hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14505.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFFO2 | Intermediate filament family orphan 2 | 2 | UniProt NCBI |
| LIG4 | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | 5 | UniProt NCBI |
| XRCC4 | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | 5 | UniProt NCBI |
| APTX | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:344 | 5.12628525639e-06 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:345 | 5.12628525639e-06 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:352 | 5.12628525639e-06 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:354 | 5.12628525639e-06 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:206 | 5.12628525639e-06 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:359 | 5.12628525639e-06 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4-XLF complex |
| CORUM:348 | 5.12628525639e-06 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:336 | 1.53774525569e-05 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4-AHNK complex |
| CORUM:350 | 1.53774525569e-05 | 0.5 | LIG4 XRCC4 | DNA ligase IV-XRCC4-PNK complex |
| CORUM:1189 | 5.12488211613e-05 | 0.5 | LIG4 XRCC4 | DNA double-strand break end-joining complex |
| WP:WP438 | 9.18788843787e-05 | 0.5 | LIG4 XRCC4 | Non homologous end joining |
| KEGG:03450 | 0.000137838736806 | 0.5 | LIG4 XRCC4 | Non-homologous end-joining |
| REAC:R-HSA-164843 | 0.000215205765992 | 0.5 | LIG4 XRCC4 | 2-LTR circle formation |
| REAC:R-HSA-162592 | 0.000368856835097 | 0.5 | LIG4 XRCC4 | Integration of provirus |
| REAC:R-HSA-162594 | 0.000798898068561 | 0.5 | LIG4 XRCC4 | Early Phase of HIV Life Cycle |
| GO:0032807 | 0.0028092043205 | 0.5 | LIG4 XRCC4 | DNA ligase IV complex |
| HP:0000320 | 0.00454201288615 | 0.5 | LIG4 XRCC4 | Bird-like facies |
| HP:0004430 | 0.0051092979876 | 0.5 | LIG4 XRCC4 | Severe combined immunodeficiency |
| WP:WP4946 | 0.0159973744593 | 0.5 | LIG4 XRCC4 | DNA repair pathways full network |
| HP:0005387 | 0.0165423111708 | 0.5 | LIG4 XRCC4 | Combined immunodeficiency |
| GO:0051103 | 0.0168521501606 | 0.5 | LIG4 XRCC4 | DNA ligation involved in DNA repair |
| WP:WP4673 | 0.017442995787 | 0.5 | LIG4 XRCC4 | Male infertility |
| REAC:R-HSA-5693571 | 0.0186613511621 | 0.5 | LIG4 XRCC4 | Nonhomologous End-Joining (NHEJ) |
| CORUM:213 | 0.0249718442456 | 0.25 | LIG4 | DNA ligase IV-XRCC1 complex |
| GO:0033152 | 0.0280843539964 | 0.5 | LIG4 XRCC4 | immunoglobulin V(D)J recombination |
| HPA:0160252 | 0.0287234436749 | 1.0 | APTX IFFO2 XRCC4 LIG4 | endometrium 1; cells in endometrial stroma[>=Medium] |
| HPA:0100202 | 0.0413234154024 | 1.0 | APTX IFFO2 XRCC4 LIG4 | cerebral cortex; endothelial cells[>=Medium] |
| GO:0005958 | 0.042122686785 | 0.5 | LIG4 XRCC4 | DNA-dependent protein kinase-DNA ligase 4 complex |
| HP:0003220 | 0.0441432413831 | 0.5 | LIG4 XRCC4 | Abnormality of chromosome stability |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| XRCC4 | LIG4 | 0.999 | 0.18 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| XRCC4 | IFFO2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| XRCC4 | APTX | 0.992 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFFO2 | LIG4 | 0.931 | bioplex_WMM bioplex3_WMM WMM_only | |
| LIG4 | APTX | 0.89 | 0.082 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| IFFO2 | APTX | 0.215 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes