hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14528.1
Complex Portal: CPX-25157
Confidence: Medium  
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COPS5 | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | 5 | UniProt   NCBI |
| COPS7B | COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) | 5 | UniProt   NCBI |
| CALCA | Calcitonin [Cleaved into: Calcitonin; Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)] | 5 | UniProt   NCBI |
| RBX1 | E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)] | 5 | UniProt   NCBI |
| APBB3 | Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2) | 5 | UniProt   NCBI |
| KLHL13 | Kelch-like protein 13 (BTB and kelch domain-containing protein 2) | 5 | UniProt   NCBI |
| COPS7A | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) | 5 | UniProt   NCBI |
| LRR1 | Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5) | 5 | UniProt   NCBI |
| GPS1 | COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) | 5 | UniProt   NCBI |
| COPS6 | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) | 5 | UniProt   NCBI |
| DCAF4 | DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) | 5 | UniProt   NCBI |
| PXDNL | Probable oxidoreductase PXDNL (EC 1.-.-.-) (Cardiac peroxidase) (Inactive peroxidasin-like protein) (Polysomal ribonuclease 1) (PRM1) (Vascular peroxidase 2) | 5 | UniProt   NCBI |
| BTBD2 | BTB/POZ domain-containing protein 2 | 5 | UniProt   NCBI |
| DDA1 | DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1) | 5 | UniProt   NCBI |
| RHOBTB2 | Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83) | 5 | UniProt   NCBI |
| CRBN | Protein cereblon | 5 | UniProt   NCBI |
| COPS8 | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | 5 | UniProt   NCBI |
| KLHDC3 | Kelch domain-containing protein 3 (Testis intracellular mediator protein) | 5 | UniProt   NCBI |
| CUL2 | Cullin-2 (CUL-2) | 5 | UniProt   NCBI |
| FEM1C | Protein fem-1 homolog C (FEM1c) (FEM1-gamma) | 5 | UniProt   NCBI |
| NEDD8 | NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8) | 5 | UniProt   NCBI |
| COPS3 | COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) | 5 | UniProt   NCBI |
| DDB2 | DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) | 5 | UniProt   NCBI |
| FEM1B | Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) | 5 | UniProt   NCBI |
| CUL3 | Cullin-3 (CUL-3) | 5 | UniProt   NCBI |
| COPS4 | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | 5 | UniProt   NCBI |
| LRRC14 | Leucine-rich repeat-containing protein 14 | 4 | UniProt   NCBI |
| DCAF8L2 | DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C) | 2 | UniProt   NCBI |
| DCAF16 | DDB1- and CUL4-associated factor 16 | 4 | UniProt   NCBI |
| DCAF6 | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | 5 | UniProt   NCBI |
| APPBP2 | Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1) | 5 | UniProt   NCBI |
| ERCC8 | DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) | 5 | UniProt   NCBI |
| ANKRD39 | Ankyrin repeat domain-containing protein 39 | 2 | UniProt   NCBI |
| CUL4B | Cullin-4B (CUL-4B) | 5 | UniProt   NCBI |
| RHOBTB1 | Rho-related BTB domain-containing protein 1 | 4 | UniProt   NCBI |
| DDB1 | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | 5 | UniProt   NCBI |
| BRWD3 | Bromodomain and WD repeat-containing protein 3 | 5 | UniProt   NCBI |
| BTBD1 | BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8) | 5 | UniProt   NCBI |
| KLHL24 | Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) | 5 | UniProt   NCBI |
| COPS9 | COP9 signalosome complex subunit 9 (CSN acidic protein) (CSNAP) (Myeloma-overexpressed gene 2 protein) | 5 | UniProt   NCBI |
| FBXO17 | F-box only protein 17 (F-box only protein 26) | 5 | UniProt   NCBI |
| COPS2 | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | 5 | UniProt   NCBI |
| KCTD20 | BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20) | 3 | UniProt   NCBI |
| CUL4A | Cullin-4A (CUL-4A) | 5 | UniProt   NCBI |
| BTBD10 | BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) | 4 | UniProt   NCBI |
| KLHL18 | Kelch-like protein 18 | 4 | UniProt   NCBI |
| DTL | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | 5 | UniProt   NCBI |
| KLHL42 | Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) | 5 | UniProt   NCBI |
| DCAF11 | DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) | 5 | UniProt   NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
|   REAC:R-HSA-8951664 | 2.32173261356e-42 | 0.632653061224 | COPS8 DCAF16 BTBD1 DTL DDB1 COPS6 COPS3 CUL2 DCAF6 CUL4B LRR1 KLHL42 NEDD8 FEM1C ERCC8 DDA1 GPS1 CUL3 KLHL13 COPS2 DCAF11 COPS7B COPS7A RBX1 COPS4 DCAF4 FEM1B CUL4A FBXO17 DDB2 COPS5 | Neddylation |
|   GO:0031461 | 1.49027280225e-29 | 0.489795918367 | CUL4B DCAF16 DTL DDB1 FBXO17 DCAF6 KLHL24 KLHL13 KLHL42 CRBN FEM1C ERCC8 DDA1 CUL2 CUL3 DCAF11 KLHDC3 APPBP2 RBX1 DCAF8L2 DCAF4 FEM1B CUL4A DDB2 | cullin-RING ubiquitin ligase complex |
|   CORUM:727 | 1.42518113038e-28 | 0.244897959184 | RBX1 COPS8 GPS1 COPS2 ERCC8 COPS4 COPS6 DDB1 COPS3 CUL4A COPS7A COPS5 | CSA complex |
|   CORUM:728 | 1.42518113038e-28 | 0.244897959184 | RBX1 COPS8 GPS1 COPS2 ERCC8 COPS4 COPS6 DDB1 COPS3 CUL4A COPS7A COPS5 | CSA-POLIIa complex |
|   CORUM:726 | 1.42518113038e-28 | 0.244897959184 | RBX1 COPS8 GPS1 DDB2 COPS2 DDB1 COPS4 COPS6 COPS3 CUL4A COPS7A COPS5 | DDB2 complex |
|   GO:0000151 | 3.82745304075e-24 | 0.489795918367 | CUL4B DCAF16 DTL DDB1 FBXO17 DCAF6 KLHL24 KLHL13 KLHL42 CRBN FEM1C ERCC8 DDA1 CUL2 CUL3 DCAF11 KLHDC3 APPBP2 RBX1 DCAF8L2 DCAF4 FEM1B CUL4A DDB2 | ubiquitin ligase complex |
|   REAC:R-HSA-5696394 | 8.9190537123e-24 | 0.285714285714 | GPS1 COPS8 RBX1 DDB2 COPS2 CUL4B DDB1 COPS4 COPS6 COPS3 COPS5 COPS7B CUL4A COPS7A | DNA Damage Recognition in GG-NER |
|   GO:0080008 | 5.2760831762e-22 | 0.285714285714 | RBX1 CUL4B DTL DCAF16 DCAF8L2 DCAF11 CRBN DCAF4 DDB1 CUL4A DDA1 DDB2 DCAF6 ERCC8 | Cul4-RING E3 ubiquitin ligase complex |
|   REAC:R-HSA-6781823 | 1.5812157038e-21 | 0.285714285714 | GPS1 COPS8 RBX1 DDB1 COPS2 CUL4B ERCC8 COPS4 COPS6 COPS3 COPS5 COPS7B CUL4A COPS7A | Formation of TC-NER Pre-Incision Complex |
|   REAC:R-HSA-597592 | 3.05157637917e-19 | 0.632653061224 | COPS8 DCAF16 BTBD1 DTL DDB1 COPS6 COPS3 CUL2 DCAF6 CUL4B LRR1 KLHL42 NEDD8 FEM1C ERCC8 DDA1 GPS1 CUL3 KLHL13 COPS2 DCAF11 COPS7B COPS7A RBX1 COPS4 DCAF4 FEM1B CUL4A FBXO17 DDB2 COPS5 | Post-translational protein modification |
|   GO:0032446 | 3.73627314984e-19 | 0.530612244898 | COPS8 CUL2 NEDD8 DDB1 COPS6 COPS3 CUL4B KLHL24 KLHL13 KLHL42 CRBN DDA1 ERCC8 GPS1 RBX1 KLHL18 COPS2 COPS7B COPS7A CUL3 COPS4 DTL COPS9 CUL4A DDB2 COPS5 | protein modification by small protein conjugation |
|   GO:0045116 | 3.92284277817e-19 | 0.244897959184 | GPS1 COPS8 RBX1 NEDD8 COPS2 COPS9 COPS4 COPS6 COPS3 COPS5 COPS7B COPS7A | protein neddylation |
|   REAC:R-HSA-6781827 | 7.09835973135e-19 | 0.285714285714 | GPS1 COPS8 RBX1 DDB1 COPS2 CUL4B ERCC8 COPS4 COPS6 COPS3 COPS5 COPS7B CUL4A COPS7A | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
|   REAC:R-HSA-5696398 | 1.66650243259e-18 | 0.30612244898 | GPS1 COPS8 RBX1 DDB1 DDB2 COPS2 CUL4B ERCC8 COPS4 COPS6 COPS3 COPS5 COPS7B CUL4A COPS7A | Nucleotide Excision Repair |
|   REAC:R-HSA-5696399 | 2.20505498808e-18 | 0.285714285714 | GPS1 COPS8 RBX1 DDB2 COPS2 CUL4B DDB1 COPS4 COPS6 COPS3 COPS5 COPS7B CUL4A COPS7A | Global Genome Nucleotide Excision Repair (GG-NER) |
|   CORUM:2174 | 2.66835570716e-18 | 0.163265306122 | GPS1 COPS8 COPS2 COPS4 COPS6 COPS3 COPS7A COPS5 | COP9 signalosome complex |
|   GO:0070647 | 4.65974269811e-18 | 0.530612244898 | COPS8 CUL2 NEDD8 DDB1 COPS6 COPS3 CUL4B KLHL24 KLHL13 KLHL42 CRBN DDA1 ERCC8 GPS1 RBX1 KLHL18 COPS2 COPS7B COPS7A CUL3 COPS4 DTL COPS9 CUL4A DDB2 COPS5 | protein modification by small protein conjugation or removal |
|   GO:0000338 | 1.22528933676e-17 | 0.183673469388 | GPS1 COPS8 COPS2 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | protein deneddylation |
|   CORUM:2179 | 2.39552834709e-17 | 0.163265306122 | GPS1 COPS8 COPS2 COPS4 COPS6 COPS3 COPS7A COPS5 | CNS-P53 complex |
|   GO:0043687 | 2.47146104669e-17 | 0.530612244898 | COPS8 CUL2 NEDD8 DDB1 COPS6 COPS3 CUL4B KLHL24 KLHL13 KLHL42 CRBN DDA1 ERCC8 GPS1 RBX1 KLHL18 COPS2 COPS7B COPS7A CUL3 COPS4 DTL COPS9 CUL4A DDB2 COPS5 | post-translational protein modification |
|   GO:2000434 | 3.04022696261e-16 | 0.204081632653 | GPS1 COPS8 COPS2 COPS9 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | regulation of protein neddylation |
|   REAC:R-HSA-392499 | 3.29355061992e-16 | 0.65306122449 | COPS8 DCAF16 BTBD1 CALCA DDB1 DTL COPS6 COPS3 CUL2 DCAF6 CUL4B KLHL13 KLHL42 NEDD8 FEM1C ERCC8 DDA1 COPS7A GPS1 CUL3 COPS2 LRR1 COPS7B RBX1 COPS4 DCAF11 DCAF4 FEM1B CUL4A FBXO17 DDB2 COPS5 | Metabolism of proteins |
|   GO:1990234 | 1.64235926662e-13 | 0.489795918367 | CUL4B DCAF16 DTL DDB1 FBXO17 DCAF6 KLHL24 KLHL13 KLHL42 CRBN FEM1C ERCC8 DDA1 CUL2 CUL3 DCAF11 KLHDC3 APPBP2 RBX1 DCAF8L2 DCAF4 FEM1B CUL4A DDB2 | transferase complex |
|   GO:0008180 | 2.05706761458e-13 | 0.204081632653 | GPS1 COPS8 COPS2 COPS9 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | COP9 signalosome |
|   REAC:R-HSA-73894 | 5.52430486629e-13 | 0.326530612245 | GPS1 COPS8 RBX1 DDB1 DDB2 COPS2 DTL CUL4B ERCC8 COPS4 COPS6 COPS3 COPS5 COPS7B CUL4A COPS7A | DNA Repair |
|   GO:0140535 | 6.15428205923e-13 | 0.489795918367 | CUL4B DCAF16 DTL DDB1 FBXO17 DCAF6 KLHL24 KLHL13 KLHL42 CRBN FEM1C ERCC8 DDA1 CUL2 CUL3 DCAF11 KLHDC3 APPBP2 RBX1 DCAF8L2 DCAF4 FEM1B CUL4A DDB2 | intracellular protein-containing complex |
|   GO:0031464 | 1.29459194549e-12 | 0.163265306122 | RBX1 CUL4B DDB2 CRBN DTL DDB1 ERCC8 CUL4A | Cul4A-RING E3 ubiquitin ligase complex |
|   KEGG:04120 | 4.11437212675e-11 | 0.224489795918 | CUL3 CUL4B RBX1 DDB2 RHOBTB1 ERCC8 KLHL13 DDB1 CUL2 RHOBTB2 CUL4A | Ubiquitin mediated proteolysis |
|   CORUM:1162 | 1.04697127351e-10 | 0.102040816327 | DDB1 RBX1 CUL4A CUL4B DDB2 | Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) |
|   CORUM:6482 | 1.04697127351e-10 | 0.102040816327 | GPS1 COPS2 DTL CUL4B DDB1 | CUL4B-DDB1-DTL-CSN complex |
|   REAC:R-HSA-8856825 | 1.65254713561e-10 | 0.204081632653 | GPS1 COPS8 NEDD8 COPS2 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | Cargo recognition for clathrin-mediated endocytosis |
|   GO:0043161 | 3.12460845371e-10 | 0.326530612245 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN APPBP2 FEM1B CUL4A DDA1 CUL3 DDB1 FBXO17 FEM1C KLHDC3 | proteasome-mediated ubiquitin-dependent protein catabolic process |
|   GO:0006511 | 4.81695030142e-10 | 0.367346938776 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | ubiquitin-dependent protein catabolic process |
|   GO:0019941 | 6.36996779007e-10 | 0.367346938776 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | modification-dependent protein catabolic process |
|   GO:0010498 | 7.09252847539e-10 | 0.34693877551 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN APPBP2 CUL4B FEM1B CUL4A DDA1 CUL3 DDB1 FBXO17 FEM1C KLHDC3 | proteasomal protein catabolic process |
|   GO:0043632 | 9.28164885079e-10 | 0.367346938776 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | modification-dependent macromolecule catabolic process |
|   GO:0051603 | 1.14343055027e-09 | 0.387755102041 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 CUL4B FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | proteolysis involved in protein catabolic process |
|   CORUM:2715 | 5.81900706046e-09 | 0.102040816327 | RBX1 CUL2 CUL3 COPS8 GPS1 | Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) |
|   REAC:R-HSA-8856828 | 6.0448319313e-09 | 0.204081632653 | GPS1 COPS8 NEDD8 COPS2 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | Clathrin-mediated endocytosis |
|   GO:0031465 | 1.71703288855e-08 | 0.102040816327 | DDB1 RBX1 DTL CUL4B DDB2 | Cul4B-RING E3 ubiquitin ligase complex |
|   GO:0140627 | 2.35905261316e-08 | 0.122448979592 | RBX1 CUL2 FEM1B CUL4A FEM1C KLHDC3 | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
|   CORUM:6875 | 3.39939939494e-08 | 0.0816326530612 | RBX1 CUL4A CRBN DDB1 | CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase |
|   GO:1903320 | 4.39382028451e-08 | 0.244897959184 | GPS1 CUL3 COPS8 RBX1 COPS2 COPS9 COPS4 COPS6 COPS3 COPS5 COPS7B COPS7A | regulation of protein modification by small protein conjugation or removal |
|   GO:1901873 | 5.30599946898e-08 | 0.244897959184 | GPS1 CUL3 COPS8 RBX1 COPS2 COPS9 COPS4 COPS6 COPS3 COPS5 COPS7B COPS7A | regulation of post-translational protein modification |
|   GO:0030163 | 7.80018040037e-08 | 0.387755102041 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 CUL4B FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | protein catabolic process |
|   REAC:R-HSA-9706574 | 5.20035611706e-07 | 0.122448979592 | GPS1 COPS4 CUL3 COPS2 RHOBTB1 RHOBTB2 | RHOBTB GTPase Cycle |
|   WP:WP5114 | 5.4260481958e-07 | 0.142857142857 | RBX1 CUL4B GPS1 DDB2 DDB1 ERCC8 CUL4A | Nucleotide excision repair in xeroderma pigmentosum |
|   GO:0070646 | 5.77328134783e-07 | 0.183673469388 | GPS1 COPS8 COPS2 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | protein modification by small protein removal |
|   GO:1902494 | 5.79809641454e-07 | 0.489795918367 | CUL4B DCAF16 DTL DDB1 FBXO17 DCAF6 KLHL24 KLHL13 KLHL42 CRBN FEM1C ERCC8 DDA1 CUL2 CUL3 DCAF11 KLHDC3 APPBP2 RBX1 DCAF8L2 DCAF4 FEM1B CUL4A DDB2 | catalytic complex |
|   WP:WP4753 | 7.41909449782e-07 | 0.122448979592 | RBX1 CUL4B DDB2 DDB1 CUL4A ERCC8 | Nucleotide excision repair |
|   GO:0036211 | 1.01090885387e-06 | 0.551020408163 | COPS8 CUL2 CRBN DDB1 COPS6 COPS3 CUL4B KLHL24 KLHL13 KLHL42 CALCA ERCC8 NEDD8 DDA1 GPS1 CUL3 KLHL18 COPS2 COPS7B COPS7A RBX1 COPS4 DTL COPS9 CUL4A DDB2 COPS5 | protein modification process |
|   WP:WP5381 | 2.42627505785e-06 | 0.163265306122 | GPS1 COPS8 COPS2 COPS4 COPS6 COPS3 COPS7A COPS5 | Smith Magenis and Potocki Lupski syndrome copy number variation |
|   KEGG:03420 | 2.52800513239e-06 | 0.122448979592 | RBX1 CUL4B DDB2 DDB1 CUL4A ERCC8 | Nucleotide excision repair |
|   GO:0031462 | 2.70169322595e-06 | 0.122448979592 | RBX1 CUL2 APPBP2 FEM1B KLHDC3 FEM1C | Cul2-RING ubiquitin ligase complex |
|   WP:WP4352 | 3.40550109216e-06 | 0.183673469388 | COPS8 COPS2 DCAF11 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | Ciliary landscape |
|   GO:0016567 | 3.61105194123e-06 | 0.30612244898 | RBX1 CUL3 CUL4B CUL2 DDB2 KLHL18 KLHL42 CRBN DTL DDB1 CUL4A DDA1 KLHL13 KLHL24 ERCC8 | protein ubiquitination |
|   REAC:R-HSA-9013422 | 3.68144285942e-06 | 0.102040816327 | GPS1 COPS2 COPS4 RHOBTB1 CUL3 | RHOBTB1 GTPase cycle |
|   GO:0019538 | 4.72832823937e-06 | 0.673469387755 | COPS8 CUL2 CRBN DDB1 COPS6 COPS3 FBXO17 FEM1C CUL4B KLHL24 KLHL13 KLHL42 CALCA APPBP2 ERCC8 COPS9 NEDD8 DDA1 GPS1 CUL3 KLHL18 COPS2 DCAF11 KLHDC3 COPS7B COPS7A RBX1 COPS4 DTL FEM1B CUL4A DDB2 COPS5 | protein metabolic process |
|   GO:0043412 | 7.00606817471e-06 | 0.551020408163 | COPS8 CUL2 CRBN DDB1 COPS6 COPS3 CUL4B KLHL24 KLHL13 KLHL42 CALCA ERCC8 NEDD8 DDA1 GPS1 CUL3 KLHL18 COPS2 COPS7B COPS7A RBX1 COPS4 DTL COPS9 CUL4A DDB2 COPS5 | macromolecule modification |
|   CORUM:391 | 1.0798266078e-05 | 0.0612244897959 | RBX1 CUL4A DDB1 | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
|   CORUM:2722 | 1.0798266078e-05 | 0.0612244897959 | RBX1 CUL4A DDB1 | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
|   CORUM:7525 | 1.0798266078e-05 | 0.0612244897959 | RBX1 KLHL24 CUL3 | Ubiquitin E3 ligase (CUL3, KLHL24, RBX1) |
|   CORUM:6486 | 1.0798266078e-05 | 0.0612244897959 | DDB1 CUL4A DTL | CUL4A-DDB1-DTL complex |
|   REAC:R-HSA-110314 | 1.53194100575e-05 | 0.102040816327 | RBX1 CUL4A CUL4B DTL DDB1 | Recognition of DNA damage by PCNA-containing replication complex |
|   GO:0009057 | 1.85939043436e-05 | 0.387755102041 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 CUL4B FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | macromolecule catabolic process |
|   GO:0006508 | 2.04839564175e-05 | 0.387755102041 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 CUL4B FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | proteolysis |
|   GO:1901565 | 2.1152773284e-05 | 0.387755102041 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 CUL4B FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | organonitrogen compound catabolic process |
|   CORUM:2172 | 4.30910823302e-05 | 0.0612244897959 | RBX1 CUL4A DDB1 | Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) |
|   CORUM:7523 | 4.30910823302e-05 | 0.0612244897959 | RBX1 CUL3 KLHL13 | Ubiquitin E3 ligase (CUL3, KLHL9, KLHL13, RBX1) |
|   REAC:R-HSA-5696400 | 7.83649712208e-05 | 0.102040816327 | DDB1 RBX1 CUL4A CUL4B DDB2 | Dual Incision in GG-NER |
|   GO:0160072 | 8.321365433e-05 | 0.0816326530612 | DDB1 CUL2 CUL4A CUL3 | ubiquitin ligase complex scaffold activity |
|   REAC:R-HSA-5696395 | 8.87316962773e-05 | 0.102040816327 | DDB1 RBX1 CUL4A CUL4B DDB2 | Formation of Incision Complex in GG-NER |
|   CORUM:1214 | 0.000107473379054 | 0.0612244897959 | RBX1 CUL4A DDB1 | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
|   GO:0005654 | 0.000113386250103 | 0.65306122449 | COPS8 DCAF16 BTBD1 DTL DDB1 COPS6 COPS3 CUL2 DCAF6 CUL4B COPS9 DDB2 NEDD8 FEM1C ERCC8 DDA1 COPS7A GPS1 CUL3 COPS2 DCAF11 KLHDC3 COPS7B APPBP2 BTBD10 RBX1 COPS4 DCAF4 FEM1B CUL4A APBB3 COPS5 | nucleoplasm |
|   REAC:R-HSA-73893 | 0.000158005870278 | 0.102040816327 | RBX1 CUL4A CUL4B DTL DDB1 | DNA Damage Bypass |
|   CORUM:1211 | 0.000214439357776 | 0.0612244897959 | RBX1 CUL4B DDB1 | Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) |
|   WP:WP4946 | 0.000257618194305 | 0.122448979592 | RBX1 CUL4B DDB2 DDB1 CUL4A ERCC8 | DNA repair pathways full network |
|   GO:0009411 | 0.000259965511561 | 0.163265306122 | RBX1 CUL4B DDB1 DDB2 DTL COPS9 ERCC8 CUL4A | response to UV |
|   GO:0009416 | 0.00045606188674 | 0.183673469388 | RBX1 CUL4B COPS9 DDB2 DTL DDB1 ERCC8 COPS3 CUL4A | response to light stimulus |
|   GO:0031981 | 0.000629191114105 | 0.65306122449 | COPS8 DCAF16 BTBD1 DTL DDB1 COPS6 COPS3 CUL2 DCAF6 CUL4B COPS9 DDB2 NEDD8 FEM1C ERCC8 DDA1 COPS7A GPS1 CUL3 COPS2 DCAF11 KLHDC3 COPS7B APPBP2 BTBD10 RBX1 COPS4 DCAF4 FEM1B CUL4A APBB3 COPS5 | nuclear lumen |
|   REAC:R-HSA-6782210 | 0.000695505719443 | 0.102040816327 | DDB1 RBX1 CUL4A ERCC8 CUL4B | Gap-filling DNA repair synthesis and ligation in TC-NER |
|   REAC:R-HSA-6782135 | 0.000752555066682 | 0.102040816327 | DDB1 RBX1 CUL4A ERCC8 CUL4B | Dual incision in TC-NER |
|   GO:1901564 | 0.00123891718603 | 0.673469387755 | COPS8 CUL2 CRBN DDB1 COPS6 COPS3 FBXO17 FEM1C CUL4B KLHL24 KLHL13 KLHL42 CALCA APPBP2 ERCC8 COPS9 NEDD8 DDA1 GPS1 CUL3 KLHL18 COPS2 DCAF11 KLHDC3 COPS7B COPS7A RBX1 COPS4 DTL FEM1B CUL4A DDB2 COPS5 | organonitrogen compound metabolic process |
|   REAC:R-HSA-983168 | 0.0013168010251 | 0.163265306122 | RBX1 BTBD1 CUL2 LRR1 KLHL42 KLHL13 CUL3 FBXO17 | Antigen processing: Ubiquitination & Proteasome degradation |
|   GO:0032991 | 0.0023854188997 | 0.714285714286 | COPS8 DCAF16 BTBD1 DTL DDB1 COPS6 COPS3 CUL2 DCAF6 CUL4B KLHL24 KLHL13 KLHL42 CRBN FEM1C ERCC8 DDA1 COPS9 COPS7A GPS1 CUL3 COPS2 DCAF11 KLHDC3 COPS7B APPBP2 RBX1 COPS4 DCAF8L2 DCAF4 FEM1B CUL4A FBXO17 DDB2 COPS5 | protein-containing complex |
|   CORUM:790 | 0.00335734174889 | 0.0408163265306 | DDB2 DDB1 | DDB complex |
|   CORUM:7533 | 0.00335734174889 | 0.0408163265306 | CUL3 KLHL42 | Ubiquitin E3 ligase (CUL3, KLHL42) |
|   REAC:R-HSA-199991 | 0.00545856454447 | 0.204081632653 | GPS1 COPS8 NEDD8 COPS2 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | Membrane Trafficking |
|   REAC:R-HSA-983169 | 0.00586433812178 | 0.163265306122 | RBX1 BTBD1 CUL2 LRR1 KLHL42 KLHL13 CUL3 FBXO17 | Class I MHC mediated antigen processing & presentation |
|   GO:1901575 | 0.00687759384714 | 0.387755102041 | RBX1 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 CUL4B FEM1B CUL4A DDA1 CUL3 DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | organic substance catabolic process |
|   GO:0009314 | 0.00777032994197 | 0.183673469388 | RBX1 CUL4B COPS9 DDB2 DTL DDB1 ERCC8 COPS3 CUL4A | response to radiation |
|   GO:0004842 | 0.00832355635423 | 0.204081632653 | RBX1 CUL2 DDB2 KLHL42 KLHL13 DTL ERCC8 CUL3 FBXO17 CUL4A | ubiquitin-protein transferase activity |
|   REAC:R-HSA-5653656 | 0.00871654572886 | 0.204081632653 | GPS1 COPS8 NEDD8 COPS2 COPS4 COPS6 COPS3 COPS7B COPS7A COPS5 | Vesicle-mediated transport |
|   GO:0034644 | 0.00874659561592 | 0.122448979592 | RBX1 CUL4B COPS9 DDB2 DDB1 CUL4A | cellular response to UV |
|   GO:0031463 | 0.00907656465217 | 0.102040816327 | RBX1 CUL3 KLHL24 KLHL42 KLHL13 | Cul3-RING ubiquitin ligase complex |
|   CORUM:222 | 0.0100504287145 | 0.0408163265306 | RBX1 CUL3 | CAND1-CUL3-RBX1 complex |
|   CORUM:7524 | 0.0100504287145 | 0.0408163265306 | RBX1 CUL3 | Ubiquitin E3 ligase (CUL3, KLHL20, RBX1) |
|   CORUM:7517 | 0.0100504287145 | 0.0408163265306 | RBX1 CUL3 | Ubiquitin E3 ligase (CUL3, KLHL7, RBX1) |
|   CORUM:7368 | 0.0100504287145 | 0.0408163265306 | RBX1 CUL3 | Ubiquitin E3 ligase (CUL3, KEAP1, RBX1) |
|   CORUM:6553 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4B | CUL4B-DDB1-TLE3 complex |
|   CORUM:6495 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4B | CUL4B-DDB1-GRWD1 complex |
|   CORUM:6494 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4A | CUL4A-DDB1-WDR61 complex |
|   CORUM:6493 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4A | CUL4A-DDB1-WDR57 complex |
|   CORUM:224 | 0.0100504287145 | 0.0408163265306 | RBX1 CUL4B | CAND1-CUL4B-RBX1 complex |
|   CORUM:6550 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4A | CUL4B-DDB1-TLE1 complex |
|   CORUM:6490 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4B | CUL4B-DDB1-WDR26 complex |
|   CORUM:221 | 0.0100504287145 | 0.0408163265306 | RBX1 CUL2 | CAND1-CUL2-RBX1 complex |
|   CORUM:6491 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4A | CUL4A-DDB1-RBBP5 complex |
|   CORUM:223 | 0.0100504287145 | 0.0408163265306 | RBX1 CUL4A | CAND1-CUL4A-RBX1 complex |
|   CORUM:6492 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4A | CUL4A-DDB1-WDR5B complex |
|   CORUM:6488 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4A | CUL4A-DDB1-EED complex |
|   CORUM:6489 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4A | CUL4A-DDB1-WDR5 complex |
|   CORUM:6487 | 0.0100504287145 | 0.0408163265306 | DDB1 CUL4B | CUL4B-DDB1-TLE2 complex |
|   GO:0019787 | 0.0171603984296 | 0.204081632653 | RBX1 CUL2 DDB2 KLHL42 KLHL13 DTL ERCC8 CUL3 FBXO17 CUL4A | ubiquitin-like protein transferase activity |
|   CORUM:6902 | 0.0200577663467 | 0.0408163265306 | RBX1 FBXO17 | Ubiquitin E3 ligase (CUL1, FBXO17, RBX1, SKP1) |
|   CORUM:6291 | 0.0200577663467 | 0.0408163265306 | DDB1 CUL4A | Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A) |
|   GO:0016755 | 0.0235276725508 | 0.204081632653 | RBX1 CUL2 DDB2 KLHL42 KLHL13 DTL ERCC8 CUL3 FBXO17 CUL4A | aminoacyltransferase activity |
|   GO:0071482 | 0.0260389076306 | 0.122448979592 | RBX1 CUL4B COPS9 DDB2 DDB1 CUL4A | cellular response to light stimulus |
|   CORUM:205 | 0.0333579616585 | 0.0408163265306 | RBX1 CUL2 | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) |
|   CORUM:2188 | 0.0333579616585 | 0.0408163265306 | RBX1 NEDD8 | Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) |
|   WP:WP4860 | 0.0393274875292 | 0.0408163265306 | RBX1 CUL2 | Hijack of ubiquitination by SARS CoV 2 |
|   GO:0009056 | 0.0447099387613 | 0.408163265306 | RBX1 CUL3 ERCC8 DTL CUL2 DCAF11 KLHL42 CRBN NEDD8 CUL4B DDA1 CUL4A PXDNL FEM1B DDB1 COPS3 FBXO17 FEM1C APPBP2 KLHDC3 | catabolic process |
|   GO:0051246 | 0.0455357332329 | 0.367346938776 | RBX1 COPS2 CUL3 COPS8 DTL GPS1 COPS9 COPS6 CALCA NEDD8 DDA1 COPS4 COPS7A COPS3 DDB1 COPS7B CUL4A COPS5 | regulation of protein metabolic process |
|   CORUM:7556 | 0.0499297228088 | 0.0408163265306 | RBX1 CUL2 | PRAME complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
|  COPS7B |  COPS6 | 1.0 | 0.764           |          |
|  COPS3 |  DDB2 | 1.0 | 0.114           |
mutually_exclusive (Q9H9Q2)        
|
|  CUL4A |  DDB2 | 1.0 | 0.234           |
structurally_consistent (Q16531)        
|
|  COPS8 |  COPS6 | 1.0 | 0.844           |          |
|  COPS7B |  COPS2 | 1.0 | 0.668           |
structurally_consistent (dimer)        
|
|  RHOBTB2 |  APBB3 | 1.0 |            |          |
|  GPS1 |  COPS8 | 1.0 | 0.52           |
structurally_consistent (dimer)        
|
|  COPS3 |  COPS6 | 1.0 | 0.884           |
structurally_consistent (Q96EF6)        
structurally_consistent (dimer)         |
|  GPS1 |  COPS6 | 1.0 | 0.948           |
structurally_consistent (Q9BT78)        
|
|  BTBD1 |  COPS4 | 1.0 | 0.168           |          |
|  COPS5 |  COPS2 | 1.0 | 0.958           |          |
|  COPS8 |  DDB2 | 1.0 | 0.062           |
mutually_exclusive (Q9H9Q2)        
|
|  COPS7B |  COPS8 | 1.0 | 0.534           |
structurally_consistent (P61201)        
structurally_consistent (dimer)         |
|  LRR1 |  GPS1 | 1.0 | 0.19           |          |
|  COPS8 |  COPS7A | 1.0 | 0.23           |          |
|  COPS2 |  COPS6 | 1.0 | 0.962           |          |
|  APBB3 |  RHOBTB1 | 1.0 |            |          |
|  DCAF4 |  COPS8 | 1.0 | 0.086           |          |
|  GPS1 |  DCAF4 | 1.0 | 0.086           |          |
|  CUL4B |  DDB2 | 1.0 | 0.066           |
structurally_consistent (Q16531)        
structurally_consistent (dimer)         |
|  DCAF11 |  COPS7A | 1.0 | 0.076           |          |
|  APPBP2 |  COPS2 | 1.0 | 0.098           |          |
|  CUL3 |  GPS1 | 1.0 | 0.66           |          |
|  COPS3 |  COPS4 | 1.0 | 0.94           |          |
|  GPS1 |  COPS4 | 1.0 | 0.91           |
structurally_consistent (dimer)        
|
|  CUL4A |  DCAF11 | 1.0 | 0.062           |
structurally_consistent (Q16531)        
|
|  GPS1 |  DDB2 | 1.0 | 0.21           |
mutually_exclusive (Q9H9Q2)        
|
|  COPS9 |  COPS3 | 1.0 | 0.1           |
structurally_consistent (dimer)        
|
|  BTBD2 |  COPS8 | 1.0 | 0.06           |
structurally_consistent (P61201)        
|
|  BTBD1 |  BTBD2 | 1.0 | 0.13           |
mixed_interface        
|
|  LRR1 |  COPS4 | 1.0 | 0.112           |          |
|  COPS7A |  COPS6 | 0.999 | 0.648           |          |
|  COPS8 |  COPS2 | 0.999 | 0.588           |
mutually_exclusive (Q53RE8)        
structurally_consistent (dimer)         |
|  COPS5 |  COPS6 | 0.999 | 0.96           |          |
|  COPS5 |  COPS8 | 0.999 | 0.808           |          |
|  DCAF11 |  COPS8 | 0.999 | 0.172           |          |
|  CUL2 |  KLHDC3 | 0.999 | 0.226           |
structurally_consistent (dimer)        
|
|  COPS7A |  COPS3 | 0.999 | 0.462           |
structurally_consistent (dimer)        
|
|  GPS1 |  COPS5 | 0.999 | 0.942           |          |
|  BTBD1 |  COPS7A | 0.999 | 0.136           |          |
|  COPS5 |  COPS7B | 0.999 | 0.572           |          |
|  BTBD1 |  COPS8 | 0.999 | 0.07           |          |
|  COPS2 |  COPS3 | 0.999 | 0.952           |
structurally_consistent (dimer)        
|
|  COPS6 |  COPS4 | 0.999 | 0.982           |
structurally_consistent (dimer)        
|
|  GPS1 |  COPS7A | 0.999 | 0.576           |
structurally_consistent (Q9BT78)        
structurally_consistent (dimer)         |
|  COPS6 |  DDB2 | 0.999 | 0.1           |          |
|  CUL4A |  GPS1 | 0.999 | 0.58           |
structurally_consistent (P61201)        
|
|  CUL4A |  CUL4B | 0.999 | 0.374           |          |
|  BTBD1 |  COPS6 | 0.999 | 0.232           |          |
|  COPS2 |  COPS4 | 0.999 | 0.96           |
structurally_consistent (Q13618)        
|
|  DCAF4 |  COPS5 | 0.999 | 0.084           |          |
|  CUL2 |  GPS1 | 0.999 | 0.662           |
structurally_consistent (P61201)        
|
|  CUL4B |  DCAF11 | 0.999 | 0.116           |
structurally_consistent (Q16531)        
|
|  GPS1 |  BTBD2 | 0.999 | 0.312           |
structurally_consistent (P61201)        
|
|  DCAF4 |  COPS7A | 0.999 | 0.062           |          |
|  COPS4 |  DDB2 | 0.999 | 0.088           |          |
|  DCAF4 |  COPS4 | 0.999 | 0.1           |          |
|  CUL4B |  DCAF4 | 0.999 | 0.096           |
structurally_consistent (Q16531)        
|
|  BTBD1 |  GPS1 | 0.999 | 0.162           |          |
|  COPS5 |  COPS3 | 0.999 | 0.898           |          |
|  APPBP2 |  COPS8 | 0.999 | 0.132           |          |
|  COPS8 |  COPS4 | 0.999 | 0.892           |
structurally_consistent (dimer)        
|
|  CUL3 |  COPS8 | 0.999 | 0.324           |          |
|  FEM1B |  COPS6 | 0.999 | 0.136           |          |
|  FEM1B |  COPS3 | 0.999 | 0.102           |
structurally_consistent (dimer)        
|
|  CUL4A |  DCAF4 | 0.999 | 0.17           |
structurally_consistent (Q16531)        
|
|  COPS8 |  COPS3 | 0.999 | 0.666           |
structurally_consistent (dimer)        
|
|  CUL2 |  FEM1B | 0.999 | 0.114           |          |
|  DTL |  CUL4B | 0.999 | 0.11           |
mutually_exclusive (P61201)        
|
|  BTBD1 |  COPS7B | 0.999 | 0.094           |          |
|  BTBD1 |  COPS3 | 0.999 | 0.094           |
structurally_consistent (dimer)        
|
|  CUL4A |  COPS7A | 0.999 | 0.394           |
structurally_consistent (P61201)        
|
|  COPS9 |  GPS1 | 0.999 | 0.122           |          |
|  COPS7A |  COPS4 | 0.999 | 0.278           |
structurally_consistent (dimer)        
|
|  GPS1 |  COPS2 | 0.999 | 0.914           |
structurally_consistent (dimer)        
|
|  FEM1B |  COPS8 | 0.999 | 0.142           |          |
|  BTBD2 |  COPS6 | 0.999 | 0.288           |          |
|  DDB1 |  DDA1 | 0.999 | 0.2           |
structurally_consistent (dimer)        
|
|  CUL2 |  COPS4 | 0.999 | 0.51           |          |
|  BTBD2 |  COPS7A | 0.999 | 0.126           |
structurally_consistent (P61201)        
|
|  COPS7B |  COPS3 | 0.999 | 0.412           |
structurally_consistent (dimer)        
|
|  DCAF4 |  DDB2 | 0.999 | 0.094           |
mutually_exclusive (Q16531)        
|
|  COPS9 |  COPS2 | 0.999 | 0.154           |
structurally_consistent (Q9UNS2)        
|
|  COPS7B |  COPS4 | 0.999 | 0.472           |
structurally_consistent (dimer)        
|
|  GPS1 |  DCAF11 | 0.999 | 0.158           |          |
|  CUL3 |  COPS6 | 0.999 | 0.574           |          |
|  CUL2 |  COPS6 | 0.999 | 0.462           |          |
|  DDB1 |  COPS8 | 0.999 | 0.274           |          |
|  CUL4B |  COPS8 | 0.999 | 0.146           |
structurally_consistent (P61201)        
|
|  BTBD2 |  COPS4 | 0.999 | 0.26           |          |
|  DDB1 |  DDB2 | 0.999 | 0.212           |
structurally_consistent (Q13620)        
structurally_consistent (dimer)         |
|  CUL2 |  APPBP2 | 0.999 | 0.214           |          |
|  DCAF4 |  COPS2 | 0.999 | 0.13           |          |
|  LRR1 |  DCAF4 | 0.999 | 0.106           |          |
|  CUL3 |  COPS2 | 0.999 | 0.536           |
structurally_consistent (dimer)        
|
|  GPS1 |  FEM1B | 0.999 | 0.124           |          |
|  DCAF4 |  DCAF11 | 0.999 | 0.048           |
mutually_exclusive (Q16531)        
|
|  FEM1B |  COPS2 | 0.999 | 0.18           |          |
|  LRR1 |  COPS6 | 0.999 | 0.148           |          |
|  COPS5 |  DDB2 | 0.999 | 0.142           |          |
|  DTL |  DDB2 | 0.999 | 0.086           |
mutually_exclusive (Q16531)        
|
|  CUL4A |  DDA1 | 0.999 | 0.12           |          |
|  DCAF11 |  COPS3 | 0.999 | 0.076           |          |
|  CUL2 |  LRR1 | 0.999 | 0.18           |          |
|  DTL |  CUL4A | 0.999 | 0.242           |          |
|  DTL |  DDB1 | 0.999 | 0.226           |
structurally_consistent (dimer)        
|
|  CUL2 |  COPS3 | 0.999 | 0.626           |          |
|  COPS5 |  COPS4 | 0.999 | 0.964           |          |
|  COPS2 |  COPS7A | 0.999 | 0.59           |
structurally_consistent (dimer)        
|
|  COPS7A |  DDB2 | 0.999 | 0.07           |
mutually_exclusive (Q9H9Q2)        
|
|  GPS1 |  COPS3 | 0.999 | 0.946           |
structurally_consistent (dimer)        
|
|  LRR1 |  COPS8 | 0.999 | 0.082           |          |
|  BTBD2 |  COPS5 | 0.998 | 0.506           |          |
|  CUL4B |  ERCC8 | 0.998 | 0.094           |
structurally_consistent (Q16531)        
|
|  LRR1 |  COPS3 | 0.998 | 0.134           |          |
|  DCAF11 |  DDB2 | 0.998 | 0.176           |
mutually_exclusive (Q16531)        
|
|  DDB1 |  GPS1 | 0.998 | 0.482           |          |
|  CUL4B |  GPS1 | 0.998 | 0.116           |
structurally_consistent (P61201)        
|
|  GPS1 |  APPBP2 | 0.998 | 0.132           |          |
|  CUL2 |  COPS2 | 0.998 | 0.544           |
structurally_consistent (dimer)        
|
|  KLHL42 |  CUL3 | 0.998 | 0.178           |
