hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14641.1

Complex Portal: CPX-15749

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
EMC6	ER membrane protein complex subunit 6 (Transmembrane protein 93)	5	UniProt NCBI
EMC4	ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85)	5	UniProt NCBI
EMC7	Endoplasmic reticulum membrane protein complex subunit 7 (ER membrane protein complex subunit 7)	5	UniProt NCBI
EMC9	ER membrane protein complex subunit 9 (Protein FAM158A)	4	UniProt NCBI
MPV17L2	Mpv17-like protein 2	4	UniProt NCBI
EMC8	ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)	5	UniProt NCBI
ANKH	Mineralization regulator ANKH (ATP carrier protein ANKH) (Progressive ankylosis protein homolog) (ANK)	5	UniProt NCBI
EMC2	ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)	5	UniProt NCBI
EMC10	ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1)	5	UniProt NCBI
TRDN	Triadin	5	UniProt NCBI
EMC3	ER membrane protein complex subunit 3 (Transmembrane protein 111)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0072546	7.20228030652e-21	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	EMC complex
GO:0045050	2.64035394183e-20	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO:0032977	2.0575963047e-18	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	membrane insertase activity
GO:0071816	3.88586092507e-18	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	tail-anchored membrane protein insertion into ER membrane
GO:0045048	6.84580226966e-16	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	protein insertion into ER membrane
GO:0140597	9.33347854769e-16	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	protein carrier chaperone
GO:0007029	6.70951871787e-15	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	endoplasmic reticulum organization
GO:0051205	7.78708912689e-15	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	protein insertion into membrane
GO:0140104	4.58043052966e-12	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	molecular carrier activity
GO:0140534	4.38555840055e-11	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	endoplasmic reticulum protein-containing complex
GO:0090150	1.21658123927e-08	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	establishment of protein localization to membrane
GO:0010256	4.59539465791e-08	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	endomembrane system organization
GO:0061024	4.6511756609e-07	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	membrane organization
GO:0005789	3.30771045571e-06	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	endoplasmic reticulum membrane
GO:0098827	3.80140274501e-06	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	endoplasmic reticulum subcompartment
GO:0042175	4.09732820346e-06	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	nuclear outer membrane-endoplasmic reticulum membrane network
GO:0072657	5.47934601565e-06	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	protein localization to membrane
GO:0051668	2.16031537938e-05	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	localization within membrane
GO:0031984	4.43998087158e-05	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	organelle subcompartment
GO:0033365	0.000281190176005	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	protein localization to organelle
GO:0005783	0.00136051737626	0.818181818182	EMC2 EMC8 TRDN EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	endoplasmic reticulum
GO:0098796	0.00170886144065	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	membrane protein complex
GO:0045184	0.00325416740163	0.727272727273	EMC2 EMC8 EMC9 EMC4 EMC6 EMC7 EMC3 EMC10	establishment of protein localization
GO:0031090	0.00893190093214	0.909090909091	EMC7 EMC8 EMC2 TRDN EMC9 EMC4 EMC6 EMC3 EMC10 MPV17L2	organelle membrane
GO:0006996	0.0251340410919	0.909090909091	EMC7 EMC8 EMC2 TRDN EMC9 EMC4 EMC6 EMC3 EMC10 MPV17L2	organelle organization

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
EMC7	EMC3	1.0	0.956
EMC4	EMC3	1.0	0.8
EMC10	EMC3	1.0	0.838	structurally_consistent (Q8N766)
EMC6	EMC2	1.0	0.43	structurally_consistent (dimer)
EMC9	EMC10	1.0	0.13
EMC8	EMC2	1.0	0.894	structurally_consistent (Q5UCC4) structurally_consistent (dimer)
EMC2	EMC10	1.0	0.73	structurally_consistent (Q8N766) structurally_consistent (dimer)
EMC9	EMC2	1.0	0.214	structurally_consistent (dimer)
EMC2	EMC3	1.0	0.936	structurally_consistent (dimer)
EMC7	EMC8	1.0	0.77
EMC7	EMC9	1.0	0.328
EMC4	EMC9	1.0	0.222
EMC4	EMC7	1.0	0.532
EMC8	EMC3	1.0	0.706
EMC7	EMC10	1.0	0.888
EMC4	EMC2	1.0	0.668	structurally_consistent (Q8N766) structurally_consistent (dimer)
EMC4	EMC8	1.0	0.324
EMC6	EMC9	1.0	0.15
EMC6	EMC10	1.0	0.206
EMC9	EMC3	1.0	0.21
EMC7	EMC2	1.0	0.854	structurally_consistent (Q8N766) structurally_consistent (dimer)
EMC6	EMC4	0.999	0.172
EMC6	EMC7	0.999	0.32
EMC6	EMC8	0.999	0.338
EMC6	EMC3	0.999	0.364
EMC8	EMC10	0.999	0.546	structurally_consistent (dimer)
EMC4	EMC10	0.998	0.56
ANKH	TRDN	0.996
MPV17L2	TRDN	0.984
EMC9	TRDN	0.976
EMC9	EMC8	0.971	0.288	mutually_exclusive (Q15006)
EMC8	TRDN	0.943
EMC10	TRDN	0.932
EMC2	TRDN	0.931
EMC4	TRDN	0.906
EMC7	TRDN	0.887
EMC3	TRDN	0.773
MPV17L2	EMC2	0.364	0.12
MPV17L2	ANKH	0.214	0.098
MPV17L2	EMC3	0.213	0.15
MPV17L2	EMC4	0.198	0.074
MPV17L2	EMC8	0.193	0.094
MPV17L2	EMC9	0.172	0.09
MPV17L2	EMC10	0.162	0.11
MPV17L2	EMC7	0.146	0.13
EMC9	ANKH	0.046	0.096
EMC3	ANKH	0.042	0.128
EMC10	ANKH	0.042	0.046
EMC4	ANKH	0.041	0.064
EMC8	ANKH	0.03	0.03
EMC2	ANKH	0.03	0.058
EMC7	ANKH	0.026	0.046

Related Complexes

Genename	Complexes
EMC6	huMAP3_03281.1 huMAP3_12199.1 huMAP3_13204.1 huMAP3_14641.1
EMC4	huMAP3_03281.1 huMAP3_12199.1 huMAP3_14641.1
EMC7	huMAP3_03281.1 huMAP3_11421.1 huMAP3_12199.1 huMAP3_14641.1
EMC9	huMAP3_03281.1 huMAP3_12199.1 huMAP3_14641.1
MPV17L2	huMAP3_01303.1 huMAP3_05997.1 huMAP3_09412.1 huMAP3_13082.1 huMAP3_13917.1 huMAP3_14187.1 huMAP3_14641.1
EMC8	huMAP3_03281.1 huMAP3_12199.1 huMAP3_14641.1
ANKH	huMAP3_05359.1 huMAP3_06891.1 huMAP3_09966.1 huMAP3_13881.1 huMAP3_13941.1 huMAP3_14220.1 huMAP3_14641.1 huMAP3_15226.1
EMC2	huMAP3_03281.1 huMAP3_12199.1 huMAP3_14641.1
EMC10	huMAP3_03281.1 huMAP3_12199.1 huMAP3_14641.1
TRDN	huMAP3_05997.1 huMAP3_09966.1 huMAP3_14641.1
EMC3	huMAP3_03281.1 huMAP3_12199.1 huMAP3_14641.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14641.1

Complex Portal: CPX-15749