hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14626.1

Complex Portal: CPX-24503

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
FBXW4	F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)	4	UniProt NCBI
CXorf58	Uncharacterized protein CXorf58	2	UniProt NCBI
KATNAL1	Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 5.6.1.1) (p60 katanin-like 1)	5	UniProt NCBI
PDCD5	Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)	5	UniProt NCBI
MTFR1L	Mitochondrial fission regulator 1-like	4	UniProt NCBI
PFDN2	Prefoldin subunit 2	5	UniProt NCBI
KATNBL1	KATNB1-like protein 1 (Katanin p80 subunit B-like 1)	5	UniProt NCBI
TIPARP	Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)	5	UniProt NCBI
PFDN6	Prefoldin subunit 6 (Protein Ke2)	5	UniProt NCBI
PFDN4	Prefoldin subunit 4 (Protein C-1)	5	UniProt NCBI
DCAF12	DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A)	5	UniProt NCBI
DCAF4L1	DDB1- and CUL4-associated factor 4-like protein 1 (WD repeat-containing protein 21B)	2	UniProt NCBI
WDR49	WD repeat-containing protein 49	2	UniProt NCBI
VBP1	Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)	5	UniProt NCBI
KRTAP13-3	Keratin-associated protein 13-3	5	UniProt NCBI
DCAF5	DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22)	5	UniProt NCBI
WSB2	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein)	3	UniProt NCBI
PRKG2	cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII)	5	UniProt NCBI
KATNA1	Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin)	5	UniProt NCBI
RC3H2	Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)	5	UniProt NCBI
MARCHF9	E3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9)	5	UniProt NCBI
PFDN5	Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1)	5	UniProt NCBI
PFDN1	Prefoldin subunit 1	4	UniProt NCBI
KATNB1	Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)	5	UniProt NCBI
PDRG1	p53 and DNA damage-regulated protein 1	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:112	5.15668037838e-16	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	Prefoldin complex
CORUM:33	5.15668037838e-16	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	Prefoldin complex
WP:WP4918	1.58571043112e-15	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	Cellular proteostasis
GO:0016272	6.54898408055e-13	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	prefoldin complex
CORUM:7366	2.62090379737e-10	0.16	KATNAL1 KATNA1 KATNB1 KATNBL1	KATNA1-KATNAL1-KATNB1-KATNBL1 complex
GO:1905907	3.00880252119e-10	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	negative regulation of amyloid fibril formation
REAC:R-HSA-389957	1.22965496488e-09	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	Prefoldin mediated transfer of substrate to CCT/TriC
GO:1905906	3.24502233508e-09	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	regulation of amyloid fibril formation
REAC:R-HSA-389958	3.7434584847e-09	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
REAC:R-HSA-390466	2.50924845798e-08	0.28	FBXW4 VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2	Chaperonin-mediated protein folding
REAC:R-HSA-391251	4.42000163904e-08	0.28	FBXW4 VBP1 PFDN4 PFDN6 PFDN5 PFDN1 PFDN2	Protein folding
GO:0008352	3.32854782266e-07	0.16	KATNAL1 KATNA1 KATNB1 KATNBL1	katanin complex
GO:0061077	3.50537867768e-07	0.28	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1 PDCD5	chaperone-mediated protein folding
GO:1990000	1.74453728383e-06	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	amyloid fibril formation
GO:1902904	2.27291908377e-05	0.28	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1 KATNB1	negative regulation of supramolecular fiber organization
GO:0001540	6.10526257923e-05	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	amyloid-beta binding
GO:0006457	0.00043472302943	0.28	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1 PDCD5	protein folding
GO:0051082	0.000702841638275	0.24	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1	unfolded protein binding
GO:0097435	0.00127761718141	0.4	PFDN6 KATNA1 VBP1 PFDN4 KATNBL1 PFDN5 PFDN1 KATNAL1 PFDN2 KATNB1	supramolecular fiber organization
GO:1902903	0.0119816575411	0.28	PFDN6 VBP1 PFDN4 PFDN2 PFDN5 PFDN1 KATNB1	regulation of supramolecular fiber organization
CORUM:5199	0.0130782911431	0.08	PFDN2 PDRG1	Kinase maturation complex 1
GO:1990062	0.0361493524666	0.12	PDRG1 PFDN2 PFDN6	RPAP3/R2TP/prefoldin-like complex
GO:0031122	0.0431527536574	0.16	KATNAL1 KATNA1 KATNB1 KATNBL1	cytoplasmic microtubule organization

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PFDN2	VBP1	1.0	0.924
PFDN1	VBP1	1.0	0.932	mutually_exclusive (Q9NUG6) structurally_consistent (dimer)
PFDN4	VBP1	1.0	0.848	mutually_exclusive (Q9NUG6)
KATNA1	KATNB1	1.0	0.094	structurally_consistent (dimer)
PFDN1	PFDN2	1.0	0.916
PFDN6	PFDN2	1.0	0.954
PFDN6	PFDN4	1.0	0.948	structurally_consistent (dimer)
PFDN4	PFDN2	1.0	0.928	structurally_consistent (dimer)
PFDN5	PFDN2	1.0	0.93
PFDN5	VBP1	1.0	0.866
PFDN1	PFDN5	1.0	0.936	structurally_consistent (dimer)
PFDN6	VBP1	1.0	0.91	structurally_consistent (dimer)
PDRG1	PFDN4	1.0	0.242	structurally_consistent (dimer)
PFDN4	PFDN1	1.0	0.92
PDRG1	PFDN2	1.0	0.358
PFDN6	PFDN1	0.999	0.98	structurally_consistent (dimer)
PDRG1	VBP1	0.999	0.174	structurally_consistent (dimer)
PFDN4	PFDN5	0.999	0.902
PFDN6	PDRG1	0.999	0.432
PFDN6	PFDN5	0.999	0.914	structurally_consistent (dimer)
PDRG1	PFDN1	0.998	0.164	structurally_consistent (dimer)
PFDN4	MARCHF9	0.998
KATNA1	KATNBL1	0.998	0.146	mixed_interface
KATNB1	PFDN4	0.998	0.15	structurally_consistent (dimer)
KATNBL1	KATNAL1	0.998	0.08	structurally_consistent (Q9BVA0)
PDRG1	PFDN5	0.997	0.242
PFDN4	RC3H2	0.996	0.182
MTFR1L	PFDN1	0.996	0.054	structurally_consistent (dimer)
KATNB1	PFDN1	0.995	0.112	structurally_consistent (dimer)
KATNB1	KATNBL1	0.994	0.082	mixed_interface
FBXW4	PFDN2	0.99
WSB2	PFDN5	0.989
CXorf58	DCAF5	0.987
PFDN6	DCAF5	0.986	0.18
PDCD5	PFDN1	0.986	0.478	mutually_exclusive (O15212)
FBXW4	VBP1	0.984
WSB2	PFDN2	0.984
PDCD5	FBXW4	0.982
KATNA1	PFDN1	0.979	0.246	structurally_consistent (Q9BVA0)
MARCHF9	VBP1	0.979
PFDN4	MTFR1L	0.977	0.034
MARCHF9	PFDN1	0.976
WSB2	VBP1	0.973
MTFR1L	PFDN2	0.971	0.056
DCAF4L1	PFDN6	0.969
KATNB1	PFDN2	0.965	0.116	structurally_consistent (Q9NQP4)
FBXW4	PFDN5	0.957
DCAF5	PFDN4	0.957	0.096
DCAF5	PFDN2	0.955	0.144
DCAF5	VBP1	0.951	0.132
DCAF5	PFDN5	0.95	0.102	mutually_exclusive (O60925)
PFDN1	FBXW4	0.947
WSB2	PFDN1	0.945
PDCD5	PFDN2	0.94	0.572
PFDN4	FBXW4	0.932
KATNA1	KATNAL1	0.911	0.078
RC3H2	PFDN1	0.909	0.21
DCAF12	PFDN2	0.905	0.046
PDRG1	DCAF5	0.901	0.048
DCAF4L1	PDCD5	0.901
TIPARP	PFDN2	0.9
RC3H2	PFDN2	0.894	0.258
PFDN4	WSB2	0.891
PFDN6	FBXW4	0.875
MARCHF9	PFDN5	0.869
DCAF12	PFDN5	0.865	0.108
PDRG1	FBXW4	0.862
PFDN6	PDCD5	0.849	0.544	structurally_consistent (dimer)
DCAF5	PFDN1	0.848	0.162	structurally_consistent (dimer)
PRKG2	PFDN5	0.846
PRKG2	VBP1	0.846
PRKG2	PFDN6	0.846
KATNAL1	PFDN1	0.845	0.074	structurally_consistent (Q9BVA0)
PDRG1	MARCHF9	0.841
RC3H2	MTFR1L	0.834	0.08
DCAF12	VBP1	0.833	0.09
VBP1	KRTAP13-3	0.822
DCAF12	PFDN4	0.822	0.07
DCAF4L1	PFDN4	0.821
PFDN6	WSB2	0.819
PFDN1	KRTAP13-3	0.819
KATNA1	RC3H2	0.815	0.264
PDRG1	MTFR1L	0.814	0.076
PFDN2	KRTAP13-3	0.807
KATNB1	KATNAL1	0.797	0.08	structurally_consistent (dimer)
PFDN6	MTFR1L	0.797	0.076
MTFR1L	VBP1	0.796	0.032	mutually_exclusive (O60925)
MTFR1L	PFDN5	0.786	0.074
PFDN5	KRTAP13-3	0.785
KATNA1	PFDN6	0.772	0.272
PFDN6	KRTAP13-3	0.757
KATNB1	MTFR1L	0.754	0.056
PFDN4	KRTAP13-3	0.744
KATNA1	PDRG1	0.735	0.136
DCAF5	PDCD5	0.733	0.046
PFDN6	DCAF12	0.732	0.088
KATNA1	MTFR1L	0.73	0.062
KATNA1	VBP1	0.728	0.108
KATNB1	DCAF5	0.72	0.046
PFDN6	MARCHF9	0.716
DCAF4L1	VBP1	0.691
KATNA1	PFDN4	0.678	0.072
RC3H2	MARCHF9	0.675
MARCHF9	PFDN2	0.661
PDRG1	RC3H2	0.656	0.076
KATNA1	PFDN5	0.618	0.132
DCAF4L1	PFDN5	0.6
RC3H2	PFDN5	0.533	0.414
PFDN6	TIPARP	0.53
KATNB1	PDRG1	0.53	0.068
KATNB1	RC3H2	0.529	0.164
DCAF5	DCAF12	0.528	0.05
TIPARP	FBXW4	0.502
DCAF12	PFDN1	0.497	0.088
KATNB1	PFDN6	0.477	0.174	structurally_consistent (Q9NQP4)
KATNB1	VBP1	0.467	0.128
KATNA1	DCAF5	0.434	0.084
PDCD5	KRTAP13-3	0.43
KATNB1	PFDN5	0.418	0.096
RC3H2	WSB2	0.378
MTFR1L	WSB2	0.356
KATNA1	WSB2	0.334
KATNB1	DCAF12	0.321	0.076
PDCD5	PFDN5	0.304	0.438	mutually_exclusive (O15212)
KATNA1	DCAF12	0.299	0.07
PFDN6	RC3H2	0.279	0.208
PFDN4	PDCD5	0.278	0.4996
KATNA1	PFDN2	0.277	0.252
KATNA1	PDCD5	0.266	0.11
PDRG1	KRTAP13-3	0.222
PDRG1	TIPARP	0.222
KATNB1	WSB2	0.22
KATNA1	MARCHF9	0.218
MARCHF9	MTFR1L	0.218
PFDN4	TIPARP	0.218
DCAF4L1	PFDN2	0.215
TIPARP	PFDN5	0.213
KATNB1	MARCHF9	0.202
RC3H2	VBP1	0.196	0.462
DCAF5	MTFR1L	0.192	0.074	mutually_exclusive (O60925)
DCAF12	TIPARP	0.172
KATNB1	TIPARP	0.172
DCAF12	FBXW4	0.164
DCAF4L1	PFDN1	0.161
TIPARP	VBP1	0.156
DCAF5	RC3H2	0.154	0.07
TIPARP	WSB2	0.146
PDRG1	WSB2	0.145
KATNB1	FBXW4	0.143
TIPARP	PFDN1	0.141
PDCD5	VBP1	0.115	0.38	mutually_exclusive (O15212)
KATNAL1	MARCHF9	0.113
KATNAL1	DCAF5	0.109	0.128
KATNAL1	MTFR1L	0.095	0.08
KATNAL1	PFDN4	0.082	0.06
KATNAL1	DCAF12	0.076	0.096
PRKG2	PFDN2	0.065
KATNAL1	PDRG1	0.063	0.05
RC3H2	TIPARP	0.057
PDRG1	DCAF12	0.054	0.082
KATNAL1	PFDN6	0.053	0.063
KATNA1	TIPARP	0.046
RC3H2	FBXW4	0.046
WSB2	FBXW4	0.046
CXorf58	PFDN1	0.045
MTFR1L	FBXW4	0.042
TIPARP	MTFR1L	0.042
DCAF12	WSB2	0.042
DCAF12	RC3H2	0.042	0.134
KATNA1	FBXW4	0.042
DCAF12	MTFR1L	0.028	0.076
PDRG1	PDCD5	0.027	0.248
DCAF5	MARCHF9	0.026
KATNAL1	RC3H2	0.026	0.116
CXorf58	PDCD5	0.023
DCAF4L1	PDRG1	0.023
WSB2	PDCD5	0.023
MTFR1L	PDCD5	0.022	0.04
CXorf58	PFDN4	0.02
DCAF12	PDCD5	0.02	0.048
KATNAL1	PFDN2	0.017	0.1
CXorf58	PFDN5	0.013
DCAF4L1	KATNAL1	0.012
KATNAL1	VBP1	0.011	0.126
PRKG2	PFDN4	0.011
PRKG2	PFDN1	0.011
KATNAL1	PFDN5	0.008	0.144
RC3H2	PDCD5	0.005	0.172
TIPARP	PDCD5	0.004
CXorf58	VBP1	0.004
KATNB1	PDCD5	0.004	0.038
KATNBL1	PFDN2	0.002	0.112
CXorf58	PFDN2	0.001
KATNAL1	PDCD5	0.001	0.076

Related Complexes

Genename	Complexes
FBXW4	huMAP3_03993.1 huMAP3_04072.1 huMAP3_06614.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
CXorf58	huMAP3_00152.1 huMAP3_05659.1 huMAP3_13387.1 huMAP3_13721.1 huMAP3_14626.1
KATNAL1	huMAP3_00793.1 huMAP3_04019.1 huMAP3_09573.1 huMAP3_11361.1 huMAP3_11693.1 huMAP3_13167.1 huMAP3_14626.1
PDCD5	huMAP3_03810.1 huMAP3_03993.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1 huMAP3_14626.1
MTFR1L	huMAP3_02935.1 huMAP3_03956.1 huMAP3_08998.1 huMAP3_09234.1 huMAP3_09720.1 huMAP3_10912.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
PFDN2	huMAP3_04072.1 huMAP3_06819.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14598.1 huMAP3_14626.1
KATNBL1	huMAP3_00793.1 huMAP3_04019.1 huMAP3_09573.1 huMAP3_11361.1 huMAP3_11693.1 huMAP3_13167.1 huMAP3_14626.1
TIPARP	huMAP3_02690.1 huMAP3_10579.1 huMAP3_10797.1 huMAP3_11361.1 huMAP3_12219.1 huMAP3_14598.1 huMAP3_14626.1 huMAP3_14741.1 huMAP3_15005.1
PFDN6	huMAP3_00807.1 huMAP3_06426.1 huMAP3_06819.1 huMAP3_08487.1 huMAP3_09057.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11092.1 huMAP3_14584.1 huMAP3_14626.1
PFDN4	huMAP3_01955.1 huMAP3_08060.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
DCAF12	huMAP3_01951.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
DCAF4L1	huMAP3_00116.1 huMAP3_14584.1 huMAP3_14626.1
WDR49	huMAP3_03458.1 huMAP3_05772.1 huMAP3_14584.1 huMAP3_14626.1
VBP1	huMAP3_06614.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
KRTAP13-3	huMAP3_11361.1 huMAP3_14584.1 huMAP3_14598.1 huMAP3_14626.1
DCAF5	huMAP3_01951.1 huMAP3_06559.1 huMAP3_06819.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1 huMAP3_14626.1
WSB2	huMAP3_03772.1 huMAP3_04072.1 huMAP3_04750.1 huMAP3_05894.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_08919.1 huMAP3_09036.1 huMAP3_09980.1 huMAP3_10139.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_13601.1 huMAP3_14626.1
PRKG2	huMAP3_00184.1 huMAP3_00471.1 huMAP3_04280.1 huMAP3_07508.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
KATNA1	huMAP3_00326.1 huMAP3_04019.1 huMAP3_09573.1 huMAP3_11361.1 huMAP3_11693.1 huMAP3_13167.1 huMAP3_14626.1
RC3H2	huMAP3_01955.1 huMAP3_04521.1 huMAP3_08060.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
MARCHF9	huMAP3_01955.1 huMAP3_08998.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
PFDN5	huMAP3_04072.1 huMAP3_06614.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
PFDN1	huMAP3_03956.1 huMAP3_04396.1 huMAP3_06212.1 huMAP3_07725.1 huMAP3_08998.1 huMAP3_09191.1 huMAP3_09234.1 huMAP3_10656.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
KATNB1	huMAP3_00326.1 huMAP3_04019.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_11693.1 huMAP3_13167.1 huMAP3_14626.1
PDRG1	huMAP3_00807.1 huMAP3_06426.1 huMAP3_08487.1 huMAP3_09057.1 huMAP3_11092.1 huMAP3_14318.1 huMAP3_14626.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14626.1

Complex Portal: CPX-24503