structurally_consistent (dimer)        
|
|  NEDD8 |  COPS8 | 0.998 | 0.21           |
structurally_consistent (Q9BQ90)        
|
|  CUL4A |  RBX1 | 0.998 | 0.878           |          |
|  GPS1 |  NEDD8 | 0.998 | 0.312           |
structurally_consistent (Q9BT78)        
|
|  DCAF11 |  COPS4 | 0.998 | 0.134           |
mutually_exclusive (Q15843)        
|
|  BTBD1 |  COPS5 | 0.998 | 0.32           |
structurally_consistent (dimer)        
|
|  DTL |  GPS1 | 0.998 | 0.186           |
structurally_consistent (P61201)        
|
|  COPS9 |  COPS5 | 0.998 | 0.094           |          |
|  LRR1 |  COPS2 | 0.998 | 0.134           |          |
|  COPS2 |  DDB2 | 0.998 | 0.212           |
mutually_exclusive (Q13620)        
|
|  DCAF4 |  COPS6 | 0.998 | 0.104           |          |
|  CUL4A |  COPS8 | 0.998 | 0.218           |          |
|  CUL3 |  COPS3 | 0.998 | 0.532           |
structurally_consistent (P61201)        
|
|  DCAF4 |  COPS3 | 0.998 | 0.082           |          |
|  CUL4B |  COPS7A | 0.998 | 0.118           |
structurally_consistent (P61201)        
|
|  DCAF11 |  COPS5 | 0.998 | 0.14           |
mutually_exclusive (Q15843)        
|
|  DCAF11 |  COPS2 | 0.998 | 0.136           |          |
|  BTBD2 |  COPS2 | 0.998 | 0.174           |
structurally_consistent (Q13618)        
structurally_consistent (dimer)         |
|  DTL |  DCAF4 | 0.998 | 0.142           |
mutually_exclusive (Q16531)        
|
|  BTBD2 |  COPS3 | 0.998 | 0.136           |          |
|  CUL4B |  DDB1 | 0.998 | 0.272           |
structurally_consistent (dimer)        
|
|  NEDD8 |  COPS2 | 0.998 | 0.38           |          |
|  GPS1 |  COPS7B | 0.998 | 0.414           |
structurally_consistent (dimer)        
|
|  DCAF4 |  COPS7B | 0.998 | 0.064           |          |
|  DTL |  COPS4 | 0.998 | 0.264           |          |
|  COPS5 |  COPS7A | 0.998 | 0.644           |          |
|  CRBN |  CUL4B | 0.997 | 0.136           |
structurally_consistent (Q16531)        
|
|  DTL |  DDA1 | 0.997 | 0.14           |
structurally_consistent (Q16531)        
|
|  COPS5 |  FBXO17 | 0.997 | 0.118           |          |
|  CUL3 |  BTBD1 | 0.997 | 0.225870002477           |
mixed_interface        
|
|  COPS9 |  COPS8 | 0.997 | 0.12           |          |
|  CUL2 |  DCAF4 | 0.997 | 0.206           |          |
|  DCAF11 |  COPS7B | 0.997 | 0.134           |          |
|  CUL3 |  BTBD2 | 0.997 | 0.33317571885           |
mixed_interface        
|
|  CUL4B |  DCAF16 | 0.997 | 0.128           |          |
|  FBXO17 |  COPS7B | 0.997 | 0.054           |          |
|  CUL2 |  COPS5 | 0.997 | 0.64           |
structurally_consistent (Q9BQ90)        
|
|  CUL4B |  BTBD2 | 0.997 | 0.1           |          |
|  COPS7B |  DDB2 | 0.997 | 0.084           |
structurally_consistent (dimer)        
|
|  CUL2 |  COPS7B | 0.997 | 0.43           |
structurally_consistent (P61201)        
|
|  CUL2 |  BTBD1 | 0.997 | 0.118           |          |
|  COPS7B |  APPBP2 | 0.997 | 0.136           |
structurally_consistent (Q9UNS2)        
|
|  CUL4B |  BTBD1 | 0.996 | 0.098           |          |
|  DDA1 |  GPS1 | 0.996 | 0.3           |          |
|  FBXO17 |  COPS2 | 0.996 | 0.134           |          |
|  DDA1 |  DCAF11 | 0.996 | 0.096           |          |
|  DTL |  COPS8 | 0.996 | 0.218           |
structurally_consistent (P61201)        
|
|  KLHL18 |  GPS1 | 0.996 | 0.308           |          |
|  NEDD8 |  KLHDC3 | 0.996 | 0.12           |
structurally_consistent (Q92905)        
structurally_consistent (dimer)         |
|  KLHL13 |  CUL3 | 0.996 | 0.176230769231           |
structurally_consistent (dimer)        
|
|  CUL4A |  BRWD3 | 0.996 |            |          |
|  CUL4B |  RBX1 | 0.996 | 0.138           |          |
|  KLHL18 |  COPS6 | 0.996 | 0.274           |          |
|  FBXO17 |  COPS8 | 0.996 | 0.082           |          |
|  ERCC8 |  COPS8 | 0.996 | 0.092           |
structurally_consistent (dimer)        
|
|  APPBP2 |  COPS3 | 0.996 | 0.066           |
structurally_consistent (dimer)        
|
|  CUL4B |  COPS9 | 0.996 | 0.038           |          |
|  BTBD1 |  COPS2 | 0.996 | 0.132           |          |
|  LRR1 |  COPS5 | 0.995 | 0.162           |          |
|  BTBD1 |  DDB2 | 0.995 | 0.088           |          |
|  DTL |  COPS3 | 0.995 | 0.1           |
structurally_consistent (P61201)        
|
|  ANKRD39 |  GPS1 | 0.995 | 0.106           |          |
|  ANKRD39 |  COPS7B | 0.995 | 0.13           |          |
|  CUL4A |  DDB1 | 0.995 | 0.628           |
structurally_consistent (dimer)        
|
|  DDB1 |  DCAF11 | 0.995 | 0.142           |
structurally_consistent (dimer)        
|
|  BTBD2 |  COPS7B | 0.994 | 0.134           |          |
|  NEDD8 |  COPS3 | 0.994 | 0.33           |
structurally_consistent (Q9BQ90)        
|
|  DDB1 |  COPS6 | 0.994 | 0.582           |
structurally_consistent (Q8TEB1)        
|
|  BTBD1 |  LRR1 | 0.994 | 0.114           |          |
|  KLHL42 |  GPS1 | 0.994 | 0.312           |          |
|  FEM1C |  GPS1 | 0.994 |            |          |
|  DCAF6 |  COPS2 | 0.994 | 0.126           |
structurally_consistent (Q13098)        
|
|  ERCC8 |  COPS3 | 0.994 | 0.294           |
mutually_exclusive (Q99627)        
|
|  DCAF6 |  GPS1 | 0.994 | 0.192           |
structurally_consistent (dimer)        
|
|  FBXO17 |  COPS6 | 0.994 | 0.146           |
structurally_consistent (dimer)        
|
|  DTL |  COPS6 | 0.994 | 0.288           |          |
|  BTBD2 |  DDB2 | 0.994 | 0.238           |          |
|  CUL4B |  DDA1 | 0.994 | 0.092           |
structurally_consistent (Q16531)        
|
|  CUL3 |  COPS7A | 0.994 | 0.182           |          |
|  DDA1 |  COPS6 | 0.994 | 0.232           |          |
|  ANKRD39 |  COPS8 | 0.994 | 0.184           |
structurally_consistent (dimer)        
|
|  ANKRD39 |  COPS2 | 0.993 | 0.12           |
structurally_consistent (dimer)        
|
|  CUL4A |  COPS9 | 0.993 | 0.066           |          |
|  COPS7B |  COPS7A | 0.993 | 0.248           |
mutually_exclusive (Q9BT78)        
structurally_consistent (dimer)         |
|  COPS7B |  RHOBTB1 | 0.993 |            |          |
|  COPS9 |  COPS6 | 0.993 | 0.044           |
structurally_consistent (Q9UNS2)        
|
|  FBXO17 |  COPS4 | 0.993 | 0.1           |
structurally_consistent (dimer)        
|
|  DDA1 |  COPS8 | 0.993 | 0.246           |          |
|  KLHL24 |  COPS2 | 0.993 |            |
structurally_consistent (Q13618)        
|
|  COPS9 |  COPS7B | 0.993 | 0.074           |
structurally_consistent (Q9UNS2)        
|
|  COPS9 |  COPS4 | 0.993 | 0.102           |          |
|  ANKRD39 |  COPS6 | 0.992 | 0.256           |          |
|  ANKRD39 |  COPS4 | 0.992 | 0.112           |
structurally_consistent (dimer)        
|
|  COPS9 |  COPS7A | 0.992 | 0.106           |
structurally_consistent (Q9UNS2)        
|
|  CUL4B |  LRR1 | 0.992 | 0.088           |          |
|  CUL4B |  COPS7B | 0.992 | 0.062           |
structurally_consistent (P61201)        
|
|  NEDD8 |  COPS6 | 0.992 | 0.256           |
structurally_consistent (Q9BT78)        
|
|  GPS1 |  FBXO17 | 0.992 | 0.152           |          |
|  KCTD20 |  COPS6 | 0.992 | 0.16           |          |
|  CRBN |  COPS8 | 0.992 | 0.214153846154           |
structurally_consistent (dimer)        
|
|  DTL |  COPS2 | 0.992 | 0.258           |
structurally_consistent (dimer)        
|
|  DDA1 |  DCAF4 | 0.992 | 0.084           |          |
|  CUL3 |  COPS4 | 0.991 | 0.378           |
structurally_consistent (dimer)        
|
|  CUL2 |  RHOBTB1 | 0.991 |            |          |
|  BTBD10 |  COPS8 | 0.991 | 0.064           |          |
|  DDA1 |  COPS7A | 0.991 | 0.116           |          |
|  DDB1 |  BRWD3 | 0.991 |            |          |
|  DDB1 |  DCAF4 | 0.991 | 0.162           |
structurally_consistent (dimer)        
|
|  KCTD20 |  COPS3 | 0.991 | 0.098           |          |
|  KCTD20 |  COPS4 | 0.991 | 0.09           |
mutually_exclusive (Q13618)        
|
|  KLHL18 |  COPS3 | 0.991 | 0.228           |          |
|  LRR1 |  BTBD2 | 0.991 | 0.08           |          |
|  LRR1 |  FEM1B | 0.991 | 0.158           |          |
|  COPS9 |  APPBP2 | 0.991 | 0.104           |          |
|  KLHL24 |  CUL3 | 0.991 |            |
structurally_consistent (dimer)        
|
|  COPS9 |  BTBD2 | 0.991 | 0.176           |          |
|  FEM1C |  CUL2 | 0.99 |            |          |
|  FBXO17 |  COPS7A | 0.99 | 0.054           |
structurally_consistent (dimer)        
|
|  BTBD10 |  BTBD1 | 0.99 | 0.144           |
mutually_exclusive (Q13618)        
|
|  ERCC8 |  GPS1 | 0.99 | 0.142           |          |
|  KCTD20 |  BTBD1 | 0.99 | 0.102           |
mutually_exclusive (Q13618)        
|
|  CUL4A |  COPS7B | 0.99 | 0.25           |          |
|  CUL4A |  BTBD2 | 0.99 | 0.29           |          |
|  FBXO17 |  COPS3 | 0.99 | 0.086           |
structurally_consistent (dimer)        
|
|  CUL4B |  CUL2 | 0.989 | 0.112           |          |
|  APBB3 |  COPS7B | 0.989 |            |
structurally_consistent (Q9BT78)        
|
|  CUL4A |  FEM1B | 0.989 | 0.108           |          |
|  KCTD20 |  COPS2 | 0.989 | 0.132           |
structurally_consistent (Q13618)        
|
|  DDA1 |  COPS4 | 0.989 | 0.212           |          |
|  KCTD20 |  GPS1 | 0.989 | 0.108           |          |
|  CUL4A |  BTBD1 | 0.989 | 0.232           |          |
|  CUL3 |  COPS5 | 0.989 | 0.684           |          |
|  BRWD3 |  DDA1 | 0.989 |            |          |
|  ANKRD39 |  COPS7A | 0.988 | 0.206           |          |
|  COPS3 |  LRRC14 | 0.988 | 0.15           |
structurally_consistent (dimer)        
|
|  KLHDC3 |  COPS2 | 0.988 | 0.196           |          |
|  ANKRD39 |  COPS3 | 0.988 | 0.17           |
structurally_consistent (dimer)        
|
|  DDA1 |  DDB2 | 0.988 | 0.056           |          |
|  BTBD10 |  COPS4 | 0.988 | 0.147           |
mutually_exclusive (Q13618)        
|
|  LRR1 |  DDB2 | 0.988 | 0.138           |          |
|  DCAF11 |  COPS6 | 0.987 | 0.134           |
structurally_consistent (dimer)        
|
|  KCTD20 |  BTBD10 | 0.987 | 0.09           |
mutually_exclusive (Q13618)        
|
|  KCTD20 |  CUL3 | 0.987 | 0.186           |
structurally_consistent (dimer)        
|
|  DTL |  COPS5 | 0.987 | 0.298           |          |
|  CUL2 |  COPS9 | 0.987 | 0.056           |          |
|  FEM1B |  COPS4 | 0.987 | 0.118           |          |
|  CUL2 |  BTBD2 | 0.987 | 0.296           |          |
|  KLHL24 |  BTBD10 | 0.987 |            |
mutually_exclusive (Q13618)        
|
|  BTBD10 |  GPS1 | 0.987 | 0.128           |          |
|  BTBD10 |  COPS3 | 0.987 | 0.096           |          |
|  BTBD1 |  DCAF11 | 0.987 | 0.056           |          |
|  GPS1 |  PXDNL | 0.986 |            |          |
|  LRR1 |  COPS7B | 0.986 | 0.082           |          |
|  COPS9 |  DCAF11 | 0.986 | 0.068           |          |
|  BTBD10 |  KLHL42 | 0.986 | 0.1           |
mutually_exclusive (Q13618)        
|
|  CUL4A |  COPS4 | 0.986 | 0.32           |          |
|  FEM1B |  COPS7B | 0.985 | 0.084           |          |
|  BTBD1 |  DCAF4 | 0.985 | 0.078           |          |
|  CRBN |  CUL4A | 0.985 | 0.228           |          |
|  COPS9 |  BTBD1 | 0.985 | 0.106           |
structurally_consistent (Q9UNS2)        
|
|  BTBD10 |  COPS7A | 0.985 | 0.102           |          |
|  DDA1 |  COPS2 | 0.984 | 0.33           |          |
|  CUL4B |  ANKRD39 | 0.984 | 0.096           |
mutually_exclusive (P61201)        
|
|  CUL3 |  COPS9 | 0.984 | 0.096           |          |
|  KLHL13 |  GPS1 | 0.984 | 0.226           |          |
|  CUL3 |  RBX1 | 0.984 | 0.566           |
structurally_consistent (dimer)        
|
|  KLHL42 |  BTBD1 | 0.984 | 0.074           |
mutually_exclusive (Q13618)        
|
|  KCTD20 |  COPS7A | 0.984 | 0.092           |          |
|  DTL |  RBX1 | 0.983 | 0.19           |          |
|  KLHL24 |  KLHL42 | 0.983 |            |
mutually_exclusive (Q13618)        
|
|  BTBD10 |  COPS2 | 0.983 | 0.148           |
structurally_consistent (Q13618)        
|
|  BTBD10 |  COPS6 | 0.983 | 0.084           |          |
|  BTBD10 |  KLHL18 | 0.983 | 0.119           |
mutually_exclusive (Q13618)        
|
|  KLHL24 |  KLHL18 | 0.983 |            |
mutually_exclusive (Q13618)        
|
|  CUL2 |  COPS8 | 0.983 | 0.378           |          |
|  CRBN |  DDB1 | 0.983 | 0.307           |
mixed_interface        
|
|  KCTD20 |  KLHL18 | 0.983 | 0.084           |
mutually_exclusive (Q13618)        
|
|  ANKRD39 |  COPS5 | 0.983 | 0.118           |          |
|  COPS9 |  LRR1 | 0.983 | 0.09           |          |
|  DCAF6 |  COPS8 | 0.982 | 0.09           |
structurally_consistent (Q13098)        
|
|  RBX1 |  DDB2 | 0.982 | 0.054           |          |
|  NEDD8 |  COPS7A | 0.982 | 0.212           |
mutually_exclusive (Q9BT78)        
|
|  BTBD10 |  CUL3 | 0.982 | 0.166           |
structurally_consistent (dimer)        
|
|  CUL4B |  FEM1B | 0.982 | 0.146           |          |
|  ERCC8 |  COPS7A | 0.982 | 0.142           |          |
|  COPS9 |  FEM1B | 0.981 | 0.1           |
structurally_consistent (Q9UNS2)        
|
|  DDA1 |  COPS5 | 0.981 | 0.268           |          |
|  KCTD20 |  BTBD2 | 0.981 | 0.106           |
mutually_exclusive (Q13618)        
|
|  CUL4A |  LRR1 | 0.981 | 0.294           |          |
|  BTBD10 |  BTBD2 | 0.981 | 0.078           |
mutually_exclusive (Q13618)        
|
|  DDB1 |  COPS3 | 0.981 | 0.33           |          |
|  KLHL24 |  KCTD20 | 0.981 |            |
mutually_exclusive (Q13618)        
|
|  DCAF16 |  DCAF6 | 0.98 | 0.054           |          |
|  LRR1 |  COPS7A | 0.98 | 0.0851428571429           |          |
|  COPS9 |  ERCC8 | 0.979 | 0.17           |          |
|  DDB1 |  COPS2 | 0.979 | 0.388           |          |
|  LRR1 |  DCAF11 | 0.979 | 0.106           |          |
|  ANKRD39 |  NEDD8 | 0.979 | 0.138           |
mutually_exclusive (Q9BT78)        
|
|  KLHDC3 |  COPS3 | 0.979 | 0.068           |
structurally_consistent (dimer)        
|
|  KLHL42 |  BTBD2 | 0.979 | 0.174           |
mutually_exclusive (Q13618)        
|
|  KLHL24 |  COPS8 | 0.979 |            |          |
|  CUL2 |  DDB2 | 0.978 | 0.118           |          |
|  BTBD1 |  FEM1B | 0.977 | 0.158           |          |
|  BTBD1 |  APPBP2 | 0.977 | 0.114           |          |
|  NEDD8 |  COPS4 | 0.977 | 0.306           |
structurally_consistent (dimer)        
|
|  COPS9 |  DDB2 | 0.977 | 0.068           |          |
|  KCTD20 |  COPS8 | 0.977 | 0.094           |          |
|  DTL |  COPS7A | 0.976 | 0.106           |
structurally_consistent (P61201)        
|
|  FEM1B |  COPS5 | 0.975 | 0.182           |          |
|  KLHL13 |  BTBD10 | 0.975 | 0.104           |
mutually_exclusive (Q13618)        
|
|  KCTD20 |  KLHL42 | 0.975 | 0.11           |
mutually_exclusive (Q13618)        
|
|  FEM1B |  APPBP2 | 0.973 | 0.186           |          |
|  DCAF16 |  GPS1 | 0.973 | 0.246           |          |
|  ERCC8 |  DCAF4 | 0.973 | 0.112           |
mutually_exclusive (Q16531)        
|
|  KLHL18 |  KLHL42 | 0.972 | 0.092           |
mutually_exclusive (Q13618)        
|
|  CRBN |  COPS2 | 0.972 | 0.34           |
mutually_exclusive (Q99627)        
|
|  APPBP2 |  COPS4 | 0.972 | 0.09           |          |
|  KLHDC3 |  COPS6 | 0.972 | 0.186           |          |
|  CUL4A |  CUL2 | 0.972 | 0.516           |          |
|  FEM1B |  DCAF4 | 0.972 | 0.09           |          |
|  CUL4B |  DCAF6 | 0.972 | 0.096           |
structurally_consistent (Q16531)        
|
|  ERCC8 |  COPS2 | 0.971 | 0.292           |          |
|  ERCC8 |  COPS5 | 0.971 | 0.346           |          |
|  LRR1 |  APPBP2 | 0.971 | 0.096           |          |
|  CUL2 |  COPS7A | 0.971 | 0.256           |
structurally_consistent (P61201)        
|
|  BTBD2 |  APPBP2 | 0.97 | 0.15           |          |
|  CUL3 |  RHOBTB1 | 0.97 |            |
structurally_consistent (dimer)        
|
|  KLHL18 |  CUL3 | 0.969 | 0.278           |
structurally_consistent (dimer)        
|
|  DDB1 |  RBX1 | 0.969 | 0.638           |          |
|  ERCC8 |  DCAF11 | 0.969 | 0.108           |
mutually_exclusive (Q16531)        
|
|  ERCC8 |  COPS4 | 0.968 | 0.154           |
mutually_exclusive (Q99627)        
|
|  DDB1 |  COPS7A | 0.967 | 0.114           |          |
|  APPBP2 |  COPS7A | 0.967 | 0.154           |
structurally_consistent (Q9UNS2)        
|
|  CUL3 |  PXDNL | 0.966 |            |          |
|  DCAF16 |  DCAF11 | 0.966 | 0.074           |          |
|  ERCC8 |  DDB2 | 0.966 | 0.09           |
mutually_exclusive (Q16531)        
|
|  KLHL18 |  COPS4 | 0.965 | 0.13           |
mutually_exclusive (Q13618)        
|
|  KLHDC3 |  COPS7A | 0.964 | 0.078           |
structurally_consistent (Q9UNS2)        
|
|  CUL4A |  DCAF6 | 0.964 | 0.154           |
structurally_consistent (Q16531)        
|
|  KLHL18 |  COPS8 | 0.964 | 0.114           |          |
|  DDB1 |  DCAF16 | 0.962 | 0.260682464455           |          |
|  COPS8 |  KLHDC3 | 0.962 | 0.108           |
structurally_consistent (dimer)        
|
|  DCAF11 |  APPBP2 | 0.962 | 0.068           |          |
|  KLHL42 |  RBX1 | 0.961 | 0.224           |          |
|  KLHL13 |  KCTD20 | 0.961 | 0.168           |
mutually_exclusive (Q13618)        
|
|  CUL3 |  ANKRD39 | 0.961 | 0.268           |          |
|  FEM1B |  DCAF11 | 0.96 | 0.08           |          |
|  DCAF4 |  BTBD2 | 0.96 | 0.068           |          |
|  KCTD20 |  COPS5 | 0.959 | 0.156           |          |
|  DTL |  DCAF16 | 0.959 | 0.106           |          |
|  FEM1B |  DDB2 | 0.959 | 0.08           |          |
|  COPS7B |  KLHDC3 | 0.959 | 0.066           |
structurally_consistent (Q9UNS2)        
|
|  CUL4A |  APPBP2 | 0.959 | 0.16           |          |
|  APPBP2 |  DDB2 | 0.958 | 0.142           |          |
|  APPBP2 |  KLHDC3 | 0.957 | 0.138           |          |
|  DDA1 |  DCAF6 | 0.956 | 0.078           |          |
|  CUL3 |  NEDD8 | 0.956 | 0.276           |          |
|  KLHL18 |  COPS2 | 0.956 | 0.28           |
structurally_consistent (Q13618)        
|
|  CUL4B |  APPBP2 | 0.955 | 0.092           |          |
|  CUL4B |  BRWD3 | 0.955 |            |          |
|  COPS5 |  APPBP2 | 0.955 | 0.108           |          |
|  KLHL18 |  COPS9 | 0.955 | 0.098           |          |
|  CUL4A |  COPS2 | 0.955 | 0.724           |
structurally_consistent (dimer)        
|
|  RHOBTB1 |  PXDNL | 0.953 |            |          |
|  COPS2 |  PXDNL | 0.953 |            |          |
|  COPS9 |  DCAF4 | 0.951 | 0.102           |          |
|  KLHL13 |  KLHL18 | 0.951 | 0.142           |
mutually_exclusive (Q13618)        
|
|  LRR1 |  FBXO17 | 0.95 | 0.072           |          |
|  RBX1 |  COPS2 | 0.949 | 0.36           |          |
|  DTL |  DCAF6 | 0.947 | 0.228           |
mutually_exclusive (Q16531)        
|
|  BTBD1 |  PXDNL | 0.947 |            |          |
|  FEM1B |  COPS7A | 0.947 | 0.124           |          |
|  DDB1 |  LRR1 | 0.945 | 0.114           |          |
|  CUL2 |  LRRC14 | 0.945 | 0.136           |          |
|  KLHL42 |  COPS6 | 0.945 | 0.248           |
structurally_consistent (Q96EF6)        
|
|  DCAF4 |  APPBP2 | 0.944 | 0.104           |          |
|  KLHL18 |  BTBD2 | 0.944 | 0.098           |
mutually_exclusive (Q13618)        
|
|  DDA1 |  ERCC8 | 0.944 | 0.17           |          |
|  KLHL24 |  COPS6 | 0.943 |            |          |
|  DDB1 |  COPS7B | 0.942 | 0.102           |
structurally_consistent (Q92466)        
|
|  COPS5 |  KLHDC3 | 0.942 | 0.278           |
structurally_consistent (dimer)        
|
|  BRWD3 |  RBX1 | 0.941 |            |          |
|  DTL |  DCAF11 | 0.941 | 0.114           |
mutually_exclusive (Q16531)        
|
|  RBX1 |  COPS6 | 0.94 | 0.7           |          |
|  ERCC8 |  COPS6 | 0.939 | 0.354           |          |
|  DCAF6 |  DCAF11 | 0.938 | 0.06           |
mutually_exclusive (Q16531)        
structurally_consistent (dimer)         |
|  DCAF6 |  COPS3 | 0.937 | 0.102           |
structurally_consistent (Q13098)        
|
|  RHOBTB2 |  COPS5 | 0.937 |            |          |
|  RHOBTB2 |  COPS7B | 0.937 |            |          |
|  DCAF11 |  NEDD8 | 0.936 | 0.078           |
structurally_consistent (dimer)        
|
|  FEM1B |  BTBD2 | 0.936 | 0.154           |          |
|  RBX1 |  COPS7A | 0.936 | 0.24           |
mutually_exclusive (Q9H9Q2)        
|
|  APPBP2 |  COPS6 | 0.936 | 0.186           |          |
|  DDA1 |  COPS3 | 0.935 | 0.33           |          |
|  DCAF4 |  FBXO17 | 0.935 | 0.094           |          |
|  KLHL13 |  COPS4 | 0.935 | 0.184           |
mutually_exclusive (Q13618)        
|
|  APBB3 |  COPS2 | 0.932 |            |          |
|  COPS9 |  FBXO17 | 0.93 | 0.098           |          |
|  RBX1 |  DCAF11 | 0.929 | 0.234           |          |
|  DCAF11 |  FBXO17 | 0.929 | 0.094           |          |
|  KLHL42 |  COPS8 | 0.927 | 0.092           |          |
|  CUL4A |  DCAF16 | 0.927 | 0.198           |          |
|  DDB1 |  COPS4 | 0.927 | 0.358           |          |
|  DCAF16 |  COPS4 | 0.926 | 0.34           |          |
|  RBX1 |  COPS8 | 0.924 | 0.214           |          |
|  KLHL18 |  COPS7B | 0.924 | 0.084           |          |
|  CRBN |  CALCA | 0.923 |            |          |
|  FBXO17 |  DDB2 | 0.923 | 0.098           |          |
|  GPS1 |  RHOBTB1 | 0.921 |            |          |
|  ANKRD39 |  FBXO17 | 0.921 | 0.08           |
structurally_consistent (dimer)        
|
|  COPS7A |  RHOBTB1 | 0.92 |            |          |
|  CUL4A |  NEDD8 | 0.92 | 0.22           |          |
|  KLHL18 |  COPS7A | 0.919 | 0.128           |          |
|  FEM1B |  FBXO17 | 0.917 | 0.092           |          |
|  DCAF6 |  DDB2 | 0.916 | 0.09           |
mutually_exclusive (Q16531)        
|
|  DDB1 |  COPS9 | 0.916 | 0.112           |          |
|  RHOBTB2 |  COPS4 | 0.916 |            |          |
|  CALCA |  DCAF6 | 0.915 |            |          |
|  RHOBTB2 |  COPS8 | 0.915 |            |          |
|  RBX1 |  GPS1 | 0.912 | 0.58           |          |
|  CUL2 |  FBXO17 | 0.912 | 0.106           |          |
|  DCAF6 |  COPS7B | 0.912 | 0.072           |
structurally_consistent (Q13098)        
|
|  CUL4A |  COPS5 | 0.912 | 0.562           |          |
|  DCAF16 |  COPS6 | 0.911 | 0.522           |          |
|  DCAF16 |  DDB2 | 0.911 | 0.062           |          |
|  DCAF6 |  COPS6 | 0.911 | 0.19           |          |
|  KLHL18 |  BTBD1 | 0.911 | 0.12           |
mutually_exclusive (Q13618)        
|
|  DCAF6 |  COPS5 | 0.91 | 0.174           |          |
|  KLHL42 |  ANKRD39 | 0.91 | 0.122           |
structurally_consistent (Q96EF6)        
|
|  KLHL24 |  COPS3 | 0.909 |            |          |
|  RHOBTB2 |  GPS1 | 0.908 |            |          |
|  DDB1 |  COPS5 | 0.906 | 0.76           |          |
|  FBXO17 |  APPBP2 | 0.904 | 0.098           |          |
|  CUL4B |  FBXO17 | 0.904 | 0.064           |          |
|  DCAF6 |  FBXO17 | 0.902 | 0.062           |          |
|  CUL3 |  COPS7B | 0.9 | 0.324           |          |
|  CUL4A |  FBXO17 | 0.898 | 0.14           |          |
|  RHOBTB2 |  COPS7A | 0.897 |            |          |
|  CUL2 |  NEDD8 | 0.896 | 0.186           |
structurally_consistent (Q9BQ90)        
|
|  KLHL42 |  COPS3 | 0.895 | 0.122           |
mutually_exclusive (Q9UBW8)        
|
|  KLHL24 |  KLHL13 | 0.894 |            |
mutually_exclusive (Q13618)        
|
|  KLHL24 |  BTBD2 | 0.89 |            |
mutually_exclusive (Q13618)        
|
|  BTBD10 |  COPS5 | 0.89 | 0.124           |          |
|  APBB3 |  COPS5 | 0.889 |            |          |
|  DCAF6 |  APPBP2 | 0.889 | 0.112           |          |
|  DDA1 |  NEDD8 | 0.888 | 0.076           |          |
|  CUL2 |  DCAF11 | 0.887 | 0.086           |          |
|  RBX1 |  COPS4 | 0.887 | 0.75           |          |
|  BTBD1 |  FBXO17 | 0.885 | 0.078           |          |
|  FEM1C |  FEM1B | 0.884 |            |          |
|  APBB3 |  COPS3 | 0.881 |            |          |
|  KLHL24 |  COPS7A | 0.881 |            |          |
|  KLHL13 |  BTBD2 | 0.878 | 0.108           |
mutually_exclusive (Q13618)        
|
|  RBX1 |  COPS5 | 0.871 | 0.538           |          |
|  KLHL24 |  BTBD1 | 0.871 |            |
mutually_exclusive (Q13618)        
|
|  DTL |  ERCC8 | 0.869 | 0.08           |
mutually_exclusive (Q16531)        
|
|  RHOBTB2 |  CUL3 | 0.869 |            |          |
|  CUL4A |  COPS6 | 0.865 | 0.482           |          |
|  KLHL24 |  GPS1 | 0.862 |            |          |
|  GPS1 |  KLHDC3 | 0.856 | 0.156           |
mutually_exclusive (Q9UNS2)        
|
|  KLHL24 |  COPS4 | 0.854 |            |
mutually_exclusive (Q13618)        
|
|  CUL4A |  COPS3 | 0.852 | 0.502           |
structurally_consistent (P61201)        
|
|  BTBD2 |  FBXO17 | 0.852 | 0.06           |          |
|  ANKRD39 |  DDB2 | 0.851 | 0.192           |          |
|  RBX1 |  BTBD2 | 0.851 | 0.244           |
structurally_consistent (Q13618)        
|
|  DCAF16 |  DDA1 | 0.849 | 0.122           |          |
|  ERCC8 |  COPS7B | 0.848 | 0.1           |          |
|  RHOBTB2 |  COPS3 | 0.848 |            |          |
|  RBX1 |  NEDD8 | 0.848 | 0.23           |          |
|  KLHL13 |  KLHL42 | 0.847 | 0.088           |
mutually_exclusive (Q13618)        
|
|  KLHL42 |  COPS4 | 0.84 | 0.214           |          |
|  CUL4A |  ERCC8 | 0.835 | 0.116           |
structurally_consistent (Q16531)        
|
|  KLHL13 |  COPS8 | 0.835 | 0.12           |          |
|  RBX1 |  BTBD1 | 0.83 | 0.2078           |          |
|  APBB3 |  COPS7A | 0.83 |            |
mutually_exclusive (Q9BT78)        
|
|  DDB1 |  DCAF6 | 0.829 | 0.256           |
mutually_exclusive (Q8TEB1)        
structurally_consistent (dimer)         |
|  FEM1C |  NEDD8 | 0.825 |            |          |
|  APBB3 |  GPS1 | 0.821 |            |          |
|  CUL2 |  DCAF6 | 0.821 | 0.2           |          |
|  RHOBTB2 |  COPS6 | 0.819 |            |          |
|  ERCC8 |  FEM1B | 0.815 | 0.094           |          |
|  CUL2 |  ERCC8 | 0.815 | 0.136           |          |
|  KLHL24 |  ANKRD39 | 0.812 |            |          |
|  KLHL18 |  PXDNL | 0.811 |            |          |
|  DDB2 |  PXDNL | 0.811 |            |          |
|  ERCC8 |  APPBP2 | 0.81 | 0.084           |          |
|  KLHL13 |  BTBD1 | 0.805 | 0.112           |
mutually_exclusive (Q13618)        
|
|  KLHDC3 |  COPS4 | 0.804 | 0.074           |          |
|  ERCC8 |  LRR1 | 0.8 | 0.074           |          |
|  BTBD2 |  DCAF11 | 0.797 | 0.13           |          |
|  RBX1 |  FEM1B | 0.797 | 0.220579710145           |          |
|  APBB3 |  COPS6 | 0.796 |            |          |
|  CRBN |  DDB2 | 0.792 | 0.094           |
mutually_exclusive (Q16531)        
|
|  APBB3 |  COPS4 | 0.791 |            |
structurally_consistent (dimer)        
|
|  RBX1 |  COPS3 | 0.79 | 0.68           |
structurally_consistent (Q96EF6)        
|
|  RBX1 |  DDA1 | 0.785 | 0.306           |          |
|  CRBN |  FBXO17 | 0.785 | 0.072           |          |
|  KLHL13 |  COPS2 | 0.782 | 0.182           |
structurally_consistent (Q13618)        
|
|  BTBD1 |  ERCC8 | 0.781 | 0.096           |          |
|  CRBN |  CUL2 | 0.78 | 0.256           |          |
|  RHOBTB2 |  RHOBTB1 | 0.78 |            |          |
|  COPS3 |  PXDNL | 0.776 |            |          |
|  COPS6 |  RHOBTB1 | 0.774 |            |          |
|  COPS9 |  LRRC14 | 0.768 | 0.072           |
structurally_consistent (Q9UNS2)        
|
|  FBXO17 |  KLHDC3 | 0.766 | 0.114           |          |
|  DCAF6 |  ERCC8 | 0.764 | 0.084           |
mutually_exclusive (Q16531)        
|
|  RBX1 |  CUL2 | 0.763 | 0.556           |
structurally_consistent (dimer)        
|
|  CRBN |  KLHDC3 | 0.76 | 0.112           |          |
|  NEDD8 |  RHOBTB1 | 0.758 |            |          |
|  CRBN |  COPS3 | 0.758 | 0.16           |
mutually_exclusive (Q99627)        
|
|  LRR1 |  PXDNL | 0.756 |            |          |
|  KLHL13 |  COPS7A | 0.754 | 0.16           |          |
|  DCAF4 |  KLHDC3 | 0.754 | 0.081           |          |
|  COPS8 |  RHOBTB1 | 0.752 |            |          |
|  CRBN |  FEM1B | 0.752 | 0.068           |          |
|  CRBN |  RBX1 | 0.75 | 0.3           |          |
|  COPS6 |  PXDNL | 0.749 |            |          |
|  CRBN |  COPS7A | 0.745 | 0.064           |          |
|  DCAF16 |  COPS3 | 0.743 | 0.15           |          |
|  CRBN |  LRR1 | 0.743 | 0.076           |          |
|  DTL |  NEDD8 | 0.743 | 0.152           |          |
|  CRBN |  DCAF4 | 0.742 | 0.09           |
mutually_exclusive (Q16531)        
|
|  CUL3 |  ERCC8 | 0.736 | 0.144           |          |
|  KLHL18 |  COPS5 | 0.735 | 0.2984           |          |
|  CUL3 |  LRR1 | 0.732 | 0.248           |          |
|  RBX1 |  DCAF4 | 0.731 | 0.156           |          |
|  ANKRD39 |  BTBD2 | 0.73 | 0.136           |          |
|  FEM1C |  APPBP2 | 0.725 |            |          |
|  ERCC8 |  BTBD2 | 0.725 | 0.154           |          |
|  CRBN |  BTBD2 | 0.725 | 0.132           |          |
|  KLHL18 |  DDB2 | 0.723 | 0.064           |          |
|  CRBN |  BTBD1 | 0.717 | 0.114           |          |
|  ERCC8 |  LRRC14 | 0.715 | 0.082           |          |
|  KLHL18 |  KLHDC3 | 0.714 | 0.126           |          |
|  APBB3 |  CUL3 | 0.713 |            |          |
|  BTBD10 |  COPS7B | 0.712 | 0.064           |          |
|  KLHL42 |  COPS2 | 0.709 | 0.308           |
structurally_consistent (Q13618)        
|
|  DCAF6 |  COPS4 | 0.699 | 0.152           |
structurally_consistent (Q13098)        
|
|  CUL3 |  CALCA | 0.697 |            |          |
|  CRBN |  APPBP2 | 0.696 | 0.136           |          |
|  DCAF6 |  KLHDC3 | 0.696 | 0.07           |          |
|  KLHL18 |  RBX1 | 0.694 | 0.174           |
structurally_consistent (Q13618)        
|
|  DCAF4 |  PXDNL | 0.692 |            |          |
|  KLHL42 |  COPS7A | 0.692 | 0.122           |
structurally_consistent (Q96EF6)        
structurally_consistent (dimer)         |
|  CRBN |  COPS5 | 0.688 | 0.278           |          |
|  CRBN |  DCAF6 | 0.688 | 0.072           |
mutually_exclusive (Q16531)        
|
|  KLHL18 |  FEM1B | 0.684 | 0.178           |          |
|  APBB3 |  COPS8 | 0.683 |            |          |
|  KLHL13 |  COPS6 | 0.68 | 0.134           |          |
|  DDB1 |  ERCC8 | 0.677 | 0.22           |
structurally_consistent (dimer)        
|
|  KLHL18 |  DDB1 | 0.676 | 0.2           |          |
|  APPBP2 |  LRRC14 | 0.675 | 0.088           |          |
|  KLHL18 |  LRRC14 | 0.675 | 0.124           |          |
|  CUL4A |  PXDNL | 0.674 |            |          |
|  CUL4B |  PXDNL | 0.674 |            |          |
|  CUL3 |  CRBN | 0.671 | 0.404323076923           |          |
|  COPS7B |  PXDNL | 0.668 |            |          |
|  CUL2 |  ANKRD39 | 0.666 | 0.108           |
mutually_exclusive (P61201)        
|
|  COPS7A |  PXDNL | 0.666 |            |          |
|  RHOBTB2 |  COPS2 | 0.663 |            |          |
|  COPS4 |  PXDNL | 0.656 |            |          |
|  KLHL18 |  LRR1 | 0.656 | 0.092           |          |
|  KLHL24 |  RBX1 | 0.654 |            |
structurally_consistent (Q13618)        
|
|  KLHL18 |  CUL2 | 0.654 | 0.118           |          |
|  KLHL13 |  COPS9 | 0.646 | 0.078           |          |
|  KLHL18 |  CUL4B | 0.644 | 0.114           |          |
|  CRBN |  ERCC8 | 0.641 | 0.086           |
mixed_interface        
|
|  KLHL18 |  CUL4A | 0.641 | 0.112           |          |
|  KLHL18 |  DCAF11 | 0.637 | 0.088           |          |
|  KLHL42 |  PXDNL | 0.633 |            |          |
|  COPS5 |  RHOBTB1 | 0.633 |            |          |
|  CRBN |  COPS9 | 0.633 | 0.076           |          |
|  CRBN |  COPS7B | 0.628 | 0.132           |          |
|  CRBN |  DCAF11 | 0.627 | 0.186           |
mutually_exclusive (Q16531)        
|
|  CUL2 |  PXDNL | 0.626 |            |          |
|  APPBP2 |  PXDNL | 0.625 |            |          |
|  KLHL13 |  RBX1 | 0.624 | 0.238           |
structurally_consistent (Q13618)        
|
|  CRBN |  GPS1 | 0.616 | 0.242           |
mutually_exclusive (Q99627)        
|
|  BTBD1 |  NEDD8 | 0.613 | 0.122           |
mutually_exclusive (Q92905)        
|
|  CUL3 |  FBXO17 | 0.612 | 0.19           |
structurally_consistent (Q9P2K6)        
|
|  CUL4B |  COPS4 | 0.612 | 0.192           |          |
|  COPS8 |  PXDNL | 0.611 |            |          |
|  FEM1B |  KLHDC3 | 0.609 | 0.068           |          |
|  LRR1 |  KLHDC3 | 0.607 | 0.122           |          |
|  KLHL13 |  COPS3 | 0.607 | 0.042           |          |
|  DCAF11 |  PXDNL | 0.605 |            |          |
|  FEM1B |  PXDNL | 0.603 |            |          |
|  CUL4B |  NEDD8 | 0.601 | 0.112           |          |
|  COPS3 |  RHOBTB1 | 0.599 |            |          |
