hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14537.1

Complex Portal: CPX-15907

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
KLK14	Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6)	5	UniProt NCBI
NUCB2	Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]	5	UniProt NCBI
CES2	Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)	5	UniProt NCBI
TMPRSS11D	Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]	5	UniProt NCBI
RNF39	RING finger protein 39 (Protein HZFw)	5	UniProt NCBI
ADH1C	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma)	5	UniProt NCBI
CXCL17	C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]	5	UniProt NCBI
SARG	Specifically androgen-regulated gene protein	5	UniProt NCBI
MGP	Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein)	5	UniProt NCBI
AGR2	Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)	5	UniProt NCBI
CEACAM5	Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)	5	UniProt NCBI
FUT3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III)	5	UniProt NCBI
MUC1	Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]	5	UniProt NCBI
STATH	Statherin	5	UniProt NCBI
SAMD9	Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9)	5	UniProt NCBI
TPPP3	Tubulin polymerization-promoting protein family member 3 (TPPP/p20)	4	UniProt NCBI
GPX3	Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)	5	UniProt NCBI
CD14	Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]	5	UniProt NCBI
RPTN	Repetin	4	UniProt NCBI
KLK13	Kallikrein-13 (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4)	4	UniProt NCBI
TREM2	Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2)	5	UniProt NCBI
GBP6	Guanylate-binding protein 6 (EC 3.6.5.-) (GTP-binding protein 6) (GBP-6) (Guanine nucleotide-binding protein 6)	5	UniProt NCBI
VSIG10L	V-set and immunoglobulin domain-containing protein 10-like (VSIG10-like protein)	4	UniProt NCBI
DPP4	Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HPA:0131322	0.000491948029436	0.227272727273	CEACAM5 FUT3 CES2 DPP4 AGR2	colon; enterocytes - Microvilli[>=Medium]
HPA:0131321	0.000688710943424	0.227272727273	CEACAM5 FUT3 CES2 DPP4 AGR2	colon; enterocytes - Microvilli[>=Low]
HPA:0401301	0.00559387485015	0.272727272727	ADH1C FUT3 CEACAM5 AGR2 CES2 DPP4	rectum; enterocytes[>=Low]
HPA:0031292	0.01463215303	0.227272727273	ADH1C FUT3 CES2 CEACAM5 AGR2	appendix; endocrine cells[>=Medium]
HPA:0031302	0.0148543692619	0.227272727273	ADH1C FUT3 CES2 CEACAM5 AGR2	appendix; enterocytes[>=Medium]
HPA:0030891	0.016004869498	0.227272727273	ADH1C FUT3 CES2 CEACAM5 AGR2	appendix; goblet cells[>=Low]
HPA:0151321	0.0167986932195	0.181818181818	FUT3 CES2 DPP4 AGR2	duodenum; enterocytes - Microvilli[>=Low]
HPA:0401292	0.0216077208513	0.227272727273	CEACAM5 FUT3 CES2 TPPP3 AGR2	rectum; endocrine cells[>=Medium]
HPA:0131292	0.0228272878725	0.227272727273	CEACAM5 FUT3 CES2 TPPP3 AGR2	colon; endocrine cells[>=Medium]
HPA:0031291	0.0247552381384	0.227272727273	ADH1C FUT3 CES2 CEACAM5 AGR2	appendix; endocrine cells[>=Low]
HPA:0481321	0.0283736792708	0.181818181818	ADH1C CES2 DPP4 FUT3	small intestine; enterocytes - Microvilli[>=Low]
HPA:0401291	0.0337496618239	0.227272727273	CEACAM5 FUT3 CES2 TPPP3 AGR2	rectum; endocrine cells[>=Low]
HPA:0131291	0.0337496618239	0.227272727273	CEACAM5 FUT3 CES2 TPPP3 AGR2	colon; endocrine cells[>=Low]
HPA:0151292	0.0377004626427	0.227272727273	ADH1C FUT3 CES2 TPPP3 AGR2	duodenum; endocrine cells[>=Medium]
REAC:R-HSA-6809371	0.0401325950378	0.136363636364	KLK14 RPTN KLK13	Formation of the cornified envelope
REAC:R-HSA-6805567	0.043807763412	0.136363636364	KLK14 RPTN KLK13	Keratinization
HPA:0031301	0.0471983416278	0.227272727273	ADH1C FUT3 CES2 CEACAM5 AGR2	appendix; enterocytes[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD
GBP6	MUC1	0.904
TPPP3	RNF39	0.904
KLK14	TMPRSS11D	0.904
MUC1	KLK13	0.904
KLK14	FUT3	0.904
GBP6	ADH1C	0.904
CEACAM5	SAMD9	0.904	0.048
MUC1	GPX3	0.904
KLK14	CEACAM5	0.904
TPPP3	MUC1	0.904	0.126
SAMD9	FUT3	0.904
GBP6	MGP	0.904
RPTN	DPP4	0.902
TMPRSS11D	VSIG10L	0.902
MUC1	RPTN	0.902
GBP6	CXCL17	0.902
STATH	RPTN	0.902
STATH	DPP4	0.902
CEACAM5	CXCL17	0.902
GBP6	RPTN	0.902
CXCL17	VSIG10L	0.902
STATH	CXCL17	0.902
CEACAM5	MUC1	0.902	0.222
TMPRSS11D	DPP4	0.902
RPTN	TMPRSS11D	0.902
MUC1	DPP4	0.902	0.158
STATH	VSIG10L	0.902
CEACAM5	RPTN	0.902
VSIG10L	DPP4	0.902
MUC1	CXCL17	0.902
MUC1	VSIG10L	0.902
CXCL17	DPP4	0.902
GBP6	DPP4	0.902	0.05
RPTN	VSIG10L	0.902
CXCL17	RPTN	0.902
GBP6	VSIG10L	0.902
CXCL17	TMPRSS11D	0.902
CEACAM5	STATH	0.902
CEACAM5	DPP4	0.902	0.084
MUC1	STATH	0.902
GBP6	STATH	0.902
CEACAM5	VSIG10L	0.902
MUC1	TMPRSS11D	0.902
STATH	TMPRSS11D	0.902
CEACAM5	TMPRSS11D	0.902
MUC1	CD14	0.902	0.1
KLK13	VSIG10L	0.902
KLK14	CXCL17	0.902
TMPRSS11D	CD14	0.902
SARG	DPP4	0.902	0.1
RPTN	GPX3	0.902
CEACAM5	CD14	0.902	0.102
KLK14	ADH1C	0.902
KLK14	VSIG10L	0.902
SAMD9	ADH1C	0.902	0.072
MGP	SAMD9	0.902	0.036
CXCL17	GPX3	0.902
SARG	VSIG10L	0.902
KLK14	MGP	0.902
DPP4	GPX3	0.902	0.07
CXCL17	ADH1C	0.902
VSIG10L	GPX3	0.902
MUC1	ADH1C	0.902	0.078
MGP	CXCL17	0.902
MGP	RPTN	0.902
KLK14	MUC1	0.902
RPTN	ADH1C	0.902
KLK13	DPP4	0.902
CEACAM5	SARG	0.902
CXCL17	CD14	0.902
KLK14	DPP4	0.902
RPTN	SARG	0.902
MUC1	SARG	0.902
KLK14	STATH	0.902
KLK14	RPTN	0.902
DPP4	CD14	0.902	0.132
VSIG10L	CD14	0.902
CXCL17	FUT3	0.902
FUT3	ADH1C	0.902
MGP	STATH	0.902
MGP	DPP4	0.902	0.078
TPPP3	CXCL17	0.902
TPPP3	STATH	0.902
CES2	STATH	0.902
TMPRSS11D	ADH1C	0.902
CEACAM5	MGP	0.902
DPP4	AGR2	0.902	0.138
TPPP3	DPP4	0.902	0.04
RPTN	FUT3	0.902
TMPRSS11D	FUT3	0.902
VSIG10L	FUT3	0.902
CEACAM5	CES2	0.902	0.112
CXCL17	AGR2	0.902
STATH	AGR2	0.902
CEACAM5	FUT3	0.902
TPPP3	RPTN	0.902
CES2	DPP4	0.902	0.132
CES2	RPTN	0.902
STATH	FUT3	0.902
CXCL17	KLK13	0.902
MGP	FUT3	0.902
MGP	VSIG10L	0.902
SAMD9	STATH	0.902
VSIG10L	AGR2	0.902
SAMD9	VSIG10L	0.902
DPP4	ADH1C	0.902	0.044
MGP	MUC1	0.902
SAMD9	RPTN	0.902
CEACAM5	ADH1C	0.902	0.17
DPP4	FUT3	0.902
SAMD9	CXCL17	0.902
STATH	ADH1C	0.902
STATH	KLK13	0.902
CXCL17	SARG	0.902
VSIG10L	ADH1C	0.902
CES2	TMPRSS11D	0.902
STATH	GPX3	0.902
TPPP3	VSIG10L	0.902
RPTN	CD14	0.902
RPTN	AGR2	0.902
MGP	TMPRSS11D	0.902
CES2	VSIG10L	0.902
SAMD9	DPP4	0.902	0.056
STATH	SARG	0.902
MGP	ADH1C	0.902
RPTN	KLK13	0.902
SARG	TMPRSS11D	0.902
CES2	CXCL17	0.902
MUC1	FUT3	0.902
STATH	CD14	0.902
SAMD9	MUC1	0.902	0.06
CES2	MUC1	0.902	0.114
NUCB2	TREM2	0.879
NUCB2	STATH	0.875
NUCB2	CXCL17	0.875
NUCB2	RPTN	0.875
NUCB2	VSIG10L	0.875
NUCB2	DPP4	0.875	0.3
MUC1	AGR2	0.869	0.215
KLK14	SAMD9	0.869
GBP6	TMPRSS11D	0.796
KLK13	TMPRSS11D	0.796
GBP6	SAMD9	0.796	0.118
GBP6	KLK13	0.796
SAMD9	TMPRSS11D	0.773
GBP6	CEACAM5	0.768
TMPRSS11D	GPX3	0.768
TPPP3	TMPRSS11D	0.768
GBP6	CD14	0.768	0.094
GBP6	FUT3	0.768
CEACAM5	TPPP3	0.768	0.05
CEACAM5	GPX3	0.768
CEACAM5	KLK13	0.768
GBP6	CES2	0.768	0.154
GBP6	SARG	0.768	0.176
NUCB2	MUC1	0.737	0.112
GBP6	KLK14	0.73
TMPRSS11D	AGR2	0.73
CEACAM5	AGR2	0.73	0.118
SAMD9	CD14	0.722	0.042
MGP	TPPP3	0.722	0.03
KLK14	CES2	0.722
KLK14	SARG	0.722
KLK14	CD14	0.722
TPPP3	ADH1C	0.722	0.044
CES2	SAMD9	0.722	0.062
SARG	ADH1C	0.717
MGP	SARG	0.717	0.11
CD14	ADH1C	0.717	0.062
CES2	ADH1C	0.717	0.15
SARG	FUT3	0.717
MGP	CD14	0.717
CD14	FUT3	0.717
CES2	MGP	0.717	0.056
CES2	FUT3	0.717
GBP6	GPX3	0.715	0.128774193548
GBP6	TPPP3	0.715
GPX3	ADH1C	0.714
MGP	GPX3	0.714	0.09
KLK13	ADH1C	0.714
MGP	KLK13	0.714
SARG	CD14	0.698	0.158
CES2	CD14	0.698	0.074
CES2	SARG	0.698	0.126
NUCB2	TMPRSS11D	0.696
NUCB2	CEACAM5	0.696	0.066
GBP6	AGR2	0.675	0.106
AGR2	ADH1C	0.638	0.162
MGP	AGR2	0.638	0.074
SARG	GPX3	0.633	0.116
SARG	KLK13	0.633
GBP6	NUCB2	0.63	0.048
SAMD9	SARG	0.602	0.084
SAMD9	KLK13	0.49
TPPP3	FUT3	0.478
GPX3	FUT3	0.468
KLK13	CD14	0.468
GPX3	CD14	0.468	0.168
CES2	GPX3	0.468	0.09
CES2	KLK13	0.468
KLK13	FUT3	0.468
TPPP3	SARG	0.455	0.086
CES2	TPPP3	0.455	0.052
TPPP3	CD14	0.455	0.09
NUCB2	ADH1C	0.437	0.084
KLK14	TPPP3	0.427
TPPP3	SAMD9	0.427	0.042
SARG	AGR2	0.418	0.118
KLK14	GPX3	0.418
AGR2	CD14	0.418	0.22
KLK14	KLK13	0.418
AGR2	FUT3	0.418
CES2	AGR2	0.418	0.136
SAMD9	GPX3	0.418	0.07
NUCB2	MGP	0.406	0.046
KLK14	AGR2	0.401
SAMD9	AGR2	0.401	0.08
TPPP3	KLK13	0.401
