hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14633.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LEPR | Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) | 5 | UniProt NCBI |
| BMP4 | Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) | 5 | UniProt NCBI |
| LEP | Leptin (Obese protein) (Obesity factor) | 5 | UniProt NCBI |
| IL20 | Interleukin-20 (IL-20) (Cytokine Zcyto10) | 5 | UniProt NCBI |
| TWSG1 | Twisted gastrulation protein homolog 1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5400 | 9.18788843787e-05 | 0.5 | LEP LEPR | 6q16 copy number variation |
| WP:WP3934 | 0.000114838123418 | 0.5 | LEP LEPR | Leptin and adiponectin |
| KEGG:04630 | 0.000124866609719 | 0.75 | LEP LEPR IL20 | JAK-STAT signaling pathway |
| WP:WP3935 | 0.000306067313039 | 0.5 | LEP LEPR | Leptin insulin signaling overlap |
| KEGG:04060 | 0.000426496412782 | 0.75 | LEP LEPR IL20 | Cytokine-cytokine receptor interaction |
| HP:0005419 | 0.000501460556964 | 0.5 | LEP LEPR | Decreased T cell activation |
| HP:0410035 | 0.000501460556964 | 0.5 | LEP LEPR | Abnormal T cell activation |
| HP:0003292 | 0.00183784982408 | 0.5 | LEP LEPR | Decreased serum leptin |
| HP:0004361 | 0.00260592941411 | 0.5 | LEP LEPR | Abnormal circulating leptin concentration |
| HP:0004926 | 0.00303997345979 | 0.5 | LEP LEPR | Orthostatic hypotension due to autonomic dysfunction |
| WP:WP1403 | 0.00464837292584 | 0.5 | LEP LEPR | AMP activated protein kinase signaling |
| KEGG:04920 | 0.00487132756685 | 0.5 | LEP LEPR | Adipocytokine signaling pathway |
| WP:WP2034 | 0.00578263137464 | 0.5 | LEP LEPR | Leptin signaling pathway |
| HP:0500267 | 0.0092117244708 | 0.5 | LEP LEPR | Abnormal proportion of CD4-positive helper T cells |
| HP:0005407 | 0.0092117244708 | 0.5 | LEP LEPR | Decreased proportion of CD4-positive helper T cells |
| HP:0008187 | 0.0108451581837 | 0.5 | LEP LEPR | Absence of secondary sex characteristics |
| HP:0032218 | 0.0145105245688 | 0.5 | LEP LEPR | Decreased proportion of CD4-positive T cells |
| HP:0000831 | 0.0155098335254 | 0.5 | LEP LEPR | Insulin-resistant diabetes mellitus |
| KEGG:04152 | 0.0157117070582 | 0.5 | LEP LEPR | AMPK signaling pathway |
| HP:0008245 | 0.0165423111708 | 0.5 | LEP LEPR | Pituitary hypothyroidism |
| HP:0001278 | 0.018706736024 | 0.5 | LEP LEPR | Orthostatic hypotension |
| HP:0031392 | 0.021003726131 | 0.5 | LEP LEPR | Abnormal proportion of CD4-positive T cells |
| HP:0008214 | 0.0234332085093 | 0.5 | LEP LEPR | Decreased serum estradiol |
| WP:WP4396 | 0.023499356813 | 0.5 | LEP LEPR | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.0237566589162 | 0.5 | LEP LEPR | Non-alcoholic fatty liver disease |
| CORUM:1992 | 0.0249718442456 | 0.25 | LEPR | LEPR homodimer complex |
| CORUM:1970 | 0.0249718442456 | 0.25 | TWSG1 | BMP4-TWSG1 complex |
| HP:0025132 | 0.034474601612 | 0.5 | LEP LEPR | Abnormal circulating estrogen level |
| HP:0025133 | 0.034474601612 | 0.5 | LEP LEPR | Abnormal serum estradiol |
| HP:0011840 | 0.034474601612 | 0.5 | LEP LEPR | Abnormality of T cell physiology |
| HP:0005403 | 0.0375654511359 | 0.5 | LEP LEPR | T lymphocytopenia |
| HP:0040171 | 0.0375654511359 | 0.5 | LEP LEPR | Decreased serum testosterone concentration |
| HP:0000815 | 0.0375654511359 | 0.5 | LEP LEPR | Hypergonadotropic hypogonadism |
| HP:0030349 | 0.040788355352 | 0.5 | LEP LEPR | Decreased circulating androgen concentration |
| HPA:0120233 | 0.0424284218432 | 0.25 | LEPR | choroid plexus; ependymal cells[High] |
| KEGG:04080 | 0.0428875882852 | 0.5 | LEP LEPR | Neuroactive ligand-receptor interaction |
| CORUM:3711 | 0.049938562206 | 0.25 | TWSG1 | CHL2-BMP2-TSG complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LEPR | LEP | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TWSG1 | BMP4 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BMP4 | IL20 | 0.932 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BMP4 | LEP | 0.86 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BMP4 | LEPR | 0.175 | bioplex3_WMM WMM_only |
Related Complexes