hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14614.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DLG3 | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | 5 | UniProt NCBI |
| DLGAP2 | DLG associated protein 2 | 1 | UniProt NCBI |
| DLGAP4 | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | 5 | UniProt NCBI |
| PRDM16 | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | 5 | UniProt NCBI |
| DLG2 | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6794361 | 6.95446825874e-08 | 0.8 | DLGAP4 DLG2 DLG3 DLGAP2 | Neurexins and neuroligins |
| REAC:R-HSA-6794362 | 3.9023921419e-07 | 0.8 | DLGAP4 DLG2 DLG3 DLGAP2 | Protein-protein interactions at synapses |
| WP:WP5420 | 3.07885103634e-05 | 0.8 | DLGAP4 DLG2 DLG3 DLGAP2 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-112316 | 0.000135335223169 | 0.8 | DLGAP4 DLG2 DLG3 DLGAP2 | Neuronal System |
| GO:0099572 | 0.000969335687232 | 0.8 | DLGAP4 DLG2 DLG3 DLGAP2 | postsynaptic specialization |
| REAC:R-HSA-442982 | 0.0013810496636 | 0.4 | DLG3 DLG2 | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 0.00206313859056 | 0.4 | DLG3 DLG2 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.00206313859056 | 0.4 | DLG3 DLG2 | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 0.00232071308473 | 0.4 | DLG3 DLG2 | Long-term potentiation |
| REAC:R-HSA-442742 | 0.00350190276731 | 0.4 | DLG3 DLG2 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-9609736 | 0.0106339701454 | 0.4 | DLG3 DLG2 | Assembly and cell surface presentation of NMDA receptors |
| GO:0098794 | 0.0119018018062 | 0.8 | DLGAP4 DLG2 DLG3 DLGAP2 | postsynapse |
| WP:WP5417 | 0.0212523049113 | 0.4 | DLG3 DLG2 | Cell lineage map for neuronal differentiation |
| REAC:R-HSA-438064 | 0.0343168520054 | 0.4 | DLG3 DLG2 | Post NMDA receptor activation events |
| KEGG:04530 | 0.0427854405203 | 0.4 | DLG3 DLG2 | Tight junction |
| KEGG:04390 | 0.0471742362289 | 0.4 | DLG3 DLG2 | Hippo signaling pathway |
| REAC:R-HSA-442755 | 0.0475253950332 | 0.4 | DLG3 DLG2 | Activation of NMDA receptors and postsynaptic events |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DLG3 | DLG2 | 0.982 | 0.14 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| PRDM16 | DLGAP4 | 0.977 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DLG3 | DLGAP4 | 0.843 | 0.062 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| DLG3 | huMAP3_00720.1 huMAP3_01851.1 huMAP3_10326.1 huMAP3_14542.1 huMAP3_14614.1 |
| DLGAP2 | huMAP3_14542.1 huMAP3_14614.1 |
| DLGAP4 | huMAP3_03064.1 huMAP3_14542.1 huMAP3_14614.1 |
| PRDM16 | huMAP3_01416.1 huMAP3_03064.1 huMAP3_10266.1 huMAP3_11623.1 huMAP3_12062.1 huMAP3_14614.1 |
| DLG2 | huMAP3_00720.1 huMAP3_14542.1 huMAP3_14614.1 |