1 huMAP3_13837.1 huMAP3_14477.1
IKBKG	huMAP3_00283.1 huMAP3_01074.1 huMAP3_02424.1 huMAP3_06738.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_12825.1 huMAP3_13837.1 huMAP3_14477.1
CFAP54	huMAP3_04833.1 huMAP3_14477.1
EPHB6	huMAP3_11714.1 huMAP3_11794.1 huMAP3_13703.1 huMAP3_14009.1 huMAP3_14477.1
UNC45B	huMAP3_01040.1 huMAP3_01350.1 huMAP3_06978.1 huMAP3_07570.1 huMAP3_08596.1 huMAP3_10304.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14185.1 huMAP3_14477.1
CHUK	huMAP3_00133.1 huMAP3_00283.1 huMAP3_01074.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_12825.1 huMAP3_13837.1 huMAP3_14477.1
CTDSPL2	huMAP3_03822.1 huMAP3_06216.1 huMAP3_08322.1 huMAP3_09698.1 huMAP3_10304.1 huMAP3_10336.1 huMAP3_13254.1 huMAP3_14185.1 huMAP3_14202.1 huMAP3_14477.1 huMAP3_14920.1
FKBP5	huMAP3_00133.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_11794.1 huMAP3_13837.1 huMAP3_14477.1
STK11	huMAP3_00133.1 huMAP3_01132.1 huMAP3_01890.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14477.1
IKBKB	huMAP3_00283.1 huMAP3_01074.1 huMAP3_06738.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_12825.1 huMAP3_13837.1 huMAP3_14477.1
A6NIL8	huMAP3_00133.1 huMAP3_05923.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_11443.1 huMAP3_12825.1 huMAP3_13837.1 huMAP3_14477.1 huMAP3_15024.1