hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14612.1

Complex Portal: CPX-25116

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RAD50	DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)	5	UniProt NCBI
ASTN2	Astrotactin-2	5	UniProt NCBI
BMP1	Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)	5	UniProt NCBI
MRE11	Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)	5	UniProt NCBI
AK1	Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.10) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase)	5	UniProt NCBI
CFAP161	Cilia- and flagella-associated protein 161	4	UniProt NCBI
TLL1	Tolloid-like protein 1 (EC 3.4.24.-)	5	UniProt NCBI
NBN	Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:173	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	MRN complex (MRE11-RAD50-NBN complex)
CORUM:972	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	MRN complex (MRE11-RAD50-NBN complex)
CORUM:71	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	MRN complex (MRE11-RAD50-NBN complex)
CORUM:1081	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	MRN complex (MRE11-RAD50-NBN complex)
CORUM:73	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	MRN complex (MRE11-RAD50-NBN complex)
CORUM:618	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	MRN complex (MRE11-RAD50-NBN complex)
CORUM:2767	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	RAD50-MRE11-NBN-p200-p350 complex
CORUM:331	7.02338504734e-09	0.428571428571	RAD50 NBN MRE11	MRN complex (MRE11-RAD50-NBN complex)
CORUM:627	2.80877722849e-08	0.428571428571	RAD50 NBN MRE11	MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex)
CORUM:619	2.80877722849e-08	0.428571428571	RAD50 NBN MRE11	MRE11A-RAD50-NBN-TRF2 complex
CORUM:2218	2.80877722849e-08	0.428571428571	RAD50 NBN MRE11	MDC1-MRE11-RAD50-NBS1 complex
CORUM:964	2.80877722849e-08	0.428571428571	RAD50 NBN MRE11	BRCA1-RAD50-MRE11-NBS1 complex
CORUM:202	2.80877722849e-08	0.428571428571	RAD50 NBN MRE11	BRCA1-RAD50-MRE11-NBS1 complex
CORUM:1189	7.02050133195e-08	0.428571428571	RAD50 NBN MRE11	DNA double-strand break end-joining complex
CORUM:5197	1.4038119659e-07	0.428571428571	RAD50 NBN MRE11	PTIP-DNA damage response complex
CORUM:2217	1.4038119659e-07	0.428571428571	RAD50 NBN MRE11	MDC1-MRN-ATM-FANCD2 complex
WP:WP2942	2.13134737724e-07	0.428571428571	RAD50 NBN MRE11	DDX1 as a regulatory component of the Drosha microprocessor
REAC:R-HSA-5693548	2.60630206073e-07	0.428571428571	RAD50 NBN MRE11	Sensing of DNA Double Strand Breaks
CORUM:2815	3.92905941962e-07	0.428571428571	RAD50 NBN MRE11	BRCA1-BARD1-BACH1-DNA damage complex II
WP:WP5118	1.00395295036e-06	0.428571428571	RAD50 NBN MRE11	SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome
WP:WP186	1.3383290138e-06	0.428571428571	RAD50 NBN MRE11	Homologous recombination
CORUM:433	1.54229147311e-06	0.428571428571	RAD50 NBN MRE11	BASC complex (BRCA1-associated genome surveillance complex)
REAC:R-HSA-5685939	2.1479923589e-06	0.428571428571	RAD50 NBN MRE11	HDR through MMEJ (alt-NHEJ)
GO:0031860	1.34540429244e-05	0.428571428571	RAD50 NBN MRE11	telomeric 3' overhang formation
