hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14618.1
Complex Portal: CPX-16444
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HMGB2 | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | 5 | UniProt NCBI |
| API5 | Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) | 5 | UniProt NCBI |
| LRRC47 | Leucine-rich repeat-containing protein 47 | 4 | UniProt NCBI |
| HMGB1 | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | 5 | UniProt NCBI |
| HMGB3 | High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:280 | 4.09448956317e-05 | 0.4 | HMGB2 HMGB1 | HMGB1-HMGB2-HSC70-ERP60-GAPDH complex |
| GO:0008301 | 0.000158467845213 | 0.6 | HMGB2 HMGB1 HMGB3 | DNA binding, bending |
| GO:0000400 | 0.000652677252708 | 0.6 | HMGB2 HMGB1 HMGB3 | four-way junction DNA binding |
| REAC:R-HSA-140342 | 0.0011839189519 | 0.4 | HMGB2 HMGB1 | Apoptosis induced DNA fragmentation |
| GO:0000217 | 0.00522817157061 | 0.6 | HMGB2 HMGB1 HMGB3 | DNA secondary structure binding |
| HPA:0400653 | 0.0142735424602 | 0.4 | HMGB2 HMGB1 | rectum; fibroblasts[High] |
| REAC:R-HSA-75153 | 0.0177620315324 | 0.4 | HMGB2 HMGB1 | Apoptotic execution phase |
| WP:WP2446 | 0.0212523049113 | 0.4 | HMGB2 HMGB1 | Retinoblastoma gene in cancer |
| GO:0032392 | 0.0224016609185 | 0.6 | HMGB2 HMGB1 HMGB3 | DNA geometric change |
| HPA:0461423 | 0.0293695047038 | 0.4 | HMGB2 HMGB1 | skin 1; eccrine glands[High] |
| HPA:0030443 | 0.031453796633 | 0.4 | HMGB2 HMGB1 | appendix; non-germinal center cells[High] |
| HPA:0400203 | 0.031453796633 | 0.4 | HMGB2 HMGB1 | rectum; endothelial cells[High] |
| GO:0071103 | 0.0327001087246 | 0.6 | HMGB2 HMGB1 HMGB3 | DNA conformation change |
| HPA:0400243 | 0.0373565138275 | 0.4 | HMGB2 HMGB1 | rectum; peripheral nerve/ganglion[High] |
| HPA:0400652 | 0.0412996825225 | 0.4 | HMGB2 HMGB1 | rectum; fibroblasts[>=Medium] |
| GO:0097100 | 0.0468008499735 | 0.4 | HMGB2 HMGB1 | supercoiled DNA binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HMGB1 | HMGB2 | 0.972 | 0.722 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction | |
| HMGB3 | LRRC47 | 0.921 | 0.1 | bioplex_WMM bioplex3_WMM fraction | |
| HMGB1 | HMGB3 | 0.9 | 0.33 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| HMGB2 | LRRC47 | 0.879 | 0.222 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| HMGB2 | HMGB3 | 0.866 | 0.37 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| API5 | LRRC47 | 0.855 | 0.222 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| API5 | HMGB3 | 0.819 | 0.11 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| HMGB1 | LRRC47 | 0.708 | 0.228 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| API5 | HMGB2 | 0.493 | 0.326 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM fraction | |
| API5 | HMGB1 | 0.081 | 0.39 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
Related Complexes