hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14656.1

Complex Portal: CPX-21846

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CFHR2	Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2)	5	UniProt NCBI
CFI	Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]	5	UniProt NCBI
C8G	Complement component C8 gamma chain	5	UniProt NCBI
MMP12	Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)	5	UniProt NCBI
KYNU	Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)	5	UniProt NCBI
GSTM5	Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5)	5	UniProt NCBI
SERPINF2	Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2)	5	UniProt NCBI
STEAP4	Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)	5	UniProt NCBI
APOBEC3A	DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1)	5	UniProt NCBI
ABCA12	Glucosylceramide transporter ABCA12 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 12) (ATP-binding cassette transporter 12) (ATP-binding cassette 12)	5	UniProt NCBI
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	5	UniProt NCBI
C6	Complement component C6	5	UniProt NCBI
STING1	Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)	5	UniProt NCBI
C8A	Complement component C8 alpha chain (Complement component 8 subunit alpha)	5	UniProt NCBI
AMBP	Protein AMBP (Protein HC) [Cleaved into: Alpha-1-microglobulin (EC 1.6.2.-) (Alpha-1 microglycoprotein) (Complex-forming glycoprotein heterogeneous in charge); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (EDC1) (HI-30) (Uronic-acid-rich protein); Trypstatin]	5	UniProt NCBI
CYB5R2	NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2)	5	UniProt NCBI
F12	Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]	5	UniProt NCBI
FERMT1	Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1)	5	UniProt NCBI
CFHR1	Complement factor H-related protein 1 (FHR-1) (H factor-like protein 1) (FHL-1) (H-factor-like 1) (H36)	5	UniProt NCBI
PRSS27	Serine protease 27 (EC 3.4.21.-) (Marapsin) (Pancreasin)	4	UniProt NCBI
PDLIM2	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04610	2.08109190352e-10	0.35	C8G CFI F12 C8A CFHR1 SERPINF2 CFHR2	Complement and coagulation cascades
REAC:R-HSA-977606	6.30078123133e-07	0.25	C8G CFHR1 C8A CFHR2 CFI	Regulation of Complement cascade
REAC:R-HSA-166658	1.43105773559e-06	0.25	C8G CFHR1 C8A CFHR2 CFI	Complement cascade
WP:WP558	5.40677784663e-05	0.2	C8G F12 CFI SERPINF2	Complement and coagulation cascades
WP:WP2806	0.000399560687837	0.2	F12 C8A CFHR2 CFI	Complement system
GO:0072562	0.00968835432513	0.25	C8G CFHR1 AMBP C8A SERPINF2	blood microparticle
HP:0005369	0.0126874425851	0.1	CFI CFHR1	Decreased circulating complement factor H concentration
REAC:R-HSA-166665	0.0153949190344	0.1	C8G C8A	Terminal pathway of complement
HP:0005356	0.0211283748318	0.1	CFI CFHR1	Decreased circulating complement factor I concentration
HP:0005416	0.0211283748318	0.1	CFI CFHR1	Decreased circulating complement factor B concentration
WP:WP5090	0.0285040101412	0.15	C8G CFI C8A	Complement system in neuronal development and plasticity
WP:WP545	0.029506639233	0.1	C8G C8A	Complement activation
HP:0004431	0.0310925435904	0.15	CFHR1 CFI C8A	Complement deficiency
WP:WP272	0.0331677310052	0.1	SERPINF2 F12	Blood clotting cascade
HP:0005339	0.0381452529772	0.15	CFHR1 CFI C8A	Abnormality of complement system
HP:0025574	0.0442967587625	0.1	CFI CFHR1	Macular hemorrhage

