hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14506.1
Complex Portal: CPX-25297
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TOP2B | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | 5 | UniProt NCBI |
| PIAS4 | E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) | 5 | UniProt NCBI |
| ZNF451 | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4615885 | 0.00585997836812 | 0.666666666667 | PIAS4 TOP2B | SUMOylation of DNA replication proteins |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIAS4 | TOP2B | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZNF451 | TOP2B | 0.949 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only |
Related Complexes