hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14604.1
Complex Portal: CPX-21488
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCDHA6 | Protocadherin alpha-6 (PCDH-alpha-6) | 5 | UniProt NCBI |
| PCDHA13 | Protocadherin alpha-13 (PCDH-alpha-13) | 4 | UniProt NCBI |
| PCDHA11 | Protocadherin alpha-11 (PCDH-alpha-11) | 4 | UniProt NCBI |
| PCDHA3 | Protocadherin alpha-3 (PCDH-alpha-3) | 5 | UniProt NCBI |
| PCDHGA10 | Protocadherin gamma-A10 (PCDH-gamma-A10) | 4 | UniProt NCBI |
| PCDHA8 | Protocadherin alpha-8 (PCDH-alpha-8) | 4 | UniProt NCBI |
| PCDHA4 | Protocadherin alpha-4 (PCDH-alpha-4) | 5 | UniProt NCBI |
| TCL1A | T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) | 5 | UniProt NCBI |
| PCDHA12 | Protocadherin alpha-12 (PCDH-alpha-12) | 4 | UniProt NCBI |
| PCDHA2 | Protocadherin alpha-2 (PCDH-alpha-2) | 5 | UniProt NCBI |
| DNMT3A | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | 5 | UniProt NCBI |
| DNMT3B | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) | 5 | UniProt NCBI |
| PCDHA7 | Protocadherin alpha-7 (PCDH-alpha-7) | 5 | UniProt NCBI |
| PCDHA10 | Protocadherin alpha-10 (PCDH-alpha-10) | 5 | UniProt NCBI |
| PCDHA1 | Protocadherin alpha-1 (PCDH-alpha-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| TF:M06624 | 1.5650377959e-14 | 0.6 | PCDHA7 PCDHA12 PCDHA2 PCDHA1 PCDHA11 PCDHA13 PCDHA4 PCDHA8 PCDHA6 | Factor: ZNF2; motif: NSATCGATCCGA |
| TF:M00162_1 | 2.95192542029e-11 | 0.733333333333 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 | Factor: Oct-1; motif: CWNAWTKWSATRYN; match class: 1 |
| MIRNA:hsa-miR-221-3p | 5.2401233992e-11 | 0.733333333333 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 | hsa-miR-221-3p |
| MIRNA:hsa-miR-181a-5p | 2.01315113228e-09 | 0.733333333333 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 | hsa-miR-181a-5p |
| GO:0007155 | 6.63244347682e-08 | 0.8 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHGA10 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 | cell adhesion |
| TF:M11633_1 | 5.84644759066e-05 | 0.866666666667 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHGA10 TCL1A PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 PCDHA2 | Factor: Sox-10; motif: AACAATGGNCCATTGTT; match class: 1 |
| TF:M07050 | 0.00010887447376 | 0.533333333333 | PCDHA7 PCDHA10 PCDHA8 PCDHA2 PCDHA1 PCDHA3 PCDHA4 PCDHA12 | Factor: MITF; motif: NNCACATGNNN |
| TF:M11633 | 0.000405356004797 | 0.866666666667 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHGA10 TCL1A PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 PCDHA2 | Factor: Sox-10; motif: AACAATGGNCCATTGTT |
| TF:M05609 | 0.000548786278506 | 0.6 | DNMT3B PCDHA1 PCDHA10 PCDHA12 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA8 | Factor: SALL3; motif: NMTTTTGRAYN |
| TF:M06531 | 0.000598118405577 | 0.4 | PCDHA12 PCDHA2 PCDHA11 PCDHA4 PCDHA8 PCDHA6 | Factor: ZNF555; motif: NCRWGTTTGKCC |
| TF:M10116 | 0.00144319702673 | 0.666666666667 | PCDHA7 PCDHA12 PCDHA10 PCDHA6 PCDHGA10 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA8 | Factor: ZID; motif: GGNGMTGGAGCCN |
| TF:M10533 | 0.00321989316611 | 0.666666666667 | PCDHA7 PCDHA12 PCDHA10 PCDHA6 PCDHGA10 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA8 | Factor: ZID; motif: NGGNGCTGGAGCCNS |
| TF:M07459 | 0.00372474027885 | 0.8 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 TCL1A PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 PCDHA2 | Factor: HSF1; motif: GAANNTTCTNGN |
