hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14479.1
Complex Portal: CPX-21421
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EPHA8 | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | 5 | UniProt NCBI |
| EFNA5 | Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7) | 5 | UniProt NCBI |
| EPHA7 | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | 5 | UniProt NCBI |
| RAB3C | Ras-related protein Rab-3C | 5 | UniProt NCBI |
| EPHA3 | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | 5 | UniProt NCBI |
| EPHA10 | Ephrin type-A receptor 10 (EC 2.7.10.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3928663 | 3.64404491129e-06 | 0.75 | EFNA5 EPHA10 EPHA7 | EPHA-mediated growth cone collapse |
| REAC:R-HSA-3928665 | 1.85450342998e-05 | 0.75 | EFNA5 EPHA10 EPHA7 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-2682334 | 0.000123764584817 | 0.75 | EFNA5 EPHA10 EPHA7 | EPH-Ephrin signaling |
| GO:0048013 | 0.00350727150095 | 0.75 | EFNA5 EPHA10 EPHA7 | ephrin receptor signaling pathway |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | EFNA5 EPHA10 EPHA7 | Axon guidance |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | EFNA5 EPHA10 EPHA7 | Nervous system development |
| KEGG:04360 | 0.0291410886797 | 0.5 | EFNA5 EPHA7 | Axon guidance |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EFNA5 | EPHA7 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EPHA7 | EPHA10 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EPHA8 | EFNA5 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EPHA3 | EPHA7 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EPHA8 | EPHA7 | 0.983 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAB3C | EPHA8 | 0.892 | bioplex3_WMM WMM_only | ||
| EPHA3 | EFNA5 | 0.832 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| EFNA5 | EPHA10 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EPHA3 | EPHA10 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EPHA8 | EPHA10 | 0.214 | bioplex3_WMM WMM_only | ||
| EPHA3 | EPHA8 | 0.106 | bioplex3_WMM WMM_only |
Related Complexes