|  KLHL24 |  PXDNL | 0.597 |            |          |
|  KLHL18 |  APPBP2 | 0.594 | 0.118           |          |
|  CUL4B |  KLHDC3 | 0.593 | 0.08           |          |
|  COPS5 |  PXDNL | 0.593 |            |          |
|  ERCC8 |  KLHDC3 | 0.587 | 0.134           |          |
|  COPS9 |  PXDNL | 0.587 |            |          |
|  COPS9 |  NEDD8 | 0.587 | 0.052           |          |
|  KLHL42 |  DCAF11 | 0.582 | 0.08           |          |
|  DTL |  BTBD2 | 0.581 | 0.17           |          |
|  RHOBTB2 |  NEDD8 | 0.572 |            |          |
|  APBB3 |  NEDD8 | 0.566 |            |          |
|  FEM1C |  DCAF4 | 0.565 |            |          |
|  KLHL13 |  APPBP2 | 0.563 | 0.11           |          |
|  COPS4 |  RHOBTB1 | 0.56 |            |
mutually_exclusive (Q13618)        
|
|  RBX1 |  LRR1 | 0.557 | 0.24           |          |
|  FEM1C |  LRR1 | 0.553 |            |          |
|  CUL3 |  KLHDC3 | 0.552 | 0.316           |          |
|  NEDD8 |  COPS7B | 0.55 | 0.096           |          |
|  CRBN |  DCAF16 | 0.545 | 0.13           |          |
|  BTBD1 |  KLHDC3 | 0.532 | 0.07           |          |
|  KLHL18 |  DCAF4 | 0.532 | 0.166           |          |
|  CRBN |  COPS6 | 0.53 | 0.292           |          |
|  NEDD8 |  COPS5 | 0.53 | 0.36           |
structurally_consistent (dimer)        
|
|  CUL3 |  DCAF4 | 0.525 | 0.232326300985           |          |
|  DCAF6 |  LRR1 | 0.522 | 0.076           |          |
|  DDB1 |  APPBP2 | 0.522 | 0.188           |          |
|  CUL4A |  ANKRD39 | 0.511 | 0.154           |
mutually_exclusive (P61201)        
|
|  DCAF6 |  COPS7A | 0.511 | 0.164           |
structurally_consistent (Q13098)        
|
|  DCAF6 |  DCAF4 | 0.508 | 0.1           |
mutually_exclusive (Q16531)        
|
|  DDB1 |  FEM1B | 0.504 | 0.246           |          |
|  DCAF16 |  COPS5 | 0.504 | 0.512           |          |
|  DDB1 |  PXDNL | 0.5 |            |          |
|  LRR1 |  LRRC14 | 0.499 | 0.154           |          |
|  KLHDC3 |  LRRC14 | 0.49 | 0.056           |          |
|  KCTD20 |  RBX1 | 0.483 | 0.206           |
structurally_consistent (Q13618)        
|
|  CUL4A |  KLHDC3 | 0.481 | 0.182           |          |
|  KLHL18 |  ERCC8 | 0.48 | 0.124           |          |
|  DTL |  CUL2 | 0.474 | 0.148           |          |
|  FEM1C |  PXDNL | 0.472 |            |          |
|  CRBN |  COPS4 | 0.47 | 0.198           |
mutually_exclusive (Q99627)        
|
|  ERCC8 |  FBXO17 | 0.47 | 0.124           |          |
|  KLHL18 |  FBXO17 | 0.468 | 0.1           |          |
|  KLHL42 |  FEM1C | 0.465 |            |          |
|  RBX1 |  DCAF16 | 0.461 | 0.274           |          |
|  COPS7B |  LRRC14 | 0.458 | 0.116           |
structurally_consistent (Q9UNS2)        
|
|  COPS2 |  LRRC14 | 0.458 | 0.228           |          |
|  CUL4B |  COPS3 | 0.455 | 0.212           |
structurally_consistent (P61201)        
|
|  KLHL13 |  COPS5 | 0.447 | 0.314           |          |
|  DTL |  BTBD1 | 0.445 | 0.146           |          |
|  KLHDC3 |  DDB2 | 0.444 | 0.092           |          |
|  DCAF16 |  ANKRD39 | 0.444 | 0.124           |          |
|  BRWD3 |  DCAF11 | 0.443 |            |          |
|  DCAF16 |  COPS7B | 0.443 | 0.198           |          |
|  FEM1B |  LRRC14 | 0.439 | 0.154           |          |
|  DCAF11 |  KLHDC3 | 0.438 | 0.076           |          |
|  FEM1C |  KLHDC3 | 0.436 |            |          |
|  FEM1C |  COPS4 | 0.436 |            |          |
|  DCAF16 |  ERCC8 | 0.435 | 0.084           |          |
|  KLHL13 |  LRR1 | 0.434 | 0.142           |          |
|  FBXO17 |  PXDNL | 0.432 |            |          |
|  FEM1C |  COPS3 | 0.431 |            |          |
|  KLHL18 |  FEM1C | 0.431 |            |          |
|  DCAF6 |  PXDNL | 0.43 |            |          |
|  KCTD20 |  NEDD8 | 0.426 | 0.102           |          |
|  BTBD10 |  NEDD8 | 0.421 | 0.052           |          |
|  DDB1 |  FBXO17 | 0.419 | 0.18           |          |
|  BTBD2 |  KLHDC3 | 0.418 | 0.094           |          |
|  COPS2 |  RHOBTB1 | 0.416 |            |
structurally_consistent (Q13618)        
|
|  FEM1C |  COPS5 | 0.414 |            |          |
|  DTL |  LRR1 | 0.413 | 0.144           |          |
|  KLHL24 |  KLHDC3 | 0.412 |            |          |
|  FEM1C |  COPS2 | 0.407 |            |          |
|  FEM1C |  COPS7B | 0.407 |            |          |
|  KLHL13 |  DCAF4 | 0.404 | 0.096           |          |
|  RBX1 |  FBXO17 | 0.403 | 0.164           |
structurally_consistent (dimer)        
|
|  FEM1C |  COPS9 | 0.401 |            |          |
|  CRBN |  ANKRD39 | 0.397 | 0.092           |
mutually_exclusive (Q99627)        
|
|  ERCC8 |  ANKRD39 | 0.389 | 0.098           |
mutually_exclusive (Q99627)        
|
|  COPS7A |  LRRC14 | 0.387 | 0.066           |
structurally_consistent (Q9UNS2)        
|
|  COPS5 |  LRRC14 | 0.387 | 0.366           |          |
|  GPS1 |  LRRC14 | 0.387 | 0.218           |          |
|  COPS6 |  LRRC14 | 0.387 | 0.3           |          |
|  COPS4 |  LRRC14 | 0.374 | 0.21           |          |
|  KLHL18 |  CRBN | 0.37 | 0.112           |          |
|  DCAF16 |  COPS7A | 0.361 | 0.162           |          |
|  COPS9 |  KLHDC3 | 0.36 | 0.062           |
structurally_consistent (Q9UNS2)        
|
|  COPS8 |  LRRC14 | 0.357 | 0.31           |          |
|  DCAF4 |  LRRC14 | 0.356 | 0.086           |          |
|  BTBD10 |  RBX1 | 0.351 | 0.132           |
structurally_consistent (Q13618)        
|
|  RBX1 |  DCAF6 | 0.346 | 0.308579710145           |          |
|  DCAF6 |  BTBD2 | 0.345 | 0.098           |          |
|  BTBD2 |  PXDNL | 0.342 |            |          |
|  DDB2 |  LRRC14 | 0.334 | 0.092           |          |
|  ANKRD39 |  PXDNL | 0.333 |            |          |
|  BTBD10 |  ANKRD39 | 0.333 | 0.15           |          |
|  KLHL13 |  CALCA | 0.317 |            |          |
|  CUL4B |  LRRC14 | 0.311 | 0.134           |          |
|  DDB1 |  LRRC14 | 0.311 | 0.28           |          |
|  COPS9 |  DCAF6 | 0.311 | 0.078           |          |
|  KLHL24 |  FBXO17 | 0.31 |            |          |
|  DCAF11 |  LRRC14 | 0.308 | 0.066           |          |
|  FEM1C |  COPS7A | 0.303 |            |          |
|  LRR1 |  RHOBTB1 | 0.3 |            |          |
|  KLHL13 |  KLHDC3 | 0.289 | 0.164           |          |
|  KLHL42 |  APPBP2 | 0.289 | 0.174           |          |
|  BRWD3 |  COPS2 | 0.288 |            |          |
|  BRWD3 |  COPS6 | 0.288 |            |          |
|  BRWD3 |  COPS8 | 0.288 |            |          |
|  NEDD8 |  FBXO17 | 0.288 | 0.15           |
structurally_consistent (Q9BT78)        
|
|  DCAF16 |  COPS2 | 0.288 | 0.358           |          |
|  FEM1C |  DCAF11 | 0.283 |            |          |
|  DCAF6 |  FEM1B | 0.282 | 0.14           |          |
|  FEM1C |  COPS6 | 0.275 |            |          |
|  FEM1C |  COPS8 | 0.269 |            |          |
|  DDA1 |  LRR1 | 0.267 | 0.126           |          |
|  KLHL13 |  PXDNL | 0.265 |            |          |
|  CUL3 |  APPBP2 | 0.26 | 0.381215189873           |          |
|  DDA1 |  CUL2 | 0.257 | 0.27           |          |
|  KLHL18 |  DCAF6 | 0.251 | 0.086           |          |
|  RHOBTB2 |  FEM1C | 0.25 |            |          |
|  FEM1C |  LRRC14 | 0.25 |            |          |
|  ANKRD39 |  LRRC14 | 0.25 | 0.074           |          |
|  CUL4B |  COPS6 | 0.247 | 0.226           |          |
|  KLHL24 |  CRBN | 0.246 |            |          |
|  CUL4A |  LRRC14 | 0.245 | 0.192           |          |
|  LRR1 |  NEDD8 | 0.244 | 0.208           |          |
|  FEM1C |  BTBD1 | 0.244 |            |          |
|  FEM1C |  DCAF6 | 0.239 |            |          |
|  DTL |  FEM1C | 0.237 |            |          |
|  FEM1C |  DDB2 | 0.234 |            |          |
|  DCAF6 |  BTBD1 | 0.233 | 0.108           |          |
|  BTBD10 |  DDB2 | 0.232 | 0.076           |          |
|  RBX1 |  ERCC8 | 0.232 | 0.162           |          |
|  BTBD10 |  DCAF11 | 0.232 | 0.068           |          |
|  KCTD20 |  CUL4B | 0.232 | 0.1           |          |
|  BTBD10 |  LRR1 | 0.232 | 0.112           |          |
|  KCTD20 |  LRR1 | 0.232 | 0.106           |          |
|  BTBD10 |  CUL2 | 0.232 | 0.096           |          |
|  KCTD20 |  CUL2 | 0.232 | 0.146           |          |
|  CUL3 |  DDB2 | 0.231 | 0.256           |          |
|  KLHL24 |  COPS5 | 0.23 |            |          |
|  KLHL18 |  RHOBTB1 | 0.23 |            |
mutually_exclusive (Q13618)        
|
|  KLHL42 |  CRBN | 0.229 | 0.092           |          |
|  DDB1 |  NEDD8 | 0.226 | 0.42           |
structurally_consistent (Q8TEB1)        
|
|  BRWD3 |  GPS1 | 0.226 |            |          |
|  BRWD3 |  COPS3 | 0.226 |            |          |
|  KLHL13 |  DCAF11 | 0.225 | 0.072           |          |
|  KLHL42 |  DDB2 | 0.222 | 0.052           |          |
|  DTL |  APPBP2 | 0.219 | 0.124           |          |
|  KLHL24 |  CUL2 | 0.217 |            |          |
|  DDB1 |  BTBD1 | 0.215 | 0.188           |          |
|  BTBD2 |  RHOBTB1 | 0.215 |            |
mutually_exclusive (Q13618)        
|
|  KLHL18 |  ANKRD39 | 0.213 | 0.176           |          |
|  KLHL42 |  COPS7B | 0.207 | 0.04           |
mutually_exclusive (Q9UBW8)        
|
|  KLHL24 |  DCAF11 | 0.206 |            |          |
|  KLHL24 |  COPS7B | 0.205 |            |          |
|  NEDD8 |  DDB2 | 0.205 | 0.096           |          |
|  KLHL42 |  NEDD8 | 0.202 | 0.098           |          |
|  CUL3 |  FEM1B | 0.201 | 0.246           |          |
|  KLHL42 |  FEM1B | 0.198 | 0.136           |          |
|  KCTD20 |  COPS7B | 0.196 | 0.098           |          |
|  KLHL13 |  COPS7B | 0.195 | 0.038           |          |
|  KLHL42 |  CUL4B | 0.192 | 0.062           |          |
|  KCTD20 |  DDB2 | 0.192 | 0.13           |          |
|  BRWD3 |  ERCC8 | 0.192 |            |          |
|  BRWD3 |  NEDD8 | 0.192 |            |          |
|  KCTD20 |  DCAF4 | 0.192 | 0.072           |          |
|  BTBD10 |  DCAF4 | 0.192 | 0.054           |          |
|  KCTD20 |  DCAF11 | 0.192 | 0.134           |          |
|  CUL4B |  FEM1C | 0.188 |            |          |
|  BRWD3 |  COPS4 | 0.186 |            |          |
|  KLHL42 |  KLHDC3 | 0.184 | 0.09           |          |
|  DTL |  CRBN | 0.18 | 0.094           |
mutually_exclusive (Q16531)        
|
|  KLHL42 |  COPS5 | 0.179 | 0.3           |          |
|  BTBD1 |  RHOBTB1 | 0.172 |            |
mutually_exclusive (Q13618)        
|
|  KCTD20 |  ANKRD39 | 0.172 | 0.176           |          |
|  KLHL18 |  NEDD8 | 0.171 | 0.178           |          |
|  DDB1 |  FEM1C | 0.17 |            |          |
|  CUL4A |  FEM1C | 0.17 |            |          |
|  CUL3 |  CUL2 | 0.17 | 0.54           |          |
|  DDB1 |  BTBD2 | 0.168 | 0.166           |          |
|  KLHL42 |  DCAF6 | 0.168 | 0.094           |          |
|  KLHL42 |  CUL2 | 0.167 | 0.148           |          |
