hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14594.1
Complex Portal: CPX-20638
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACACA | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | 5 | UniProt NCBI |
| TSSK4 | Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) (Serine/threonine-protein kinase 22E) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| THRSP | Thyroid hormone-inducible hepatic protein (Spot 14 protein) (S14) (SPOT14) | 5 | UniProt NCBI |
| OR52H1 | Olfactory receptor 52H1 (Olfactory receptor OR11-45) | 3 | UniProt NCBI |
| SAMD3 | Sterile alpha motif domain-containing protein 3 (SAM domain-containing protein 3) | 5 | UniProt NCBI |
| MID1IP1 | Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499) (Spot 14-related protein) (S14R) (Spot 14-R) | 4 | UniProt NCBI |
| ACACB | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-200425 | 5.59299191682e-09 | 0.5 | THRSP ACACA ACACB MID1IP1 | Carnitine metabolism |
| REAC:R-HSA-8978868 | 0.000137990388058 | 0.5 | THRSP ACACA ACACB MID1IP1 | Fatty acid metabolism |
| WP:WP5031 | 0.000859567015467 | 0.25 | ACACA ACACB | Biotin metabolism including IMDs |
| REAC:R-HSA-163765 | 0.00116989543065 | 0.25 | ACACA ACACB | ChREBP activates metabolic gene expression |
| KEGG:00061 | 0.00135803898635 | 0.25 | ACACA ACACB | Fatty acid biosynthesis |
| REAC:R-HSA-196780 | 0.0030606580132 | 0.25 | ACACA ACACB | Biotin transport and metabolism |
| WP:WP4206 | 0.0045229597893 | 0.25 | ACACA ACACB | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| WP:WP357 | 0.00499769201238 | 0.25 | ACACA ACACB | Fatty acid biosynthesis |
| KEGG:00640 | 0.00598787744984 | 0.25 | ACACA ACACB | Propanoate metabolism |
| KEGG:00620 | 0.0115899115219 | 0.25 | ACACA ACACB | Pyruvate metabolism |
| GO:0003989 | 0.0131096201623 | 0.25 | ACACA ACACB | acetyl-CoA carboxylase activity |
| REAC:R-HSA-2426168 | 0.0367988237757 | 0.25 | ACACA ACACB | Activation of gene expression by SREBF (SREBP) |
| REAC:R-HSA-556833 | 0.0396307382637 | 0.5 | THRSP ACACA ACACB MID1IP1 | Metabolism of lipids |
| WP:WP1403 | 0.0430766937311 | 0.25 | ACACA ACACB | AMP activated protein kinase signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ACACB | MID1IP1 | 0.995 | 0.078 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MID1IP1 | ACACA | 0.99 | 0.076 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MID1IP1 | THRSP | 0.99 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ACACB | TSSK4 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2D1 | THRSP | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ACACB | SAMD3 | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| OR52H1 | ACACB | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| THRSP | ACACA | 0.945 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ACACB | THRSP | 0.908 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ACACB | ACACA | 0.884 | 0.952 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | |
| OR52H1 | MID1IP1 | 0.078 | bioplex3_WMM WMM_only | ||
| OR52H1 | ACACA | 0.076 | bioplex3_WMM WMM_only | ||
| ACACA | SAMD3 | 0.02 | bioplex3_HCT116 WMM_only | ||
| ACACA | TSSK4 | 0.019 | bioplex3_HCT116 WMM_only | ||
| UBE2D1 | ACACA | 0.014 | 0.104 | WMM_only | |
| ACACB | UBE2D1 | 0.014 | 0.178 | WMM_only |
Related Complexes