TPPP3	GPX3	0.401	0.13
NUCB2	FUT3	0.388
KLK14	NUCB2	0.376
NUCB2	SAMD9	0.376	0.018
KLK13	GPX3	0.366
NUCB2	CES2	0.357	0.104
NUCB2	SARG	0.357	0.026
NUCB2	CD14	0.357	0.028
TPPP3	AGR2	0.356	0.096
NUCB2	TPPP3	0.262	0.042
NUCB2	KLK13	0.244
NUCB2	AGR2	0.244	0.308
NUCB2	GPX3	0.244	0.094
AGR2	GPX3	0.22	0.186
KLK13	AGR2	0.22

Related Complexes

Genename	Complexes
KLK14	huMAP3_00980.1 huMAP3_08426.1 huMAP3_08861.1 huMAP3_09845.1 huMAP3_09997.1 huMAP3_14537.1
NUCB2	huMAP3_01013.1 huMAP3_04337.1 huMAP3_07584.1 huMAP3_08861.1 huMAP3_10681.1 huMAP3_11471.1 huMAP3_14537.1
CES2	huMAP3_01640.1 huMAP3_02642.1 huMAP3_03448.1 huMAP3_07879.1 huMAP3_08861.1 huMAP3_09695.1 huMAP3_10974.1 huMAP3_14537.1
TMPRSS11D	huMAP3_02265.1 huMAP3_06228.1 huMAP3_08861.1 huMAP3_14537.1
RNF39	huMAP3_02920.1 huMAP3_05999.1 huMAP3_06936.1 huMAP3_11799.1 huMAP3_14537.1
ADH1C	huMAP3_09869.1 huMAP3_09929.1 huMAP3_14537.1
CXCL17	huMAP3_02265.1 huMAP3_05657.1 huMAP3_06147.1 huMAP3_06228.1 huMAP3_06737.1 huMAP3_07223.1 huMAP3_07498.1 huMAP3_08861.1 huMAP3_14537.1
SARG	huMAP3_02265.1 huMAP3_06737.1 huMAP3_07692.1 huMAP3_08861.1 huMAP3_11660.1 huMAP3_14537.1
MGP	huMAP3_01982.1 huMAP3_02265.1 huMAP3_08861.1 huMAP3_13054.1 huMAP3_14041.1 huMAP3_14537.1 huMAP3_14675.1
AGR2	huMAP3_03184.1 huMAP3_06551.1 huMAP3_08083.1 huMAP3_08115.1 huMAP3_14537.1
CEACAM5	huMAP3_01568.1 huMAP3_02768.1 huMAP3_05438.1 huMAP3_06454.1 huMAP3_07446.1 huMAP3_08049.1 huMAP3_08861.1 huMAP3_09846.1 huMAP3_14537.1
FUT3	huMAP3_04229.1 huMAP3_08861.1 huMAP3_14537.1
MUC1	huMAP3_02265.1 huMAP3_06147.1 huMAP3_08861.1 huMAP3_14537.1
STATH	huMAP3_02265.1 huMAP3_07498.1 huMAP3_08861.1 huMAP3_14537.1
SAMD9	huMAP3_02265.1 huMAP3_03589.1 huMAP3_07223.1 huMAP3_07692.1 huMAP3_08861.1 huMAP3_10504.1 huMAP3_14537.1
TPPP3	huMAP3_02024.1 huMAP3_02920.1 huMAP3_04415.1 huMAP3_05999.1 huMAP3_07743.1 huMAP3_07812.1 huMAP3_10355.1 huMAP3_11799.1 huMAP3_14537.1
GPX3	huMAP3_03255.1 huMAP3_04676.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_14537.1
CD14	huMAP3_03593.1 huMAP3_14537.1
RPTN	huMAP3_02265.1 huMAP3_05657.1 huMAP3_06147.1 huMAP3_06228.1 huMAP3_06737.1 huMAP3_07223.1 huMAP3_07498.1 huMAP3_08861.1 huMAP3_14537.1
KLK13	huMAP3_02265.1 huMAP3_05657.1 huMAP3_08861.1 huMAP3_14537.1
TREM2	huMAP3_11471.1 huMAP3_14537.1
GBP6	huMAP3_00494.1 huMAP3_14537.1
VSIG10L	huMAP3_02265.1 huMAP3_05657.1 huMAP3_06147.1 huMAP3_06228.1 huMAP3_06737.1 huMAP3_07223.1 huMAP3_07498.1 huMAP3_08861.1 huMAP3_14537.1
DPP4	huMAP3_02265.1 huMAP3_05657.1 huMAP3_06147.1 huMAP3_06228.1 huMAP3_06737.1 huMAP3_07223.1 huMAP3_07498.1 huMAP3_08861.1 huMAP3_14537.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14537.1

Complex Portal: CPX-15907