hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14478.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
ASAP1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)	5	UniProt NCBI
SOS2	Son of sevenless homolog 2 (SOS-2)	5	UniProt NCBI
SPATA2L	Spermatogenesis-associated protein 2-like protein (SPATA2-like protein)	5	UniProt NCBI
THEMIS	Protein THEMIS (Thymocyte-expressed molecule involved in selection)	5	UniProt NCBI
SPATA2	Spermatogenesis-associated protein 2	5	UniProt NCBI
GAREM1	GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)	5	UniProt NCBI
C16orf96	Uncharacterized protein C16orf96	2	UniProt NCBI
OR6Q1	Olfactory receptor 6Q1 (Olfactory receptor OR11-226)	3	UniProt NCBI
PIK3C2B	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)	5	UniProt NCBI
GLS2	Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)	5	UniProt NCBI
PTPRE	Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)	5	UniProt NCBI
SOS1	Son of sevenless homolog 1 (SOS-1)	5	UniProt NCBI
NKX2-5	Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)	5	UniProt NCBI
GAREM2	GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like)	3	UniProt NCBI
SHC1	SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)	5	UniProt NCBI
ALK	ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)	5	UniProt NCBI
ERRFI1	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)	5	UniProt NCBI
ARHGEF35	Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein)	2	UniProt NCBI
ARHGEF5	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	5	UniProt NCBI
GRB2	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)	5	UniProt NCBI
CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4928	3.12342042716e-07	0.2	SOS1 SOS2 ALK GAREM2	MAPK pathway in congenital thyroid cancer
WP:WP437	3.51970824514e-06	0.3	PIK3C2B GRB2 ERRFI1 SOS1 SOS2 ASAP1	EGF EGFR signaling pathway
REAC:R-HSA-73887	4.16541534012e-06	0.3	ARHGEF5 SPATA2 ARHGEF35 CYLD SOS1 SOS2	Death Receptor Signaling
CORUM:6296	6.49329465809e-05	0.1	SPATA2 CYLD	SPATA2-CYLD complex
CORUM:3144	6.49329465809e-05	0.1	SOS1 GRB2	GRB2-SOS1 complex
CORUM:2917	6.49329465809e-05	0.1	SOS1 GRB2	GRB2-SOS1 complex
CORUM:2893	6.49329465809e-05	0.1	SOS1 GRB2	BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex
REAC:R-HSA-193648	9.4434821435e-05	0.2	ARHGEF5 SOS1 SOS2 ARHGEF35	NRAGE signals death through JNK
KEGG:05223	0.000117550743137	0.2	SOS1 GRB2 SOS2 ALK	Non-small cell lung cancer
WP:WP4205	0.000118693518309	0.2	SOS1 GRB2 SOS2 ALK	MET in type 1 papillary renal cell carcinoma
REAC:R-HSA-8983432	0.000192960242756	0.15	SOS1 SOS2 GRB2	Interleukin-15 signaling
WP:WP4255	0.000228301627459	0.2	SOS1 GRB2 SOS2 ALK	Non small cell lung cancer
