hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14646.1
Complex Portal: CPX-25714
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL13A1 | Collagen alpha-1(XIII) chain (COLXIIIA1) | 5 | UniProt NCBI |
| COL4A5 | Collagen alpha-5(IV) chain | 5 | UniProt NCBI |
| COL5A2 | Collagen alpha-2(V) chain | 5 | UniProt NCBI |
| COL17A1 | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | 5 | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | 5 | UniProt NCBI |
| ZBED2 | Zinc finger BED domain-containing protein 2 | 5 | UniProt NCBI |
| COL4A4 | Collagen alpha-4(IV) chain | 5 | UniProt NCBI |
| COL6A3 | Collagen alpha-3(VI) chain | 5 | UniProt NCBI |
| LAIR2 | Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 1.04147201904e-10 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | Collagen chain trimerization |
| REAC:R-HSA-1442490 | 1.39057873035e-09 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | Collagen degradation |
| REAC:R-HSA-1650814 | 1.8946190242e-09 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | Collagen biosynthesis and modifying enzymes |
| KEGG:04974 | 2.20211752343e-09 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | Protein digestion and absorption |
| REAC:R-HSA-1474290 | 1.01763939558e-08 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | Collagen formation |
| GO:0030020 | 2.23942064774e-08 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-1474228 | 6.99658095042e-08 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | Degradation of the extracellular matrix |
| REAC:R-HSA-2022090 | 6.32195304736e-07 | 0.571428571429 | COL4A4 COL4A1 COL5A2 COL17A1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-216083 | 2.10571370059e-06 | 0.571428571429 | COL4A4 COL4A1 COL13A1 COL5A2 | Integrin cell surface interactions |
| REAC:R-HSA-1474244 | 3.50957983152e-06 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | Extracellular matrix organization |
| GO:0005581 | 8.1295172324e-06 | 0.571428571429 | COL4A4 COL4A1 COL13A1 COL5A2 | collagen trimer |
| GO:0005201 | 2.74152774195e-05 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | extracellular matrix structural constituent |
| REAC:R-HSA-419037 | 3.79530741097e-05 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | NCAM1 interactions |
| REAC:R-HSA-375165 | 0.00014849904315 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | NCAM signaling for neurite out-growth |
| GO:0043062 | 0.000219456984395 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | extracellular structure organization |
| GO:0030198 | 0.000219456984395 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | extracellular matrix organization |
| REAC:R-HSA-3000171 | 0.000223455724258 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-186797 | 0.000223455724258 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | Signaling by PDGF |
| GO:0045229 | 0.000232620911116 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | external encapsulating structure organization |
| REAC:R-HSA-3000178 | 0.000397824819576 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | ECM proteoglycans |
| GO:0098644 | 0.00122180600483 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | complex of collagen trimers |
| GO:0005788 | 0.00135274447935 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | endoplasmic reticulum lumen |
| WP:WP2911 | 0.00271530250843 | 0.285714285714 | COL4A1 COL5A2 | miRNA targets in ECM and membrane receptors |
| REAC:R-HSA-2214320 | 0.00296507918884 | 0.285714285714 | COL4A1 COL4A4 | Anchoring fibril formation |
| GO:0062023 | 0.00363946301311 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | collagen-containing extracellular matrix |
| REAC:R-HSA-2243919 | 0.00455853850403 | 0.285714285714 | COL4A1 COL4A4 | Crosslinking of collagen fibrils |
| WP:WP306 | 0.00499056746055 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | Focal adhesion |
| GO:0031012 | 0.0100597714039 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | extracellular matrix |
| GO:0030312 | 0.0100597714039 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | external encapsulating structure |
| REAC:R-HSA-3000157 | 0.0133002920771 | 0.285714285714 | COL4A1 COL4A4 | Laminin interactions |
| WP:WP3932 | 0.0145518366115 | 0.428571428571 | COL4A1 COL5A2 COL4A4 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:04512 | 0.0223578432711 | 0.285714285714 | COL4A1 COL4A4 | ECM-receptor interaction |
| KEGG:05146 | 0.0367995848147 | 0.285714285714 | COL4A1 COL4A4 | Amoebiasis |
| KEGG:05222 | 0.0367995848147 | 0.285714285714 | COL4A1 COL4A4 | Small cell lung cancer |
| KEGG:04933 | 0.0376568492551 | 0.285714285714 | COL4A1 COL4A4 | AGE-RAGE signaling pathway in diabetic complications |
| GO:0005198 | 0.0497964309081 | 0.714285714286 | COL4A1 COL17A1 COL13A1 COL4A4 COL5A2 | structural molecule activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LAIR2 | COL13A1 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LAIR2 | COL4A1 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL4A4 | LAIR2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LAIR2 | COL4A5 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL6A3 | LAIR2 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL17A1 | LAIR2 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LAIR2 | COL5A2 | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| COL4A5 | COL4A1 | 0.98 | bioplex_WMM bioplex3_WMM WMM_only | ||
| COL17A1 | COL4A1 | 0.904 | bioplex3_WMM WMM_only | ||
| COL6A3 | COL4A1 | 0.904 | 0.626 | bioplex3_WMM WMM_only | |
| COL6A3 | COL4A5 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL4A5 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | ZBED2 | 0.902 | bioplex3_WMM WMM_only | ||
| COL6A3 | COL13A1 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL4A4 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL13A1 | 0.902 | bioplex3_WMM WMM_only | ||
| COL13A1 | COL4A5 | 0.832 | bioplex_WMM bioplex3_WMM WMM_only | ||
| COL13A1 | COL4A1 | 0.81 | bioplex_WMM bioplex3_WMM WMM_only | ||
| COL4A4 | COL4A1 | 0.796 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL13A1 | 0.783 | bioplex3_WMM WMM_only | ||
| COL13A1 | ZBED2 | 0.714 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL4A5 | 0.656 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL5A2 | 0.415 | bioplex3_WMM WMM_only | ||
| COL13A1 | COL5A2 | 0.278 | bioplex3_WMM WMM_only | ||
| COL6A3 | COL5A2 | 0.214 | 0.312670886076 | bioplex3_WMM WMM_only | |
| COL17A1 | COL5A2 | 0.214 | bioplex3_WMM WMM_only | ||
| COL5A2 | COL4A5 | 0.131 | bioplex3_WMM WMM_only | ||
| COL4A5 | ZBED2 | 0.131 | bioplex3_WMM WMM_only | ||
| COL5A2 | COL4A1 | 0.113 | 0.248 | bioplex3_WMM WMM_only | |
| COL4A1 | ZBED2 | 0.055 | bioplex3_WMM WMM_only |
Related Complexes