hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14608.1
Complex Portal: CPX-16517
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STN1 | CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) | 5 | UniProt NCBI |
| VWC2L | von Willebrand factor C domain-containing protein 2-like (VWC2-like protein) (Brorin-like) | 5 | UniProt NCBI |
| CTC1 | CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) | 5 | UniProt NCBI |
| TEN1 | CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog) | 5 | UniProt NCBI |
| UBE2R2 | Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) | 5 | UniProt NCBI |
| CDC34 | Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6075 | 4.67737426163e-09 | 0.5 | STN1 CTC1 TEN1 | CST complex |
| GO:1990879 | 1.92240082153e-06 | 0.5 | STN1 CTC1 TEN1 | CST complex |
| REAC:R-HSA-174430 | 2.01823692347e-06 | 0.5 | STN1 CTC1 TEN1 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-174411 | 1.83108883385e-05 | 0.5 | STN1 CTC1 TEN1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-174417 | 4.20912658431e-05 | 0.5 | STN1 CTC1 TEN1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 0.000146098747122 | 0.5 | STN1 CTC1 TEN1 | Extension of Telomeres |
| GO:0000782 | 0.00042234232358 | 0.5 | STN1 CTC1 TEN1 | telomere cap complex |
| GO:0000783 | 0.00042234232358 | 0.5 | STN1 CTC1 TEN1 | nuclear telomere cap complex |
| GO:0140445 | 0.000548960443183 | 0.5 | STN1 CTC1 TEN1 | chromosome, telomeric repeat region |
| REAC:R-HSA-157579 | 0.00112585873244 | 0.5 | STN1 CTC1 TEN1 | Telomere Maintenance |
| REAC:R-HSA-73886 | 0.00231149151162 | 0.5 | STN1 CTC1 TEN1 | Chromosome Maintenance |
| GO:0032211 | 0.00254971303757 | 0.5 | STN1 CTC1 TEN1 | negative regulation of telomere maintenance via telomerase |
| GO:2000279 | 0.00699636827123 | 0.5 | STN1 CTC1 TEN1 | negative regulation of DNA biosynthetic process |
| GO:1904357 | 0.00699636827123 | 0.5 | STN1 CTC1 TEN1 | negative regulation of telomere maintenance via telomere lengthening |
| REAC:R-HSA-8866652 | 0.0111743831709 | 0.333333333333 | CDC34 UBE2R2 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| GO:0016233 | 0.0125202207278 | 0.5 | STN1 CTC1 TEN1 | telomere capping |
| GO:0032205 | 0.0136563164499 | 0.5 | STN1 CTC1 TEN1 | negative regulation of telomere maintenance |
| GO:0042162 | 0.0148589937997 | 0.5 | STN1 CTC1 TEN1 | telomeric DNA binding |
| HP:0007763 | 0.0297012565438 | 0.333333333333 | STN1 CTC1 | Retinal telangiectasia |
| GO:0032210 | 0.0397388592171 | 0.5 | STN1 CTC1 TEN1 | regulation of telomere maintenance via telomerase |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UBE2R2 | CDC34 | 0.999 | 0.186 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| STN1 | TEN1 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STN1 | CTC1 | 0.998 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TEN1 | CTC1 | 0.993 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| CDC34 | CTC1 | 0.976 | 0.058 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| STN1 | CDC34 | 0.945 | 0.146 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| STN1 | VWC2L | 0.917 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| VWC2L | CTC1 | 0.895 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UBE2R2 | CTC1 | 0.76 | 0.084 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| STN1 | UBE2R2 | 0.691 | 0.0848888888889 |
structurally_consistent (Q2NKJ3)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes