hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14560.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
MT-CYB	Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit)	5	UniProt NCBI
ATP1B2	Sodium/potassium-transporting ATPase subunit beta-2 (Adhesion molecule in glia) (AMOG) (Sodium/potassium-dependent ATPase subunit beta-2)	5	UniProt NCBI
UQCRQ	Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C)	5	UniProt NCBI
COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L)	5	UniProt NCBI
UQCRC1	Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)	5	UniProt NCBI
COX7A2L	Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1)	4	UniProt NCBI
OPLAH	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase)	5	UniProt NCBI
COX5A	Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)	5	UniProt NCBI
CPQ	Carboxypeptidase Q (EC 3.4.17.-) (Lysosomal dipeptidase) (Plasma glutamate carboxypeptidase)	5	UniProt NCBI
COX6C	Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)	5	UniProt NCBI
PTGES2	Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form]	5	UniProt NCBI
COX7A2	Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL)	5	UniProt NCBI
UQCRB	Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04260	6.90554999522e-09	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Cardiac muscle contraction
WP:WP111	6.14995676232e-08	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Electron transport chain OXPHOS system in mitochondria
KEGG:00190	1.01431390851e-07	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Oxidative phosphorylation
REAC:R-HSA-611105	1.51014067495e-07	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Respiratory electron transport
KEGG:04932	1.96169774227e-07	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Non-alcoholic fatty liver disease
WP:WP4396	3.36035506311e-07	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Nonalcoholic fatty liver disease
REAC:R-HSA-163200	4.18144809868e-07	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
KEGG:05415	7.62461312826e-07	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Diabetic cardiomyopathy
KEGG:05208	1.28681623759e-06	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Chemical carcinogenesis - reactive oxygen species
KEGG:04714	1.38555246608e-06	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Thermogenesis
REAC:R-HSA-1428517	2.25764365368e-06	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	The citric acid (TCA) cycle and respiratory electron transport
KEGG:05012	2.92573586203e-06	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Parkinson disease
KEGG:05020	3.38206347207e-06	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Prion disease
WP:WP4921	4.45548396217e-06	0.375	UQCRQ MT-CYB UQCRC1	Mitochondrial complex III assembly
KEGG:05016	5.59705573391e-06	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Huntington disease
KEGG:05014	1.36296552901e-05	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Amyotrophic lateral sclerosis
KEGG:01100	1.56092584855e-05	0.875	COX6C UQCRC1 PTGES2 UQCRQ COX7A2L MT-CYB OPLAH	Metabolic pathways
GO:0005746	1.63146572742e-05	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	mitochondrial respirasome
GO:0070469	1.63146572742e-05	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	respirasome
KEGG:05010	1.73213042512e-05	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Alzheimer disease
GO:0070069	4.35075554541e-05	0.5	COX6C UQCRQ MT-CYB UQCRC1	cytochrome complex
KEGG:05022	4.60126953817e-05	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	Pathways of neurodegeneration - multiple diseases
GO:0006119	8.65298625156e-05	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	oxidative phosphorylation
GO:0009060	0.000281322020506	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	aerobic respiration
GO:0045333	0.000530546258616	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	cellular respiration
REAC:R-HSA-1430728	0.000580216861037	0.875	COX6C UQCRC1 PTGES2 UQCRQ COX7A2L MT-CYB OPLAH	Metabolism
GO:0006122	0.000886327111509	0.375	UQCRQ MT-CYB UQCRC1	mitochondrial electron transport, ubiquinol to cytochrome c
GO:0005750	0.00118146610329	0.375	UQCRQ MT-CYB UQCRC1	mitochondrial respiratory chain complex III
GO:0045275	0.00118146610329	0.375	UQCRQ MT-CYB UQCRC1	respiratory chain complex III
GO:0015980	0.00213344193493	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	energy derivation by oxidation of organic compounds
GO:0019646	0.002326053637	0.5	COX6C UQCRQ MT-CYB UQCRC1	aerobic electron transport chain
GO:0098803	0.00272226199626	0.5	COX6C UQCRQ MT-CYB UQCRC1	respiratory chain complex
GO:0042775	0.00316689333881	0.5	COX6C UQCRQ MT-CYB UQCRC1	mitochondrial ATP synthesis coupled electron transport
GO:0042773	0.00316689333881	0.5	COX6C UQCRQ MT-CYB UQCRC1	ATP synthesis coupled electron transport
GO:0022904	0.00482963771614	0.5	COX6C UQCRQ MT-CYB UQCRC1	respiratory electron transport chain
GO:0022900	0.00679043955679	0.5	COX6C UQCRQ MT-CYB UQCRC1	electron transport chain
GO:0006091	0.0164950268945	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	generation of precursor metabolites and energy
GO:0098800	0.0333274601889	0.5	COX6C UQCRQ MT-CYB UQCRC1	inner mitochondrial membrane protein complex
GO:0005743	0.0359079131582	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	mitochondrial inner membrane
HPA:0360053	0.0430434462566	0.625	COX6C UQCRQ PTGES2 MT-CYB UQCRC1	parathyroid gland; glandular cells[High]
GO:0019866	0.0475951624611	0.625	COX6C UQCRQ COX7A2L MT-CYB UQCRC1	organelle inner membrane

Edges

Protein 1	Protein 2	Score	ProteomeHD
UQCRB	UQCRC1	0.999	0.986
UQCRQ	PTGES2	0.998	0.11
UQCRQ	UQCRC1	0.998	0.962
UQCRB	UQCRQ	0.996	0.992
COX7A2L	UQCRQ	0.995	0.726
MT-CYB	UQCRQ	0.995	0.77
UQCRB	COX6C	0.994	0.944
COX7A2L	COX5A	0.993	0.686
UQCRB	PTGES2	0.993	0.122
UQCRQ	COX6C	0.992	0.936
PTGES2	UQCRC1	0.99	0.228
COX6C	COX6A1	0.99	0.602
COX7A2L	UQCRB	0.989	0.882
MT-CYB	PTGES2	0.985	0.276
COX7A2L	MT-CYB	0.983	0.652
MT-CYB	UQCRB	0.981	0.814
COX7A2L	UQCRC1	0.979	0.584
COX7A2L	PTGES2	0.973	0.06
COX7A2L	COX6A1	0.972	0.784
COX5A	COX6C	0.967	0.904
COX7A2L	COX6C	0.965	0.834
UQCRC1	COX6A1	0.955	0.466
UQCRB	COX6A1	0.953	0.836
UQCRQ	COX6A1	0.952	0.756
COX7A2	COX6A1	0.949	0.652
COX5A	UQCRC1	0.947	0.888
MT-CYB	UQCRC1	0.944	0.762
OPLAH	PTGES2	0.94	0.11
ATP1B2	UQCRB	0.938
COX5A	UQCRQ	0.93	0.792
COX6C	UQCRC1	0.927	0.95
COX5A	COX6A1	0.927	0.62
COX7A2	COX6C	0.88	0.848
COX5A	UQCRB	0.875	0.856
COX5A	COX7A2	0.862	0.906
COX7A2L	COX7A2	0.838	0.686
CPQ	COX7A2L	0.828	0.05
MT-CYB	OPLAH	0.73	0.036
COX7A2	UQCRC1	0.676	0.802
CPQ	COX7A2	0.648	0.0769380530973
COX7A2	UQCRQ	0.562	0.85
COX7A2L	OPLAH	0.41	0.042
COX7A2	UQCRB	0.386	0.972
COX7A2	OPLAH	0.356	0.04
CPQ	UQCRQ	0.254	0.05
UQCRQ	OPLAH	0.229	0.066
COX6C	PTGES2	0.225	0.07
OPLAH	UQCRC1	0.224	0.062
COX5A	PTGES2	0.219	0.184
MT-CYB	COX6C	0.157	0.624
COX7A2	PTGES2	0.12	0.0883339882122
UQCRB	OPLAH	0.12	0.038
COX5A	MT-CYB	0.097	0.448
CPQ	COX5A	0.092	0.058
COX7A2	MT-CYB	0.063	0.44
ATP1B2	COX6C	0.015
ATP1B2	UQCRC1	0.013
OPLAH	COX6C	0.011	0.07
PTGES2	COX6A1	0.01	0.22
COX5A	ATP1B2	0.009

Related Complexes

Genename	Complexes
MT-CYB	huMAP3_02983.1 huMAP3_06133.1 huMAP3_08223.1 huMAP3_08546.1 huMAP3_09600.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1
ATP1B2	huMAP3_02138.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12708.1 huMAP3_14315.1 huMAP3_14560.1 huMAP3_14580.1
UQCRQ	huMAP3_02983.1 huMAP3_05463.1 huMAP3_06133.1 huMAP3_07069.1 huMAP3_07840.1 huMAP3_08546.1 huMAP3_09600.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1
COX6A1	huMAP3_07005.1 huMAP3_08546.1 huMAP3_09906.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1
UQCRC1	huMAP3_06133.1 huMAP3_07840.1 huMAP3_08546.1 huMAP3_09600.1 huMAP3_09982.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14018.1 huMAP3_14560.1 huMAP3_14580.1
COX7A2L	huMAP3_01464.1 huMAP3_06639.1 huMAP3_07840.1 huMAP3_08546.1 huMAP3_09600.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1
OPLAH	huMAP3_03184.1 huMAP3_06551.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12970.1 huMAP3_13084.1 huMAP3_14560.1 huMAP3_14580.1
COX5A	huMAP3_01464.1 huMAP3_07005.1 huMAP3_08024.1 huMAP3_08055.1 huMAP3_09906.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1
CPQ	huMAP3_00058.1 huMAP3_05963.1 huMAP3_08838.1 huMAP3_11861.1 huMAP3_11952.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_13274.1 huMAP3_14560.1 huMAP3_14580.1
COX6C	huMAP3_04820.1 huMAP3_07696.1 huMAP3_10623.1 huMAP3_10718.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1
PTGES2	huMAP3_05353.1 huMAP3_08546.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_12970.1 huMAP3_14560.1 huMAP3_14580.1
COX7A2	huMAP3_01629.1 huMAP3_03863.1 huMAP3_07021.1 huMAP3_07870.1 huMAP3_07890.1 huMAP3_10024.1 huMAP3_10294.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1
UQCRB	huMAP3_02983.1 huMAP3_06133.1 huMAP3_07840.1 huMAP3_08546.1 huMAP3_09600.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14560.1 huMAP3_14580.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14560.1