REAC:R-HSA-204998	0.000298576862827	0.2	ARHGEF5 SOS1 SOS2 ARHGEF35	Cell death signalling via NRAGE, NRIF and NADE
REAC:R-HSA-416482	0.000419813435298	0.2	ARHGEF5 SOS1 SOS2 ARHGEF35	G alpha (12/13) signalling events
CORUM:2922	0.000647731199222	0.1	SOS1 GRB2	LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated
WP:WP422	0.000774981250946	0.15	SOS1 SOS2 GRB2	MAPK cascade
REAC:R-HSA-193704	0.00085684752918	0.2	ARHGEF5 SOS1 SOS2 ARHGEF35	p75 NTR receptor-mediated signalling
WP:WP710	0.00118036813175	0.2	SOS1 GRB2 SOS2 PIK3C2B	DNA damage response only ATM dependent
CORUM:2480	0.00135800282338	0.1	SOS1 GRB2	CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1)
WP:WP4535	0.00221376775043	0.15	SOS1 SOS2 GRB2	Envelope proteins and their potential roles in EDMD physiopathology
KEGG:05206	0.00258208802176	0.2	GLS2 GRB2 SOS2 SOS1	MicroRNAs in cancer
KEGG:05213	0.00277875027194	0.15	SOS1 SOS2 GRB2	Endometrial cancer
KEGG:04664	0.00294290565619	0.15	SOS1 SOS2 GRB2	Fc epsilon RI signaling pathway
WP:WP2253	0.00328393756006	0.1	SOS1 GRB2	Pilocytic astrocytoma
REAC:R-HSA-451927	0.00361738182966	0.15	SOS1 SOS2 GRB2	Interleukin-2 family signaling
KEGG:05221	0.00406263293408	0.15	SOS1 SOS2 GRB2	Acute myeloid leukemia
KEGG:04917	0.00471398731322	0.15	SOS1 SOS2 GRB2	Prolactin signaling pathway
KEGG:05211	0.00543015768543	0.15	SOS1 SOS2 GRB2	Renal cell carcinoma
KEGG:04662	0.0062139700395	0.15	SOS1 SOS2 GRB2	B cell receptor signaling pathway
KEGG:05214	0.0062139700395	0.15	SOS1 SOS2 GRB2	Glioma
KEGG:04912	0.0062139700395	0.15	SOS1 SOS2 GRB2	GnRH signaling pathway
KEGG:04540	0.007068218119	0.15	SOS1 SOS2 GRB2	Gap junction
WP:WP4155	0.00755210147677	0.15	SOS1 SOS2 GRB2	Endometrial cancer
KEGG:01521	0.00799566364052	0.15	SOS1 SOS2 GRB2	EGFR tyrosine kinase inhibitor resistance
KEGG:05220	0.00799566364052	0.15	SOS1 SOS2 GRB2	Chronic myeloid leukemia
WP:WP5293	0.0083760456789	0.15	SOS1 SOS2 GRB2	Acute myeloid leukemia
KEGG:04012	0.00865597530506	0.15	SOS1 SOS2 GRB2	ErbB signaling pathway
WP:WP4685	0.0088091985821	0.15	SOS1 SOS2 GRB2	Melanoma
KEGG:05210	0.00935083415945	0.15	SOS1 SOS2 GRB2	Colorectal cancer
KEGG:01522	0.0108473666096	0.15	SOS1 SOS2 GRB2	Endocrine resistance
KEGG:05231	0.01124432617	0.15	SOS1 SOS2 GRB2	Choline metabolism in cancer
KEGG:05215	0.0142895579343	0.15	SOS1 SOS2 GRB2	Prostate cancer
KEGG:04915	0.0152481582569	0.15	SOS1 SOS2 GRB2	Estrogen signaling pathway
WP:WP2261	0.0185535691025	0.15	GRB2 PIK3C2B ERRFI1	Glioblastoma signaling pathways
KEGG:04935	0.0194973343545	0.15	SOS1 SOS2 GRB2	Growth hormone synthesis, secretion and action
KEGG:04722	0.0194973343545	0.15	SOS1 SOS2 GRB2	Neurotrophin signaling pathway
