hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14529.1
Complex Portal: CPX-25239
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHLPP2 | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | 5 | UniProt NCBI |
| USP12 | Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12) | 5 | UniProt NCBI |
| DMWD | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | 5 | UniProt NCBI |
| RAD51AP1 | RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) | 5 | UniProt NCBI |
| WDR20 | WD repeat-containing protein 20 (Protein DMR) | 5 | UniProt NCBI |
| DNAAF11 | Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Leucine-rich testis-specific protein) (Protein tilB homolog) (Testis-specific leucine-rich repeat protein) | 5 | UniProt NCBI |
| WDR48 | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | 5 | UniProt NCBI |
| VSX2 | Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) | 5 | UniProt NCBI |
| PHLPP1 | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | 5 | UniProt NCBI |
| USP46 | Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6634 | 1.68385473419e-08 | 0.3 | USP12 WDR20 WDR48 | WDR20-USP12-UAF1 complex |
| CORUM:6635 | 1.68385473419e-08 | 0.3 | USP46 WDR20 WDR48 | WDR20-USP46-UAF1 complex |
| CORUM:6521 | 5.88502576438e-07 | 0.3 | PHLPP2 WDR48 PHLPP1 | Akt-PHLPP1-PHLPP2-FANCI-FANCD2-USP1-UAF1 complex |
| CORUM:6636 | 3.07577115383e-05 | 0.2 | USP12 WDR48 | USP12-UAF1 complex |
| CORUM:6637 | 3.07577115383e-05 | 0.2 | WDR48 USP46 | USP46-UAF1 complex |
| GO:0035800 | 0.000115261178119 | 0.3 | WDR48 DMWD WDR20 | deubiquitinase activator activity |
| REAC:R-HSA-5689880 | 0.0483498248961 | 0.3 | USP12 WDR20 WDR48 | Ub-specific processing proteases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WDR20 | WDR48 | 1.0 | 0.144 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| WDR20 | USP46 | 1.0 | 0.232 |
mutually_exclusive (O75317)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM |
| WDR48 | USP46 | 0.998 | 0.224 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM | |
| WDR48 | USP12 | 0.997 | 0.082 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM |
| WDR20 | USP12 | 0.994 | 0.152 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| WDR20 | PHLPP2 | 0.993 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | ||
| DNAAF11 | PHLPP2 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| USP46 | PHLPP2 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | ||
| PHLPP1 | USP46 | 0.984 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WDR48 | DMWD | 0.983 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| VSX2 | USP12 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PHLPP1 | WDR20 | 0.967 | 0.118 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| USP46 | DMWD | 0.966 | 0.072 |
mutually_exclusive (O75317)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| USP12 | RAD51AP1 | 0.953 | 0.118 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| WDR20 | DMWD | 0.944 | 0.126 |
mutually_exclusive (P62068)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHLPP1 | PHLPP2 | 0.941 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WDR48 | PHLPP2 | 0.937 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| WDR20 | VSX2 | 0.931 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PHLPP1 | WDR48 | 0.924 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDR48 | RAD51AP1 | 0.902 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| USP46 | USP12 | 0.9 | 0.17 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| USP46 | RAD51AP1 | 0.886 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VSX2 | WDR48 | 0.751 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PHLPP2 | USP12 | 0.675 | bioplex3_WMM WMM_only | ||
| DMWD | USP12 | 0.534 | 0.044 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| PHLPP1 | DMWD | 0.366 | 0.194 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHLPP1 | USP12 | 0.267 | 0.054 | bioplex3_WMM WMM_only | |
| PHLPP2 | DMWD | 0.213 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WDR20 | RAD51AP1 | 0.095 | 0.144 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes