hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14624.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACTR3B | Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4) | 4 | UniProt NCBI |
| ARPC1B | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | 5 | UniProt NCBI |
| ARPC2 | Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) | 5 | UniProt NCBI |
| RALA | Ras-related protein Ral-A (EC 3.6.5.2) | 5 | UniProt NCBI |
| ACTR2 | Actin-related protein 2 (Actin-like protein 2) | 5 | UniProt NCBI |
| CHURC1 | Protein Churchill | 4 | UniProt NCBI |
| ARPC1A | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | 4 | UniProt NCBI |
| ARPC5 | Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) | 5 | UniProt NCBI |
| ARPC5L | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | 4 | UniProt NCBI |
| ABCG2 | Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) | 5 | UniProt NCBI |
| ACTR3 | Actin-related protein 3 (Actin-like protein 3) | 5 | UniProt NCBI |
| SORD | Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) | 5 | UniProt NCBI |
| ARPC4 | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | 5 | UniProt NCBI |
| ARPC3 | Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005885 | 4.27483811791e-25 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | Arp2/3 protein complex |
| CORUM:27 | 3.41633304177e-21 | 0.538461538462 | ACTR2 ARPC2 ARPC1B ARPC4 ACTR3 ARPC5 ARPC3 | Arp2/3 protein complex |
| KEGG:05100 | 1.26287791954e-19 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Bacterial invasion of epithelial cells |
| KEGG:04666 | 7.54879737725e-19 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Fc gamma R-mediated phagocytosis |
| KEGG:05135 | 9.7900586036e-18 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Yersinia infection |
| KEGG:04530 | 6.96469662975e-17 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Tight junction |
| GO:0034314 | 1.16000067139e-16 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | Arp2/3 complex-mediated actin nucleation |
| REAC:R-HSA-5663213 | 1.22926626294e-16 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-3928662 | 3.30697788193e-16 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | EPHB-mediated forward signaling |
| GO:0045010 | 3.75470065178e-16 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | actin nucleation |
| KEGG:05130 | 4.06066922518e-16 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Pathogenic Escherichia coli infection |
| KEGG:04810 | 2.24150779746e-15 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Regulation of actin cytoskeleton |
| REAC:R-HSA-9664422 | 5.96618362092e-15 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664417 | 5.96618362092e-15 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Leishmania phagocytosis |
| REAC:R-HSA-9664407 | 5.96618362092e-15 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Parasite infection |
| KEGG:05132 | 9.19764196501e-15 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Salmonella infection |
| REAC:R-HSA-2029482 | 9.5531505404e-15 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Regulation of actin dynamics for phagocytic cup formation |
| KEGG:05131 | 1.05291862488e-14 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Shigellosis |
| KEGG:04144 | 1.25736269263e-14 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | Endocytosis |
| REAC:R-HSA-2029480 | 1.56629964232e-13 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-2682334 | 2.37801467946e-13 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | EPH-Ephrin signaling |
| GO:0051015 | 4.53652772744e-13 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | actin filament binding |
| WP:WP2272 | 6.01088625628e-13 | 0.538461538462 | ARPC2 ARPC1B ARPC5L ARPC4 ARPC1A ARPC5 ARPC3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-9824443 | 1.54442688251e-11 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Parasitic Infection Pathways |
| REAC:R-HSA-9658195 | 1.54442688251e-11 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Leishmania infection |
| GO:0003779 | 6.67405239257e-11 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | actin binding |
| REAC:R-HSA-8856828 | 2.08313846194e-09 | 0.538461538462 | ACTR2 ARPC2 ARPC4 ACTR3 ARPC1A ARPC5 ARPC3 | Clathrin-mediated endocytosis |
| GO:0035861 | 6.48404701649e-09 | 0.538461538462 | ACTR2 ARPC2 ARPC4 ACTR3 ARPC1A ARPC5 ARPC3 | site of double-strand break |
| REAC:R-HSA-195258 | 8.29961000644e-09 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | RHO GTPase Effectors |
| GO:0005200 | 2.20477494097e-08 | 0.538461538462 | ACTR2 ARPC2 ARPC1B ARPC4 ACTR3 ARPC5 ARPC3 | structural constituent of cytoskeleton |
| GO:0090734 | 5.4259581572e-08 | 0.538461538462 | ACTR2 ARPC2 ARPC4 ACTR3 ARPC1A ARPC5 ARPC3 | site of DNA damage |
| GO:0007015 | 5.46481660465e-08 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | actin filament organization |
| GO:0015629 | 1.46630323828e-07 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | actin cytoskeleton |
| REAC:R-HSA-422475 | 4.01826530363e-07 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Axon guidance |
| REAC:R-HSA-9675108 | 5.3689936209e-07 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Nervous system development |
| GO:0008092 | 8.62175641311e-07 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | cytoskeletal protein binding |
| GO:0030036 | 3.24066847752e-06 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | actin cytoskeleton organization |
| REAC:R-HSA-194315 | 3.31261000601e-06 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 3.935826463e-06 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0030029 | 8.5504973956e-06 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | actin filament-based process |
| GO:0097435 | 1.03758786859e-05 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | supramolecular fiber organization |
| REAC:R-HSA-1266738 | 3.55873333087e-05 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Developmental Biology |
| REAC:R-HSA-5663205 | 3.89509890706e-05 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Infectious disease |
| REAC:R-HSA-168249 | 4.81677260102e-05 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Innate Immune System |
| REAC:R-HSA-199991 | 5.24099510606e-05 | 0.538461538462 | ACTR2 ARPC2 ARPC4 ACTR3 ARPC1A ARPC5 ARPC3 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 7.59113765594e-05 | 0.538461538462 | ACTR2 ARPC2 ARPC4 ACTR3 ARPC1A ARPC5 ARPC3 | Vesicle-mediated transport |
| GO:0044877 | 0.000106814963642 | 0.769230769231 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 ARPC1B ARPC4 ARPC5 ARPC3 | protein-containing complex binding |
| GO:0005925 | 0.000349081905812 | 0.538461538462 | ACTR2 ARPC2 ARPC1B ARPC5L ACTR3 ARPC5 ARPC3 | focal adhesion |
| GO:0070062 | 0.000355708860613 | 0.846153846154 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 SORD ARPC1B ARPC4 ARPC5 ARPC3 | extracellular exosome |
| GO:1903561 | 0.000392933476632 | 0.846153846154 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 SORD ARPC1B ARPC4 ARPC5 ARPC3 | extracellular vesicle |
| GO:0043230 | 0.000395229059245 | 0.846153846154 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 SORD ARPC1B ARPC4 ARPC5 ARPC3 | extracellular organelle |
| GO:0065010 | 0.000395229059245 | 0.846153846154 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 SORD ARPC1B ARPC4 ARPC5 ARPC3 | extracellular membrane-bounded organelle |
| GO:0030055 | 0.00039980332306 | 0.538461538462 | ACTR2 ARPC2 ARPC1B ARPC5L ACTR3 ARPC5 ARPC3 | cell-substrate junction |
| GO:0070358 | 0.000548960443183 | 0.230769230769 | ARPC2 ARPC3 ACTR3 | actin polymerization-dependent cell motility |
| GO:0007010 | 0.00206809318276 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | cytoskeleton organization |
| REAC:R-HSA-1643685 | 0.00245556402635 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Disease |
| GO:0005198 | 0.00426660161213 | 0.538461538462 | ACTR2 ARPC2 ARPC1B ARPC4 ACTR3 ARPC5 ARPC3 | structural molecule activity |
| REAC:R-HSA-168256 | 0.00638100826047 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Immune System |
| GO:0005615 | 0.0121488272242 | 0.846153846154 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 SORD ARPC1B ARPC4 ARPC5 ARPC3 | extracellular space |
| GO:0070161 | 0.0153609640443 | 0.538461538462 | ACTR2 ARPC2 ARPC1B ARPC5L ACTR3 ARPC5 ARPC3 | anchoring junction |
| REAC:R-HSA-162582 | 0.0244930985656 | 0.615384615385 | ACTR2 ARPC2 ARPC1B ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 | Signal Transduction |
| GO:0005576 | 0.0341140134152 | 0.846153846154 | ACTR2 ARPC2 ACTR3B ARPC1A ARPC5L ACTR3 SORD ARPC1B ARPC4 ARPC5 ARPC3 | extracellular region |
| GO:0005856 | 0.0346909655115 | 0.692307692308 | ACTR2 ARPC2 ARPC1B ARPC1A ARPC5L ACTR3 ARPC4 ARPC5 ARPC3 | cytoskeleton |
| GO:0010592 | 0.0481879293545 | 0.230769230769 | ACTR2 ARPC2 ACTR3 | positive regulation of lamellipodium assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| ACTR3 | ARPC4 | 1.0 | 0.962 |
| ACTR2 | ACTR3 | 1.0 | 0.938 |
| ARPC1B | ACTR3 | 1.0 | 0.924 |
| ACTR2 | ARPC1B | 1.0 | 0.874 |
| ARPC1A | ARPC3 | 1.0 | 0.324 |
| ACTR2 | ARPC5 | 1.0 | 0.866 |
| ACTR3 | ARPC3 | 1.0 | 0.956 |
| ACTR2 | ARPC4 | 1.0 | 0.932 |
| ACTR2 | ARPC1A | 1.0 | 0.524 |
| ARPC1A | ARPC4 | 1.0 | 0.346 |
| ARPC1B | ARPC4 | 1.0 | 0.854 |
| ARPC1A | ARPC5 | 1.0 | 0.184 |
| ACTR3 | ARPC5L | 1.0 | 0.356 |
| ARPC1A | ARPC5L | 1.0 | 0.176 |
| ARPC5 | ACTR3 | 1.0 | 0.894 |
| ACTR2 | ARPC3 | 1.0 | 0.942 |
| ACTR3B | ARPC4 | 1.0 | 0.902 |
| ARPC3 | ARPC5L | 1.0 | 0.282 |
| ACTR2 | ARPC2 | 1.0 | 0.99 |
| ARPC2 | ARPC4 | 1.0 | 0.978 |
| ARPC2 | ACTR3 | 1.0 | 0.966 |
| ACTR3B | ARPC3 | 1.0 | 0.81 |
| ARPC1A | ACTR3 | 1.0 | 0.476 |
| ARPC2 | ARPC5 | 1.0 | 0.934 |
| ACTR3B | ARPC5L | 0.999 | 0.190714893617 |
| ARPC1B | ARPC2 | 0.999 | 0.936 |
| ARPC2 | ARPC3 | 0.999 | 0.982 |
| ARPC1B | ARPC3 | 0.999 | 0.846 |
| ACTR3B | ARPC1A | 0.999 | 0.184714893617 |
| ARPC5 | ARPC4 | 0.999 | 0.786 |
| ARPC4 | ARPC5L | 0.999 | 0.276 |
| ACTR3B | ARPC1B | 0.999 | 0.522 |
| ARPC1A | ARPC2 | 0.999 | 0.456 |
| ARPC5 | ARPC3 | 0.999 | 0.936 |
| ACTR3B | ARPC5 | 0.999 | 0.458 |
| ARPC4 | ARPC3 | 0.999 | 0.946 |
| ACTR3B | ACTR2 | 0.999 | 0.884 |
| CHURC1 | ARPC3 | 0.999 | 0.092 |
| ACTR3B | ARPC2 | 0.999 | 0.866 |
| ARPC1B | ARPC5 | 0.999 | 0.806 |
| ARPC2 | ARPC5L | 0.999 | 0.33 |
| ACTR2 | ARPC5L | 0.998 | 0.35 |
| ACTR3B | CHURC1 | 0.998 | 0.158 |
| ARPC1B | ARPC5L | 0.998 | 0.08 |
| ARPC5 | ARPC5L | 0.998 | 0.168 |
| CHURC1 | ACTR2 | 0.997 | 0.114 |
| CHURC1 | ACTR3 | 0.993 | 0.094 |
| ACTR3B | ACTR3 | 0.992 | 0.826 |
| ARPC1A | ARPC1B | 0.987 | 0.212 |
| SORD | ARPC3 | 0.971 | 0.052 |
| CHURC1 | ARPC4 | 0.968 | 0.064 |
| CHURC1 | ARPC2 | 0.962 | 0.08 |
| SORD | ARPC5L | 0.935 | 0.076 |
| SORD | ARPC2 | 0.914 | 0.074 |
| RALA | ARPC5 | 0.894 | 0.04 |
| ABCG2 | ACTR2 | 0.894 | 0.084 |
| RALA | ARPC2 | 0.862 | 0.086 |
| RALA | ARPC3 | 0.861 | 0.152 |
| ABCG2 | ARPC1B | 0.861 | 0.062 |
| ABCG2 | ARPC2 | 0.86 | 0.072 |
| ABCG2 | ARPC5L | 0.854 | 0.04 |
| RALA | ACTR2 | 0.852 | 0.048 |
| CHURC1 | ARPC5 | 0.85 | 0.074 |
| RALA | ARPC1B | 0.823 | 0.104 |
| ABCG2 | ARPC3 | 0.814 | 0.082 |
| ABCG2 | ARPC5 | 0.803 | 0.118 |
| RALA | ARPC4 | 0.801 | 0.132 |
| RALA | ARPC5L | 0.78 | 0.164 |
| CHURC1 | ARPC1A | 0.772 | 0.082 |
| RALA | ACTR3 | 0.737 | 0.058 |
| CHURC1 | ARPC5L | 0.705 | 0.114 |
| ABCG2 | ACTR3 | 0.435 | 0.084 |
| CHURC1 | ARPC1B | 0.42 | 0.068 |
| SORD | ACTR3 | 0.336 | 0.146 |
| SORD | ARPC4 | 0.249 | 0.08 |
| ABCG2 | ARPC1A | 0.243 | 0.048 |
| SORD | ACTR2 | 0.151 | 0.116 |
| RALA | ABCG2 | 0.121 | 0.078 |
| ABCG2 | ARPC4 | 0.059 | 0.0925714285714 |
| RALA | ARPC1A | 0.027 | 0.126 |
| SORD | ARPC1B | 0.027 | 0.09 |
| RALA | CHURC1 | 0.022 | 0.12 |
| RALA | ACTR3B | 0.021 | 0.114714893617 |
| ABCG2 | ACTR3B | 0.018 | 0.128 |
| SORD | ACTR3B | 0.015 | 0.110714893617 |
| SORD | ARPC5 | 0.014 | 0.038 |
| RALA | SORD | 0.012 | 0.052 |
| SORD | CHURC1 | 0.003 | 0.066 |
| SORD | ARPC1A | 0.003 | 0.07 |
| ABCG2 | SORD | 0.002 | 0.09 |
Related Complexes