hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14486.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | 5 | UniProt NCBI |
| SLC2A7 | Solute carrier family 2, facilitated glucose transporter member 7 (Glucose transporter type 7) (GLUT-7) (hGLUT7) | 5 | UniProt NCBI |
| RNF10 | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| OR5F1 | Olfactory receptor 5F1 (Olfactory receptor 11-10) (OR11-10) (Olfactory receptor OR11-167) | 3 | UniProt NCBI |
| UBE2E3 | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | 5 | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
| ADAMTS3 | A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061631 | 3.21062267157e-07 | 0.5 | UBE2D3 UBE2D4 UBE2E3 UBE2D1 UBE2D2 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 7.30343591783e-07 | 0.5 | UBE2D3 UBE2D4 UBE2E3 UBE2D1 UBE2D2 | ubiquitin-like protein conjugating enzyme activity |
| KEGG:04120 | 7.63314246302e-07 | 0.5 | UBE2D3 UBE2D4 UBE2E3 UBE2D1 UBE2D2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983168 | 2.32683138194e-06 | 0.6 | RNF25 UBE2D1 UBE2D3 UBE2E3 UBE2D4 UBE2D2 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 7.89614166514e-06 | 0.6 | RNF25 UBE2D1 UBE2D3 UBE2E3 UBE2D4 UBE2D2 | Class I MHC mediated antigen processing & presentation |
| KEGG:03083 | 9.02638680743e-06 | 0.4 | UBE2D3 UBE2D4 UBE2D1 UBE2D2 | Polycomb repressive complex |
| GO:0004842 | 2.12740545775e-05 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | ubiquitin-protein transferase activity |
| REAC:R-HSA-8852135 | 3.00153642291e-05 | 0.4 | UBE2D3 UBE2E3 UBE2D1 UBE2D2 | Protein ubiquitination |
| GO:0070936 | 3.11463395308e-05 | 0.5 | UBE2D3 UBE2D4 UBE2E3 UBE2D1 UBE2D2 | protein K48-linked ubiquitination |
| GO:0019787 | 3.67731773843e-05 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | ubiquitin-like protein transferase activity |
| GO:0016755 | 4.67472645742e-05 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | aminoacyltransferase activity |
| REAC:R-HSA-168927 | 5.36847545384e-05 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 6.31358311141e-05 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | IKK complex recruitment mediated by RIP1 |
| REAC:R-HSA-9705462 | 9.79763261181e-05 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Inactivation of CSF3 (G-CSF) signaling |
| GO:0000209 | 9.99285821617e-05 | 0.6 | RNF25 UBE2D1 UBE2D3 UBE2E3 UBE2D4 UBE2D2 | protein polyubiquitination |
| KEGG:04141 | 0.000125640701739 | 0.4 | UBE2D3 UBE2D4 UBE2D1 UBE2D2 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-9674555 | 0.000180911267958 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-8866652 | 0.000224045063065 | 0.3 | UBE2E3 UBE2D1 UBE2D2 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| REAC:R-HSA-936440 | 0.000300756554821 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Negative regulators of DDX58/IFIH1 signaling |
| GO:0016567 | 0.000364333435574 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | protein ubiquitination |
| REAC:R-HSA-1280218 | 0.000373017332655 | 0.6 | RNF25 UBE2D1 UBE2D3 UBE2E3 UBE2D4 UBE2D2 | Adaptive Immune System |
| KEGG:05131 | 0.000556945597738 | 0.4 | UBE2D3 UBE2D4 UBE2D1 UBE2D2 | Shigellosis |
| GO:0016746 | 0.000634284937271 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | acyltransferase activity |
| REAC:R-HSA-5357905 | 0.000727178991453 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Regulation of TNFR1 signaling |
| WP:WP183 | 0.000800301241961 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Proteasome degradation |
| GO:0032446 | 0.00088947026641 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | protein modification by small protein conjugation |
| REAC:R-HSA-9033241 | 0.000948293432838 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Peroxisomal protein import |
| REAC:R-HSA-75893 | 0.0012820759141 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | TNF signaling |
| REAC:R-HSA-8866654 | 0.00135700365651 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | E3 ubiquitin ligases ubiquitinate target proteins |
