hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14644.1
Complex Portal: CPX-12764
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HYAL4 | Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4) | 5 | UniProt NCBI |
| MUSK | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | 5 | UniProt NCBI |
| SPCS2 | Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) | 5 | UniProt NCBI |
| PVRIG | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | 5 | UniProt NCBI |
| RTN4R | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) | 5 | UniProt NCBI |
| ADAM30 | Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-) | 5 | UniProt NCBI |
| WNT6 | Protein Wnt-6 | 5 | UniProt NCBI |
| SEC11C | Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21) | 5 | UniProt NCBI |
| TREM1 | Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354) | 5 | UniProt NCBI |
| CHRNE | Acetylcholine receptor subunit epsilon | 5 | UniProt NCBI |
| ALPL | Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1) | 5 | UniProt NCBI |
| SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) | 5 | UniProt NCBI |
| SEC11A | Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-400511 | 3.38091735304e-08 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| REAC:R-HSA-422085 | 7.31810120121e-08 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | Synthesis, secretion, and deacylation of Ghrelin |
| GO:0005787 | 9.40213012535e-08 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | signal peptidase complex |
| REAC:R-HSA-381771 | 2.43115552171e-07 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| REAC:R-HSA-400508 | 3.95540732843e-07 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | Incretin synthesis, secretion, and inactivation |
| KEGG:03060 | 5.82398818728e-07 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | Protein export |
| GO:0006465 | 1.33921251982e-05 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | signal peptide processing |
| REAC:R-HSA-2980736 | 7.1861960932e-05 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | Peptide hormone metabolism |
| WP:WP5408 | 0.000313870061761 | 0.230769230769 | SPCS2 SEC11A SPCS1 | 15q25 copy number variation |
| REAC:R-HSA-1799339 | 0.000563249078755 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-72766 | 0.0250718515332 | 0.307692307692 | SPCS2 SEC11C SEC11A SPCS1 | Translation |
| HP:0003402 | 0.0416568309099 | 0.153846153846 | CHRNE MUSK | Decreased miniature endplate potentials |
| HP:0030199 | 0.0499631138006 | 0.153846153846 | CHRNE MUSK | Fatigable weakness of neck muscles |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SPCS1 | SEC11C | 1.0 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| SPCS2 | SEC11C | 0.999 | 0.212 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| SPCS1 | SPCS2 | 0.997 | 0.646 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| SPCS1 | SEC11A | 0.997 | 0.606 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| SPCS1 | PVRIG | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MUSK | ADAM30 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PVRIG | SPCS2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SPCS2 | SEC11A | 0.995 | 0.9 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM | |
| SPCS1 | ADAM30 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SPCS1 | RTN4R | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SPCS2 | ADAM30 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SPCS1 | TREM1 | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TREM1 | SPCS2 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RTN4R | SPCS2 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SEC11C | SEC11A | 0.973 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| SEC11C | WNT6 | 0.95 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SEC11C | ADAM30 | 0.937 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SEC11C | CHRNE | 0.919 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RTN4R | SEC11A | 0.903 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TREM1 | SEC11A | 0.898 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PVRIG | SEC11A | 0.839 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SPCS1 | HYAL4 | 0.83 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SPCS1 | ALPL | 0.82 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SEC11A | ADAM30 | 0.748 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SPCS2 | WNT6 | 0.733 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SEC11A | ALPL | 0.719 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPCS1 | WNT6 | 0.698 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SPCS2 | ALPL | 0.599 | 0.092 |
structurally_consistent (Q9BY50)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SEC11C | ALPL | 0.347 | 0.048 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SPCS2 | HYAL4 | 0.287 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SEC11A | WNT6 | 0.23 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SEC11A | HYAL4 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SEC11A | CHRNE | 0.039 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SPCS2 | CHRNE | 0.015 | bioplex3_HEK293 WMM_only |
Related Complexes