CORUM:264	2.05265451394e-05	0.285714285714	RAD50 MRE11	R/M complex (RAD50-MRE11 complex)
CORUM:72	2.05265451394e-05	0.285714285714	RAD50 MRE11	R/M complex (RAD50-MRE11 complex)
CORUM:263	2.05265451394e-05	0.285714285714	RAD50 MRE11	R/M complex (RAD50-MRE11 complex)
HP:0030406	2.07085763531e-05	0.428571428571	RAD50 NBN MRE11	Primary peritoneal carcinoma
REAC:R-HSA-9709603	2.62784267685e-05	0.428571428571	RAD50 NBN MRE11	Impaired BRCA2 binding to PALB2
REAC:R-HSA-9701193	2.98557123546e-05	0.428571428571	RAD50 NBN MRE11	Defective homologous recombination repair (HRR) due to PALB2 loss of function
REAC:R-HSA-9704646	2.98557123546e-05	0.428571428571	RAD50 NBN MRE11	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
REAC:R-HSA-9704331	2.98557123546e-05	0.428571428571	RAD50 NBN MRE11	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
REAC:R-HSA-9701192	2.98557123546e-05	0.428571428571	RAD50 NBN MRE11	Defective homologous recombination repair (HRR) due to BRCA1 loss of function
GO:0030870	3.362820138e-05	0.428571428571	RAD50 NBN MRE11	Mre11 complex
KEGG:03440	3.44327359757e-05	0.428571428571	RAD50 NBN MRE11	Homologous recombination
REAC:R-HSA-5693554	3.79530741097e-05	0.428571428571	RAD50 NBN MRE11	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
WP:WP2516	5.1045351583e-05	0.428571428571	RAD50 NBN MRE11	ATM signaling pathway
WP:WP3878	6.44627626437e-05	0.428571428571	RAD50 NBN MRE11	ATM signaling in development and disease
GO:0070533	6.72425931667e-05	0.428571428571	RAD50 NBN MRE11	BRCA1-C complex
REAC:R-HSA-5693568	7.07065782066e-05	0.428571428571	RAD50 NBN MRE11	Resolution of D-loop Structures through Holliday Junction Intermediates
REAC:R-HSA-9709570	7.75332089956e-05	0.428571428571	RAD50 NBN MRE11	Impaired BRCA2 binding to RAD51
REAC:R-HSA-5693537	7.75332089956e-05	0.428571428571	RAD50 NBN MRE11	Resolution of D-Loop Structures
REAC:R-HSA-5685938	8.47845144152e-05	0.428571428571	RAD50 NBN MRE11	HDR through Single Strand Annealing (SSA)
REAC:R-HSA-5693616	0.000118290093408	0.428571428571	RAD50 NBN MRE11	Presynaptic phase of homologous DNA pairing and strand exchange
REAC:R-HSA-9675136	0.000127854887848	0.428571428571	RAD50 NBN MRE11	Diseases of DNA Double-Strand Break Repair
REAC:R-HSA-9701190	0.000127854887848	0.428571428571	RAD50 NBN MRE11	Defective homologous recombination repair (HRR) due to BRCA2 loss of function
WP:WP3959	0.000133340269976	0.428571428571	RAD50 NBN MRE11	DNA IR double strand breaks and cellular response via ATM
HP:0011027	0.000147554136555	0.428571428571	RAD50 NBN MRE11	Abnormal fallopian tube morphology
REAC:R-HSA-5693579	0.00014849904315	0.428571428571	RAD50 NBN MRE11	Homologous DNA Pairing and Strand Exchange
GO:0110025	0.0001882019462	0.428571428571	RAD50 NBN MRE11	DNA strand resection involved in replication fork processing
CORUM:2766	0.000205125012531	0.285714285714	RAD50 MRE11	TERF2-RAP1 complex
CORUM:1193	0.000205125012531	0.285714285714	RAD50 MRE11	Rap1 complex
REAC:R-HSA-9675135	0.000237979963395	0.428571428571	RAD50 NBN MRE11	Diseases of DNA repair
