hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14658.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAML1 | Mastermind-like protein 1 (Mam-1) | 5 | UniProt NCBI |
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | 5 | UniProt NCBI |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor) | 5 | UniProt NCBI |
| NOTCH1 | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3113 | 7.01606139244e-10 | 0.75 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2897 | 7.01606139244e-10 | 0.75 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2890 | 7.01606139244e-10 | 0.75 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2639 | 1.54282047245e-07 | 0.75 | MAML1 RBPJ NOTCH1 | HES1 promoter-Notch enhancer complex |
| REAC:R-HSA-210744 | 2.31434954766e-07 | 0.75 | MAML1 RBPJ NOTCH1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-8941856 | 2.31434954766e-07 | 0.75 | MAML1 RBPJ NOTCH1 | RUNX3 regulates NOTCH signaling |
| WP:WP3845 | 3.38413923581e-07 | 0.75 | MAML1 RBPJ NOTCH1 | Canonical and non canonical Notch signaling |
| GO:0002193 | 3.84480164306e-07 | 0.75 | MAML1 RBPJ NOTCH1 | MAML1-RBP-Jkappa- ICN1 complex |
| GO:0007221 | 3.84480164306e-07 | 0.75 | MAML1 RBPJ NOTCH1 | positive regulation of transcription of Notch receptor target |
| REAC:R-HSA-9013695 | 6.38068337719e-07 | 0.75 | MAML1 RBPJ NOTCH1 | NOTCH4 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9793380 | 1.14413965008e-06 | 0.75 | MAML1 RBPJ NOTCH1 | Formation of paraxial mesoderm |
| REAC:R-HSA-9013508 | 1.59826617962e-06 | 0.75 | MAML1 RBPJ NOTCH1 | NOTCH3 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-350054 | 2.1588394976e-06 | 0.75 | MAML1 RBPJ NOTCH1 | Notch-HLH transcription pathway |
| REAC:R-HSA-186712 | 3.2237438451e-06 | 0.75 | MAML1 RBPJ NOTCH1 | Regulation of beta-cell development |
| WP:WP61 | 4.61939945286e-06 | 0.75 | MAML1 RBPJ NOTCH1 | Notch signaling pathway |
| CORUM:2946 | 5.12628525639e-06 | 0.5 | NOTCH1 RBPJ | YY1-Notch1-RBP-Jkappa complex |
| CORUM:2907 | 5.12628525639e-06 | 0.5 | NOTCH1 RBPJ | RBP-Jkappa-Notch1 complex |
| KEGG:04330 | 5.92375820233e-06 | 0.75 | MAML1 RBPJ NOTCH1 | Notch signaling pathway |
| REAC:R-HSA-9758941 | 1.08839322026e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Gastrulation |
| REAC:R-HSA-9012852 | 1.28002609524e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH3 |
| REAC:R-HSA-2122947 | 1.38374083551e-05 | 0.75 | MAML1 RBPJ NOTCH1 | NOTCH1 Intracellular Domain Regulates Transcription |
| KEGG:04658 | 2.21720662311e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Th1 and Th2 cell differentiation |
| REAC:R-HSA-2644606 | 2.27017011202e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 2.27017011202e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2894858 | 2.27017011202e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644602 | 2.27017011202e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 2.27017011202e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-1980143 | 4.54859086639e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 |
| REAC:R-HSA-9013694 | 8.69606201761e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH4 |
| WP:WP4147 | 9.18788843787e-05 | 0.5 | NOTCH1 RBPJ | PTF1A related regulatory pathway |
| REAC:R-HSA-1912408 | 9.82762051365e-05 | 0.75 | MAML1 RBPJ NOTCH1 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-8878159 | 0.000153311097908 | 0.75 | MAML1 RBPJ NOTCH1 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-1912422 | 0.000175410417245 | 0.75 | MAML1 RBPJ NOTCH1 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-2197563 | 0.000215205765992 | 0.5 | MAML1 RBPJ | NOTCH2 intracellular domain regulates transcription |
| WP:WP5269 | 0.00103429913449 | 0.5 | NOTCH1 RBPJ | Genetic causes of porto sinusoidal vascular disease |
| KEGG:05165 | 0.00141764261548 | 0.75 | MAML1 RBPJ NOTCH1 | Human papillomavirus infection |
| WP:WP268 | 0.00160392090455 | 0.5 | MAML1 NOTCH1 | Notch signaling |
| REAC:R-HSA-157118 | 0.00193618063067 | 0.75 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH |
| REAC:R-HSA-1980145 | 0.00282403231951 | 0.5 | MAML1 RBPJ | Signaling by NOTCH2 |
| HP:0004050 | 0.00454201288615 | 0.5 | NOTCH1 RBPJ | Absent hand |
| WP:WP2840 | 0.00528146385782 | 0.5 | NOTCH1 RBPJ | Hair follicle development cytodifferentiation part 3 of 3 |
| WP:WP4674 | 0.00612927993034 | 0.5 | MAML1 NOTCH1 | Head and neck squamous cell carcinoma |
| WP:WP2064 | 0.00685264055756 | 0.5 | NOTCH1 RBPJ | Neural crest differentiation |
| HP:0001362 | 0.0100118295947 | 0.5 | NOTCH1 RBPJ | Calvarial skull defect |
| HP:0004935 | 0.0108451581837 | 0.5 | NOTCH1 RBPJ | Pulmonary artery atresia |
| REAC:R-HSA-5663202 | 0.0116223099825 | 0.75 | MAML1 RBPJ NOTCH1 | Diseases of signal transduction by growth factor receptors and second messengers |
| WP:WP4787 | 0.0130350149263 | 0.5 | NOTCH1 RBPJ | Osteoblast differentiation and related diseases |
| HP:0002132 | 0.0135443934278 | 0.5 | NOTCH1 RBPJ | Porencephalic cyst |
| GO:0035051 | 0.0152210712647 | 0.75 | MAML1 RBPJ NOTCH1 | cardiocyte differentiation |
| HP:0001817 | 0.0165423111708 | 0.5 | NOTCH1 RBPJ | Absent fingernail |
| GO:0060379 | 0.0168521501606 | 0.5 | NOTCH1 RBPJ | cardiac muscle cell myoblast differentiation |
| HP:0002040 | 0.021003726131 | 0.5 | NOTCH1 RBPJ | Esophageal varix |
| HP:0001057 | 0.021003726131 | 0.5 | NOTCH1 RBPJ | Aplasia cutis congenita |
| WP:WP4239 | 0.0218193051527 | 0.5 | NOTCH1 RBPJ | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0002612 | 0.0246976114972 | 0.5 | NOTCH1 RBPJ | Congenital hepatic fibrosis |
| CORUM:2947 | 0.0249718442456 | 0.25 | NOTCH1 | YY1-Notch1 complex |
| HP:0008070 | 0.0252831794818 | 0.75 | NOTCH1 RBPJ NSMF | Sparse hair |
| HP:0001804 | 0.0273256954732 | 0.5 | NOTCH1 RBPJ | Hypoplastic fingernail |
| GO:0003205 | 0.0280178993418 | 0.75 | MAML1 RBPJ NOTCH1 | cardiac chamber development |
| GO:0003160 | 0.0280843539964 | 0.5 | NOTCH1 RBPJ | endocardium morphogenesis |
| HP:0006970 | 0.03008608933 | 0.5 | NOTCH1 RBPJ | Periventricular leukomalacia |
| GO:0007219 | 0.0364824972322 | 0.75 | MAML1 RBPJ NOTCH1 | Notch signaling pathway |
| HP:0100026 | 0.0391604009626 | 0.5 | NOTCH1 RBPJ | Arteriovenous malformation |
| GO:0071371 | 0.042122686785 | 0.5 | NOTCH1 NSMF | cellular response to gonadotropin stimulus |
| GO:0003222 | 0.042122686785 | 0.5 | NOTCH1 RBPJ | ventricular trabecula myocardium morphogenesis |
| HP:0001798 | 0.0458701548093 | 0.5 | NOTCH1 RBPJ | Anonychia |
| HP:0010760 | 0.049422876951 | 0.5 | NOTCH1 RBPJ | Absent toe |
| CORUM:2908 | 0.049938562206 | 0.25 | RBPJ | RBP-Jkappa-SHARP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 0.998 | 0.076 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| NOTCH1 | RBPJ | 0.98 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| MAML1 | NOTCH1 | 0.979 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| NSMF | RBPJ | 0.855 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes