hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14640.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCLO | Protein piccolo (Aczonin) | 5 | UniProt NCBI |
| LMO2 | Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2) | 5 | UniProt NCBI |
| MN1 | Transcriptional activator MN1 (Probable tumor suppressor protein MN1) | 5 | UniProt NCBI |
| RNF31 | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | 5 | UniProt NCBI |
| SHARPIN | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | 5 | UniProt NCBI |
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| ZBED4 | Zinc finger BED domain-containing protein 4 | 5 | UniProt NCBI |
| GORAB | RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) | 5 | UniProt NCBI |
| MEX3C | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | 5 | UniProt NCBI |
| IPMK | Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) | 5 | UniProt NCBI |
| RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | 5 | UniProt NCBI |
| LIPN | Lipase member N (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 4) | 5 | UniProt NCBI |
| LIPF | Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6178 | 3.08880131998e-08 | 0.230769230769 | RNF31 SHARPIN RBCK1 | LUBAC complex |
| GO:0071797 | 2.74903317479e-05 | 0.230769230769 | RNF31 SHARPIN RBCK1 | LUBAC complex |
| GO:0097039 | 0.000274621184043 | 0.230769230769 | RNF31 SHARPIN RBCK1 | protein linear polyubiquitination |
| REAC:R-HSA-5357786 | 0.000300784921147 | 0.230769230769 | RNF31 SHARPIN RBCK1 | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-5357956 | 0.000734078614392 | 0.230769230769 | RNF31 SHARPIN RBCK1 | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-5357905 | 0.00194806094355 | 0.230769230769 | RNF31 SHARPIN RBCK1 | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 0.00342983267549 | 0.230769230769 | RNF31 SHARPIN RBCK1 | TNF signaling |
| CORUM:6344 | 0.00371160916176 | 0.153846153846 | RNF31 RBCK1 | TNF-R1-associated signaling complex |
| KEGG:04217 | 0.0123081381889 | 0.230769230769 | RNF31 SHARPIN RBCK1 | Necroptosis |
| KEGG:04621 | 0.0148480763161 | 0.230769230769 | RNF31 SHARPIN RBCK1 | NOD-like receptor signaling pathway |
| REAC:R-HSA-73887 | 0.0469871596173 | 0.230769230769 | RNF31 SHARPIN RBCK1 | Death Receptor Signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| RBCK1 | RNF31 | 1.0 | 0.276 |
| RNF31 | SHARPIN | 1.0 | 0.288 |
| RBCK1 | SHARPIN | 0.999 | 0.144 |
| PCLO | LMO2 | 0.997 | |
| GORAB | LMO2 | 0.997 | |
| LIPN | LIPF | 0.996 | |
| LMO2 | IPMK | 0.995 | |
| LMO2 | TCAIM | 0.995 | |
| RNF31 | LMO2 | 0.994 | |
| MN1 | LMO2 | 0.994 | |
| MEX3C | LMO2 | 0.993 | |
| RBCK1 | LMO2 | 0.987 | |
| RNF31 | LIPF | 0.976 | |
| LIPF | SHARPIN | 0.976 | |
| SHARPIN | LMO2 | 0.967 | |
| LMO2 | ZBED4 | 0.961 | |
| GORAB | IPMK | 0.572 | |
| MEX3C | IPMK | 0.572 | |
| IPMK | TCAIM | 0.572 | |
| MN1 | IPMK | 0.557 | |
| RNF31 | PCLO | 0.343 | 0.052 |
| ZBED4 | IPMK | 0.337 | |
| GORAB | MN1 | 0.333 | |
| SHARPIN | IPMK | 0.333 | |
| GORAB | TCAIM | 0.333 | |
| GORAB | MEX3C | 0.333 | 0.07 |
| RBCK1 | IPMK | 0.333 | |
| LIPN | SHARPIN | 0.333 | |
| MEX3C | TCAIM | 0.303 | |
| MN1 | TCAIM | 0.303 | |
| MN1 | MEX3C | 0.303 | |
| PCLO | IPMK | 0.214 | |
| PCLO | MEX3C | 0.214 | 0.1 |
| PCLO | TCAIM | 0.214 | |
| GORAB | PCLO | 0.214 | 0.054 |
| PCLO | MN1 | 0.214 | |
| RBCK1 | ZBED4 | 0.213 | 0.072 |
| SHARPIN | ZBED4 | 0.213 | 0.096 |
| RNF31 | MN1 | 0.187 | |
| RNF31 | TCAIM | 0.187 | |
| RNF31 | MEX3C | 0.187 | 0.066 |
| GORAB | ZBED4 | 0.172 | 0.16 |
| MEX3C | ZBED4 | 0.164 | 0.136 |
| ZBED4 | TCAIM | 0.164 | |
| SHARPIN | MEX3C | 0.164 | 0.082 |
| GORAB | SHARPIN | 0.164 | 0.07 |
| MN1 | SHARPIN | 0.164 | |
| RBCK1 | MN1 | 0.164 | |
| SHARPIN | TCAIM | 0.164 | |
| RNF31 | ZBED4 | 0.159 | 0.064 |
| MN1 | ZBED4 | 0.156 | |
| GORAB | RNF31 | 0.143 | 0.15 |
| RNF31 | LIPN | 0.143 | |
| GORAB | RBCK1 | 0.143 | 0.058 |
| RBCK1 | TCAIM | 0.143 | |
| RNF31 | IPMK | 0.143 | |
| RBCK1 | MEX3C | 0.143 | 0.07 |
| PCLO | SHARPIN | 0.055 | 0.046 |
| PCLO | ZBED4 | 0.055 | 0.108 |
| RBCK1 | PCLO | 0.046 | 0.052 |
Related Complexes