WP:WP1530	0.000262838994257	0.428571428571	RAD50 NBN MRE11	miRNA regulation of DNA damage response
WP:WP707	0.000262838994257	0.428571428571	RAD50 NBN MRE11	DNA damage response
HP:0100787	0.000309191477582	0.428571428571	RAD50 NBN MRE11	Prostate neoplasm
HP:0012125	0.000309191477582	0.428571428571	RAD50 NBN MRE11	Prostate cancer
WP:WP4016	0.000439084830524	0.428571428571	RAD50 NBN MRE11	DNA IR damage and cellular response via ATR
REAC:R-HSA-5693571	0.000463730815151	0.428571428571	RAD50 NBN MRE11	Nonhomologous End-Joining (NHEJ)
HP:0008775	0.000517268544057	0.428571428571	RAD50 NBN MRE11	Abnormal prostate morphology
KEGG:03450	0.000563322084139	0.285714285714	RAD50 MRE11	Non-homologous end-joining
REAC:R-HSA-5685942	0.000589010657253	0.428571428571	RAD50 NBN MRE11	HDR through Homologous Recombination (HRR)
REAC:R-HSA-2559586	0.000616493605077	0.428571428571	RAD50 NBN MRE11	DNA Damage/Telomere Stress Induced Senescence
REAC:R-HSA-5693565	0.000734927167534	0.428571428571	RAD50 NBN MRE11	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
REAC:R-HSA-912446	0.000766722633593	0.428571428571	RAD50 NBN MRE11	Meiotic recombination
REAC:R-HSA-5693606	0.000766722633593	0.428571428571	RAD50 NBN MRE11	DNA Double Strand Break Response
HP:0033019	0.000977145370486	0.428571428571	RAD50 NBN MRE11	Male reproductive system neoplasm
REAC:R-HSA-69473	0.00135845178782	0.428571428571	RAD50 NBN MRE11	G2/M DNA damage checkpoint
WP:WP4946	0.00139501838032	0.428571428571	RAD50 NBN MRE11	DNA repair pathways full network
REAC:R-HSA-6804756	0.00145485785287	0.428571428571	RAD50 NBN MRE11	Regulation of TP53 Activity through Phosphorylation
REAC:R-HSA-5693607	0.00150471527401	0.428571428571	RAD50 NBN MRE11	Processing of DNA double-strand break ends
KEGG:04218	0.00152804474169	0.428571428571	RAD50 NBN MRE11	Cellular senescence
GO:0000729	0.00187892941497	0.428571428571	RAD50 NBN MRE11	DNA double-strand break processing
REAC:R-HSA-1500620	0.00200524097522	0.428571428571	RAD50 NBN MRE11	Meiosis
HP:0000022	0.00223657697318	0.428571428571	RAD50 NBN MRE11	Abnormal male internal genitalia morphology
WP:WP4262	0.00227439079054	0.428571428571	RAD50 NBN MRE11	Breast cancer pathway
HP:0100615	0.00245910381067	0.428571428571	RAD50 NBN MRE11	Ovarian neoplasm
HP:0003002	0.00269585339169	0.428571428571	RAD50 NBN MRE11	Breast carcinoma
HP:0002861	0.00281969683749	0.428571428571	RAD50 NBN MRE11	Melanoma
REAC:R-HSA-1474165	0.00290605023767	0.428571428571	RAD50 NBN MRE11	Reproduction
GO:0031954	0.00382182132582	0.428571428571	RAD50 NBN MRE11	positive regulation of protein autophosphorylation
REAC:R-HSA-5693567	0.00384976500914	0.428571428571	RAD50 NBN MRE11	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
HP:0002894	0.00443918702397	0.428571428571	RAD50 NBN MRE11	Neoplasm of the pancreas
REAC:R-HSA-5693538	0.00444068087029	0.428571428571	RAD50 NBN MRE11	Homology Directed Repair
HP:0010785	0.00573669071792	0.428571428571	RAD50 NBN MRE11	Gonadal neoplasm
HP:0100013	0.00614874082901	0.428571428571	RAD50 NBN MRE11	Neoplasm of the breast
REAC:R-HSA-5633007	0.00725596819608	0.428571428571	RAD50 NBN MRE11	Regulation of TP53 Activity