|  KLHL13 |  DDB2 | 0.166 | 0.088           |          |
|  DCAF16 |  FEM1C | 0.165 |            |          |
|  KLHL13 |  FEM1B | 0.162 | 0.158           |          |
|  DDA1 |  BTBD2 | 0.16 | 0.098           |          |
|  DCAF6 |  LRRC14 | 0.157 | 0.076           |          |
|  DCAF4 |  RHOBTB1 | 0.156 |            |          |
|  NEDD8 |  APPBP2 | 0.155 | 0.108           |          |
|  KLHL13 |  FEM1C | 0.152 |            |          |
|  ANKRD39 |  DCAF11 | 0.151 | 0.09           |          |
|  DTL |  FEM1B | 0.151 | 0.122           |          |
|  DCAF16 |  COPS8 | 0.15 | 0.308           |          |
|  KLHL42 |  CUL4A | 0.149 | 0.106           |          |
|  DTL |  BRWD3 | 0.149 |            |          |
|  DDB2 |  RHOBTB1 | 0.148 |            |          |
|  BTBD1 |  ANKRD39 | 0.146 | 0.114           |
structurally_consistent (Q9UNS2)        
|
|  FEM1B |  RHOBTB1 | 0.144 |            |          |
|  CRBN |  FEM1C | 0.143 |            |          |
|  KLHL24 |  CUL4B | 0.139 |            |          |
|  CUL3 |  DCAF6 | 0.138 | 0.242           |          |
|  KLHL13 |  ANKRD39 | 0.135 | 0.116           |          |
|  KLHL13 |  CUL2 | 0.134 | 0.11           |          |
|  DDA1 |  COPS7B | 0.133 | 0.246           |          |
|  BTBD1 |  LRRC14 | 0.133 | 0.122           |          |
|  RBX1 |  FEM1C | 0.131 |            |          |
|  KLHL24 |  NEDD8 | 0.13 |            |          |
|  KLHL42 |  COPS9 | 0.129 | 0.068           |          |
|  CRBN |  PXDNL | 0.129 |            |          |
|  KLHL13 |  CUL4A | 0.129 | 0.128           |          |
|  CUL4A |  RHOBTB1 | 0.125 |            |          |
|  CUL3 |  FEM1C | 0.123 |            |          |
|  KLHL24 |  DDB2 | 0.123 |            |          |
|  KLHL42 |  LRR1 | 0.119 | 0.106           |          |
|  KLHL13 |  CUL4B | 0.118 | 0.086           |          |
|  RHOBTB2 |  CUL4A | 0.116 |            |          |
|  KLHL24 |  FEM1B | 0.114 |            |          |
|  KLHL13 |  DDA1 | 0.114 | 0.12           |          |
|  DCAF16 |  DCAF4 | 0.114 | 0.076           |          |
|  FEM1C |  ANKRD39 | 0.113 |            |          |
|  RHOBTB2 |  FEM1B | 0.11 |            |          |
|  KLHL42 |  RHOBTB1 | 0.109 |            |
mutually_exclusive (Q13618)        
|
|  DCAF4 |  NEDD8 | 0.108 | 0.092           |          |
|  BRWD3 |  COPS7A | 0.108 |            |          |
|  FEM1B |  NEDD8 | 0.107 | 0.098           |          |
|  KLHL24 |  COPS9 | 0.107 |            |          |
|  KLHL42 |  DCAF4 | 0.107 | 0.09           |          |
|  RHOBTB2 |  KLHL42 | 0.105 |            |          |
|  DTL |  FBXO17 | 0.103 | 0.076           |          |
|  RHOBTB2 |  DDB2 | 0.102 |            |          |
|  ANKRD39 |  DCAF4 | 0.102 | 0.12           |          |
|  DTL |  ANKRD39 | 0.102 | 0.2           |          |
|  FEM1C |  BTBD2 | 0.101 |            |          |
|  ERCC8 |  NEDD8 | 0.101 | 0.134           |          |
|  KLHL24 |  LRR1 | 0.1 |            |          |
|  KLHL42 |  DCAF16 | 0.099 | 0.138           |          |
|  RHOBTB2 |  KLHL24 | 0.097 |            |          |
|  ANKRD39 |  KLHDC3 | 0.097 | 0.128           |          |
|  DCAF16 |  APPBP2 | 0.097 | 0.086           |          |
|  BTBD2 |  LRRC14 | 0.096 | 0.096           |          |
|  RHOBTB2 |  FBXO17 | 0.095 |            |          |
|  FEM1C |  RHOBTB1 | 0.095 |            |          |
|  DDB1 |  ANKRD39 | 0.094 | 0.122           |          |
|  RBX1 |  KLHDC3 | 0.094 | 0.168           |
structurally_consistent (Q13617)        
|
|  DTL |  CUL3 | 0.094 | 0.322           |          |
|  KLHL24 |  RHOBTB1 | 0.092 |            |
mutually_exclusive (Q13618)        
|
|  DTL |  COPS7B | 0.09 | 0.052           |
structurally_consistent (P61201)        
|
|  RHOBTB2 |  DCAF4 | 0.089 |            |          |
|  RHOBTB2 |  KLHL18 | 0.089 |            |          |
|  KLHL13 |  FBXO17 | 0.088 | 0.078           |          |
|  KLHL42 |  CALCA | 0.087 |            |          |
|  DTL |  RHOBTB1 | 0.087 |            |          |
|  RHOBTB2 |  APPBP2 | 0.087 |            |          |
|  KLHL24 |  DCAF4 | 0.087 |            |          |
|  RHOBTB2 |  DCAF16 | 0.085 |            |          |
|  DDA1 |  FEM1B | 0.085 | 0.142           |          |
|  CUL4B |  RHOBTB1 | 0.083 |            |          |
|  NEDD8 |  LRRC14 | 0.081 | 0.106           |          |
|  KLHL13 |  ERCC8 | 0.08 | 0.086           |          |
|  KLHL42 |  FBXO17 | 0.079 | 0.07           |
structurally_consistent (dimer)        
|
|  FEM1C |  FBXO17 | 0.078 |            |          |
|  RHOBTB2 |  ERCC8 | 0.078 |            |          |
|  RHOBTB2 |  PXDNL | 0.076 |            |          |
|  ERCC8 |  RHOBTB1 | 0.076 |            |          |
|  ANKRD39 |  LRR1 | 0.076 | 0.12           |          |
|  RHOBTB2 |  LRR1 | 0.076 |            |          |
|  FEM1C |  ERCC8 | 0.076 |            |          |
|  RHOBTB2 |  DTL | 0.076 |            |          |
|  FBXO17 |  RHOBTB1 | 0.076 |            |          |
|  DDA1 |  BTBD1 | 0.076 | 0.076           |          |
|  CUL3 |  LRRC14 | 0.075 | 0.146           |          |
|  DDB1 |  KLHDC3 | 0.074 | 0.17           |          |
|  DTL |  PXDNL | 0.073 |            |          |
|  KLHL13 |  CRBN | 0.073 | 0.114           |          |
|  KLHL18 |  DDA1 | 0.073 | 0.114           |          |
|  KLHL13 |  NEDD8 | 0.072 | 0.072           |          |
|  KLHL24 |  APPBP2 | 0.071 |            |          |
|  KLHL24 |  CUL4A | 0.069 |            |          |
|  BTBD2 |  NEDD8 | 0.068 | 0.146           |          |
|  KLHL42 |  DDB1 | 0.068 | 0.14           |          |
|  RHOBTB2 |  CUL4B | 0.065 |            |          |
|  RHOBTB2 |  CUL2 | 0.064 |            |          |
|  ERCC8 |  PXDNL | 0.064 |            |          |
|  ANKRD39 |  FEM1B | 0.064 | 0.164           |          |
|  KLHL13 |  DDB1 | 0.064 | 0.112           |          |
|  RHOBTB2 |  DDA1 | 0.064 |            |          |
|  BTBD10 |  DDA1 | 0.063 | 0.084           |          |
|  RHOBTB2 |  BTBD1 | 0.063 |            |          |
|  DCAF16 |  RHOBTB1 | 0.063 |            |          |
|  BTBD10 |  CUL4B | 0.063 | 0.066           |          |
|  DTL |  KCTD20 | 0.063 | 0.24           |          |
|  KCTD20 |  CUL4A | 0.063 | 0.2225           |          |
|  BRWD3 |  DCAF4 | 0.063 |            |          |
|  BRWD3 |  DDB2 | 0.063 |            |          |
|  KLHL24 |  FEM1C | 0.063 |            |          |
|  ANKRD39 |  APPBP2 | 0.062 | 0.154           |          |
|  CRBN |  NEDD8 | 0.061 | 0.134           |          |
|  KLHL24 |  DCAF16 | 0.061 |            |          |
|  APPBP2 |  RHOBTB1 | 0.06 |            |          |
|  RHOBTB2 |  DCAF6 | 0.06 |            |          |
|  RHOBTB2 |  DCAF11 | 0.06 |            |          |
|  DCAF16 |  NEDD8 | 0.059 | 0.16           |          |
|  CRBN |  DDA1 | 0.058 | 0.034           |          |
|  NEDD8 |  PXDNL | 0.057 |            |          |
|  RBX1 |  COPS7B | 0.057 | 0.226           |
structurally_consistent (dimer)        
|
|  DTL |  KLHL13 | 0.057 | 0.136           |          |
|  DTL |  KLHDC3 | 0.056 | 0.114           |          |
|  CUL4B |  COPS5 | 0.055 | 0.252           |          |
|  DCAF16 |  FEM1B | 0.055 | 0.1           |          |
|  RHOBTB2 |  COPS9 | 0.055 |            |          |
|  DCAF16 |  CUL2 | 0.055 | 0.15           |          |
|  KLHL18 |  DCAF16 | 0.054 | 0.104           |          |
|  CUL3 |  DCAF11 | 0.053 | 0.225715189873           |          |
|  RHOBTB2 |  BTBD2 | 0.053 |            |          |
|  DCAF16 |  FBXO17 | 0.053 | 0.066           |          |
|  CUL3 |  BRWD3 | 0.052 |            |          |
|  KLHL13 |  DCAF6 | 0.052 | 0.132           |          |
|  DTL |  KLHL24 | 0.051 |            |          |
|  DTL |  KLHL18 | 0.05 | 0.128           |          |
|  DTL |  BTBD10 | 0.049 | 0.142           |          |
|  KLHL42 |  ERCC8 | 0.049 | 0.13           |          |
|  CUL3 |  DCAF16 | 0.049 | 0.291215189873           |          |
|  RHOBTB2 |  KLHL13 | 0.049 |            |          |
|  KLHL13 |  RHOBTB1 | 0.048 |            |
mutually_exclusive (Q13618)        
|
|  BTBD10 |  CUL4A | 0.048 | 0.082           |          |
|  DCAF16 |  BTBD2 | 0.046 | 0.176           |          |
|  KLHL13 |  LRRC14 | 0.046 | 0.108           |          |
|  CUL3 |  CUL4B | 0.046 | 0.228           |          |
|  DCAF6 |  ANKRD39 | 0.046 | 0.138           |          |
|  DCAF6 |  NEDD8 | 0.045 | 0.064           |
structurally_consistent (Q8TEB1)        
|
|  DCAF11 |  RHOBTB1 | 0.045 |            |          |
|  DCAF6 |  RHOBTB1 | 0.045 |            |          |
|  DCAF16 |  LRR1 | 0.044 | 0.142           |          |
|  KLHL24 |  ERCC8 | 0.044 |            |          |
|  DDA1 |  ANKRD39 | 0.044 | 0.13           |          |
|  KLHDC3 |  PXDNL | 0.044 |            |          |
|  DTL |  KLHL42 | 0.043 | 0.142           |          |
|  DDA1 |  FEM1C | 0.043 |            |          |
|  KLHL24 |  DDB1 | 0.042 |            |          |
|  COPS9 |  RHOBTB1 | 0.042 |            |          |
|  RBX1 |  APPBP2 | 0.042 | 0.142           |          |
|  CUL3 |  CUL4A | 0.039 | 0.54           |          |
|  DDA1 |  FBXO17 | 0.039 | 0.102           |          |
|  DDA1 |  COPS9 | 0.038 | 0.096           |          |
|  DTL |  COPS9 | 0.038 | 0.076           |          |
|  CALCA |  BTBD2 | 0.037 |            |          |
|  DDB1 |  CUL2 | 0.036 | 0.722           |          |
|  DDA1 |  RHOBTB1 | 0.036 |            |          |
|  DCAF16 |  BTBD1 | 0.035 | 0.106           |          |
|  KCTD20 |  DDA1 | 0.035 | 0.242           |          |
|  KLHL42 |  DDA1 | 0.035 | 0.078           |          |
|  BRWD3 |  COPS7B | 0.034 |            |          |
|  KLHL13 |  DCAF16 | 0.033 | 0.1           |          |
|  DDA1 |  APPBP2 | 0.028 | 0.066           |          |
|  BRWD3 |  COPS5 | 0.028 |            |          |
|  DDA1 |  KLHDC3 | 0.027 | 0.126           |          |
|  CUL4B |  COPS2 | 0.026 | 0.188           |
structurally_consistent (dimer)        
|
|  APBB3 |  CUL2 | 0.026 |            |          |
|  DCAF16 |  COPS9 | 0.026 | 0.09           |          |
|  DCAF16 |  KLHDC3 | 0.024 | 0.108           |          |
|  DDA1 |  PXDNL | 0.023 |            |          |
|  RHOBTB2 |  DDB1 | 0.022 |            |          |
|  CALCA |  COPS8 | 0.022 |            |          |
|  CALCA |  DDA1 | 0.022 |            |          |
|  DDB1 |  CALCA | 0.021 |            |          |
|  DCAF16 |  PXDNL | 0.021 |            |          |
|  APBB3 |  KLHL13 | 0.02 |            |          |
|  CUL3 |  DDA1 | 0.019 | 0.29           |          |
|  CUL3 |  DDB1 | 0.015 | 0.61           |          |
|  KLHL24 |  DCAF6 | 0.01 |            |          |
|  DDB1 |  RHOBTB1 | 0.008 |            |          |
|  KLHL24 |  DDA1 | 0.004 |            |          |
|  APBB3 |  DDB1 | 0.003 |            |          |
Related Complexes