| GO:0070647 | 0.00176090365143 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | protein modification by small protein conjugation or removal |
| REAC:R-HSA-1234176 | 0.00216552468633 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| GO:0043687 | 0.0027700145986 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2E3 UBE2D3 UBE2D2 | post-translational protein modification |
| REAC:R-HSA-1234174 | 0.00297757372044 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Cellular response to hypoxia |
| REAC:R-HSA-168928 | 0.00366640411985 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0085020 | 0.00418195709292 | 0.3 | UBE2D3 UBE2D4 RNF25 | protein K6-linked ubiquitination |
| REAC:R-HSA-168164 | 0.00655835959712 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.00700036206772 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.00700036206772 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | MyD88-independent TLR4 cascade |
| GO:0006511 | 0.0130588724203 | 0.6 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2D3 UBE2D2 | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 0.0143680008842 | 0.6 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2D3 UBE2D2 | modification-dependent protein catabolic process |
| REAC:R-HSA-166016 | 0.0161495944471 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Toll Like Receptor 4 (TLR4) Cascade |
| GO:0043632 | 0.0163434963921 | 0.6 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2D3 UBE2D2 | modification-dependent macromolecule catabolic process |
| REAC:R-HSA-73887 | 0.0177651546753 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Death Receptor Signaling |
| GO:0061630 | 0.018600223798 | 0.5 | UBE2D3 RNF10 UBE2D1 RNF25 UBE2D2 | ubiquitin protein ligase activity |
| REAC:R-HSA-9609507 | 0.0217797090467 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Protein localization |
| REAC:R-HSA-168898 | 0.0247610923631 | 0.3 | UBE2D3 UBE2D1 UBE2D2 | Toll-like Receptor Cascades |
| GO:0061659 | 0.0251283584247 | 0.5 | UBE2D3 RNF10 UBE2D1 RNF25 UBE2D2 | ubiquitin-like protein ligase activity |
| REAC:R-HSA-201451 | 0.0302795201711 | 0.2 | UBE2D3 UBE2D1 | Signaling by BMP |
| GO:0070979 | 0.0374486324673 | 0.3 | UBE2D3 UBE2D4 UBE2E3 | protein K11-linked ubiquitination |
| REAC:R-HSA-2173795 | 0.0409184848695 | 0.2 | UBE2D3 UBE2D1 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| GO:0051603 | 0.0442859893992 | 0.6 | RNF25 UBE2D1 RNF10 UBE2D4 UBE2D3 UBE2D2 | proteolysis involved in protein catabolic process |
| GO:0006508 | 0.0495346868368 | 0.7 | RNF25 UBE2D1 RNF10 UBE2D4 ADAMTS3 UBE2D3 UBE2D2 | proteolysis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF25 | UBE2E3 | 0.999 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D3 | 0.998 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF25 | UBE2D4 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RNF10 | UBE2E3 | 0.981 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D3 | UBE2D2 | 0.975 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D3 | RNF10 | 0.954 | 0.204 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF10 | UBE2D4 | 0.946 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2E3 | 0.945 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
| RNF25 | SLC2A7 | 0.912 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D3 | UBE2D4 | 0.909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RNF10 | ADAMTS3 | 0.902 | bioplex3_WMM WMM_only | |
| UBE2D1 | UBE2E3 | 0.869 | 0.295222222222 | bioplex3_WMM WMM_only |
| RNF10 | UBE2D1 | 0.869 | 0.3551 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D2 | OR5F1 | 0.857 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBE2D3 | UBE2E3 | 0.823 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| RNF25 | RNF10 | 0.531 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D2 | UBE2D1 | 0.388 | 0.308 | bioplex3_WMM youn_WMM WMM_only |
| UBE2D4 | UBE2E3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D1 | UBE2D4 | 0.214 | bioplex3_WMM WMM_only | |
| UBE2D2 | RNF10 | 0.178 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D2 | UBE2D4 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes