hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14587.1
Complex Portal: CPX-12212
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMAD3 | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | 5 | UniProt NCBI |
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | 5 | UniProt NCBI |
| ACO1 | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) | 5 | UniProt NCBI |
| SMAD9 | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | 5 | UniProt NCBI |
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | 5 | UniProt NCBI |
| FZD6 | Frizzled-6 (Fz-6) (hFz6) | 5 | UniProt NCBI |
| SEMA4A | Semaphorin-4A (Semaphorin-B) (Sema B) | 5 | UniProt NCBI |
| GAS7 | Growth arrest-specific protein 7 (GAS-7) | 5 | UniProt NCBI |
| LEMD3 | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | 5 | UniProt NCBI |
| ZFYVE9 | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP560 | 4.25328472332e-09 | 0.5 | SMAD2 ZFYVE9 SMAD3 SMAD1 SMAD9 | TGF beta receptor signaling |
| WP:WP4816 | 5.39531511466e-09 | 0.5 | SMAD2 ZFYVE9 SMAD3 SMAD1 SMAD9 | TGF beta receptor signaling in skeletal dysplasias |
| CORUM:1827 | 6.73299894294e-08 | 0.3 | SMAD2 SMAD3 ZFYVE9 | PML-SMAD2/3-SARA complex |
| KEGG:04350 | 8.24783163378e-08 | 0.5 | SMAD2 ZFYVE9 SMAD3 SMAD1 SMAD9 | TGF-beta signaling pathway |
| GO:0071141 | 1.93207287326e-07 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | SMAD protein complex |
| GO:0071144 | 1.93207287326e-07 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | heteromeric SMAD protein complex |
| WP:WP4331 | 3.87562426749e-07 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | Neovascularisation processes |
| KEGG:04550 | 4.21397192953e-07 | 0.5 | SMAD2 FZD6 SMAD3 SMAD1 SMAD9 | Signaling pathways regulating pluripotency of stem cells |
| GO:0070411 | 7.51529801094e-06 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | I-SMAD binding |
| GO:0007179 | 1.03052082877e-05 | 0.6 | LEMD3 SMAD1 ZFYVE9 SMAD2 SMAD9 SMAD3 | transforming growth factor beta receptor signaling pathway |
| WP:WP5353 | 1.22306700697e-05 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | A network map of Macrophage stimulating protein MSP signaling |
| GO:0071560 | 2.29088190833e-05 | 0.6 | LEMD3 SMAD1 ZFYVE9 SMAD2 SMAD9 SMAD3 | cellular response to transforming growth factor beta stimulus |
| GO:0071559 | 2.72986893544e-05 | 0.6 | LEMD3 SMAD1 ZFYVE9 SMAD2 SMAD9 SMAD3 | response to transforming growth factor beta |
| CORUM:6513 | 3.07577115383e-05 | 0.2 | SMAD2 LEMD3 | MAN1-SMAD2 complex |
| CORUM:2834 | 9.22394575203e-05 | 0.2 | SMAD2 SMAD3 | SMAD4-SMAD2-SMAD3 complex |
| CORUM:2830 | 9.22394575203e-05 | 0.2 | SMAD2 SMAD3 | TIF1gamma-SMAD2-SMAD3 complex |
| KEGG:04390 | 9.64533591753e-05 | 0.4 | SMAD2 FZD6 SMAD3 SMAD1 | Hippo signaling pathway |
| GO:0141091 | 0.00011153855885 | 0.6 | LEMD3 SMAD1 ZFYVE9 SMAD2 SMAD9 SMAD3 | transforming growth factor beta receptor superfamily signaling pathway |
| REAC:R-HSA-9006936 | 0.000138239115309 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | Signaling by TGFB family members |
| GO:0007178 | 0.000153289284109 | 0.6 | LEMD3 SMAD1 ZFYVE9 SMAD2 SMAD9 SMAD3 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| WP:WP4535 | 0.00018914847288 | 0.3 | SMAD2 SMAD3 LEMD3 | Envelope proteins and their potential roles in EDMD physiopathology |
| REAC:R-HSA-3311021 | 0.000305236852181 | 0.2 | SMAD2 SMAD3 | SMAD4 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3315487 | 0.000305236852181 | 0.2 | SMAD2 SMAD3 | SMAD2/3 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3304347 | 0.000305236852181 | 0.2 | SMAD2 SMAD3 | Loss of Function of SMAD4 in Cancer |
| WP:WP4879 | 0.000362390605784 | 0.3 | SMAD2 SMAD3 LEMD3 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| GO:0070410 | 0.00040312426486 | 0.3 | SMAD2 SMAD3 SMAD1 | co-SMAD binding |
| REAC:R-HSA-3656532 | 0.000610250897391 | 0.2 | SMAD2 SMAD3 | TGFBR1 KD Mutants in Cancer |
| REAC:R-HSA-3304356 | 0.000610250897391 | 0.2 | SMAD2 SMAD3 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| REAC:R-HSA-3656534 | 0.00101671361746 | 0.2 | SMAD2 SMAD3 | Loss of Function of TGFBR1 in Cancer |
| REAC:R-HSA-3304349 | 0.00101671361746 | 0.2 | SMAD2 SMAD3 | Loss of Function of SMAD2/3 in Cancer |
| CORUM:2829 | 0.00110445178695 | 0.2 | SMAD2 SMAD3 | RSmad complex |
| REAC:R-HSA-3304351 | 0.00152451380898 | 0.2 | SMAD2 SMAD3 | Signaling by TGF-beta Receptor Complex in Cancer |
| WP:WP3876 | 0.00186090881862 | 0.2 | SMAD9 SMAD1 | BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation |
| GO:0046332 | 0.00199509778647 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | SMAD binding |
| GO:0060395 | 0.00246977648377 | 0.4 | SMAD2 SMAD3 SMAD1 SMAD9 | SMAD protein signal transduction |
| WP:WP5382 | 0.00272734094269 | 0.2 | SMAD2 SMAD3 | TGF Smad signaling pathway |
| WP:WP3931 | 0.00354552579336 | 0.3 | FZD6 SMAD9 SMAD1 | Embryonic stem cell pluripotency pathways |
| REAC:R-HSA-9796292 | 0.0036548283771 | 0.2 | SMAD2 SMAD3 | Formation of axial mesoderm |
| REAC:R-HSA-9823730 | 0.0036548283771 | 0.2 | SMAD2 SMAD3 | Formation of definitive endoderm |
| WP:WP4787 | 0.00376207852359 | 0.3 | FZD6 SMAD9 SMAD1 | Osteoblast differentiation and related diseases |
| KEGG:05226 | 0.00406147233016 | 0.3 | SMAD2 SMAD3 FZD6 | Gastric cancer |
| HP:0008419 | 0.00412666115323 | 0.2 | SMAD2 SMAD3 | Intervertebral disc degeneration |
| GO:0071363 | 0.00429534362863 | 0.6 | LEMD3 SMAD1 ZFYVE9 SMAD2 SMAD9 SMAD3 | cellular response to growth factor stimulus |
| WP:WP3859 | 0.00433420215397 | 0.2 | SMAD2 SMAD3 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition |
| WP:WP3874 | 0.00433420215397 | 0.2 | SMAD2 SMAD3 | Canonical and non canonical TGF B signaling |
| REAC:R-HSA-1502540 | 0.00456686801865 | 0.2 | SMAD2 SMAD3 | Signaling by Activin |
| GO:0070848 | 0.00525050768571 | 0.6 | LEMD3 SMAD1 ZFYVE9 SMAD2 SMAD9 SMAD3 | response to growth factor |
| WP:WP366 | 0.00596292421694 | 0.3 | SMAD2 SMAD3 ZFYVE9 | TGF beta signaling pathway |
| GO:0031053 | 0.00642915610421 | 0.3 | SMAD2 SMAD3 SMAD1 | primary miRNA processing |
| REAC:R-HSA-9754189 | 0.00669318453569 | 0.2 | SMAD2 SMAD3 | Germ layer formation at gastrulation |
| WP:WP5103 | 0.00704825789595 | 0.2 | SMAD2 SMAD3 | Progeria associated lipodystrophy |
| KEGG:05225 | 0.0072184537911 | 0.3 | SMAD2 SMAD3 FZD6 | Hepatocellular carcinoma |
| WP:WP2857 | 0.00723895082243 | 0.3 | SMAD2 SMAD3 SMAD1 | Mesodermal commitment pathway |
| WP:WP4239 | 0.00812075814624 | 0.3 | SMAD2 SMAD3 FZD6 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP2895 | 0.00864943763047 | 0.2 | SMAD9 SMAD1 | Differentiation of white and brown adipocyte |
| HP:0000987 | 0.0105878524491 | 0.3 | SMAD2 SMAD3 LEMD3 | Atypical scarring of skin |
| WP:WP3668 | 0.0113553886492 | 0.2 | SMAD2 SMAD3 | Hypothesized pathways in pathogenesis of cardiovascular disease |
| REAC:R-HSA-9617828 | 0.0121516690115 | 0.2 | SMAD2 SMAD3 | FOXO-mediated transcription of cell cycle genes |
| GO:0030509 | 0.0131193192467 | 0.4 | SMAD2 LEMD3 SMAD9 SMAD1 | BMP signaling pathway |
| HP:0100718 | 0.0148343034129 | 0.2 | SMAD2 SMAD3 | Uterine rupture |
| HP:0005086 | 0.0148343034129 | 0.2 | SMAD2 SMAD3 | Knee osteoarthritis |
| GO:0071772 | 0.0149986773182 | 0.4 | SMAD2 LEMD3 SMAD9 SMAD1 | response to BMP |
| GO:0071773 | 0.0149986773182 | 0.4 | SMAD2 LEMD3 SMAD9 SMAD1 | cellular response to BMP stimulus |
| REAC:R-HSA-1181150 | 0.0154820698392 | 0.2 | SMAD2 SMAD3 | Signaling by NODAL |
| WP:WP2870 | 0.0155292506893 | 0.2 | SMAD2 SMAD3 | Extracellular vesicle mediated signaling in recipient cells |
| WP:WP3850 | 0.0178579187559 | 0.2 | SMAD2 SMAD3 | Factors and pathways affecting insulin like growth factor IGF1 Akt signaling |
| KEGG:05321 | 0.0188748047605 | 0.2 | SMAD2 SMAD3 | Inflammatory bowel disease |
| KEGG:04144 | 0.0216951669056 | 0.3 | SMAD2 SMAD3 ZFYVE9 | Endocytosis |
| GO:0005637 | 0.0231700664584 | 0.3 | LEMD3 SMAD3 SMAD1 | nuclear inner membrane |
| HP:0100699 | 0.0249015500331 | 0.3 | SMAD2 SMAD3 LEMD3 | Scarring |
| REAC:R-HSA-2173788 | 0.0255543807721 | 0.2 | SMAD2 SMAD3 | Downregulation of TGF-beta receptor signaling |
| HP:0005294 | 0.0271664548802 | 0.2 | SMAD2 SMAD3 | Arterial dissection |
| HP:0008843 | 0.0271664548802 | 0.2 | SMAD2 SMAD3 | Hip osteoarthritis |
| REAC:R-HSA-9615017 | 0.0302795201711 | 0.2 | SMAD2 SMAD3 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| REAC:R-HSA-201451 | 0.0302795201711 | 0.2 | SMAD9 SMAD1 | Signaling by BMP |
| WP:WP1971 | 0.0319043985122 | 0.2 | SMAD2 SMAD3 | Integrated cancer pathway |
| GO:0032924 | 0.033448305627 | 0.3 | SMAD2 SMAD3 LEMD3 | activin receptor signaling pathway |
| REAC:R-HSA-2173795 | 0.0409184848695 | 0.2 | SMAD2 SMAD3 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| WP:WP5144 | 0.0441033585523 | 0.2 | SMAD2 SMAD3 | NRP1 triggered signaling pathways in pancreatic cancer |
| WP:WP5352 | 0.0441033585523 | 0.2 | SMAD9 SMAD1 | 10q11 21q11 23 copy number variation syndrome |
| REAC:R-HSA-5689880 | 0.0483498248961 | 0.3 | SMAD2 SMAD3 SMAD1 | Ub-specific processing proteases |
| CORUM:3733 | 0.0499436884912 | 0.1 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3729 | 0.0499436884912 | 0.1 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3199 | 0.0499436884912 | 0.1 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3198 | 0.0499436884912 | 0.1 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3039 | 0.0499436884912 | 0.1 | SMAD2 | SMAD2-FAST1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SMAD3 | LEMD3 | 0.999 | 0.124 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| SMAD9 | LEMD3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ZFYVE9 | SMAD2 | 0.998 | 0.088 |
mutually_exclusive (Q99717)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SMAD2 | LEMD3 | 0.997 | 0.076 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZFYVE9 | SMAD3 | 0.996 | 0.212 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| SMAD2 | SMAD3 | 0.993 | 0.29 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMAD3 | SMAD9 | 0.989 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SEMA4A | LEMD3 | 0.97 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SMAD2 | SMAD9 | 0.965 |
mutually_exclusive (P84022)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LEMD3 | SMAD1 | 0.929 | 0.092 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| ZFYVE9 | GAS7 | 0.902 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZFYVE9 | LEMD3 | 0.841 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SMAD9 | ACO1 | 0.835 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_HCT116 | ||
| LEMD3 | FZD6 | 0.804 | 0.138 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ZFYVE9 | SMAD9 | 0.353 |
mutually_exclusive (P84022)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD3 | SMAD1 | 0.079 | 0.152 | bioplex3_WMM WMM_only | |
| SMAD2 | SMAD1 | 0.076 | 0.112 | bioplex3_WMM WMM_only | |
| SMAD1 | FZD6 | 0.057 | 0.106 | bioplex3_WMM WMM_only | |
| ACO1 | FZD6 | 0.007 | 0.08 | bioplex3_WMM WMM_only | |
| LEMD3 | ACO1 | 0.004 | 0.094 | bioplex_WMM WMM_only |
Related Complexes