hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14496.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIX5 | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | 5 | UniProt NCBI |
| EYA1 | Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) | 5 | UniProt NCBI |
| MTM1 | Myotubularin (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| EYA4 | Eyes absent homolog 4 (EC 3.1.3.48) | 5 | UniProt NCBI |
| PTPN9 | Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2) | 5 | UniProt NCBI |
| CERT1 | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011388 | 0.000648041335154 | 0.333333333333 | EYA1 SIX5 | Enlarged cochlear aqueduct |
| HP:0009796 | 0.00161951205762 | 0.333333333333 | EYA1 SIX5 | Branchial cyst |
| HP:0008586 | 0.0022669030801 | 0.333333333333 | EYA1 SIX5 | Hypoplasia of the cochlea |
| HP:0011395 | 0.00302198579101 | 0.333333333333 | EYA1 SIX5 | Aplasia/Hypoplasia of the cochlea |
| HP:0008774 | 0.00388470114881 | 0.333333333333 | EYA1 SIX5 | Aplasia/Hypoplasia of the inner ear |
| GO:0004721 | 0.00499622573874 | 0.666666666667 | PTPN9 EYA1 EYA4 MTM1 | phosphoprotein phosphatase activity |
| HP:0004452 | 0.0164828756284 | 0.333333333333 | EYA1 SIX5 | Abnormality of the middle ear ossicles |
| HP:0009794 | 0.0164828756284 | 0.333333333333 | EYA1 SIX5 | Branchial anomaly |
| HP:0000074 | 0.0184186741717 | 0.333333333333 | EYA1 SIX5 | Ureteropelvic junction obstruction |
| HP:0010628 | 0.0186233915395 | 0.5 | EYA1 SIX5 MTM1 | Facial palsy |
| HP:0010827 | 0.01897859059 | 0.5 | EYA1 SIX5 MTM1 | Abnormal seventh cranial physiology |
| HP:0008609 | 0.0349615340576 | 0.333333333333 | EYA1 SIX5 | Abnormal middle ear morphology |
| HP:0030319 | 0.0371191829266 | 0.5 | EYA1 SIX5 MTM1 | Weakness of facial musculature |
| HP:0000375 | 0.037751561683 | 0.333333333333 | EYA1 SIX5 | Abnormal cochlea morphology |
| HP:0000071 | 0.037751561683 | 0.333333333333 | EYA1 SIX5 | Ureteral stenosis |
| GO:0016791 | 0.0379514736875 | 0.666666666667 | PTPN9 EYA1 EYA4 MTM1 | phosphatase activity |
| HP:0000402 | 0.0467604957305 | 0.333333333333 | EYA1 SIX5 | Stenosis of the external auditory canal |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PTPN9 | MTM1 | 0.983 | 0.074 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| EYA4 | SIX5 | 0.975 | 0.154 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| EYA1 | CERT1 | 0.928 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PTPN9 | CERT1 | 0.898 | 0.03 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| EYA1 | SIX5 | 0.897 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PTPN9 | EYA1 | 0.804 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA1 | EYA4 | 0.528 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes