hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14512.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASP3 | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | 5 | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | 5 | UniProt NCBI |
| MORN3 | MORN repeat-containing protein 3 | 5 | UniProt NCBI |
| SLC35A1 | CMP-sialic acid transporter (CMP-SA-Tr) (CMP-Sia-Tr) (CST) (Solute carrier family 35 member A1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111459 | 0.000102497642323 | 0.5 | XIAP CASP3 | Activation of caspases through apoptosome-mediated cleavage |
| REAC:R-HSA-111469 | 0.000153732433522 | 0.5 | XIAP CASP3 | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111464 | 0.000153732433522 | 0.5 | XIAP CASP3 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| REAC:R-HSA-111463 | 0.000153732433522 | 0.5 | XIAP CASP3 | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-111461 | 0.000676052383047 | 0.5 | XIAP CASP3 | Cytochrome c-mediated apoptotic response |
| KEGG:04215 | 0.00101582950709 | 0.5 | XIAP CASP3 | Apoptosis - multiple species |
| REAC:R-HSA-111471 | 0.0013924419067 | 0.5 | XIAP CASP3 | Apoptotic factor-mediated response |
| WP:WP3286 | 0.002406667175 | 0.5 | XIAP CASP3 | Copper homeostasis |
| KEGG:01524 | 0.00601982850302 | 0.5 | XIAP CASP3 | Platinum drug resistance |
| WP:WP254 | 0.00666804419641 | 0.5 | XIAP CASP3 | Apoptosis |
| WP:WP1772 | 0.00761604886135 | 0.5 | XIAP CASP3 | Apoptosis modulation and signaling |
| KEGG:05222 | 0.00909742323246 | 0.5 | XIAP CASP3 | Small cell lung cancer |
| WP:WP5090 | 0.00992155513194 | 0.5 | XIAP CASP3 | Complement system in neuronal development and plasticity |
| KEGG:05145 | 0.0101879335017 | 0.5 | XIAP CASP3 | Toxoplasmosis |
| KEGG:04668 | 0.011104386562 | 0.5 | XIAP CASP3 | TNF signaling pathway |
| REAC:R-HSA-109606 | 0.0135329645116 | 0.5 | XIAP CASP3 | Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-5218859 | 0.0140623832262 | 0.5 | XIAP CASP3 | Regulated Necrosis |
| KEGG:04210 | 0.0177164397058 | 0.5 | XIAP CASP3 | Apoptosis |
| CORUM:6292 | 0.049938562206 | 0.25 | XIAP | HAX-1-XIAP complex |
| REAC:R-HSA-5619037 | 0.0499436884912 | 0.25 | SLC35A1 | Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) |
| REAC:R-HSA-5663020 | 0.0499436884912 | 0.25 | SLC35A1 | Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CASP3 | XIAP | 0.979 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MORN3 | XIAP | 0.975 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC35A1 | CASP3 | 0.883 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SLC35A1 | XIAP | 0.005 | 0.09 | youn_WMM WMM_only |
Related Complexes