Edges

Protein 1	Protein 2	Score	ProteomeHD
CFHR1	CFHR2	0.996
PFKFB3	AMBP	0.904	0.018
PFKFB3	PRSS27	0.904
C8A	ABCA12	0.904
GSTM5	C6	0.904
C8A	F12	0.904
GSTM5	CFHR1	0.904
GSTM5	PDLIM2	0.904
CYB5R2	F12	0.904
C8G	CFHR1	0.904
CFI	C8G	0.904
APOBEC3A	F12	0.904
FERMT1	F12	0.904
C8G	C6	0.904
STEAP4	C6	0.904
C8G	PDLIM2	0.904
CFI	GSTM5	0.904
STING1	C6	0.904
F12	C6	0.902
PRSS27	AMBP	0.902
F12	PRSS27	0.902
F12	AMBP	0.902
C6	AMBP	0.902
PRSS27	C6	0.902
STEAP4	AMBP	0.902
STING1	AMBP	0.902	0.026
C8G	F12	0.902
GSTM5	AMBP	0.902
STING1	F12	0.902
ABCA12	C6	0.902
STEAP4	PRSS27	0.902
PDLIM2	PRSS27	0.902
APOBEC3A	PRSS27	0.902
C8G	AMBP	0.902
CFHR1	PDLIM2	0.902
CFI	ABCA12	0.902
ABCA12	AMBP	0.902	0.048
GSTM5	ABCA12	0.902
ABCA12	PRSS27	0.902
GSTM5	PRSS27	0.902
CFHR1	AMBP	0.902
CFHR1	PRSS27	0.902
CFHR1	ABCA12	0.902
C8A	AMBP	0.902
CFI	C6	0.902
KYNU	C6	0.902
C8G	ABCA12	0.902
CFI	PRSS27	0.902
CFHR1	C6	0.902
CYB5R2	MMP12	0.902
CFI	CFHR1	0.902
STEAP4	MMP12	0.902
KYNU	PRSS27	0.902
C8A	PRSS27	0.902
FERMT1	PRSS27	0.902
SERPINF2	PRSS27	0.902
STING1	PRSS27	0.902
KYNU	F12	0.902
STEAP4	F12	0.902
PDLIM2	AMBP	0.902	0.058
CYB5R2	AMBP	0.902	0.086
PDLIM2	C6	0.902
CFHR1	F12	0.902
GSTM5	F12	0.902
APOBEC3A	AMBP	0.902
C8G	PRSS27	0.902
STING1	MMP12	0.902
ABCA12	F12	0.902
KYNU	AMBP	0.902	0.062
CFI	AMBP	0.902	0.396
PDLIM2	F12	0.902
FERMT1	AMBP	0.902	0.03
CYB5R2	PRSS27	0.902
SERPINF2	AMBP	0.902	0.486
CFI	F12	0.902
CFI	PDLIM2	0.902	0.018
CFHR1	MMP12	0.902
FERMT1	C6	0.892
C8G	GSTM5	0.869
SERPINF2	F12	0.869
PFKFB3	F12	0.768
C8A	C6	0.768
APOBEC3A	C6	0.768
CYB5R2	C6	0.768
PFKFB3	ABCA12	0.768	0.028
C8A	PDLIM2	0.768
CFHR1	C8A	0.768
CFI	C8A	0.768
PFKFB3	STEAP4	0.742	0.042
GSTM5	C8A	0.73
C8G	C8A	0.73
SERPINF2	C6	0.73
C8G	KYNU	0.722
STEAP4	PDLIM2	0.722	0.056
GSTM5	KYNU	0.722
CFI	STEAP4	0.722
CFHR1	KYNU	0.717
PDLIM2	KYNU	0.717	0.036
STEAP4	ABCA12	0.717
ABCA12	KYNU	0.717	0.04
CFI	KYNU	0.717	0.034
PFKFB3	C6	0.715
PFKFB3	GSTM5	0.715
PFKFB3	CFHR1	0.715
PFKFB3	PDLIM2	0.715	0.028
CFI	PFKFB3	0.715	0.024
STING1	PFKFB3	0.715	0.02
C8G	PFKFB3	0.715
PFKFB3	KYNU	0.715	0.018
CYB5R2	ABCA12	0.714	0.086
ABCA12	FERMT1	0.714	0.068
STING1	KYNU	0.714	0.046
APOBEC3A	PFKFB3	0.703
CFI	STING1	0.703	0.002
STING1	PDLIM2	0.703	0.07
STEAP4	KYNU	0.703	0.062
APOBEC3A	ABCA12	0.703
STING1	ABCA12	0.698	0.07
CFHR1	FERMT1	0.688
CFI	FERMT1	0.688	0.018
FERMT1	KYNU	0.688	0.158
PDLIM2	FERMT1	0.688	0.064
PFKFB3	CYB5R2	0.675	0.016
PFKFB3	FERMT1	0.675	0.014
SERPINF2	PFKFB3	0.675	0.03
PFKFB3	C8A	0.675
SERPINF2	ABCA12	0.647	0.042
GSTM5	STEAP4	0.647
C8G	STEAP4	0.647
CYB5R2	FERMT1	0.634	0.058
SERPINF2	STING1	0.633	0.042
STEAP4	FERMT1	0.633	0.042
STING1	C8A	0.633
SERPINF2	CYB5R2	0.633	0.076
CYB5R2	C8A	0.633
CYB5R2	STEAP4	0.633	0.102
STING1	STEAP4	0.633	0.088
CFHR1	CYB5R2	0.633
SERPINF2	C8A	0.633
STING1	GSTM5	0.626
C8G	STING1	0.626
STING1	CFHR1	0.602
CFHR1	STEAP4	0.602
ABCA12	PDLIM2	0.578	0.034
APOBEC3A	STEAP4	0.49
C8A	KYNU	0.478
C8G	FERMT1	0.468
GSTM5	FERMT1	0.468
CFI	CYB5R2	0.468	0.046
APOBEC3A	KYNU	0.468
CYB5R2	PDLIM2	0.468	0.058
CYB5R2	KYNU	0.468	0.064
CFI	APOBEC3A	0.455
APOBEC3A	CFHR1	0.455
APOBEC3A	PDLIM2	0.455
STING1	FERMT1	0.445	0.082
STEAP4	C8A	0.427
SERPINF2	PDLIM2	0.427	0.042
SERPINF2	CFHR1	0.427
SERPINF2	CFI	0.427	0.364
C8A	FERMT1	0.418
C8G	CYB5R2	0.418
GSTM5	CYB5R2	0.418
APOBEC3A	STING1	0.418
SERPINF2	GSTM5	0.41
SERPINF2	C8G	0.41
APOBEC3A	GSTM5	0.405
C8G	APOBEC3A	0.405
SERPINF2	KYNU	0.405	0.05
SERPINF2	FERMT1	0.401	0.04
APOBEC3A	FERMT1	0.396
SERPINF2	STEAP4	0.388	0.088
APOBEC3A	C8A	0.388
STING1	CYB5R2	0.387	0.138
APOBEC3A	CYB5R2	0.378
SERPINF2	APOBEC3A	0.356

Related Complexes

Genename	Complexes
CFHR2	huMAP3_01713.1 huMAP3_14445.1 huMAP3_14656.1
CFI	huMAP3_00689.1 huMAP3_07054.1 huMAP3_08988.1 huMAP3_14295.1 huMAP3_14445.1 huMAP3_14656.1
C8G	huMAP3_01115.1 huMAP3_02438.1 huMAP3_04806.1 huMAP3_09201.1 huMAP3_10615.1 huMAP3_11128.1 huMAP3_14445.1 huMAP3_14656.1 huMAP3_14699.1
MMP12	huMAP3_02169.1 huMAP3_06558.1 huMAP3_08257.1 huMAP3_08839.1 huMAP3_14429.1 huMAP3_14656.1 huMAP3_14855.1
KYNU	huMAP3_13401.1 huMAP3_14445.1 huMAP3_14656.1
GSTM5	huMAP3_01673.1 huMAP3_14445.1 huMAP3_14656.1 huMAP3_14934.1
SERPINF2	huMAP3_00178.1 huMAP3_03904.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_08889.1 huMAP3_11660.1 huMAP3_14445.1 huMAP3_14656.1
STEAP4	huMAP3_02169.1 huMAP3_03589.1 huMAP3_06558.1 huMAP3_07692.1 huMAP3_08257.1 huMAP3_10504.1 huMAP3_14445.1 huMAP3_14656.1
APOBEC3A	huMAP3_01177.1 huMAP3_02115.1 huMAP3_08844.1 huMAP3_10183.1 huMAP3_11063.1 huMAP3_12785.1 huMAP3_14445.1 huMAP3_14656.1
ABCA12	huMAP3_02780.1 huMAP3_06413.1 huMAP3_06482.1 huMAP3_06861.1 huMAP3_07038.1 huMAP3_07078.1 huMAP3_07878.1 huMAP3_14429.1 huMAP3_14445.1 huMAP3_14656.1 huMAP3_14855.1
PFKFB3	huMAP3_01672.1 huMAP3_14445.1 huMAP3_14656.1
C6	huMAP3_14445.1 huMAP3_14656.1
STING1	huMAP3_01478.1 huMAP3_01945.1 huMAP3_03054.1 huMAP3_03558.1 huMAP3_05729.1 huMAP3_09751.1 huMAP3_10136.1 huMAP3_10342.1 huMAP3_10460.1 huMAP3_10781.1 huMAP3_11141.1 huMAP3_11660.1 huMAP3_14656.1
C8A	huMAP3_02219.1 huMAP3_05479.1 huMAP3_06036.1 huMAP3_06053.1 huMAP3_07125.1 huMAP3_07608.1 huMAP3_08238.1 huMAP3_11660.1 huMAP3_14445.1 huMAP3_14656.1
AMBP	huMAP3_14445.1 huMAP3_14656.1
CYB5R2	huMAP3_02024.1 huMAP3_02883.1 huMAP3_05678.1 huMAP3_05751.1 huMAP3_07484.1 huMAP3_07747.1 huMAP3_07812.1 huMAP3_08231.1 huMAP3_08238.1 huMAP3_08637.1 huMAP3_10374.1 huMAP3_10391.1 huMAP3_11660.1 huMAP3_14656.1
F12	huMAP3_14445.1 huMAP3_14656.1
FERMT1	huMAP3_03613.1 huMAP3_14445.1 huMAP3_14656.1
CFHR1	huMAP3_01713.1 huMAP3_08257.1 huMAP3_14445.1 huMAP3_14656.1
PRSS27	huMAP3_14445.1 huMAP3_14656.1
PDLIM2	huMAP3_02780.1 huMAP3_06413.1 huMAP3_06482.1 huMAP3_06861.1 huMAP3_07038.1 huMAP3_07078.1 huMAP3_07878.1 huMAP3_14445.1 huMAP3_14656.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14656.1

Complex Portal: CPX-21846