hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14542.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DLG3 | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | 5 | UniProt NCBI |
| DLGAP2 | DLG associated protein 2 | 1 | UniProt NCBI |
| DLGAP4 | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | 5 | UniProt NCBI |
| DLG2 | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6794361 | 1.5670900333e-08 | 1.0 | DLGAP4 DLG3 DLG2 DLGAP2 | Neurexins and neuroligins |
| REAC:R-HSA-6794362 | 8.80508022231e-08 | 1.0 | DLGAP4 DLG3 DLG2 DLGAP2 | Protein-protein interactions at synapses |
| WP:WP5420 | 4.51953416757e-06 | 1.0 | DLGAP4 DLG3 DLG2 DLGAP2 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-112316 | 3.09235191422e-05 | 1.0 | DLGAP4 DLG3 DLG2 DLGAP2 | Neuronal System |
| GO:0099572 | 0.000195074084076 | 1.0 | DLGAP4 DLG3 DLG2 DLGAP2 | postsynaptic specialization |
| REAC:R-HSA-442982 | 0.000931962666506 | 0.5 | DLG3 DLG2 | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 0.0013924419067 | 0.5 | DLG3 DLG2 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.0013924419067 | 0.5 | DLG3 DLG2 | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 0.00156635412759 | 0.5 | DLG3 DLG2 | Long-term potentiation |
| REAC:R-HSA-442742 | 0.00236402400204 | 0.5 | DLG3 DLG2 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| GO:0098794 | 0.00240858219907 | 1.0 | DLGAP4 DLG3 DLG2 DLGAP2 | postsynapse |
| REAC:R-HSA-9609736 | 0.00718390333861 | 0.5 | DLG3 DLG2 | Assembly and cell surface presentation of NMDA receptors |
| WP:WP5417 | 0.0092628309276 | 0.5 | DLG3 DLG2 | Cell lineage map for neuronal differentiation |
| REAC:R-HSA-438064 | 0.0232149434748 | 0.5 | DLG3 DLG2 | Post NMDA receptor activation events |
| KEGG:04530 | 0.0237566589162 | 0.5 | DLG3 DLG2 | Tight junction |
| KEGG:04390 | 0.02620193588 | 0.5 | DLG3 DLG2 | Hippo signaling pathway |
| REAC:R-HSA-442755 | 0.0321680026233 | 0.5 | DLG3 DLG2 | Activation of NMDA receptors and postsynaptic events |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DLG3 | DLG2 | 0.982 | 0.14 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| DLG3 | DLGAP4 | 0.843 | 0.062 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| DLG3 | huMAP3_00720.1 huMAP3_01851.1 huMAP3_10326.1 huMAP3_14542.1 huMAP3_14614.1 |
| DLGAP2 | huMAP3_14542.1 huMAP3_14614.1 |
| DLGAP4 | huMAP3_03064.1 huMAP3_14542.1 huMAP3_14614.1 |
| DLG2 | huMAP3_00720.1 huMAP3_14542.1 huMAP3_14614.1 |