WP:WP4806	0.0200224081209	0.15	SOS1 SOS2 GRB2	EGFR tyrosine kinase inhibitor resistance
KEGG:04660	0.0212684523724	0.15	SOS1 SOS2 GRB2	T cell receptor signaling pathway
WP:WP673	0.0215649273898	0.15	SOS1 SOS2 GRB2	ErbB signaling pathway
KEGG:04926	0.0244453246516	0.15	SOS1 SOS2 GRB2	Relaxin signaling pathway
KEGG:04650	0.0251152500826	0.15	SOS1 SOS2 GRB2	Natural killer cell mediated cytotoxicity
KEGG:04068	0.0279130441331	0.15	SOS1 SOS2 GRB2	FoxO signaling pathway
KEGG:04072	0.0301378087421	0.15	SOS1 SOS2 GRB2	Phospholipase D signaling pathway
WP:WP4321	0.0304389728412	0.15	SOS1 SOS2 GRB2	Thermogenesis
KEGG:04910	0.0383675583404	0.15	SOS1 SOS2 GRB2	Insulin signaling pathway
KEGG:05224	0.0392615375476	0.15	SOS1 SOS2 GRB2	Breast cancer
REAC:R-HSA-9703648	0.0427101208228	0.1	SOS1 GRB2	Signaling by FLT3 ITD and TKD mutants
REAC:R-HSA-428540	0.0427101208228	0.1	SOS1 SOS2	Activation of RAC1
KEGG:05160	0.0429706405059	0.15	SOS1 SOS2 GRB2	Hepatitis C
KEGG:04630	0.0429706405059	0.15	SOS1 SOS2 GRB2	JAK-STAT signaling pathway
KEGG:05226	0.0429706405059	0.15	SOS1 SOS2 GRB2	Gastric cancer
KEGG:04217	0.0489426466655	0.15	SPATA2L CYLD SPATA2	Necroptosis
WP:WP581	0.0499126318911	0.1	SOS1 GRB2	EPO receptor signaling
CORUM:2895	0.0499436884912	0.05	GRB2	SHC-GRB2 complex
CORUM:3096	0.0499436884912	0.05	GRB2	ITGA6-ITGB4-SHC1-GRB2 complex
CORUM:2892	0.0499436884912	0.05	GRB2	BCR-ABL (p185 fusion protein)-GRB2 complex
CORUM:2540	0.0499436884912	0.05	GRB2	BCR-ABL (p210 fusion protein)-GRB2 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
SOS2	GRB2	1.0	0.192
GRB2	ASAP1	0.999	0.066
GRB2	SOS1	0.999	0.134
GRB2	GAREM1	0.999
GAREM2	GAREM1	0.998
ERRFI1	GRB2	0.998	0.202
GAREM1	OR6Q1	0.997
ARHGEF35	ARHGEF5	0.994
GRB2	CYLD	0.994	0.263837209302
SHC1	GAREM1	0.988
GRB2	GAREM2	0.985
GRB2	PTPRE	0.982	0.212
SHC1	GRB2	0.976
GLS2	GRB2	0.974	0.2
C16orf96	GRB2	0.968
ARHGEF35	GRB2	0.965
NKX2-5	GRB2	0.955
ARHGEF5	GRB2	0.954	0.134
GRB2	SPATA2L	0.948
GRB2	SPATA2	0.923	0.132
PIK3C2B	GRB2	0.908	0.130726027397
SOS2	ARHGEF35	0.904
ERRFI1	ARHGEF35	0.904
SOS2	PTPRE	0.904	0.088
GAREM2	OR6Q1	0.902
ARHGEF35	PTPRE	0.902
GRB2	THEMIS	0.901	0.19
SOS2	ASAP1	0.9	0.058
ARHGEF35	SOS1	0.892
SHC1	OR6Q1	0.892
SOS1	PTPRE	0.892	0.112
ASAP1	SOS1	0.883	0.152
SOS2	SOS1	0.877	0.118
SOS2	ARHGEF5	0.869	0.092
SOS2	ERRFI1	0.844	0.09
SHC1	ALK	0.827
SHC1	GAREM2	0.796
ARHGEF5	SOS1	0.768	0.138
ARHGEF35	ASAP1	0.768
ERRFI1	ASAP1	0.73	0.098
ERRFI1	SOS1	0.73	0.116
ERRFI1	PTPRE	0.722	0.11
SHC1	ARHGEF35	0.715
ARHGEF5	PTPRE	0.676	0.094
SHC1	SOS1	0.675
SHC1	SOS2	0.675
ERRFI1	ARHGEF5	0.626	0.15
C16orf96	SOS2	0.557
C16orf96	ERRFI1	0.557
C16orf96	SPATA2L	0.557
C16orf96	GAREM2	0.557
GAREM2	SPATA2L	0.557