| TF:M00162 | 0.00381779456166 | 0.8 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHGA10 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 | Factor: Oct-1; motif: CWNAWTKWSATRYN |
| TF:M11632_1 | 0.00509450782387 | 0.866666666667 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHGA10 TCL1A PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 PCDHA2 | Factor: Sox-10; motif: AACAATRGNCYATTGTT; match class: 1 |
| TF:M12706 | 0.0165218922287 | 0.666666666667 | PCDHA7 PCDHA12 PCDHA10 PCDHA6 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 | Factor: ZNF450; motif: NNNAGGTCCTGGMAGNK |
| TF:M11632 | 0.0182323837168 | 0.866666666667 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHGA10 TCL1A PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 PCDHA2 | Factor: Sox-10; motif: AACAATRGNCYATTGTT |
| WP:WP3657 | 0.0184937836061 | 0.133333333333 | DNMT3A DNMT3B | Hematopoietic stem cell gene regulation by GABP alpha beta complex |
| WP:WP4288 | 0.0184937836061 | 0.133333333333 | DNMT3A DNMT3B | MTHFR deficiency |
| TF:M10991 | 0.0209073086571 | 0.6 | PCDHA7 PCDHA10 PCDHA4 PCDHA2 PCDHA1 PCDHA11 PCDHA13 PCDHA12 PCDHA6 | Factor: lmx1b; motif: CTCGTTAA |
| TF:M11002 | 0.0280815813657 | 0.6 | PCDHA7 PCDHA10 PCDHA4 PCDHA2 PCDHA1 PCDHA11 PCDHA13 PCDHA12 PCDHA6 | Factor: LHX5; motif: NTCGTTAN |
| TF:M12964 | 0.0294294347401 | 0.866666666667 | DNMT3A PCDHA12 PCDHA7 PCDHA1 PCDHA10 PCDHA6 TCL1A PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 PCDHA2 | Factor: CTCF; motif: CTGCAGTNCNNNNNNNNNNCCASYAGRKGGCRSYN |
| TF:M10755 | 0.0295684907203 | 0.733333333333 | PCDHA7 PCDHA12 PCDHA1 PCDHA10 PCDHA6 PCDHA2 PCDHA3 PCDHA11 PCDHA13 PCDHA4 PCDHA8 | Factor: hoxd1; motif: NTCRTTAN |
| WP:WP241 | 0.0297612433347 | 0.133333333333 | DNMT3A DNMT3B | One carbon metabolism |
| REAC:R-HSA-4655427 | 0.0306722226983 | 0.133333333333 | DNMT3A DNMT3B | SUMOylation of DNA methylation proteins |
| TF:M10683 | 0.0320803113146 | 0.6 | PCDHA7 PCDHA10 PCDHA4 PCDHA2 PCDHA1 PCDHA11 PCDHA13 PCDHA12 PCDHA6 | Factor: HOXB7; motif: GTCRTTAN |
| GO:0090116 | 0.0491610756088 | 0.133333333333 | DNMT3A DNMT3B | C-5 methylation of cytosine |
| CORUM:2650 | 0.0498224659463 | 0.0666666666667 | DNMT3B | DNMT3B-DNMT3L complex |
| CORUM:2651 | 0.0498224659463 | 0.0666666666667 | DNMT3A | DNMT3L-DNMT3A complex |
| CORUM:3849 | 0.0498224659463 | 0.0666666666667 | TCL1A | TCL1 homotrimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PCDHA11 | PCDHA12 | 1.0 | ||
| PCDHA8 | PCDHA2 | 0.999 |
structurally_consistent (dimer)
|
|
| PCDHA8 | PCDHA7 | 0.998 |
mutually_exclusive (Q9Y5H9)
|
|
| TCL1A | DNMT3B | 0.998 |
structurally_consistent (dimer)
|
|
| PCDHA8 | PCDHA12 | 0.998 |
mutually_exclusive (Q9UN74)
structurally_consistent (dimer) |
|
| PCDHA4 | PCDHA1 | 0.998 | ||
| PCDHA3 | PCDHA1 | 0.998 |
structurally_consistent (dimer)
|
|
| PCDHA6 | PCDHA3 | 0.997 |
mutually_exclusive (Q9Y5H6)
structurally_consistent (dimer) |
|
| TCL1A | DNMT3A | 0.997 | 0.104 |
structurally_consistent (dimer)
|
| PCDHA8 | PCDHA1 | 0.996 |
structurally_consistent (dimer)
|
|
| PCDHA8 | PCDHA10 | 0.996 |
mutually_exclusive (Q9Y5I0)
|
|
| PCDHA7 | PCDHA10 | 0.995 |
structurally_consistent (dimer)
|
|
| PCDHA2 | PCDHA10 | 0.995 |
mutually_exclusive (Q9UN72)
|
|
| PCDHA4 | PCDHA10 | 0.994 | ||
| PCDHA12 | PCDHA10 | 0.994 | ||
| PCDHA3 | PCDHA10 | 0.993 | ||
| PCDHA6 | PCDHA10 | 0.993 | ||
| PCDHA13 | PCDHA10 | 0.993 |
structurally_consistent (dimer)
|
|
| PCDHA2 | PCDHA7 | 0.99 |
structurally_consistent (dimer)
|
|
| DNMT3A | DNMT3B | 0.989 |
mutually_exclusive (P56279)
|
|
| PCDHA11 | PCDHA10 | 0.989 | ||
| PCDHA4 | PCDHA7 | 0.989 | ||
| PCDHA7 | PCDHA12 | 0.988 | ||
| PCDHA4 | TCL1A | 0.984 | ||
| PCDHA12 | PCDHGA10 | 0.983 | ||
| PCDHA8 | PCDHGA10 | 0.983 | ||
| PCDHA4 | PCDHA12 | 0.982 |
structurally_consistent (dimer)
|
|
| PCDHA11 | PCDHGA10 | 0.981 |
structurally_consistent (dimer)
|
|
| PCDHA4 | DNMT3A | 0.981 | ||
| PCDHA4 | DNMT3B | 0.981 | ||
| PCDHA8 | PCDHA3 | 0.978 |
structurally_consistent (dimer)
|
|
| PCDHA13 | PCDHA8 | 0.977 |
structurally_consistent (dimer)
|
|
| TCL1A | PCDHGA10 | 0.976 | ||
| PCDHA8 | PCDHA6 | 0.975 |
mutually_exclusive (Q9Y5H8)
structurally_consistent (dimer) |
|
| PCDHA4 | PCDHA8 | 0.975 |
structurally_consistent (dimer)
|
|
| PCDHA11 | PCDHA1 | 0.961 |
structurally_consistent (dimer)
|
|
| PCDHA3 | PCDHA11 | 0.949 |
mutually_exclusive (Q9Y5I3)
structurally_consistent (dimer) |
|
| PCDHA2 | PCDHA1 | 0.904 |
mutually_exclusive (Q9Y5H6)
|
|
| TCL1A | PCDHA1 | 0.902 | ||
| PCDHA13 | PCDHA1 | 0.902 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA4 | PCDHGA10 | 0.871 | ||
| DNMT3A | PCDHA1 | 0.869 | ||
| PCDHA13 | PCDHA6 | 0.843 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA13 | PCDHA3 | 0.843 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA13 | PCDHA2 | 0.835 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA1 | PCDHA12 | 0.824 | ||
| PCDHA13 | PCDHA12 | 0.823 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA13 | PCDHA7 | 0.823 |
mutually_exclusive (Q9Y5I2)
|
|
| PCDHA4 | PCDHA13 | 0.823 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA4 | PCDHA11 | 0.82 | ||
| PCDHA4 | PCDHA3 | 0.814 | ||
| PCDHA3 | PCDHA12 | 0.814 | ||
| PCDHA6 | PCDHA12 | 0.814 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA4 | PCDHA6 | 0.814 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA6 | PCDHA1 | 0.814 | ||
| PCDHA7 | PCDHA6 | 0.814 | ||
| PCDHA7 | PCDHA3 | 0.814 | ||
| PCDHA4 | PCDHA2 | 0.814 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA2 | PCDHA3 | 0.812 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA2 | PCDHA6 | 0.812 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA2 | PCDHA12 | 0.786 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA7 | PCDHA1 | 0.782 | ||
| PCDHA7 | PCDHA11 | 0.775 | ||
| DNMT3B | PCDHA1 | 0.768 | ||
| DNMT3B | PCDHGA10 | 0.634 | ||
| DNMT3A | PCDHGA10 | 0.634 | ||
| PCDHA1 | PCDHGA10 | 0.617 | ||
| PCDHA7 | PCDHGA10 | 0.597 | ||
| PCDHA13 | PCDHGA10 | 0.418 | ||
| PCDHA2 | PCDHGA10 | 0.401 | ||
| PCDHA3 | PCDHGA10 | 0.401 |
mutually_exclusive (Q9Y5I1)
|
|
| PCDHA6 | PCDHGA10 | 0.401 | ||
| PCDHA8 | PCDHA11 | 0.35 | ||
| PCDHA13 | PCDHA11 | 0.35 | ||
| PCDHA6 | PCDHA11 | 0.335 |
mutually_exclusive (Q9Y5H8)
|
|
| PCDHA2 | PCDHA11 | 0.333 | ||
| PCDHA1 | PCDHA10 | 0.214 | ||
| TCL1A | PCDHA12 | 0.131 | ||
| TCL1A | PCDHA7 | 0.131 | ||
| TCL1A | PCDHA11 | 0.131 | ||
| DNMT3A | PCDHA12 | 0.055 | ||
| DNMT3A | PCDHA11 | 0.055 | ||
| DNMT3B | PCDHA11 | 0.046 | ||
| DNMT3B | PCDHA12 | 0.046 | ||
| PCDHA10 | PCDHGA10 | 0.046 | ||
| DNMT3B | PCDHA7 | 0.046 | ||
| DNMT3A | PCDHA7 | 0.046 |
Related Complexes