hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14497.1
Complex Portal: CPX-16012
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRY1 | Cryptochrome-1 | 5 | UniProt NCBI |
| PER1 | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | 5 | UniProt NCBI |
| GAPVD1 | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | 5 | UniProt NCBI |
| FAM110C | Protein FAM110C | 5 | UniProt NCBI |
| PER3 | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | 5 | UniProt NCBI |
| LONRF2 | LON peptidase N-terminal domain and RING finger protein 2 (Neuroblastoma apoptosis-related protease) (RING finger protein 192) | 5 | UniProt NCBI |
| HNRNPA1L2 | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | 3 | UniProt NCBI |
| CRY2 | Cryptochrome-2 | 5 | UniProt NCBI |
| ZNF618 | Zinc finger protein 618 | 5 | UniProt NCBI |
| SNX22 | Sorting nexin-22 | 4 | UniProt NCBI |
| FBXL3 | F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A) | 5 | UniProt NCBI |
| PER2 | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | 5 | UniProt NCBI |
| CSNK1D | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | 5 | UniProt NCBI |
| SNX24 | Sorting nexin-24 | 3 | UniProt NCBI |
| STOX2 | Storkhead-box protein 2 | 3 | UniProt NCBI |
| CSNK1E | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 8.57829224989e-17 | 0.5 | CRY2 PER1 PER3 FBXL3 PER2 CSNK1D CRY1 CSNK1E | Circadian rhythm |
| WP:WP3298 | 3.96601355703e-14 | 0.4375 | CRY2 PER1 PER3 PER2 CSNK1D CRY1 CSNK1E | Melatonin metabolism and effects |
| REAC:R-HSA-400253 | 5.02290961193e-11 | 0.4375 | CRY2 PER1 FBXL3 PER2 CSNK1D CRY1 CSNK1E | Circadian Clock |
| WP:WP3594 | 2.18848123995e-10 | 0.5 | CRY2 PER1 PER3 FBXL3 PER2 CSNK1D CRY1 CSNK1E | Circadian rhythm genes |
| GO:0042752 | 4.29323927883e-10 | 0.5 | CRY2 PER1 PER3 FBXL3 PER2 CSNK1D CRY1 CSNK1E | regulation of circadian rhythm |
| GO:0043153 | 2.18884152854e-09 | 0.375 | CRY2 PER1 PER3 FBXL3 PER2 CRY1 | entrainment of circadian clock by photoperiod |
| GO:0009648 | 2.95963500272e-09 | 0.375 | CRY2 PER1 PER3 FBXL3 PER2 CRY1 | photoperiodism |
| GO:0009649 | 5.18624588901e-09 | 0.375 | CRY2 PER1 PER3 FBXL3 PER2 CRY1 | entrainment of circadian clock |
| GO:0032922 | 6.72372090922e-09 | 0.4375 | CRY2 PER1 PER3 PER2 CSNK1D CRY1 CSNK1E | circadian regulation of gene expression |
| GO:0007623 | 2.16445944587e-08 | 0.5 | CRY2 PER1 PER3 FBXL3 PER2 CSNK1D CRY1 CSNK1E | circadian rhythm |
| GO:0048511 | 6.12516905859e-08 | 0.5 | CRY2 PER1 PER3 FBXL3 PER2 CSNK1D CRY1 CSNK1E | rhythmic process |