REAC:R-HSA-5693532	0.00814566466165	0.428571428571	RAD50 NBN MRE11	DNA Double-Strand Break Repair
REAC:R-HSA-69481	0.00830059661954	0.428571428571	RAD50 NBN MRE11	G2/M Checkpoints
REAC:R-HSA-2559583	0.0110497496792	0.428571428571	RAD50 NBN MRE11	Cellular Senescence
GO:0031952	0.0135831041104	0.428571428571	RAD50 NBN MRE11	regulation of protein autophosphorylation
WP:WP1971	0.0137733753117	0.285714285714	RAD50 MRE11	Integrated cancer pathway
HP:0010787	0.0194185705854	0.428571428571	RAD50 NBN MRE11	Genital neoplasm
GO:0016233	0.0218744047191	0.428571428571	RAD50 NBN MRE11	telomere capping
GO:0022616	0.0259578682575	0.428571428571	RAD50 NBN MRE11	DNA strand elongation
HPA:0301362	0.0322525779597	0.571428571429	RAD50 AK1 NBN MRE11	lung; alveolar cells type I[>=Medium]
WP:WP4656	0.0435709553271	0.285714285714	RAD50 MRE11	Joubert syndrome
REAC:R-HSA-69620	0.0441050291819	0.428571428571	RAD50 NBN MRE11	Cell Cycle Checkpoints
GO:0031297	0.0473277551461	0.428571428571	RAD50 NBN MRE11	replication fork processing
GO:0032508	0.0473277551461	0.428571428571	RAD50 NBN MRE11	DNA duplex unwinding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
BMP1	TLL1	0.972		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RAD50	ASTN2	0.955	0.094	bioplex3_WMM bioplex3_HCT116 WMM_only
RAD50	NBN	0.951	0.522	bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction
BMP1	NBN	0.947	0.066	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BMP1	MRE11	0.942	0.106	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
MRE11	AK1	0.926	0.026	hein_WMM bioplex_WMM bioplex3_WMM hein ()
NBN	CFAP161	0.925		bioplex3_HEK293 bioplex3_WMM WMM_only
BMP1	RAD50	0.896	0.19	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
MRE11	RAD50	0.872	0.796	bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM
RAD50	CFAP161	0.865		bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only
MRE11	NBN	0.844	0.486	bioplex_WMM bioplex3_WMM WMM_only
MRE11	CFAP161	0.502		bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only
TLL1	NBN	0.333		bioplex_WMM bioplex3_WMM WMM_only
TLL1	MRE11	0.155		bioplex_WMM bioplex3_WMM WMM_only
TLL1	RAD50	0.143		bioplex_WMM bioplex3_WMM WMM_only
RAD50	AK1	0.05	0.12	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NBN	AK1	0.009	0.038	bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
RAD50	huMAP3_04970.1 huMAP3_05537.1 huMAP3_09295.1 huMAP3_10560.1 huMAP3_11272.1 huMAP3_14612.1
ASTN2	huMAP3_04970.1 huMAP3_05537.1 huMAP3_10560.1 huMAP3_14574.1 huMAP3_14612.1
BMP1	huMAP3_01471.1 huMAP3_07663.1 huMAP3_09494.1 huMAP3_10247.1 huMAP3_14612.1
MRE11	huMAP3_02263.1 huMAP3_04707.1 huMAP3_11272.1 huMAP3_11903.1 huMAP3_14612.1
AK1	huMAP3_11903.1 huMAP3_13695.1 huMAP3_14442.1 huMAP3_14612.1 huMAP3_14906.1
CFAP161	huMAP3_11272.1 huMAP3_13306.1 huMAP3_14612.1
TLL1	huMAP3_01471.1 huMAP3_07663.1 huMAP3_09494.1 huMAP3_10247.1 huMAP3_14612.1
NBN	huMAP3_05537.1 huMAP3_08871.1 huMAP3_09295.1 huMAP3_10560.1 huMAP3_11272.1 huMAP3_13306.1 huMAP3_14612.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14612.1

Complex Portal: CPX-25116