hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14586.1

Complex Portal: CPX-14400

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
BTBD7	BTB/POZ domain-containing protein 7	4	UniProt NCBI
TSEN54	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	5	UniProt NCBI
TSEN15	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	5	UniProt NCBI
PHLDA2	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	5	UniProt NCBI
GREB1L	GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein)	5	UniProt NCBI
AMMECR1	Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein)	5	UniProt NCBI
CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	5	UniProt NCBI
PCF11	Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)	5	UniProt NCBI
GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI
XRCC2	DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)	5	UniProt NCBI
ARL4C	ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7) (ADP-ribosylation factor-like protein LAK)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	1.302095624e-14	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	tRNA splicing endonuclease
HP:0006850	5.87343548758e-09	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the ventral pons
HP:0012765	5.87343548758e-09	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Widened cerebellar subarachnoid space
HP:0200049	2.73823562594e-08	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Upper limb hypertonia
CORUM:5284	3.08880131998e-08	0.230769230769	CLP1 TSEN54 TSEN2	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
HP:0003558	1.28897474085e-07	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Viral infection-induced rhabdomyolysis
HP:0031162	1.93250909762e-07	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Impaired oropharyngeal swallow response
REAC:R-HSA-6784531	2.15320027879e-07	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	tRNA processing in the nucleus
HP:0002268	9.2687804265e-07	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Paroxysmal dystonia
HP:0011171	2.3262323028e-06	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Simple febrile seizure
REAC:R-HSA-72306	4.33866746217e-06	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	tRNA processing
GO:0006388	6.18707875607e-06	0.307692307692	CLP1 TSEN54 TSEN34 TSEN2	tRNA splicing, via endonucleolytic cleavage and ligation
HP:0000253	6.76419767297e-06	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Progressive microcephaly
GO:0000394	9.27604366858e-06	0.307692307692	CLP1 TSEN54 TSEN34 TSEN2	RNA splicing, via endonucleolytic cleavage and ligation
HP:0006895	1.58107937884e-05	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Lower limb hypertonia
GO:0000379	2.74903317479e-05	0.230769230769	TSEN2 TSEN54 TSEN34	tRNA-type intron splice site recognition and cleavage
GO:0000214	2.74903317479e-05	0.230769230769	CLP1 TSEN54 TSEN2	tRNA-intron endonuclease complex
HP:0012704	3.1686434685e-05	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Widened subarachnoid space
HP:0003201	3.1686434685e-05	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Rhabdomyolysis
HP:0200136	3.1686434685e-05	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Oral-pharyngeal dysphagia
HP:0025190	3.51897781501e-05	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Bilateral tonic-clonic seizure with generalized onset
HP:0006989	3.89748377886e-05	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Dysplastic corpus callosum
HP:0009062	4.30561959733e-05	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Infantile axial hypotonia
HP:0002509	0.000101601371688	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Limb hypertonia
HP:0100704	0.000105234238397	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Cerebral visual impairment
HP:0007598	0.000130354574291	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Bilateral single transverse palmar creases
HP:0000340	0.000228413053125	0.384615384615	TSEN15 XRCC2 TSEN54 TSEN34 TSEN2	Sloping forehead
HP:0005484	0.000313817482456	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Secondary microcephaly
HP:0012703	0.000485304933709	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal subarachnoid space morphology
HP:0012110	0.000539034044123	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the pons
HP:0007362	0.000539034044123	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the brainstem
HP:0002365	0.000539034044123	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the brainstem
HP:0011471	0.000837413338937	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Gastrostomy tube feeding in infancy
HP:0007361	0.00135161920136	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal pons morphology
HP:0002363	0.00155772303957	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Abnormal brainstem morphology
HP:0001266	0.0017153980613	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Choreoathetosis
HP:0002373	0.00256512335057	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Febrile seizure (within the age range of 3 months to 6 years)
HP:0032894	0.00256512335057	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Seizure precipitated by febrile infection
HP:0032892	0.00256512335057	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Infection-related seizure
HP:0008936	0.00310213379209	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Axial hypotonia
CORUM:1141	0.00318297641196	0.153846153846	CLP1 PCF11	CF IIAm complex (Cleavage factor IIAm complex)
HP:0002123	0.00324771444048	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Generalized myoclonic seizure
HP:0002033	0.00357812982285	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Poor suck
REAC:R-HSA-8953854	0.00363395798839	0.461538461538	TSEN34 TSEN15 TSEN54 CLP1 TSEN2 PCF11	Metabolism of RNA
HP:0012469	0.00444562197482	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Infantile spasms
HP:0002305	0.00663685091265	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Athetosis
HP:0002350	0.00719474349145	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar cyst
HP:0002536	0.00782839256586	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Abnormal cortical gyration
HP:0000290	0.0103732293697	0.538461538462	TSEN34 TSEN15 XRCC2 TSEN54 TSEN2 CLP1 AMMECR1	Abnormality of the forehead
HP:0032677	0.0110372602157	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Generalized-onset motor seizure
HP:0007308	0.0113895015741	0.153846153846	TSEN2 TSEN54	Extrapyramidal dyskinesia
HP:0002119	0.012517405651	0.461538461538	TSEN34 TSEN15 XRCC2 TSEN54 CLP1 TSEN2	Ventriculomegaly
HP:0011097	0.0129942117184	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Epileptic spasm
HP:0008947	0.0148660959068	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Infantile muscular hypotonia
HP:0033454	0.0158732976527	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Tube feeding
HP:0001560	0.0159544339094	0.384615384615	AMMECR1 XRCC2 TSEN54 TSEN2 GREB1L	Abnormality of the amniotic fluid
HP:0000954	0.0165721795618	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Single transverse palmar crease
HP:0010576	0.0176627547611	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Intracranial cystic lesion
HP:0030724	0.0184186398962	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Central nervous system cyst
HP:0011344	0.0191981313867	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Severe global developmental delay
HP:0002079	0.0195514522158	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Hypoplasia of the corpus callosum
HP:0002269	0.0212049865247	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Abnormality of neuronal migration
HP:0002104	0.0258443744681	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Apnea
HP:0002020	0.0259628658352	0.384615384615	TSEN15 TSEN34 TSEN54 TSEN2 CLP1	Gastroesophageal reflux
HP:0002072	0.027871183597	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Chorea
HP:0032794	0.0305664808022	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Myoclonic seizure
HP:0010490	0.0334489249338	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of the palmar creases
REAC:R-HSA-77595	0.0338349899843	0.153846153846	CLP1 PCF11	Processing of Intronless Pre-mRNAs
GO:0000213	0.0365196561665	0.153846153846	TSEN2 TSEN34	tRNA-intron endonuclease activity
HP:0001018	0.0365265554956	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal palmar dermatoglyphics
HP:0002438	0.0418771958629	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar malformation
HP:0001446	0.0425843252801	0.307692307692	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of the musculature of the upper limbs
HP:0002118	0.045553646219	0.461538461538	TSEN34 TSEN15 XRCC2 TSEN54 CLP1 TSEN2	Abnormal cerebral ventricle morphology

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
TSEN15	TSEN34	1.0	0.22
TSEN15	TSEN2	0.999	0.084	structurally_consistent (dimer)
CLP1	TSEN2	0.999	0.166
TSEN2	TSEN34	0.999	0.108
TSEN2	TSEN54	0.999	0.116	structurally_consistent (dimer)
CLP1	TSEN54	0.999	0.124	structurally_consistent (dimer)
TSEN15	CLP1	0.998	0.07
CLP1	TSEN34	0.998	0.12
CLP1	PCF11	0.997	0.27	structurally_consistent (dimer)
TSEN15	TSEN54	0.994	0.098	structurally_consistent (Q8NCE0)
ARL4C	GADD45A	0.982
CLP1	AMMECR1	0.981	0.11
TSEN34	TSEN54	0.971	0.156
ARL4C	XRCC2	0.97
ARL4C	TSEN54	0.969	0.104
PHLDA2	CLP1	0.952	0.062
ARL4C	TSEN34	0.917	0.118
TSEN2	XRCC2	0.911
TSEN54	AMMECR1	0.907	0.104
TSEN15	BTBD7	0.881
CLP1	GREB1L	0.832
ARL4C	TSEN2	0.809	0.08
TSEN2	GREB1L	0.797
TSEN15	PCF11	0.796	0.05
ARL4C	CLP1	0.781	0.126
GADD45A	TSEN2	0.632
GADD45A	TSEN54	0.489
PCF11	GREB1L	0.385
GADD45A	XRCC2	0.303
PCF11	TSEN54	0.287	0.134	mutually_exclusive (Q92989)
TSEN15	GREB1L	0.265
GADD45A	CLP1	0.239
PCF11	TSEN34	0.215	0.056
PCF11	TSEN2	0.209	0.09
TSEN34	GREB1L	0.188
TSEN54	GREB1L	0.188
GADD45A	TSEN34	0.17
PHLDA2	PCF11	0.135	0.058
PHLDA2	TSEN2	0.122	0.062
CLP1	XRCC2	0.121
CLP1	BTBD7	0.101
XRCC2	TSEN54	0.094
TSEN15	PHLDA2	0.086	0.08
TSEN34	XRCC2	0.071
PHLDA2	TSEN54	0.069	0.08
PCF11	XRCC2	0.063
PHLDA2	TSEN34	0.063	0.064
TSEN2	AMMECR1	0.061	0.152
PHLDA2	GREB1L	0.04
ARL4C	PHLDA2	0.022	0.15
GADD45A	PHLDA2	0.019
BTBD7	TSEN54	0.013
PHLDA2	BTBD7	0.013
TSEN34	BTBD7	0.013
TSEN2	BTBD7	0.013
PHLDA2	XRCC2	0.008

Related Complexes

Genename	Complexes
BTBD7	huMAP3_03873.1 huMAP3_06096.1 huMAP3_10939.1 huMAP3_11939.1 huMAP3_13639.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_15245.1
TSEN54	huMAP3_04582.1 huMAP3_06042.1 huMAP3_07243.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN15	huMAP3_02940.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_15245.1
PHLDA2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_11956.1 huMAP3_13483.1 huMAP3_13693.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_14984.1
GREB1L	huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
AMMECR1	huMAP3_04582.1 huMAP3_08573.1 huMAP3_08812.1 huMAP3_10697.1 huMAP3_11762.1 huMAP3_13483.1 huMAP3_13511.1 huMAP3_14586.1 huMAP3_14839.1
CLP1	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
PCF11	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_12111.1 huMAP3_13730.1 huMAP3_14483.1 huMAP3_14586.1
GADD45A	huMAP3_01737.1 huMAP3_01965.1 huMAP3_05425.1 huMAP3_07243.1 huMAP3_07720.1 huMAP3_07918.1 huMAP3_10622.1 huMAP3_12847.1 huMAP3_13865.1 huMAP3_14298.1 huMAP3_14586.1 huMAP3_14839.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
XRCC2	huMAP3_03417.1 huMAP3_07905.1 huMAP3_12173.1 huMAP3_12847.1 huMAP3_14586.1
ARL4C	huMAP3_01199.1 huMAP3_07243.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14586.1

Complex Portal: CPX-14400