C16orf96	GAREM1	0.543
PIK3C2B	C16orf96	0.502
GAREM1	SPATA2L	0.502
C16orf96	CYLD	0.502
C16orf96	ASAP1	0.502
C16orf96	SPATA2	0.502
SOS2	GAREM2	0.487
C16orf96	SOS1	0.487
ERRFI1	SPATA2L	0.487
SOS2	SPATA2L	0.487
ERRFI1	GAREM2	0.487
ASAP1	PTPRE	0.478	0.056
SHC1	PTPRE	0.401
ARHGEF5	ASAP1	0.388	0.084
PIK3C2B	ERRFI1	0.387	0.092
GRB2	OR6Q1	0.377
CYLD	SPATA2	0.366	0.088
GAREM2	SPATA2	0.35
NKX2-5	C16orf96	0.35
SHC1	ASAP1	0.343
SHC1	ERRFI1	0.343
SOS1	SPATA2L	0.337
SOS1	GAREM2	0.337
ASAP1	SPATA2L	0.333
CYLD	GAREM2	0.333
ASAP1	GAREM2	0.333
SHC1	ARHGEF5	0.331
ERRFI1	GAREM1	0.33
PIK3C2B	GAREM2	0.303
SOS2	GAREM1	0.303
SPATA2	SPATA2L	0.287
ERRFI1	CYLD	0.265	0.03
NKX2-5	ASAP1	0.262
C16orf96	PTPRE	0.214
ARHGEF35	SPATA2L	0.214
C16orf96	ARHGEF5	0.214
PTPRE	SPATA2L	0.214
ARHGEF5	SPATA2L	0.214
ARHGEF5	GAREM2	0.214
GAREM2	PTPRE	0.214
C16orf96	ARHGEF35	0.214
ARHGEF35	GAREM2	0.214
PIK3C2B	SPATA2L	0.213
CYLD	GAREM1	0.191
PIK3C2B	GAREM1	0.191
NKX2-5	PIK3C2B	0.189
ASAP1	CYLD	0.176	0.132
CYLD	SPATA2L	0.173
SOS2	SPATA2	0.172	0.102
NKX2-5	GAREM2	0.172
SOS1	SPATA2	0.172	0.156
SOS1	CYLD	0.172	0.162
ERRFI1	SPATA2	0.172	0.082
SOS2	CYLD	0.172	0.162
NKX2-5	SPATA2L	0.172
NKX2-5	SPATA2	0.164
ASAP1	SPATA2	0.164	0.09
ASAP1	GAREM1	0.164
PIK3C2B	SOS1	0.164	0.12
NKX2-5	SOS1	0.164
PIK3C2B	SOS2	0.164	0.084
NKX2-5	CYLD	0.164
GAREM1	SPATA2	0.164
SOS1	GAREM1	0.164
PIK3C2B	ASAP1	0.164	0.052
NKX2-5	SOS2	0.164
NKX2-5	ERRFI1	0.164
NKX2-5	GAREM1	0.143
ARHGEF35	GAREM1	0.131
SHC1	C16orf96	0.131
GAREM1	PTPRE	0.131
PTPRE	SPATA2	0.131	0.076
ARHGEF35	SPATA2	0.128
GLS2	SPATA2L	0.122
GLS2	GAREM2	0.122
C16orf96	GLS2	0.122
PIK3C2B	GLS2	0.11	0.168
NKX2-5	GLS2	0.11
GLS2	CYLD	0.11	0.09
GLS2	SOS1	0.11	0.062
ERRFI1	GLS2	0.11	0.066
SOS2	GLS2	0.11	0.154
GLS2	ASAP1	0.11	0.092
GLS2	GAREM1	0.11
GLS2	SPATA2	0.11	0.092
ARHGEF5	GAREM1	0.1
PIK3C2B	CYLD	0.082	0.174
PIK3C2B	ARHGEF5	0.07	0.148
ARHGEF5	SPATA2	0.07	0.098
CYLD	PTPRE	0.055	0.138
PIK3C2B	ARHGEF35	0.046
NKX2-5	ARHGEF35	0.046
PIK3C2B	PTPRE	0.046	0.076
NKX2-5	PTPRE	0.046
PIK3C2B	SHC1	0.044
NKX2-5	ARHGEF5	0.043
NKX2-5	SHC1	0.042
ARHGEF5	CYLD	0.039	0.246
PIK3C2B	SPATA2	0.038	0.098
GRB2	ALK	0.027
SHC1	SPATA2L	0.025
ARHGEF35	CYLD	0.025
SHC1	CYLD	0.022
SHC1	SPATA2	0.016
ARHGEF5	GLS2	0.015	0.104
ARHGEF35	GLS2	0.015
GLS2	PTPRE	0.015	0.072
SHC1	GLS2	0.013
ALK	SPATA2	0.012
CYLD	ALK	0.008

Related Complexes

Genename	Complexes
ASAP1	huMAP3_02478.1 huMAP3_06265.1 huMAP3_10120.1 huMAP3_12900.1 huMAP3_13626.1 huMAP3_14478.1 huMAP3_14965.1 huMAP3_15054.1
SOS2	huMAP3_02129.1 huMAP3_04552.1 huMAP3_06243.1 huMAP3_07305.1 huMAP3_07767.1 huMAP3_08669.1 huMAP3_09299.1 huMAP3_10500.1 huMAP3_10717.1 huMAP3_13626.1 huMAP3_14478.1
SPATA2L	huMAP3_12679.1 huMAP3_13626.1 huMAP3_14478.1
THEMIS	huMAP3_12679.1 huMAP3_13626.1 huMAP3_14478.1
SPATA2	huMAP3_12369.1 huMAP3_12447.1 huMAP3_12679.1 huMAP3_13626.1 huMAP3_14478.1
GAREM1	huMAP3_04552.1 huMAP3_04682.1 huMAP3_05996.1 huMAP3_10500.1 huMAP3_10717.1 huMAP3_12679.1 huMAP3_13555.1 huMAP3_13626.1 huMAP3_14478.1 huMAP3_14611.1
C16orf96	huMAP3_02129.1 huMAP3_04552.1 huMAP3_06243.1 huMAP3_07305.1 huMAP3_07767.1 huMAP3_08669.1 huMAP3_09299.1 huMAP3_10500.1 huMAP3_10717.1 huMAP3_12679.1 huMAP3_13626.1 huMAP3_14478.1
OR6Q1	huMAP3_04682.1 huMAP3_05996.1 huMAP3_10717.1 huMAP3_12679.1 huMAP3_13555.1 huMAP3_13626.1 huMAP3_14478.1 huMAP3_14611.1
PIK3C2B	huMAP3_00461.1 huMAP3_01055.1 huMAP3_06540.1 huMAP3_08531.1 huMAP3_09952.1 huMAP3_10580.1 huMAP3_11849.1 huMAP3_12364.1 huMAP3_13626.1 huMAP3_14478.1
GLS2	huMAP3_02129.1 huMAP3_03848.1 huMAP3_07305.1 huMAP3_07767.1 huMAP3_08669.1 huMAP3_09299.1 huMAP3_10717.1 huMAP3_12679.1 huMAP3_13626.1 huMAP3_14478.1
PTPRE	huMAP3_05167.1 huMAP3_05762.1 huMAP3_13626.1 huMAP3_14478.1
SOS1	huMAP3_02816.1 huMAP3_13135.1 huMAP3_13161.1 huMAP3_13626.1 huMAP3_14478.1
NKX2-5	huMAP3_00142.1 huMAP3_00279.1 huMAP3_06265.1 huMAP3_06792.1 huMAP3_07767.1 huMAP3_08948.1 huMAP3_10120.1 huMAP3_10198.1 huMAP3_12679.1 huMAP3_13005.1 huMAP3_13944.1 huMAP3_14259.1 huMAP3_14478.1 huMAP3_14677.1
GAREM2	huMAP3_04552.1 huMAP3_04682.1 huMAP3_07305.1 huMAP3_07767.1 huMAP3_08669.1 huMAP3_09299.1 huMAP3_10500.1 huMAP3_10717.1 huMAP3_12679.1 huMAP3_13555.1 huMAP3_13626.1 huMAP3_14478.1 huMAP3_14611.1
SHC1	huMAP3_01479.1 huMAP3_04269.1 huMAP3_07305.1 huMAP3_09299.1 huMAP3_10717.1 huMAP3_12595.1 huMAP3_13555.1 huMAP3_13626.1 huMAP3_14478.1 huMAP3_14611.1 huMAP3_14845.1
ALK	huMAP3_12321.1 huMAP3_13555.1 huMAP3_13804.1 huMAP3_13917.1 huMAP3_14478.1 huMAP3_14611.1 huMAP3_14845.1
ERRFI1	huMAP3_02129.1 huMAP3_04051.1 huMAP3_07305.1 huMAP3_07767.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10717.1 huMAP3_12897.1 huMAP3_13626.1 huMAP3_14478.1
ARHGEF35	huMAP3_02129.1 huMAP3_03994.1 huMAP3_07767.1 huMAP3_08669.1 huMAP3_09299.1 huMAP3_10717.1 huMAP3_13626.1 huMAP3_14478.1
ARHGEF5	huMAP3_02129.1 huMAP3_03994.1 huMAP3_07767.1 huMAP3_08669.1 huMAP3_09299.1 huMAP3_10717.1 huMAP3_11516.1 huMAP3_12385.1 huMAP3_13626.1 huMAP3_14478.1 huMAP3_15205.1
GRB2	huMAP3_02129.1 huMAP3_04552.1 huMAP3_06243.1 huMAP3_07305.1 huMAP3_07767.1 huMAP3_08669.1 huMAP3_09299.1 huMAP3_10500.1 huMAP3_10717.1 huMAP3_12679.1 huMAP3_13626.1 huMAP3_14478.1
CYLD	huMAP3_03578.1 huMAP3_04721.1 huMAP3_12240.1 huMAP3_12369.1 huMAP3_12679.1 huMAP3_13621.1 huMAP3_13626.1 huMAP3_13962.1 huMAP3_14044.1 huMAP3_14478.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14478.1