hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14556.1
Complex Portal: CPX-11952
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EPX | Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] | 5 | UniProt NCBI |
| CYP3A43 | Cytochrome P450 3A43 (EC 1.14.14.1) | 5 | UniProt NCBI |
| BPI | Bactericidal permeability-increasing protein (BPI) (CAP 57) | 5 | UniProt NCBI |
| CYP3A4 | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | 5 | UniProt NCBI |
| CYP3A5 | Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05204 | 0.000224021038984 | 1.0 | CYP3A43 CYP3A4 | Chemical carcinogenesis - DNA adducts |
| REAC:R-HSA-211981 | 0.000358839967947 | 1.0 | CYP3A43 CYP3A4 | Xenobiotics |
| WP:WP43 | 0.00036647347272 | 1.0 | CYP3A43 CYP3A4 | Oxidation by cytochrome P450 |
| REAC:R-HSA-211897 | 0.00169167413461 | 1.0 | CYP3A43 CYP3A4 | Cytochrome P450 - arranged by substrate type |
| GO:0050649 | 0.0028092043205 | 1.0 | CYP3A43 CYP3A4 | testosterone 6-beta-hydroxylase activity |
| WP:WP702 | 0.00384988683014 | 1.0 | CYP3A43 CYP3A4 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-211945 | 0.00499983688673 | 1.0 | CYP3A43 CYP3A4 | Phase I - Functionalization of compounds |
| WP:WP2536 | 0.00622025938483 | 0.5 | CYP3A4 | Colchicine metabolic pathway |
| GO:0101020 | 0.00983221512175 | 1.0 | CYP3A43 CYP3A4 | estrogen 16-alpha-hydroxylase activity |
| WP:WP2640 | 0.0124400931326 | 0.5 | CYP3A43 | Aripiprazole metabolic pathway |
| WP:WP2646 | 0.0124400931326 | 0.5 | CYP3A4 | Lidocaine metabolism |
| WP:WP2816 | 0.0124400931326 | 0.5 | CYP3A4 | Felbamate metabolism |
| WP:WP4174 | 0.0124400931326 | 0.5 | CYP3A4 | Metabolism of tetrahydrocannabinol THC |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | CYP3A43 CYP3A4 | Biological oxidations |
| WP:WP2826 | 0.0248784837172 | 0.5 | CYP3A4 | Cocaine metabolism |
| GO:0008395 | 0.0365196561665 | 1.0 | CYP3A43 CYP3A4 | steroid hydroxylase activity |
| WP:WP699 | 0.0435328773163 | 0.5 | CYP3A4 | Aflatoxin B1 metabolism |
| GO:0070989 | 0.0491610756088 | 1.0 | CYP3A43 CYP3A4 | oxidative demethylation |
| WP:WP2874 | 0.049750157242 | 0.5 | CYP3A4 | Liver X receptor pathway |
| WP:WP696 | 0.049750157242 | 0.5 | CYP3A4 | Benzo a pyrene metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CYP3A5 | CYP3A43 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EPX | CYP3A43 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CYP3A5 | CYP3A4 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CYP3A43 | BPI | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CYP3A4 | CYP3A43 | 0.902 | bioplex3_WMM WMM_only | ||
| EPX | BPI | 0.356 | 0.218 | bioplex3_WMM WMM_only |
Related Complexes