| HP:0031873 | 4.6775048923e-06 | 0.1875 | PER3 CSNK1D PER2 | Early chronotype |
| WP:WP410 | 1.05415177374e-05 | 0.25 | CRY1 PER2 PER1 CRY2 | Exercise induced circadian regulation |
| HP:0006979 | 5.34102770456e-05 | 0.25 | PER3 CSNK1D FBXL3 PER2 | Sleep-wake cycle disturbance |
| CORUM:2773 | 0.000306067313039 | 0.125 | CRY2 FBXL3 | Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) |
| CORUM:2772 | 0.000306067313039 | 0.125 | CRY1 FBXL3 | Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3) |
| GO:2000323 | 0.0010743908712 | 0.1875 | CRY1 PER1 CRY2 | negative regulation of glucocorticoid receptor signaling pathway |
| GO:0009416 | 0.00136707247733 | 0.375 | CRY2 PER1 PER3 FBXL3 PER2 CRY1 | response to light stimulus |
| GO:2000322 | 0.00187892941497 | 0.1875 | CRY1 PER1 CRY2 | regulation of glucocorticoid receptor signaling pathway |
| GO:0042754 | 0.00187892941497 | 0.1875 | CRY1 PER2 CRY2 | negative regulation of circadian rhythm |
| KEGG:04713 | 0.00378998957703 | 0.1875 | PER3 PER1 PER2 | Circadian entrainment |
| GO:0042921 | 0.00883419058623 | 0.1875 | CRY1 PER1 CRY2 | glucocorticoid receptor signaling pathway |
| GO:0031958 | 0.00883419058623 | 0.1875 | CRY1 PER1 CRY2 | corticosteroid receptor signaling pathway |
| GO:0009314 | 0.00963510010554 | 0.375 | CRY2 PER1 PER3 FBXL3 PER2 CRY1 | response to radiation |
| WP:WP5381 | 0.0489650408042 | 0.1875 | CRY1 PER1 CRY2 | Smith Magenis and Potocki Lupski syndrome copy number variation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| CRY2 | CRY1 | 1.0 | 0.048 |
mutually_exclusive (Q9UKT7)
structurally_consistent (dimer) |
| CSNK1E | PER1 | 1.0 | 0.1 |
mutually_exclusive (Q16526)
|
| SNX24 | SNX22 | 1.0 |
mutually_exclusive (P48730)
|
|
| SNX24 | GAPVD1 | 1.0 | ||
| PER1 | CRY1 | 1.0 | 0.08 |
structurally_consistent (dimer)
|
| CRY2 | PER1 | 0.999 | 0.124 |
mutually_exclusive (Q16526)
|
| CSNK1D | PER1 | 0.999 | 0.15 | |
| CRY2 | CSNK1E | 0.999 | 0.1176 |
structurally_consistent (dimer)
|
| CSNK1E | PER2 | 0.999 | ||
| CSNK1D | PER2 | 0.999 | ||
| PER2 | CRY1 | 0.999 |
mutually_exclusive (Q9UKT7)
|
|
| CSNK1E | CRY1 | 0.999 | 0.094 |
structurally_consistent (dimer)
|
| CSNK1D | GAPVD1 | 0.998 | ||
| CRY2 | PER2 | 0.998 |
mutually_exclusive (Q9UKT7)
|
|
| PER2 | PER1 | 0.998 | ||
| CSNK1D | SNX24 | 0.998 | 0.084 |
structurally_consistent (dimer)
|
| FBXL3 | CRY2 | 0.997 |
mutually_exclusive (Q16526)
structurally_consistent (dimer) |
|
| FBXL3 | CRY1 | 0.997 |
structurally_consistent (dimer)
|
|
| CSNK1D | CSNK1E | 0.997 | 0.28 |
structurally_consistent (dimer)
|
| PER1 | PER3 | 0.997 | ||
| CSNK1E | SNX24 | 0.996 | 0.084 |
mutually_exclusive (P48730)
structurally_consistent (dimer) |
| CSNK1D | CRY1 | 0.996 | 0.196 | |
| ZNF618 | SNX24 | 0.994 | ||
| CSNK1E | GAPVD1 | 0.99 | ||
| CRY2 | CSNK1D | 0.989 | 0.258 | |
| STOX2 | CSNK1E | 0.987 | ||
| CRY2 | PER3 | 0.984 | ||
| PER2 | GAPVD1 | 0.984 | ||
| ZNF618 | GAPVD1 | 0.981 | ||
| CSNK1D | SNX22 | 0.98 |
structurally_consistent (dimer)
|
|
| SNX22 | GAPVD1 | 0.979 | ||
| STOX2 | PER1 | 0.974 | ||
| LONRF2 | SNX24 | 0.972 | 0.078 | |
| CSNK1E | FAM110C | 0.97 | ||
| ZNF618 | CSNK1D | 0.967 | ||
| STOX2 | GAPVD1 | 0.965 | ||
| ZNF618 | CSNK1E | 0.964 | ||
| ZNF618 | PER2 | 0.952 | ||
| HNRNPA1L2 | CRY1 | 0.91 | 0.252 | |
| FBXL3 | PER2 | 0.903 |
structurally_consistent (dimer)
|
|
| FAM110C | PER2 | 0.902 | ||
| FAM110C | SNX24 | 0.902 | ||
| FAM110C | GAPVD1 | 0.892 | ||
| PER2 | PER3 | 0.77 | ||
| ZNF618 | SNX22 | 0.763 | ||
| CRY2 | GAPVD1 | 0.756 | ||
| PER2 | SNX24 | 0.737 | ||
| FBXL3 | PER1 | 0.727 |
mutually_exclusive (Q16526)
|
|
| CRY2 | FAM110C | 0.703 | ||
| FAM110C | CRY1 | 0.676 | ||
| PER1 | SNX24 | 0.608 | 0.066 | |
| CRY1 | GAPVD1 | 0.605 | ||
| FBXL3 | CSNK1E | 0.581 |
mutually_exclusive (Q49AN0)
|
|
| ZNF618 | PER1 | 0.528 | ||
| CRY2 | STOX2 | 0.501 | ||
| PER3 | CRY1 | 0.49 | ||
| FBXL3 | CSNK1D | 0.445 | ||
| FAM110C | PER1 | 0.437 | ||
| STOX2 | CRY1 | 0.425 | ||
| PER1 | GAPVD1 | 0.377 | ||
| HNRNPA1L2 | PER2 | 0.335 | ||
| STOX2 | SNX24 | 0.248 | ||
| CSNK1E | SNX22 | 0.233 | ||
| SNX24 | CRY1 | 0.232 | 0.102 |
structurally_consistent (P49674)
|
| CSNK1E | PER3 | 0.222 | ||
| CRY2 | ZNF618 | 0.218 | ||
| CRY2 | SNX24 | 0.206 | 0.068 |
structurally_consistent (P49674)
|
| ZNF618 | CRY1 | 0.201 | ||
| PER1 | SNX22 | 0.177 | ||
| CSNK1D | PER3 | 0.177 | ||
| PER2 | SNX22 | 0.172 | ||
| FBXL3 | HNRNPA1L2 | 0.163 | ||
| CSNK1D | STOX2 | 0.159 | ||
| ZNF618 | FAM110C | 0.146 | ||
| LONRF2 | SNX22 | 0.143 | ||
| SNX22 | CRY1 | 0.143 | ||
| CRY2 | SNX22 | 0.143 | ||
| HNRNPA1L2 | PER1 | 0.1 | 0.148 | |
| LONRF2 | GAPVD1 | 0.089 | ||
| CSNK1D | LONRF2 | 0.084 | 0.16 | |
| ZNF618 | STOX2 | 0.076 | ||
| CSNK1D | HNRNPA1L2 | 0.046 | 0.242 | |
| CSNK1D | FAM110C | 0.043 | ||
| ZNF618 | LONRF2 | 0.041 | ||
| HNRNPA1L2 | CSNK1E | 0.038 | 0.35 | |
| CSNK1E | LONRF2 | 0.027 | 0.092 | |
| CRY2 | HNRNPA1L2 | 0.026 | 0.730772694551 | |
| FBXL3 | STOX2 | 0.017 | ||
| HNRNPA1L2 | SNX24 | 0.012 | 0.138 | |
| HNRNPA1L2 | GAPVD1 | 0.001 |
Related Complexes